| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yukiko Hori, Tadafumi Hashimoto, Hidetoshi Nomoto, Bradley T Hyman, Takeshi Iwatsub. Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO. The Journal of biological chemistry. vol 290. issue 24. 2015-09-10. PMID:25918154. |
human apoe ϵ4 allele is a strong genetic risk factor of alzheimer disease. |
2015-09-10 |
2023-08-13 |
mouse |
| Giuseppe Tosto, Hongjun Fu, Badri N Vardarajan, Joseph H Lee, Rong Cheng, Dolly Reyes-Dumeyer, Rafael Lantigua, Martin Medrano, Ivonne Z Jimenez-Velazquez, Mitchell S V Elkind, Clinton B Wright, Ralph L Sacco, Margaret Pericak-Vance, Lindsay Farrer, Ekaterina Rogaeva, Peter St George-Hyslop, Christiane Reitz, Richard Mayeu. F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease. Annals of clinical and translational neurology. vol 2. issue 8. 2015-09-04. PMID:26339675. |
in the context of late-onset alzheimer's disease (load) over 20 genes have been identified but, aside apoe, all show small effect sizes, leaving a large part of the genetic component unexplained. |
2015-09-04 |
2023-08-13 |
Not clear |
| Lars Nyberg, Alireza Salam. The APOE ε4 allele in relation to brain white-matter microstructure in adulthood and aging. Scandinavian journal of psychology. vol 55. issue 3. 2015-09-03. PMID:24506254. |
the apolipoprotein e (apoe) ε4 allele is a major genetic risk factor for sporadic alzheimer's disease and has been associated with structural and functional brain alterations across the adult life span. |
2015-09-03 |
2023-08-12 |
Not clear |
| Pamela M Greenwood, Thomas Espeseth, Ming-Kuan Lin, Ivar Reinvang, Raja Parasurama. Longitudinal change in working memory as a function of APOE genotype in midlife and old age. Scandinavian journal of psychology. vol 55. issue 3. 2015-09-03. PMID:24853824. |
we have advanced a "cognitive phenotype" hypothesis arguing that the ε4 allele of the apolipoprotein e gene (apoe) is associated with lower efficiency of neuronal plasticity thereby resulting in poorer cognitive performance independently of the pathology of alzheimer's disease (greenwood et al., ). |
2015-09-03 |
2023-08-13 |
Not clear |
| Seppo Helisalmi, Anette Hall, Esa-Heikki Meriläinen, Viljami Väisänen, Anne Maria Koivisto, Sanna-Kaisa Herukka, Marjo Laitinen, Hilkka Soininen, Mikko Hiltune. The effect of TOMM40 poly-T repeat lengths on age of onset and cerebrospinal fluid biomarkers in Finnish Alzheimer's disease patients. Neuro-degenerative diseases. vol 14. issue 4. 2015-09-03. PMID:25500937. |
poly-t repeat lengths of rs10524523 in tomm40 together with apoe polymorphism have been reported to affect the risk of late-onset alzheimer's disease (load) and the age of onset (aoo). |
2015-09-03 |
2023-08-13 |
Not clear |
| Saeed Mohammad Al-Asmary, Saeed Kadasah, Misbahul Arfin, Mohammad Tariq, Abdulrahman Al-Asmar. Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis. Archives of medical science : AMS. vol 11. issue 4. 2015-08-31. PMID:26322100. |
apolipoprotein e (apoe) genotypes influence the phenotype of several neurodegenerative disorders including alzheimer's and parkinson disease and may affect schizophrenia pathogenesis. |
2015-08-31 |
2023-08-13 |
Not clear |
| Carlos Velez-Pardo, Winston Rojas, Marlene Jimenez-Del-Rio, Gabriel Bedoy. Distribution of APOE polymorphism in the "Paisa" population from northwest Colombia (Antioquia). Annals of human biology. vol 42. issue 2. 2015-08-28. PMID:25026367. |
since the discovery of the apoe*2 and apoe*4 as the major susceptibility alleles for several diseases including dyslipidemia, atherosclerosis, coronary heart disease, late-onset and early alzheimer's disease, the apoe genotype might be considered as a potential predictive factor for both epidemiological research and diagnosis. |
2015-08-28 |
2023-08-13 |
Not clear |
| Allen H J Yang, Kuangwen Hsieh, Adriana S Patterson, B Scott Ferguson, Michael Eisenstein, Kevin W Plaxco, H Tom So. Accurate zygote-specific discrimination of single-nucleotide polymorphisms using microfluidic electrochemical DNA melting curves. Angewandte Chemie (International ed. in English). vol 53. issue 12. 2015-08-26. PMID:24520069. |
as an example, we used our sensor to analyze two snps in the apolipoprotein e (apoe) gene, where homozygous and heterozygous mutations greatly affect the risk of late-onset alzheimer's disease. |
2015-08-26 |
2023-08-12 |
Not clear |
| John J Graybeal, P Lorenzo Bozzelli, Lacey L Graybeal, Caitlin M Groeber, Patrick E McKnight, Daniel N Cox, Jane M Flin. Human ApoE ε4 alters circadian rhythm activity, IL-1β, and GFAP in CRND8 mice. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25159669. |
these data are congruent with other studies showing that human apoe ε4 is protective early in life in transgenic mice modeling alzheimer's disease. |
2015-08-21 |
2023-08-13 |
mouse |
| Midori Suenaga, Akiko Furuta, Koichi Wakabayashi, Toshiji Saibara, Yoichi Matsunag. Monocytic elastase-mediated apolipoprotein-E degradation: Potential involvement of microglial elastase-like proteases in apolipoprotein-E proteolysis in brains with Alzheimers disease. Biochimica et biophysica acta. vol 1854. issue 8. 2015-08-21. PMID:25956321. |
impaired clearance of soluble aβ (amyloid-β) promotes aβ aggregation in brains with alzheimer's disease (ad), while apolipoprotein-e (apoe) in microglia mediates aβ clearance. |
2015-08-21 |
2023-08-13 |
mouse |
| Retraction: Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease. Nature. vol 523. issue 7562. 2015-08-20. PMID:26083746. |
retraction: integrative genomics identifies apoe ε4 effectors in alzheimer's disease. |
2015-08-20 |
2023-08-13 |
Not clear |
| Caroline S Casey, Yuka Atagi, Yu Yamazaki, Mitsuru Shinohara, Masaya Tachibana, Yuan Fu, Guojun Bu, Takahisa Kanekiy. Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway. The Journal of biological chemistry. vol 290. issue 22. 2015-08-18. PMID:25903128. |
these small contractile cells produce large quantities of apolipoprotein e (apoe) whose isoforms influence cerebrovascular functions and determine the genetic risk for alzheimer disease. |
2015-08-18 |
2023-08-13 |
Not clear |
| Caroline S Casey, Yuka Atagi, Yu Yamazaki, Mitsuru Shinohara, Masaya Tachibana, Yuan Fu, Guojun Bu, Takahisa Kanekiy. Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway. The Journal of biological chemistry. vol 290. issue 22. 2015-08-18. PMID:25903128. |
we found that knockdown of apoe expression significantly accelerates pericyte migration, an effect that can be rescued by exogenous apoe3, but not apoe4, a risk factor for alzheimer disease. |
2015-08-18 |
2023-08-13 |
Not clear |
| David D Ward, Mathew J Summers, Nichole L Saunders, Pierce Janssen, Kimberley E Stuart, James C Vicker. APOE and BDNF Val66Met polymorphisms combine to influence episodic memory function in older adults. Behavioural brain research. vol 271. 2015-08-14. PMID:24946073. |
recent investigations have suggested that apoe polymorphisms do not contribute to non-pathological cognitive function and that any effect is likely due to prodromal alzheimer's disease (ad). |
2015-08-14 |
2023-08-13 |
human |
| Jalal Gharesouran, Maryam Rezazadeh, Aziz Khorrami, Morteza Ghojazadeh, Mahnaz Taleb. Genetic evidence for the involvement of variants at APOE, BIN1, CR1, and PICALM loci in risk of late-onset Alzheimer's disease and evaluation for interactions with APOE genotypes. Journal of molecular neuroscience : MN. vol 54. issue 4. 2015-08-14. PMID:25022885. |
genetic evidence for the involvement of variants at apoe, bin1, cr1, and picalm loci in risk of late-onset alzheimer's disease and evaluation for interactions with apoe genotypes. |
2015-08-14 |
2023-08-13 |
human |
| Edmond Teng, Nicole Chow, Kristy S Hwang, Paul M Thompson, Karen H Gylys, Gregory M Cole, Clifford R Jack, Leslie M Shaw, John Q Trojanowski, Holly D Soares, Michael W Weiner, Liana G Apostolov. Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dementia and geriatric cognitive disorders. vol 39. issue 3-4. 2015-08-07. PMID:25547651. |
low plasma apoe levels are associated with smaller hippocampal size in the alzheimer's disease neuroimaging initiative cohort. |
2015-08-07 |
2023-08-13 |
human |
| Edmond Teng, Nicole Chow, Kristy S Hwang, Paul M Thompson, Karen H Gylys, Gregory M Cole, Clifford R Jack, Leslie M Shaw, John Q Trojanowski, Holly D Soares, Michael W Weiner, Liana G Apostolov. Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dementia and geriatric cognitive disorders. vol 39. issue 3-4. 2015-08-07. PMID:25547651. |
apolipoprotein e (apoe) genotype is the strongest known genetic risk factor for sporadic alzheimer's disease (ad), but the utility of plasma apoe levels for assessing the severity of underlying neurodegenerative changes remains uncertain. |
2015-08-07 |
2023-08-13 |
human |
| Edmond Teng, Nicole Chow, Kristy S Hwang, Paul M Thompson, Karen H Gylys, Gregory M Cole, Clifford R Jack, Leslie M Shaw, John Q Trojanowski, Holly D Soares, Michael W Weiner, Liana G Apostolov. Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dementia and geriatric cognitive disorders. vol 39. issue 3-4. 2015-08-07. PMID:25547651. |
here, we examined cross-sectional associations between plasma apoe levels and volumetric magnetic resonance imaging indices of the hippocampus from 541 participants [57 with normal cognition (nc), 375 with mild cognitive impairment (mci), and 109 with mild ad] who were enrolled in the alzheimer's disease neuroimaging initiative. |
2015-08-07 |
2023-08-13 |
human |
| Keith A Josephs, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Matthew L Senjem, Val J Lowe, Clifford R Jack, Jennifer L Whitwel. APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 6. 2015-07-30. PMID:24985533. |
apolipoprotein e ε4 (apoe ε4) is a risk factor for β-amyloid deposition in alzheimer's disease dementia. |
2015-07-30 |
2023-08-13 |
Not clear |
| Daniel M Michaelso. APOE ε4: the most prevalent yet understudied risk factor for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 6. 2015-07-30. PMID:25217293. |
apoe ε4: the most prevalent yet understudied risk factor for alzheimer's disease. |
2015-07-30 |
2023-08-13 |
Not clear |