| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Songli Wang, Paul Wen, Stephen Woo. Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats. F1000Research. vol 5. 2016-05-30. PMID:27239272. |
alzheimer's disease (ad) is characterized pathologically by the presence of amyloid plaques and neurofibrillary tangles. the amyloid hypothesis contends that the abnormal accumulation of aβ, the principal component of amyloid plaques, plays an essential role in initiating the disease. impaired clearance of soluble aβ from the brain, a process facilitated by apolipoprotein e (apoe), is believed to be a contributing factor in plaque formation. |
2016-05-30 |
2023-08-13 |
rat |
| Shiran Salomon-Zimri, Ori Liraz, Daniel M Michaelso. Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them. Alzheimer's & dementia (Amsterdam, Netherlands). vol 1. issue 2. 2016-05-30. PMID:27239500. |
apolipoprotein e4 (apoe ε4) is the most prevalent genetic risk factor for alzheimer's disease (ad). |
2016-05-30 |
2023-08-13 |
mouse |
| Robert C Green, Kurt D Christensen, L Adrienne Cupples, Norman R Relkin, Peter J Whitehouse, Charmaine D M Royal, Thomas O Obisesan, Robert Cook-Deegan, Erin Linnenbringer, Melissa Barber Butson, Grace-Ann Fasaye, Elana Levinson, J Scott Robert. A randomized noninferiority trial of condensed protocols for genetic risk disclosure of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 10. 2016-05-23. PMID:25499536. |
conventional multisession genetic counseling is currently recommended when disclosing apolipoprotein e (apoe) genotype for the risk of alzheimer's disease (ad) in cognitively normal individuals. |
2016-05-23 |
2023-08-13 |
Not clear |
| Lindsey I Sinclair, Katherine S Button, Marcus R Munafò, Ian N M Day, Glyn Lewi. Possible Association of APOE Genotype with Working Memory in Young Adults. PloS one. vol 10. issue 8. 2016-05-18. PMID:26287823. |
possession of the ε4 allele of the apolipoprotein e (apoe) gene is associated with an increased risk of alzheimer's disease. |
2016-05-18 |
2023-08-13 |
Not clear |
| Matthew A Albrecht, Cassandra Szoeke, Paul Maruff, Greg Savage, Nicola T Lautenschlager, Kathryn A Ellis, Kevin Taddei, Ralph Martins, Colin L Masters, David Ames, Jonathan K Foste. Longitudinal cognitive decline in the AIBL cohort: The role of APOE ε4 status. Neuropsychologia. vol 75. 2016-05-16. PMID:26102189. |
the ε4 polymorphism of the apoe gene confers a substantially increased risk of developing alzheimer's disease. |
2016-05-16 |
2023-08-13 |
human |
| Qingqin S Li, Antonio R Parrado, Mahesh N Samtani, Vaibhav A Naraya. Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level. PloS one. vol 10. issue 8. 2016-05-08. PMID:26252872. |
the genome-wide association study was performed via a meta-analysis of two non-overlapping discovery sample sets to identify genetic variants other than apoe ε4 predictive of the csf biomarker level (aβ1-42, t-tau, p-tau181p, t-tau:aβ1-42 ratio, and p-tau181p:aβ1-42 ratio) in patients enrolled in the alzheimer's disease neuroimaging initiative (adni) study. |
2016-05-08 |
2023-08-13 |
Not clear |
| Nicholas F Fitz, Victor Tapias, Andrea A Cronican, Emilie L Castranio, Muzamil Saleem, Alexis Y Carter, Martina Lefterova, Iliya Lefterov, Radosveta Koldamov. Opposing effects of Apoe/Apoa1 double deletion on amyloid-β pathology and cognitive performance in APP mice. Brain : a journal of neurology. vol 138. issue Pt 12. 2016-05-04. PMID:26510953. |
as the ε4 allele of apoe is the major genetic risk factor for late-onset alzheimer's disease, abca1 role as a modifier of apoe lipidation is of significance for this disease. |
2016-05-04 |
2023-08-13 |
mouse |
| Stéphanie Deroo, Florian Stengel, Azadeh Mohammadi, Nicolas Henry, Ellen Hubin, Eva-Maria Krammer, Ruedi Aebersold, Vincent Raussen. Chemical cross-linking/mass spectrometry maps the amyloid β peptide binding region on both apolipoprotein E domains. ACS chemical biology. vol 10. issue 4. 2016-05-03. PMID:25546376. |
apolipoprotein e (apoe) binds the amyloid β peptide (aβ), one of the major culprits in alzheimer's disease development. |
2016-05-03 |
2023-08-13 |
Not clear |
| Stéphanie Deroo, Florian Stengel, Azadeh Mohammadi, Nicolas Henry, Ellen Hubin, Eva-Maria Krammer, Ruedi Aebersold, Vincent Raussen. Chemical cross-linking/mass spectrometry maps the amyloid β peptide binding region on both apolipoprotein E domains. ACS chemical biology. vol 10. issue 4. 2016-05-03. PMID:25546376. |
however, the binding interface between apoe and aβ is poorly defined despite substantial previous research efforts, and the exact role of apoe in the pathology of alzheimer's disease remains largely elusive. |
2016-05-03 |
2023-08-13 |
Not clear |
| Haiqing Song, Haixia Long, Xiumei Zuo, Chunshui Yu, Bing Liu, Zhiqun Wang, Qi Wang, Fen Wang, Ying Han, Jianping Ji. APOE Effects on Default Mode Network in Chinese Cognitive Normal Elderly: Relationship with Clinical Cognitive Performance. PloS one. vol 10. issue 7. 2016-05-03. PMID:26177270. |
functional connectivity in default mode network (dmn) may be changed in alzheimer's disease (ad) patients and related risk populations, such as amnestic mild cognitive impairment (amci) patients and apoe ε4 carriers. |
2016-05-03 |
2023-08-13 |
Not clear |
| Kimberly A Toops, Li Xuan Tan, Aparna Lakkaraj. Apolipoprotein E Isoforms and AMD. Advances in experimental medicine and biology. vol 854. 2016-04-18. PMID:26427386. |
apoe isoforms confer genetic risk for several diseases of aging including atherosclerosis, alzheimer's disease, and age-related macular degeneration (amd). |
2016-04-18 |
2023-08-13 |
Not clear |
| Kimberly A Toops, Li Xuan Tan, Aparna Lakkaraj. Apolipoprotein E Isoforms and AMD. Advances in experimental medicine and biology. vol 854. 2016-04-18. PMID:26427386. |
current thinking about different functions of apoe isoforms comes largely from studies on alzheimer's disease. |
2016-04-18 |
2023-08-13 |
Not clear |
| Kimberly A Toops, Li Xuan Tan, Aparna Lakkaraj. Apolipoprotein E Isoforms and AMD. Advances in experimental medicine and biology. vol 854. 2016-04-18. PMID:26427386. |
here, we propose that apoe serves a fundamentally different purpose in regulating cholesterol homeostasis in the retinal pigment epithelium and this could explain why allelic risk factors are flipped for amd compared to alzheimer's disease. |
2016-04-18 |
2023-08-13 |
Not clear |
| Ileana Soto, Leah C Graham, Hannah J Richter, Stephen N Simeone, Jake E Radell, Weronika Grabowska, W Keith Funkhouser, Megan C Howell, Gareth R Howel. APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction. PLoS biology. vol 13. issue 10. 2016-04-12. PMID:26512759. |
exercise prevents these changes, but not in the absence of apoe, opening up new avenues for understanding the complex interactions between neurovascular and neuroinflammatory responses in aging and neurodegenerative diseases such as alzheimer's disease. |
2016-04-12 |
2023-08-13 |
mouse |
| Andreas Lazaris, Kristy S Hwang, Naira Goukasian, Leslie M Ramirez, Jennifer Eastman, Anna E Blanken, Edmond Teng, Karen Gylys, Greg Cole, Andrew J Saykin, Leslie M Shaw, John Q Trojanowski, William J Jagust, Michael W Weiner, Liana G Apostolov. Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding. Neurology. Genetics. vol 1. issue 3. 2016-04-12. PMID:27066559. |
alzheimer risk genes modulate the relationship between plasma apoe and cortical pib binding. |
2016-04-12 |
2023-08-13 |
Not clear |
| Andreas Lazaris, Kristy S Hwang, Naira Goukasian, Leslie M Ramirez, Jennifer Eastman, Anna E Blanken, Edmond Teng, Karen Gylys, Greg Cole, Andrew J Saykin, Leslie M Shaw, John Q Trojanowski, William J Jagust, Michael W Weiner, Liana G Apostolov. Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding. Neurology. Genetics. vol 1. issue 3. 2016-04-12. PMID:27066559. |
we investigated the association between apoe protein plasma levels and brain amyloidosis and the effect of the top 10 alzheimer disease (ad) risk genes on this association. |
2016-04-12 |
2023-08-13 |
Not clear |
| Hong Y Choi, Yun Liu, Christian Tennert, Yoshie Sugiura, Andromachi Karakatsani, Stephan Kröger, Eric B Johnson, Robert E Hammer, Weichun Lin, Joachim Her. APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. eLife. vol 2. 2016-04-11. PMID:23986861. |
apoe, apoe receptors and app cooperate in the pathogenesis of alzheimer's disease. |
2016-04-11 |
2023-08-12 |
mouse |
| Espen Lien, Guro Andersen, Yongde Bao, Heather Gordish-Dressman, Jon S Skranes, James A Blackman, Torstein Vi. Genes determining the severity of cerebral palsy: the role of single nucleotide polymorphisms on the amount and structure of apolipoprotein E. Acta paediatrica (Oslo, Norway : 1992). vol 104. issue 7. 2016-03-31. PMID:25703783. |
genes determining the severity of cerebral palsy: the role of single nucleotide polymorphisms on the amount and structure of apolipoprotein e. apolipoprotein e (apoe) influences repair and other processes in the brain, and the apoe4 variant is a risk factor for alzheimer's disease and for prolonged recovery following traumatic brain injury. |
2016-03-31 |
2023-08-13 |
Not clear |
| Benfeard Williams, Marino Convertino, Jhuma Das, Nikolay V Dokholya. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations. PLoS computational biology. vol 11. issue 10. 2016-03-31. PMID:26506597. |
the increased risk of developing alzheimer's disease (ad) is associated with the apoe gene, which encodes for three variants of apolipoprotein e, namely e2, e3, e4, differing only by two amino acids at positions 112 and 158. |
2016-03-31 |
2023-08-13 |
Not clear |
| Lauren E Oberlin, Stephen B Manuck, Peter J Gianaros, Robert E Ferrell, Matthew F Muldoon, J Richard Jennings, Janine D Flory, Kirk I Erickso. Blood pressure interacts with APOE ε4 to predict memory performance in a midlife sample. Neuropsychology. vol 29. issue 5. 2016-03-29. PMID:25730733. |
elevated blood pressure and the apolipoprotein ε4 allele (apoe ε4) are independent risk factors for alzheimer's disease. |
2016-03-29 |
2023-08-13 |
Not clear |