| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Basavaraj V Hooli, Antonio R Parrado, Kristina Mullin, Wai-Ki Yip, Tian Liu, Johannes T Roehr, Dandi Qiao, Frank Jessen, Oliver Peters, Tim Becker, Alfredo Ramirez, Christoph Lange, Lars Bertram, Rudolph E Tanz. The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology. vol 83. issue 15. 2014-12-17. PMID:25186855. |
recently, 2 independent studies reported that a rare missense variant, rs75932628 (r47h), in exon 2 of the gene encoding the "triggering receptor expressed on myeloid cells 2" (trem2) significantly increases the risk of alzheimer disease (ad) with an effect size comparable to that of the apoe ε4 allele. |
2014-12-17 |
2023-08-13 |
Not clear |
| Andrea Flex, Silvia Giovannini, Federico Biscetti, Rosa Liperoti, Gianfranco Spalletta, Giuseppe Straface, Francesco Landi, Flavia Angelini, Carlo Caltagirone, Giovanni Ghirlanda, Roberto Bernabe. Effect of proinflammatory gene polymorphisms on the risk of Alzheimer's disease. Neuro-degenerative diseases. vol 13. issue 4. 2014-12-16. PMID:24022074. |
a number of studies associate alzheimer's disease (ad) with apoe polymorphism and alleles which favor the increased expression of immunological mediators such as cytokines or acute-phase proteins. |
2014-12-16 |
2023-08-12 |
Not clear |
| Eva Bagyinszky, Young Chul Youn, Seong Soo A An, SangYun Ki. The genetics of Alzheimer's disease. Clinical interventions in aging. vol 9. 2014-12-15. PMID:24729694. |
the apolipoprotein e (apoe) e4 allele has been found to be a main risk factor for late-onset alzheimer's disease. |
2014-12-15 |
2023-08-13 |
Not clear |
| Vanja Kljajevic, Peter Meyer, Carsten Holzmann, Martin Dyrba, Elisabeth Kasper, Arun L W Bokde, Andreas Fellgiebel, Thomas Meindl, Harald Hampel, Stefan Teipe. The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3. 2014-12-10. PMID:23706516. |
in this multicenter study, we investigated a possible association between the apoe ε4 allele and white matter (wm) integrity in alzheimer's disease (ad) using diffusion tensor imaging (dti). |
2014-12-10 |
2023-08-12 |
Not clear |
| Richard E Kennedy, Gary R Cutter, Lon S Schneide. Effect of APOE genotype status on targeted clinical trials outcomes and efficiency in dementia and mild cognitive impairment resulting from Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3. 2014-12-10. PMID:23712001. |
effect of apoe genotype status on targeted clinical trials outcomes and efficiency in dementia and mild cognitive impairment resulting from alzheimer's disease. |
2014-12-10 |
2023-08-12 |
Not clear |
| Richard E Kennedy, Gary R Cutter, Lon S Schneide. Effect of APOE genotype status on targeted clinical trials outcomes and efficiency in dementia and mild cognitive impairment resulting from Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3. 2014-12-10. PMID:23712001. |
the apolipoprotein e (apoe) ε4 genotype has been recommended as a potential inclusion or exclusion criterion in targeted clinical trials for alzheimer's disease (ad) and mild cognitive impairment (mci) resulting from ad, and has been implemented in trials of immunotherapeutic agents. |
2014-12-10 |
2023-08-12 |
Not clear |
| Yu-Ling Chang, Christine Fennema-Notestine, Dominic Holland, Linda K McEvoy, Nikki H Stricker, David P Salmon, Anders M Dale, Mark W Bond. APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3. 2014-12-10. PMID:23896613. |
apoe interacts with age to modify rate of decline in cognitive and brain changes in alzheimer's disease. |
2014-12-10 |
2023-08-12 |
Not clear |
| Yu-Ling Chang, Christine Fennema-Notestine, Dominic Holland, Linda K McEvoy, Nikki H Stricker, David P Salmon, Anders M Dale, Mark W Bond. APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3. 2014-12-10. PMID:23896613. |
to determine (1) whether age-standardized cognitive declines and brain morphometric change differ between young-old patients with alzheimer's disease (yoad) and very-old patients with alzheimer's disease (voad), and (2) whether the apolipoprotein e (apoe) genotype modifies these neuropsychological and morphometric changes. |
2014-12-10 |
2023-08-12 |
Not clear |
| David A Raichlen, Gene E Alexande. Exercise, APOE genotype, and the evolution of the human lifespan. Trends in neurosciences. vol 37. issue 5. 2014-12-09. PMID:24690272. |
however, our longevity evolved when our ancestors had two copies of the apolipoprotein e (apoe) ɛ4 allele, a genotype that leads to a high risk of alzheimer's disease (ad), cardiovascular disease, and increased mortality. |
2014-12-09 |
2023-08-13 |
human |
| Timothy A Couttas, Nupur Kain, Benjamin Daniels, Xin Ying Lim, Claire Shepherd, Jillian Kril, Russell Pickford, Hongyun Li, Brett Garner, Anthony S Do. Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. Acta neuropathologica communications. vol 2. 2014-12-08. PMID:24456642. |
the greatest genetic risk factor for late-onset alzheimer's disease (ad) is the ϵ4 allele of apolipoprotein e (apoe). |
2014-12-08 |
2023-08-12 |
human |
| Sun Ju Chung, Mi-Jung Kim, Young Jin Kim, Juyeon Kim, Sooyeoun You, Eun Hye Jang, Seong Yoon Kim, Jae-Hong Le. CR1, ABCA7, and APOE genes affect the features of cognitive impairment in Alzheimer's disease. Journal of the neurological sciences. vol 339. issue 1-2. 2014-12-08. PMID:24530172. |
cr1, abca7, and apoe genes affect the features of cognitive impairment in alzheimer's disease. |
2014-12-08 |
2023-08-12 |
Not clear |
| Jesus J Gomar, Marc L Gordon, Dwight Dickinson, Peter B Kingsley, Aziz M Uluğ, Lynda Keehlisen, Sarah Huet, Justin J Buthorn, Jeremy Koppel, Erica Christen, Concepcion Conejero-Goldberg, Peter Davies, Terry E Goldber. APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain. Biological psychiatry. vol 75. issue 9. 2014-12-04. PMID:23831342. |
we aimed to quantify brain metabolite changes in healthy subjects in relation to age and the presence of the apoe e4 genetic risk factor for alzheimer's disease. |
2014-12-04 |
2023-08-12 |
human |
| Jon B Toledo, Xiao Da, Michael W Weiner, David A Wolk, Sharon X Xie, Steven E Arnold, Christos Davatzikos, Leslie M Shaw, John Q Trojanowsk. CSF Apo-E levels associate with cognitive decline and MRI changes. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24385135. |
apolipoprotein e (apoe) ε4 allele is the most important genetic risk factor for alzheimer's disease (ad) and it is thought to do so by modulating levels of its product, apolipoprotein e (apo-e), and regulating amyloid-β (aβ) clearance. |
2014-12-03 |
2023-08-12 |
human |
| Eduardo Martínez-Morillo, Oskar Hansson, Yuka Atagi, Guojun Bu, Lennart Minthon, Eleftherios P Diamandis, Henrietta M Nielse. Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls. Acta neuropathologica. vol 127. issue 5. 2014-12-03. PMID:24633805. |
the apolipoprotein e (apoe) ε4 allele is the strongest risk factor of sporadic alzheimer's disease (ad), however, the fluid concentrations of apoe and its different isoforms (apoe2, apoe3 and apoe4) in ad patients and among apoe genotypes (apoe ε2, ε3, ε4) remain controversial. |
2014-12-03 |
2023-08-12 |
human |
| M Chaudhry, S Hasnain, B E Snitz, X Wang, S Rosenthal, F Y Demirci, M I Kambo. Association of APOE polymorphisms and stressful life events with dementia in a Pakistani population. Neuroscience letters. vol 570. 2014-12-01. PMID:24746929. |
alzheimer's disease (ad) is a major form of dementia and the apoe 4 allele is an established genetic risk factor for ad. |
2014-12-01 |
2023-08-13 |
human |
| Florence F Roussotte, Boris A Gutman, Sarah K Madsen, John B Colby, Katherine L Narr, Paul M Thompso. Apolipoprotein E epsilon 4 allele is associated with ventricular expansion rate and surface morphology in dementia and normal aging. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24411483. |
brain structure and function depend on apoe genotype not just for alzheimer's disease patients but also in healthy elderly individuals, and even in asymptomatic young individuals. |
2014-11-25 |
2023-08-12 |
human |
| Florence F Roussotte, Boris A Gutman, Sarah K Madsen, John B Colby, Katherine L Narr, Paul M Thompso. Apolipoprotein E epsilon 4 allele is associated with ventricular expansion rate and surface morphology in dementia and normal aging. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24411483. |
apoe genotyping is considered critical in clinical trials of alzheimer's disease. |
2014-11-25 |
2023-08-12 |
human |
| Ricardo S Osorio, Indu Ayappa, Janna Mantua, Tyler Gumb, Andrew Varga, Anne M Mooney, Omar E Burschtin, Zachary Taxin, Emmanuel During, Nicole Spector, Milton Biagioni, Elizabeth Pirraglia, Hiuyan Lau, Henrik Zetterberg, Kaj Blennow, Shou-En Lu, Lisa Mosconi, Lidia Glodzik, David M Rapoport, Mony J de Leo. Interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24439479. |
in the present study, we analyzed the relationship between sdb severity, cerebrospinal fluid (csf) alzheimer's disease-biomarkers, and the apoe alleles. |
2014-11-25 |
2023-08-12 |
human |
| Donald M Lyall, Sarah E Harris, Mark E Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W Lutz, Ann M Saunders, Allen D Roses, Maria del C Valdés Hernández, Natalie A Royle, John M Starr, David J Porteous, Joanna M Wardlaw, Ian J Dear. Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24508314. |
alzheimer's disease susceptibility genes apoe and tomm40, and brain white matter integrity in the lothian birth cohort 1936. |
2014-11-25 |
2023-08-12 |
human |
| Donald M Lyall, Sarah E Harris, Mark E Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W Lutz, Ann M Saunders, Allen D Roses, Maria del C Valdés Hernández, Natalie A Royle, John M Starr, David J Porteous, Joanna M Wardlaw, Ian J Dear. Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24508314. |
apolipoprotein e (apoe) ε genotype has previously been significantly associated with cognitive, brain imaging, and alzheimer's disease-related phenotypes (e.g., age of onset). |
2014-11-25 |
2023-08-12 |
human |