| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benfeard Williams, Marino Convertino, Jhuma Das, Nikolay V Dokholya. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations. PLoS computational biology. vol 11. issue 10. 2016-03-31. PMID:26506597. |
the increased risk of developing alzheimer's disease (ad) is associated with the apoe gene, which encodes for three variants of apolipoprotein e, namely e2, e3, e4, differing only by two amino acids at positions 112 and 158. |
2016-03-31 |
2023-08-13 |
Not clear |
| Lauren E Oberlin, Stephen B Manuck, Peter J Gianaros, Robert E Ferrell, Matthew F Muldoon, J Richard Jennings, Janine D Flory, Kirk I Erickso. Blood pressure interacts with APOE ε4 to predict memory performance in a midlife sample. Neuropsychology. vol 29. issue 5. 2016-03-29. PMID:25730733. |
elevated blood pressure and the apolipoprotein ε4 allele (apoe ε4) are independent risk factors for alzheimer's disease. |
2016-03-29 |
2023-08-13 |
Not clear |
| Anja Soldan, Corinne Pettigrew, Yi Lu, Mei-Cheng Wang, Ola Selnes, Marilyn Albert, Timothy Brown, J Tilak Ratnanather, Laurent Younes, Michael I Mille. Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease. Human brain mapping. vol 36. issue 7. 2016-03-29. PMID:25879865. |
relationship of medial temporal lobe atrophy, apoe genotype, and cognitive reserve in preclinical alzheimer's disease. |
2016-03-29 |
2023-08-13 |
human |
| Heather Woo. Alzheimer disease: Iron--the missing link between ApoE and Alzheimer disease? Nature reviews. Neurology. vol 11. issue 7. 2016-03-28. PMID:26055466. |
alzheimer disease: iron--the missing link between apoe and alzheimer disease? |
2016-03-28 |
2023-08-13 |
Not clear |
| Scott Ayton, Noel G Faux, Ashley I Bus. Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nature communications. vol 6. 2016-03-25. PMID:25988319. |
ferritin levels in the cerebrospinal fluid predict alzheimer's disease outcomes and are regulated by apoe. |
2016-03-25 |
2023-08-13 |
human |
| Susan M Resnick, Murat Bilgel, Abhay Moghekar, Yang An, Qing Cai, Mei-Cheng Wang, Madhav Thambisetty, Jerry L Prince, Yun Zhou, Anja Soldan, Dean F Wong, Richard J O'Brien, Luigi Ferrucci, Marilyn S Alber. Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts. Neurobiology of aging. vol 36. issue 8. 2016-03-17. PMID:26004017. |
apolipoprotein e (apoe) genotype influences onset age of alzheimer's disease but effects on disease progression are less clear. |
2016-03-17 |
2023-08-13 |
human |
| Susan M Resnick, Murat Bilgel, Abhay Moghekar, Yang An, Qing Cai, Mei-Cheng Wang, Madhav Thambisetty, Jerry L Prince, Yun Zhou, Anja Soldan, Dean F Wong, Richard J O'Brien, Luigi Ferrucci, Marilyn S Alber. Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts. Neurobiology of aging. vol 36. issue 8. 2016-03-17. PMID:26004017. |
apoe ε4 carriers may be further along in the disease process, consistent with earlier brain aβ deposition and providing a biological basis for apoe genotype effects on onset age of alzheimer's disease. |
2016-03-17 |
2023-08-13 |
human |
| Lieke L Smits, Yolande A L Pijnenburg, Annelies E van der Vlies, Esther L G E Koedam, Femke H Bouwman, Ilona E W Reuling, Philip Scheltens, Wiesje M van der Flie. Early onset APOE E4-negative Alzheimer's disease patients show faster cognitive decline on non-memory domains. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 7. 2016-03-14. PMID:25891378. |
early onset apoe e4-negative alzheimer's disease patients show faster cognitive decline on non-memory domains. |
2016-03-14 |
2023-08-13 |
Not clear |
| Lieke L Smits, Yolande A L Pijnenburg, Annelies E van der Vlies, Esther L G E Koedam, Femke H Bouwman, Ilona E W Reuling, Philip Scheltens, Wiesje M van der Flie. Early onset APOE E4-negative Alzheimer's disease patients show faster cognitive decline on non-memory domains. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 7. 2016-03-14. PMID:25891378. |
age at onset and apoe e4-genotype have been shown to influence clinical manifestation of alzheimer's disease (ad). |
2016-03-14 |
2023-08-13 |
Not clear |
| Corina Roman, Elena V Fuior, Violeta G Trusca, Dimitris Kardassis, Maya Simionescu, Anca V Gafenc. Thyroid hormones upregulate apolipoprotein E gene expression in astrocytes. Biochemical and biophysical research communications. vol 468. issue 1-2. 2016-03-11. PMID:26519880. |
apolipoprotein e (apoe), a protein mainly involved in lipid metabolism, is associated with several neurodegenerative disorders including alzheimer's disease. |
2016-03-11 |
2023-08-13 |
Not clear |
| Sana Suri, Clare E Mackay, Michael E Kelly, Michael Germuska, Elizabeth M Tunbridge, Giovanni B Frisoni, Paul M Matthews, Klaus P Ebmeier, Daniel P Bulte, Nicola Filippin. Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 6. 2016-03-02. PMID:25160043. |
functional magnetic resonance imaging (mri) studies have shown that apoe ε2- and ε4-carriers have similar patterns of blood-oxygenation-level-dependent (bold) activation suggesting that we need to look beyond the bold signal to link apoe's effect on the brain to alzheimer's disease (ad)-risk. |
2016-03-02 |
2023-08-13 |
Not clear |
| G Davies, N Armstrong, J C Bis, J Bressler, V Chouraki, S Giddaluru, E Hofer, C A Ibrahim-Verbaas, M Kirin, J Lahti, S J van der Lee, S Le Hellard, T Liu, R E Marioni, C Oldmeadow, I Postmus, A V Smith, J A Smith, A Thalamuthu, R Thomson, V Vitart, J Wang, L Yu, L Zgaga, W Zhao, R Boxall, S E Harris, W D Hill, D C Liewald, M Luciano, H Adams, D Ames, N Amin, P Amouyel, A A Assareh, R Au, J T Becker, A Beiser, C Berr, L Bertram, E Boerwinkle, B M Buckley, H Campbell, J Corley, P L De Jager, C Dufouil, J G Eriksson, T Espeseth, J D Faul, I Ford, R F Gottesman, M E Griswold, V Gudnason, T B Harris, G Heiss, A Hofman, E G Holliday, J Huffman, S L R Kardia, N Kochan, D S Knopman, J B Kwok, J-C Lambert, T Lee, G Li, S-C Li, M Loitfelder, O L Lopez, A J Lundervold, A Lundqvist, K A Mather, S S Mirza, L Nyberg, B A Oostra, A Palotie, G Papenberg, A Pattie, K Petrovic, O Polasek, B M Psaty, P Redmond, S Reppermund, J I Rotter, H Schmidt, M Schuur, P W Schofield, R J Scott, V M Steen, D J Stott, J C van Swieten, K D Taylor, J Trollor, S Trompet, A G Uitterlinden, G Weinstein, E Widen, B G Windham, J W Jukema, A F Wright, M J Wright, Q Yang, H Amieva, J R Attia, D A Bennett, H Brodaty, A J M de Craen, C Hayward, M A Ikram, U Lindenberger, L-G Nilsson, D J Porteous, K Räikkönen, I Reinvang, I Rudan, P S Sachdev, R Schmidt, P R Schofield, V Srikanth, J M Starr, S T Turner, D R Weir, J F Wilson, C van Duijn, L Launer, A L Fitzpatrick, S Seshadri, T H Mosley, I J Dear. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Molecular psychiatry. vol 20. issue 2. 2016-03-02. PMID:25644384. |
in hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with alzheimer's disease: tomm40, apoe, abcg1 and mef2c. |
2016-03-02 |
2023-08-13 |
human |
| Chengzhi Mou, Tao Han, Min Wang, Meng Jiang, Bin Liu, Jia H. Correlation of polymorphism of APOE and LRP genes to cognitive impairment and behavioral and psychological symptoms of dementia in Alzheimer's disease and vascular dementia. International journal of clinical and experimental medicine. vol 8. issue 11. 2016-02-17. PMID:26885125. |
correlation of polymorphism of apoe and lrp genes to cognitive impairment and behavioral and psychological symptoms of dementia in alzheimer's disease and vascular dementia. |
2016-02-17 |
2023-08-13 |
Not clear |
| Chengzhi Mou, Tao Han, Min Wang, Meng Jiang, Bin Liu, Jia H. Correlation of polymorphism of APOE and LRP genes to cognitive impairment and behavioral and psychological symptoms of dementia in Alzheimer's disease and vascular dementia. International journal of clinical and experimental medicine. vol 8. issue 11. 2016-02-17. PMID:26885125. |
to discuss the correlation of polymorphism of apoe and lrp genes to cognitive impairment and behavioral and psychological symptoms of dementia (bpsd) in alzheimer's disease (ad) and vascular dementia (vd). |
2016-02-17 |
2023-08-13 |
Not clear |
| Charles C Bailey, Lindsey B DeVaux, Michael Farza. The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E. The Journal of biological chemistry. vol 290. issue 43. 2016-02-16. PMID:26374897. |
furthermore, the alzheimer disease-associated r47h mutation, and other artificial mutations introduced in the same location, markedly reduced the affinity of trem2 for apoe. |
2016-02-16 |
2023-08-13 |
human |
| Gülhan Kaya, Esra Gündüz, Muradiye Acar, Ömer Faruk Hatipoğlu, Burcu Acar, Atilla Ilhan, Mehmet Gündü. Potential genetic biomarkers in the early diagnosis of Alzheimer disease: APOE and BIN1. Turkish journal of medical sciences. vol 45. issue 5. 2016-02-09. PMID:26738348. |
potential genetic biomarkers in the early diagnosis of alzheimer disease: apoe and bin1. |
2016-02-09 |
2023-08-13 |
Not clear |
| Burcu Acar Çinleti, Nilgül Yardimci, Zübeyde Aytürk, Atilla Ilhan, Gülhan Kaya, Muradiye Acar, Emine Rabia Koç, Esra Gündüz, Mehmet Gündü. The effects and interactions of APOE and APH-1A polymorphisms in Alzheimer disease. Turkish journal of medical sciences. vol 45. issue 5. 2016-02-09. PMID:26738354. |
the effects and interactions of apoe and aph-1a polymorphisms in alzheimer disease. |
2016-02-09 |
2023-08-13 |
Not clear |
| Swetha Vijayaraghavan, Walter Maetzler, Matthias Reimold, Christina Unger Lithner, Inga Liepelt-Scarfone, Daniela Berg, Taher Darreh-Shor. High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 5. 2016-02-04. PMID:23978325. |
apolipoprotein e ε4 allele (apoe ε4) increases the apolipoprotein e (apoe) protein levels in alzheimer's disease (ad) cerebrospinal fluid (csf). |
2016-02-04 |
2023-08-12 |
Not clear |
| Colton Linnertz, Lauren Anderson, William Gottschalk, Donna Crenshaw, Michael W Lutz, Jawara Allen, Sunita Saith, Mirta Mihovilovic, James R Burke, Kathleen A Welsh-Bohmer, Allen D Roses, Ornit Chiba-Fale. The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 5. 2016-02-04. PMID:24439168. |
we investigated the genomic region spanning the translocase of the outer mitochondrial membrane 40-kd (tomm40) and apolipoprotein e (apoe) genes, that has been associated with the risk and age of onset of late-onset alzheimer's disease (load) to determine whether a highly polymorphic, intronic poly-t within this region (rs10524523; hereafter, 523) affects expression of the apoe and tomm40 genes. |
2016-02-04 |
2023-08-12 |
Not clear |
| Hemi Malkk. Alzheimer disease: APOE*ε4-associated increase in AD risk linked to phospholipid dysregulation. Nature reviews. Neurology. vol 11. issue 11. 2016-02-04. PMID:26416537. |
alzheimer disease: apoe*ε4-associated increase in ad risk linked to phospholipid dysregulation. |
2016-02-04 |
2023-08-13 |
Not clear |