| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rik Ossenkoppele, Yolande A L Pijnenburg, David C Perry, Brendan I Cohn-Sheehy, Nienke M E Scheltens, Jacob W Vogel, Joel H Kramer, Annelies E van der Vlies, Renaud La Joie, Howard J Rosen, Wiesje M van der Flier, Lea T Grinberg, Annemieke J Rozemuller, Eric J Huang, Bart N M van Berckel, Bruce L Miller, Frederik Barkhof, William J Jagust, Philip Scheltens, William W Seeley, Gil D Rabinovic. The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26141491. |
dysexecutive alzheimer's disease presented as a primarily cognitive phenotype with minimal behavioural abnormalities and intermediate apoe ε4 prevalence. |
2015-11-16 |
2023-08-13 |
Not clear |
| Jon B Toledo, Henrik Zetterberg, Argonde C van Harten, Lidia Glodzik, Pablo Martinez-Lage, Luisella Bocchio-Chiavetto, Lorena Rami, Oskar Hansson, Reisa Sperling, Sebastiaan Engelborghs, Ricardo S Osorio, Hugo Vanderstichele, Manu Vandijck, Harald Hampel, Stefan Teipl, Abhay Moghekar, Marilyn Albert, William T Hu, Jose A Monge Argilés, Ana Gorostidi, Charlotte E Teunissen, Peter P De Deyn, Bradley T Hyman, Jose L Molinuevo, Giovanni B Frisoni, Gurutz Linazasoro, Mony J de Leon, Wiesje M van der Flier, Philip Scheltens, Kaj Blennow, Leslie M Shaw, John Q Trojanowsk. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26220940. |
in a large multicentre sample of cognitively normal subjects, as a function of age, gender and apoe genotype, we studied the frequency of abnormal cerebrospinal fluid levels of alzheimer's disease biomarkers including: total tau, phosphorylated tau and amyloid-β1-42. |
2015-11-16 |
2023-08-13 |
human |
| Yasser Iturria-Medina, Roberto C Sotero, Paule J Toussaint, Alan C Evan. Epidemic spreading model to characterize misfolded proteins propagation in aging and associated neurodegenerative disorders. PLoS computational biology. vol 10. issue 11. 2015-11-13. PMID:25412207. |
furthermore, this model strongly supports a) the leading role of aß clearance deficiency and early aß onset age during alzheimer's disease progression, b) that effective anatomical distance from aß outbreak region explains regional aß arrival time and aß deposition likelihood, c) the multi-factorial impact of apoe e4 genotype, gender and educational level on lifetime intra-brain aß propagation, and d) the modulatory impact of aß propagation history on tau proteins concentrations, supporting the hypothesis of an interrelated pathway between aß pathophysiology and tauopathy. |
2015-11-13 |
2023-08-13 |
human |
| Yen Ying Lim, Victor L Villemagne, Robert H Pietrzak, David Ames, Kathryn A Ellis, Karra Harrington, Peter J Snyder, Ralph N Martins, Colin L Masters, Christopher C Rowe, Paul Maruf. APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease. Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25559335. |
apoe ε4 moderates amyloid-related memory decline in preclinical alzheimer's disease. |
2015-11-12 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Victor L Villemagne, Robert H Pietrzak, David Ames, Kathryn A Ellis, Karra Harrington, Peter J Snyder, Ralph N Martins, Colin L Masters, Christopher C Rowe, Paul Maruf. APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease. Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25559335. |
the apolipoprotein e (apoe) ɛ4 allele and high levels of beta-amyloid (aβ) are associated with episodic memory decline and risk for alzheimer's disease. |
2015-11-12 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Victor L Villemagne, Robert H Pietrzak, David Ames, Kathryn A Ellis, Karra Harrington, Peter J Snyder, Ralph N Martins, Colin L Masters, Christopher C Rowe, Paul Maruf. APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease. Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25559335. |
aβ positivity coupled with apoe ɛ4 was associated with moderately increased decline in memory over a 54-month assessment period, suggesting that, in the preclinical stages of alzheimer's disease, the manifestation of memory decline in older adults with high aβ is exacerbated by the presence of apoe ɛ4. |
2015-11-12 |
2023-08-13 |
Not clear |
| Neena Theresa Kumar, Knut Liestøl, Else Marit Løberg, Henrik Mikael Reims, Jan Mæhle. Apolipoprotein E allelotype is associated with neuropathological findings in Alzheimer's disease. Virchows Archiv : an international journal of pathology. vol 467. issue 2. 2015-11-03. PMID:25898889. |
in a consecutive hospital-based autopsy series, we examined the relationship between apolipoprotein e (apoe) and alzheimer's disease (ad) and investigated the clinicopathological relationship in ad. |
2015-11-03 |
2023-08-13 |
Not clear |
| D M Lyall, S E Harris, M E Bastin, S Muñoz Maniega, C Murray, M W Lutz, A M Saunders, A D Roses, M del C Valdés Hernández, N A Royle, J M Starr, D J Porteous, J M Wardlaw, I J Dear. Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity? Translational psychiatry. vol 4. 2015-11-02. PMID:25247594. |
genetic polymorphisms in the apoe ɛ and tomm40 '523' poly-t repeat gene loci have been associated with significantly increased risk of alzheimer's disease. |
2015-11-02 |
2023-08-13 |
human |
| Mohammed Goryawala, Qi Zhou, Ranjan Duara, David Loewenstein, Mercedes Cabrerizo, Warren Barker, Malek Adjouad. Altered small-world anatomical networks in Apolipoprotein-E4 (ApoE4) carriers using MRI. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2014. 2015-10-30. PMID:25570490. |
apolipoprotein e (apoe) gene and primarily its allele e4 have been identified as a risk factor for alzheimer's disease (ad). |
2015-10-30 |
2023-08-13 |
human |
| Mengying Liu, Chen Bian, Jiqiang Zhang, Feng We. Apolipoprotein E gene polymorphism and Alzheimer's disease in Chinese population: a meta-analysis. Scientific reports. vol 4. 2015-10-20. PMID:24632849. |
the relationship between apolipoprotein e (apoe) genotype and the risk of alzheimer's disease (ad) is relatively well established in caucasians, but less established in other ethnicities. |
2015-10-20 |
2023-08-12 |
human |
| Zane Jaunmuktane, Simon Mead, Matthew Ellis, Jonathan D F Wadsworth, Andrew J Nicoll, Joanna Kenny, Francesca Launchbury, Jacqueline Linehan, Angela Richard-Loendt, A Sarah Walker, Peter Rudge, John Collinge, Sebastian Brandne. Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy. Nature. vol 525. issue 7568. 2015-10-14. PMID:26354483. |
none of these patients had pathogenic mutations, apoe ε4 or other high-risk alleles associated with early-onset alzheimer's disease. |
2015-10-14 |
2023-08-13 |
mouse |
| Chao Wang, Yongjian Cui, Jingci Yang, Jinrong Zhang, Dongcai Yuan, Yan Wei, Yumei Li, Yali Duo, Shengjun Li, Wenyi Zhu, Lei Zhen. Combining serum and urine biomarkers in the early diagnosis of mild cognitive impairment that evolves into Alzheimer's disease in patients with the apolipoprotein E ϵ4 genotype. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. vol 20. issue 1. 2015-10-13. PMID:25532446. |
possession of the apolipoprotein e (apoe) ϵ4 genotype is a major predictor of progression to alzheimer's disease (ad), particularly in patients with mild cognitive impairment (mci). |
2015-10-13 |
2023-08-13 |
Not clear |
| H Mentz, M Horan, A Payton, W Ollier, N Pendleton, S Hamd. Homozygosity in the ApoE 4 polymorphism is associated with dysphagic symptoms in older adults. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 28. issue 1. 2015-09-21. PMID:24261350. |
apolipoprotein e (apoe) is the most well-described genetic risk factor for alzheimer's disease and nonpathological cognitive decline. |
2015-09-21 |
2023-08-12 |
human |
| Florian Riese, Anton Gietl, Niklaus Zölch, Anke Henning, Ruth O'Gorman, Andrea M Kälin, Sandra E Leh, Alfred Buck, Geoffrey Warnock, Richard A E Edden, Roger Luechinger, Christoph Hock, Spyros Kollias, Lars Michel. Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25169676. |
because gaba and glx do not seem to reflect amyloid β deposition or apoe genotype, they are less likely biomarker candidates for preclinical alzheimer's disease. |
2015-09-21 |
2023-08-13 |
human |
| b' Pablo Cuesta, Pilar Garc\\xc3\\xa9s, Nazareth P Castellanos, Maria Eugenia L\\xc3\\xb3pez, Sara Aurtenetxe, Ricardo Bajo, Jos\\xc3\\xa9 Angel Pineda-Pardo, Ricardo Bru\\xc3\\xb1a, Antonio Garc\\xc3\\xada Mar\\xc3\\xadn, Marisa Delgado, Ana Barabash, In\\xc3\\xa9s Anc\\xc3\\xadn, Jose Antonio Cabranes, Alberto Fernandez, Francisco Del Pozo, Miguel Sancho, Alberto Marcos, Akinori Nakamura, Fernando Maest\\xc3\\xb. Influence of the APOE \\xce\\xb54 allele and mild cognitive impairment diagnosis in the disruption of the MEG resting state functional connectivity in sources space. Journal of Alzheimer\'s disease : JAD. vol 44. issue 2. 2015-09-21. PMID:25281603.' |
the apolipoprotein e (apoe) ε4 allele constitutes the major genetic risk for the development of late onset alzheimer's disease (ad). |
2015-09-21 |
2023-08-13 |
human |
| Richard J Caselli, Amylou C Dueck, Dona E C Locke, Leslie C Baxter, Bryan K Woodruff, Yonas E Ged. Sex-based memory advantages and cognitive aging: a challenge to the cognitive reserve construct? Journal of the International Neuropsychological Society : JINS. vol 21. issue 2. 2015-09-21. PMID:25665170. |
memory decline was assessed in a cohort of healthy men and women enriched for apoe ɛ4 who completed two verbal [rey auditory verbal learning test (avlt), buschke selective reminding test (srt)] and two visuospatial [rey-osterrieth complex figure test (cft), and benton visual retention test (vrt)] memory tests, as well as in a separate larger and older cohort [national alzheimer's coordinating center (nacc)] who completed a verbal memory test (logical memory). |
2015-09-21 |
2023-08-13 |
Not clear |
| Zvinka Z Zlatar, Christina E Wierenga, Katherine J Bangen, Thomas T Liu, Amy J Ja. Increased hippocampal blood flow in sedentary older adults at genetic risk for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 41. issue 3. 2015-09-18. PMID:24685629. |
resting cerebral blood flow (cbf) decreases with age; however regulatory increases in hippocampal cbf have been associated with genetic risk (apolipoprotein e [apoe] ε4 carriers) for alzheimer's disease (ad). |
2015-09-18 |
2023-08-12 |
Not clear |
| Ping Wu, Hong-Lei Li, Zhi-Jun Liu, Qing-Qing Tao, Miao Xu, Qi-Hao Guo, Zhen Hong, Yi-Min Su. Associations between apolipoprotein E gene polymorphisms and Alzheimer's disease risk in a large Chinese Han population. Clinical interventions in aging. vol 10. 2015-09-18. PMID:25673977. |
apolipoprotein e gene (apoe) polymorphisms contributing to the risk of sporadic alzheimer's disease (ad) have been identified for decades, but it has not been investigated in large ad samples of chinese han population. |
2015-09-18 |
2023-08-13 |
Not clear |
| Yukiko Hori, Tadafumi Hashimoto, Hidetoshi Nomoto, Bradley T Hyman, Takeshi Iwatsub. Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO. The Journal of biological chemistry. vol 290. issue 24. 2015-09-10. PMID:25918154. |
human apoe ϵ4 allele is a strong genetic risk factor of alzheimer disease. |
2015-09-10 |
2023-08-13 |
mouse |
| Giuseppe Tosto, Hongjun Fu, Badri N Vardarajan, Joseph H Lee, Rong Cheng, Dolly Reyes-Dumeyer, Rafael Lantigua, Martin Medrano, Ivonne Z Jimenez-Velazquez, Mitchell S V Elkind, Clinton B Wright, Ralph L Sacco, Margaret Pericak-Vance, Lindsay Farrer, Ekaterina Rogaeva, Peter St George-Hyslop, Christiane Reitz, Richard Mayeu. F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease. Annals of clinical and translational neurology. vol 2. issue 8. 2015-09-04. PMID:26339675. |
in the context of late-onset alzheimer's disease (load) over 20 genes have been identified but, aside apoe, all show small effect sizes, leaving a large part of the genetic component unexplained. |
2015-09-04 |
2023-08-13 |
Not clear |