| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beata Ferencz, Erika J Laukka, Anna-Karin Welmer, Grégoria Kalpouzos, Sara Angleman, Lina Keller, Caroline Graff, Martin Lövdén, Lars Bäckma. The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning. Psychology and aging. vol 29. issue 2. 2015-03-18. PMID:24660791. |
picalm, bin1, clu, and apoe are top candidate genes for alzheimer's disease, and they influence episodic memory performance in old age. |
2015-03-18 |
2023-08-12 |
human |
| Wael Alata, Yue Ye, Isabelle St-Amour, Milène Vandal, Frédéric Calo. Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 1. 2015-03-17. PMID:25335802. |
human apolipoprotein e (apoe) exists in three isoforms ɛ2, ɛ3, and ɛ4, of which apoe4 is the main genetic risk factor of alzheimer's disease (ad). |
2015-03-17 |
2023-08-13 |
mouse |
| Verena Heise, Nicola Filippini, Aaron J Trachtenberg, Sana Suri, Klaus P Ebmeier, Clare E Macka. Apolipoprotein E genotype, gender and age modulate connectivity of the hippocampus in healthy adults. NeuroImage. vol 98. 2015-03-09. PMID:24814213. |
important risk factors for alzheimer's disease (ad) are ageing and the apolipoprotein e (apoe) ε4 allele, with female apoe ε4 carriers having the greatest risk. |
2015-03-09 |
2023-08-13 |
human |
| William T Hu, Kelly D Watts, Leslie M Shaw, Jennifer C Howell, John Q Trojanowski, Sundeep Basra, Jonathan D Glass, James J Lah, Allan I Leve. CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease? Annals of clinical and translational neurology. vol 2. issue 2. 2015-03-09. PMID:25750918. |
to characterize biological and technical factors which influence cerebrospinal fluid (csf) alzheimer's disease (ad) biomarker levels, including the presence of apolipoprotein e (apoe) ε4 allele, ad diagnosis, aβ-binding proteins, sample processing, and preanalytical handling. |
2015-03-09 |
2023-08-13 |
Not clear |
| Adam C Naj, Gyungah Jun, Christiane Reitz, Brian W Kunkle, William Perry, Yo Son Park, Gary W Beecham, Ruchita A Rajbhandary, Kara L Hamilton-Nelson, Li-San Wang, John S K Kauwe, Matthew J Huentelman, Amanda J Myers, Thomas D Bird, Bradley F Boeve, Clinton T Baldwin, Gail P Jarvik, Paul K Crane, Ekaterina Rogaeva, M Michael Barmada, F Yesim Demirci, Carlos Cruchaga, Patricia L Kramer, Nilufer Ertekin-Taner, John Hardy, Neill R Graff-Radford, Robert C Green, Eric B Larson, Peter H St George-Hyslop, Joseph D Buxbaum, Denis A Evans, Julie A Schneider, Kathryn L Lunetta, M Ilyas Kamboh, Andrew J Saykin, Eric M Reiman, Philip L De Jager, David A Bennett, John C Morris, Thomas J Montine, Alison M Goate, Deborah Blacker, Debby W Tsuang, Hakon Hakonarson, Walter A Kukull, Tatiana M Foroud, Eden R Martin, Jonathan L Haines, Richard P Mayeux, Lindsay A Farrer, Gerard D Schellenberg, Margaret A Pericak-Vance, Marilyn S Albert, Roger L Albin, Liana G Apostolova, Steven E Arnold, Robert Barber, Lisa L Barnes, Thomas G Beach, James T Becker, Duane Beekly, Eileen H Bigio, James D Bowen, Adam Boxer, James R Burke, Nigel J Cairns, Laura B Cantwell, Chuanhai Cao, Chris S Carlson, Regina M Carney, Minerva M Carrasquillo, Steven L Carroll, Helena C Chui, David G Clark, Jason Corneveaux, David H Cribbs, Elizabeth A Crocco, Charles DeCarli, Steven T DeKosky, Malcolm Dick, Dennis W Dickson, Ranjan Duara, Kelley M Faber, Kenneth B Fallon, Martin R Farlow, Steven Ferris, Matthew P Frosch, Douglas R Galasko, Mary Ganguli, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Jonathan D Glass, John H Growdon, Ronald L Hamilton, Lindy E Harrell, Elizabeth Head, Lawrence S Honig, Christine M Hulette, Bradley T Hyman, Gregory A Jicha, Lee-Way Jin, Anna Karydas, Jeffrey A Kaye, Ronald Kim, Edward H Koo, Neil W Kowall, Joel H Kramer, Frank M LaFerla, James J Lah, James B Leverenz, Allan I Levey, Ge Li, Andrew P Lieberman, Chiao-Feng Lin, Oscar L Lopez, Constantine G Lyketsos, Wendy J Mack, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Jill R Murrell, John M Olichney, Vernon S Pankratz, Joseph E Parisi, Henry L Paulson, Elaine Peskind, Ronald C Petersen, Aimee Pierce, Wayne W Poon, Huntington Potter, Joseph F Quinn, Ashok Raj, Murray Raskind, Barry Reisberg, John M Ringman, Erik D Roberson, Howard J Rosen, Roger N Rosenberg, Mary Sano, Lon S Schneider, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Rudolph E Tanzi, Tricia A Thornton-Wells, John Q Trojanowski, Juan C Troncoso, Otto Valladares, Vivianna M Van Deerlin, Linda J Van Eldik, Badri N Vardarajan, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Jennifer Williamson, Sarah Wishnek, Randall L Woltjer, Clinton B Wright, Steven G Younkin, Chang-En Yu, Lei Y. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA neurology. vol 71. issue 11. 2015-03-04. PMID:25199842. |
because apoe locus variants contribute to risk of late-onset alzheimer disease (load) and to differences in age at onset (aao), it is important to know whether other established load risk loci also affect aao in affected participants. |
2015-03-04 |
2023-08-13 |
human |
| Jie Shi, Natasha Leporé, Boris A Gutman, Paul M Thompson, Leslie C Baxter, Richard J Caselli, Yalin Wan. Genetic influence of apolipoprotein E4 genotype on hippocampal morphometry: An N = 725 surface-based Alzheimer's disease neuroimaging initiative study. Human brain mapping. vol 35. issue 8. 2015-02-27. PMID:24453132. |
the apolipoprotein e (apoe) e4 allele is the most prevalent genetic risk factor for alzheimer's disease (ad). |
2015-02-27 |
2023-08-12 |
human |
| Jie Shi, Natasha Leporé, Boris A Gutman, Paul M Thompson, Leslie C Baxter, Richard J Caselli, Yalin Wan. Genetic influence of apolipoprotein E4 genotype on hippocampal morphometry: An N = 725 surface-based Alzheimer's disease neuroimaging initiative study. Human brain mapping. vol 35. issue 8. 2015-02-27. PMID:24453132. |
here we examined the effect of apoe e4 on hippocampal morphometry in a large imaging database-the alzheimer's disease neuroimaging initiative (adni). |
2015-02-27 |
2023-08-12 |
human |
| André Karch, Henrike Manthey, Claudia Ponto, Peter Hermann, Uta Heinemann, Christian Schmidt, Inga Zer. Investigating the association of ApoE genotypes with blood-brain barrier dysfunction measured by cerebrospinal fluid-serum albumin ratio in a cohort of patients with different types of dementia. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386372. |
since more than a decade apoe is known to be a strong risk factor for alzheimer's disease (ad); however, molecular pathways mediating this risk are still unclear. |
2015-02-23 |
2023-08-12 |
Not clear |
| Kanchan Garai, Philip B Verghese, Berevan Baban, David M Holtzman, Carl Friede. The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation. Biochemistry. vol 53. issue 40. 2015-02-19. PMID:25207746. |
deposition of amyloid-β (aβ) in alzheimer's disease (ad) is strongly correlated with the apoe genotype. |
2015-02-19 |
2023-08-13 |
Not clear |
| I I Nizamutdinov, T V Andreeva, V A Stepanov, A V Marusin, E I Rogaev, A S Zasedatelev, T V Nasedkin. [Biochip for determination of genetic markers of sporadic Alzheimer's disease in the Russian Slavic population]. Molekuliarnaia biologiia. vol 47. issue 6. 2015-02-10. PMID:25509857. |
based on the results of genotyping of 166 patients and 128 controls apoe epsilon4 allele was found to be significantly associated with alzheimer's disease susceptibility (or = 2.275, 95% ci = 1.045-4.954,p = 0.034). |
2015-02-10 |
2023-08-13 |
Not clear |
| I I Nizamutdinov, T V Andreeva, V A Stepanov, A V Marusin, E I Rogaev, A S Zasedatelev, T V Nasedkin. [Biochip for determination of genetic markers of sporadic Alzheimer's disease in the Russian Slavic population]. Molekuliarnaia biologiia. vol 47. issue 6. 2015-02-10. PMID:25509857. |
gene-gene interaction revealed two genotype combinations associated with alzheimer's disease: apoe e3/e4 gab2 g/g (or = 2.49; ci = 1.43-4.32, p = 0.001) and apoe epsilon4 gab2 g/g (or = 3.55, ci = 1.23-10.24,p = 0.015). |
2015-02-10 |
2023-08-13 |
Not clear |
| Giovanna Viticchi, Lorenzo Falsetti, Fabrizio Vernieri, Claudia Altamura, Riccardo Altavilla, Simona Luzzi, Marco Bartolini, Leandro Provinciali, Mauro Silvestrin. Apolipoprotein E genotype and cerebrovascular alterations can influence conversion to dementia in patients with mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 41. issue 2. 2015-02-09. PMID:24625799. |
the presence of apolipoprotein e (apoe) ε4 allele is the only recognized genetic risk factor for the sporadic form of alzheimer's disease. |
2015-02-09 |
2023-08-12 |
Not clear |
| Hiroaki Kobayashi, Haru Okamoto, Akira Murakami, Takeshi Iwat. Plasma proteome analysis on cynomolgus monkey (Macaca fascicularis) pedigrees with early onset drusen formation. Experimental animals. vol 63. issue 3. 2015-02-09. PMID:25077760. |
one of the identified proteins, apolipoprotein e (apoe), is structural component of drusen and also related with other neurodegenerative disease like alzheimer disease. |
2015-02-09 |
2023-08-13 |
human |
| Julien Dumurgier, Jean-Louis Laplanche, Francois Mouton-Liger, Pauline Lapalus, Sandrine Indart, Magali Prévot, Katell Peoc'h, Jacques Hugon, Claire Paque. The screening of Alzheimer's patients with CSF biomarkers, modulates the distribution of APOE genotype: impact on clinical trials. Journal of neurology. vol 261. issue 6. 2015-02-02. PMID:24728335. |
the screening of alzheimer's patients with csf biomarkers, modulates the distribution of apoe genotype: impact on clinical trials. |
2015-02-02 |
2023-08-13 |
Not clear |
| Julien Dumurgier, Jean-Louis Laplanche, Francois Mouton-Liger, Pauline Lapalus, Sandrine Indart, Magali Prévot, Katell Peoc'h, Jacques Hugon, Claire Paque. The screening of Alzheimer's patients with CSF biomarkers, modulates the distribution of APOE genotype: impact on clinical trials. Journal of neurology. vol 261. issue 6. 2015-02-02. PMID:24728335. |
polymorphism of the apolipoprotein e gene (apoe) plays a role in the level of neuropathological lesions and in drug response in alzheimer's disease (ad). |
2015-02-02 |
2023-08-13 |
Not clear |
| Joshua D Rizak, Yuanye Ma, Xintian H. Is formaldehyde the missing link in AD pathology? The differential aggregation of amyloid-beta with APOE isoforms in vitro. Current Alzheimer research. vol 11. issue 5. 2015-02-02. PMID:24766729. |
apolipoprotein e (apoe) genetic variation and aging are the two most noted risk factors associated with the development of alzheimer's disease (ad) related dementia. |
2015-02-02 |
2023-08-13 |
Not clear |
| Xiao Wang, Huali Wang, Huiying Li, Tao Li, Xin Y. Frequency of the apolipoprotein E ε4 allele in a memory clinic cohort in Beijing: a naturalistic descriptive study. PloS one. vol 9. issue 6. 2015-01-29. PMID:24914687. |
to describe the distribution of apolipoprotein e (apoe) genotypes among an elderly chinese patient population with memory complaints treated in a memory clinic in beijing and to compare the ε4 allele frequency among individuals with subjective cognitive impairment (sci), mild cognitive impairment (mci) and alzheimer's disease (ad). |
2015-01-29 |
2023-08-13 |
Not clear |
| Guro Berge, Sigrid B Sando, Arvid Rongve, Dag Aarsland, Linda R Whit. Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort. Journal of neurology, neurosurgery, and psychiatry. vol 85. issue 11. 2015-01-26. PMID:24639435. |
results conflict concerning the relevance of apoe alleles on the development of dementia with lewy bodies (dlb), though they are well established in connection with alzheimer's disease (ad). |
2015-01-26 |
2023-08-12 |
Not clear |
| Zoltán Bochdanovits, Javier Simón-Sánchez, Marianne Jonker, Witte J Hoogendijk, Aad van der Vaart, Peter Heutin. Accurate prediction of a minimal region around a genetic association signal that contains the causal variant. European journal of human genetics : EJHG. vol 22. issue 2. 2015-01-20. PMID:23736218. |
we apply our method to two genome-wide association data sets and localize both the functional variant rep1 in the α-synuclein gene that conveys susceptibility to parkinson's disease and the apoe gene responsible for the association signal in the alzheimer's disease data set. |
2015-01-20 |
2023-08-12 |
Not clear |
| Jun Li, Fuchang Zhang, Yunliang Wang, Yan Wang, Wei Qin, Qinghe Xing, Xueqing Qian, Tingwei Guo, Xiaocai Gao, Lin He, Jianjun Ga. Association between ε2/3/4, promoter polymorphism (-491A/T, -427T/C, and -219T/G) at the apolipoprotein E gene, and mental retardation in children from an iodine deficiency area, China. BioMed research international. vol 2014. 2015-01-20. PMID:24790992. |
several common single-nucleotide polymorphisms (snps) at apolipoprotein e (apoe) have been linked with late onset sporadic alzheimer's disease and declining normative cognitive ability in elder people, but we are unclear about their relationship with cognition in children. |
2015-01-20 |
2023-08-13 |
Not clear |