| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao Wang, Jinhui Wang, Yi He, Huiying Li, Huishu Yuan, Alan Evans, Xin Yu, Yong He, Huali Wan. Apolipoprotein E ε4 Modulates Cognitive Profiles, Hippocampal Volume, and Resting-State Functional Connectivity in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 3. 2016-01-19. PMID:25624419. |
the apolipoprotein e ε4 (apoe ε4) allele is a well-established genetic risk factor for alzheimer's disease (ad). |
2016-01-19 |
2023-08-13 |
Not clear |
| Pablo Cuesta, Ana Barabash, Sara Aurtenetxe, Pilar Garcés, María Eugenia López, Ricardo Bajo, Marcos Llanero-Luque, Inés Ancín, José Antonio Cabranes, Alberto Marcos, Miguel Sancho, Akinori Nakamura, Fernando Maestú, Alberto Fernande. Source analysis of spontaneous magnetoencephalograpic activity in healthy aging and mild cognitive impairment: influence of apolipoprotein E polymorphism. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079806. |
the apolipoprotein e (apoe) ε4 allele is a genetic risk factor for the development of late-onset alzheimer's disease (ad), which affects cholinergic system functioning. |
2016-01-15 |
2023-08-13 |
human |
| Jennifer Rusted, Roxana O Carar. Are the effects of APOE ϵ4 on cognitive function in nonclinical populations age- and gender-dependent? Neurodegenerative disease management. vol 5. issue 1. 2016-01-13. PMID:25711453. |
apoe ϵ4 - one of three possible allelic variants (ϵ2, ϵ3 and ϵ4) of the polymorphic protein apoe - is well characterized in its role as the strongest risk factor (after old age) for sporadic alzheimer's disease (ad). |
2016-01-13 |
2023-08-13 |
Not clear |
| Kanayo Satoh, Sumiko Abe-Dohmae, Shinji Yokoyama, Peter St George-Hyslop, Paul E Frase. ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing. The Journal of biological chemistry. vol 290. issue 40. 2016-01-06. PMID:26260791. |
several potential loss-of-function abca7 mutations and deletions linked to alzheimer disease that in some instances have a greater impact than apoe allelic variants have recently been identified. |
2016-01-06 |
2023-08-13 |
mouse |
| Yaojing Chen, Kewei Chen, Junying Zhang, Xin Li, Ni Shu, Jun Wang, Zhanjun Zhang, Eric M Reima. Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE ɛ4 allele. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 5. 2015-12-31. PMID:25403724. |
as the apolipoprotein e (apoe) ɛ4 allele is a major genetic risk factor for sporadic alzheimer's disease (ad), which has been suggested as a disconnection syndrome manifested by the disruption of white matter (wm) integrity and functional connectivity (fc), elucidating the subtle brain structural and functional network changes in cognitively normal ɛ4 carriers is essential for identifying sensitive neuroimaging based biomarkers and understanding the preclinical ad-related abnormality development. |
2015-12-31 |
2023-08-13 |
human |
| Jinhui Wang, Xiao Wang, Yi He, Xin Yu, Huali Wang, Yong H. Apolipoprotein E ε4 modulates functional brain connectome in Alzheimer's disease. Human brain mapping. vol 36. issue 5. 2015-12-31. PMID:25619771. |
the apolipoprotein e (apoe) ɛ4 allele is a well-established genetic risk factor for alzheimer's disease (ad). |
2015-12-31 |
2023-08-13 |
Not clear |
| Theresa Pohlkamp, Murat Durakoglugil, Courtney Lane-Donovan, Xunde Xian, Eric B Johnson, Robert E Hammer, Joachim Her. Lrp4 domains differentially regulate limb/brain development and synaptic plasticity. PloS one. vol 10. issue 2. 2015-12-29. PMID:25688974. |
apolipoprotein e (apoe) genotype is the strongest predictor of alzheimer's disease (ad) risk. |
2015-12-29 |
2023-08-13 |
Not clear |
| Shan Jiang, Wanling Yang, Yu Qiu, Hong-Zhuan Che. Identification of novel quantitative traits-associated susceptibility loci for APOE ε 4 non-carriers of Alzheimer's disease. Current Alzheimer research. vol 12. issue 3. 2015-12-15. PMID:25731621. |
identification of novel quantitative traits-associated susceptibility loci for apoe ε 4 non-carriers of alzheimer's disease. |
2015-12-15 |
2023-08-13 |
human |
| Shan Jiang, Wanling Yang, Yu Qiu, Hong-Zhuan Che. Identification of novel quantitative traits-associated susceptibility loci for APOE ε 4 non-carriers of Alzheimer's disease. Current Alzheimer research. vol 12. issue 3. 2015-12-15. PMID:25731621. |
apoe ε4 allele is a major risk factor in late-onset alzheimer's disease (ad). |
2015-12-15 |
2023-08-13 |
human |
| Shan Jiang, Wanling Yang, Yu Qiu, Hong-Zhuan Che. Identification of novel quantitative traits-associated susceptibility loci for APOE ε 4 non-carriers of Alzheimer's disease. Current Alzheimer research. vol 12. issue 3. 2015-12-15. PMID:25731621. |
thus we investigated the genetic components of ad that is independent of apoe ε4 by combining genome association analysis with quantitative trait analyses in non-hispanic caucasian participants in the alzheimer' s disease neuroimaging initiative (adni) cohort. |
2015-12-15 |
2023-08-13 |
human |
| Hilmar K Luckhoff, Theresa Brand, Dawid P van Velden, Martin Kidd, Leslie R Fisher, Susan J van Rensburg, Maritha J Kotz. Clinical relevance of apolipoprotein E genotyping based on a family history of Alzheimer's disease. Current Alzheimer research. vol 12. issue 3. 2015-12-15. PMID:25731628. |
having a family history of alzheimer' s disease (ad) may potentiate cumulative risk associated with phenotypic expression of the ε-4 allele of the apolipoprotein e (apoe) gene. |
2015-12-15 |
2023-08-13 |
human |
| Azusa Suwa, Keiichiro Nishida, Keita Utsunomiya, Shinpei Nonen, Masafumi Yoshimura, Yoshiteru Takekita, Masataka Wakeno, Aran Tajika, Maki Yoshino, Yosuke Koshikawa, Masaki Kato, Toshihiko Kinoshit. Neuropsychological Evaluation and Cerebral Blood Flow Effects of Apolipoprotein E4 in Alzheimer's Disease Patients after One Year of Treatment: An Exploratory Study. Dementia and geriatric cognitive disorders extra. vol 5. issue 3. 2015-12-02. PMID:26628900. |
alzheimer's disease (ad) is affected by apolipoprotein e (apoe); however, its effects assessed by means of cognitive tests and by neuroimaging have not been sufficiently studied. |
2015-12-02 |
2023-08-13 |
Not clear |
| Anais Mounier, Danko Georgiev, Kyong Nyon Nam, Nicholas F Fitz, Emilie L Castranio, Cody M Wolfe, Andrea A Cronican, Jonathan Schug, Iliya Lefterov, Radosveta Koldamov. Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 34. 2015-11-24. PMID:26311769. |
bexarotene-activated retinoid x receptors (rxrs) ameliorate memory deficits in alzheimer's disease mouse models, including mice expressing human apolipoprotein e (apoe) isoforms. |
2015-11-24 |
2023-08-13 |
mouse |
| Sharis Shamirian, Angèle Nalbandian, Manaswitha Khare, Rudolph Castellani, Ronald Kim, Virginia E Kimoni. Early-onset Alzheimers and cortical vision impairment in a woman with valosin-containing protein disease associated with 2 APOE ε4/APOE ε4 genotype. Alzheimer disease and associated disorders. vol 29. issue 1. 2015-11-20. PMID:23715207. |
apoe [latin small letter open e]4 is a major risk factor for late-onset alzheimer disease, a progressive neurodegenerative disorder that affects memory, thinking, behavior, and emotion as a result of the excessive buildup and decreased clearance of β-amyloid proteins resulting in the appearance of neuritic plaques and neurofibrillary tangles. |
2015-11-20 |
2023-08-12 |
Not clear |
| Sharis Shamirian, Angèle Nalbandian, Manaswitha Khare, Rudolph Castellani, Ronald Kim, Virginia E Kimoni. Early-onset Alzheimers and cortical vision impairment in a woman with valosin-containing protein disease associated with 2 APOE ε4/APOE ε4 genotype. Alzheimer disease and associated disorders. vol 29. issue 1. 2015-11-20. PMID:23715207. |
in conclusion, we report a unique patient with an apoe [latin small letter open e]4/apoe [latin small letter open e]4 genotype and atypical vcp disease associated with early alzheimer disease and severe vision impairment. |
2015-11-20 |
2023-08-12 |
Not clear |
| Jennifer S Yokoyama, Allen K L Lee, Leonel T Takada, Edgar Busovaca, Luke W Bonham, Steven Z Chao, Marian Tse, Jing He, Christopher G Schwarz, Owen T Carmichael, Brandy R Matthews, Anna Karydas, Michael W Weiner, Giovanni Coppola, Charles S DeCarli, Bruce L Miller, Howard J Rose. Apolipoprotein ε4 is associated with lower brain volume in cognitively normal Chinese but not white older adults. PloS one. vol 10. issue 3. 2015-11-20. PMID:25738563. |
the ε4 allele of apolipoprotein e (apoe ε4) is a well-established risk factor for alzheimer's disease (ad), and may confer anatomic and functional effects years before clinical signs of cognitive decline are observed. |
2015-11-20 |
2023-08-13 |
human |
| C Justin Cook, Jason M Fletche. Can education rescue genetic liability for cognitive decline? Social science & medicine (1982). vol 127. 2015-11-17. PMID:25074513. |
in the spirit of some medical literature that leverages developmental abnormalities to understand mechanisms of normative functioning, we explore the ability of higher educational attainments to "rescue" biological/genetic liabilities in brain function through inheritance of a variant of the apoe gene shown to lead to cognitive decline, dementia, and alzheimer's disease in old age. |
2015-11-17 |
2023-08-13 |
Not clear |
| Davide Bruno, Michel J Grothe, Jay Nierenberg, Henrik Zetterberg, Kaj Blennow, Stefan J Teipel, Nunzio Pomar. A study on the specificity of the association between hippocampal volume and delayed primacy performance in cognitively intact elderly individuals. Neuropsychologia. vol 69. 2015-11-17. PMID:25613646. |
we conducted regression analyses of hippocampus volumes on serial position performance; other predictors included age, family history of alzheimer's disease (ad), apoe ε4 status, education, and total intracranial volume. |
2015-11-17 |
2023-08-13 |
human |
| Rik Ossenkoppele, Yolande A L Pijnenburg, David C Perry, Brendan I Cohn-Sheehy, Nienke M E Scheltens, Jacob W Vogel, Joel H Kramer, Annelies E van der Vlies, Renaud La Joie, Howard J Rosen, Wiesje M van der Flier, Lea T Grinberg, Annemieke J Rozemuller, Eric J Huang, Bart N M van Berckel, Bruce L Miller, Frederik Barkhof, William J Jagust, Philip Scheltens, William W Seeley, Gil D Rabinovic. The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26141491. |
sixty per cent of patients with behavioural alzheimer's disease and 40% of those with the dysexecutive syndrome carried at least one apoe ε4 allele. |
2015-11-16 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Yolande A L Pijnenburg, David C Perry, Brendan I Cohn-Sheehy, Nienke M E Scheltens, Jacob W Vogel, Joel H Kramer, Annelies E van der Vlies, Renaud La Joie, Howard J Rosen, Wiesje M van der Flier, Lea T Grinberg, Annemieke J Rozemuller, Eric J Huang, Bart N M van Berckel, Bruce L Miller, Frederik Barkhof, William J Jagust, Philip Scheltens, William W Seeley, Gil D Rabinovic. The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26141491. |
in conclusion, behavioural alzheimer's disease presentations are characterized by a milder and more restricted behavioural profile than in behavioural variant frontotemporal dementia, co-occurrence of memory dysfunction and high apoe ε4 prevalence. |
2015-11-16 |
2023-08-13 |
Not clear |