| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoke Hao, Jingwen Yan, Xiaohui Yao, Shannon L Risacher, Andrew J Saykin, Daoqiang Zhang, Li She. DIAGNOSIS-GUIDED METHOD FOR IDENTIFYING MULTI-MODALITY NEUROIMAGING BIOMARKERS ASSOCIATED WITH GENETIC RISK FACTORS IN ALZHEIMER'S DISEASE. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. vol 21. 2016-10-24. PMID:26776178. |
to reveal disease-relevant imaging genetic associations, we propose a novel diagnosis-guided multi-modality (dgmm) framework to discover multi-modality imaging qts that are associated with both alzheimer's disease (ad) and its top genetic risk factor (i.e., apoe snp rs429358). |
2016-10-24 |
2023-08-13 |
human |
| Jieun Lee, Joseph Choi, G William Wong, Michael J Wolfgan. Neurometabolic roles of ApoE and Ldl-R in mouse brain. Journal of bioenergetics and biomembranes. vol 48. issue 1. 2016-10-20. PMID:26686234. |
polymorphisms in apoe are highly correlated with the progression of neurodegenerative disease, in particular alzheimer's disease. |
2016-10-20 |
2023-08-13 |
mouse |
| Christophe Hirtz, Jerome Vialaret, Georges Nouadje, Susanna Schraen, Pascale Benlian, Sandrine Mary, Pascal Philibert, Laurent Tiers, Pauline Bros, Constance Delaby, Audrey Gabelle, Sylvain Lehman. Development of new quantitative mass spectrometry and semi-automatic isofocusing methods for the determination of Apolipoprotein E typing. Clinica chimica acta; international journal of clinical chemistry. vol 454. 2016-10-20. PMID:26707914. |
apoe status is known to be a major risk factor for late-onset alzheimer's and cardiovascular diseases. |
2016-10-20 |
2023-08-13 |
Not clear |
| Dimitrios Adamis, David Meagher, John Williams, Owen Mulligan, Geraldine McCarth. A systematic review and meta-analysis of the association between the apolipoprotein E genotype and delirium. Psychiatric genetics. vol 26. issue 2. 2016-10-18. PMID:26901792. |
the role of apolipoprotein e (apoe) in alzheimer's disease and other dementias has been investigated intensively. |
2016-10-18 |
2023-08-13 |
human |
| H K Lückhoff, M Kidd, S J van Rensburg, D P van Velden, M J Kotz. Apolipoprotein E genotyping and questionnaire-based assessment of lifestyle risk factors in dyslipidemic patients with a family history of Alzheimer's disease: test development for clinical application. Metabolic brain disease. vol 31. issue 1. 2016-10-17. PMID:26481640. |
mounting evidence supports the added value of apoe genotyping for the evaluation of cardiovascular risk in dyslipidemic patients beyond its established role in the diagnosis of late-onset alzheimer's disease (ad). |
2016-10-17 |
2023-08-13 |
human |
| Ni Shu, Xin Li, Chao Ma, Junying Zhang, Kewei Chen, Ying Liang, Yaojing Chen, Zhanjun Zhan. Effects of APOE promoter polymorphism on the topological organization of brain structural connectome in nondemented elderly. Human brain mapping. vol 36. issue 12. 2016-10-06. PMID:26314833. |
the polymorphism of the apolipoprotein e (apoe) promoter rs405509 can regulate the transcriptional activity of the apoe gene and is related to alzheimer's disease (ad). |
2016-10-06 |
2023-08-13 |
human |
| Puneet Talwar, Juhi Sinha, Sandeep Grover, Rachna Agarwal, Suman Kushwaha, M V Padma Srivastava, Ritushree Kukret. Meta-analysis of apolipoprotein E levels in the cerebrospinal fluid of patients with Alzheimer's disease. Journal of the neurological sciences. vol 360. 2016-10-05. PMID:26723997. |
the possible association between apolipoprotein e (apoe) levels in the cerebrospinal fluid (csf) and alzheimer's disease (ad) has been studied extensively. |
2016-10-05 |
2023-08-13 |
human |
| Laura Perna, Ute Mons, Dan Rujescu, Matthias Kliegel, Hermann Brenne. Apolipoprotein E e4 and Cognitive Function: A Modifiable Association Results from Two Independent Cohort Studies. Dementia and geriatric cognitive disorders. vol 41. issue 1-2. 2016-09-27. PMID:26495840. |
the apolipoprotein e (apoe) e4 genetic polymorphism is a major risk factor for alzheimer' s disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. |
2016-09-27 |
2023-08-13 |
Not clear |
| Eva Stening, Jonas Persson, Elias Eriksson, Lars-Olof Wahlund, Henrik Zetterberg, Hedvig Söderlun. Apolipoprotein E ϵ4 is positively related to spatial performance but unrelated to hippocampal volume in healthy young adults. Behavioural brain research. vol 299. 2016-09-27. PMID:26581118. |
the apolipoprotein e (apoe) ϵ4 allele is known to be a major genetic risk factor for alzheimer's disease (ad). |
2016-09-27 |
2023-08-13 |
Not clear |
| Jinkuk Choi, Jie Gao, Jaekwang Kim, Cynthia Hong, Jungsu Kim, Peter Tontono. The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis. Science translational medicine. vol 7. issue 314. 2016-09-26. PMID:26582899. |
apolipoprotein e (apoe) is an important modifier of alzheimer's disease (ad) pathogenesis, and its abundance has been linked to the clearance of β-amyloid (aβ) in the brain. |
2016-09-26 |
2023-08-13 |
mouse |
| Daniel Shikanai Kerr, Florindo Stella, Márcia Radanovic, Ivan Aprahamian, Paulo Henrique Ferreira Bertollucci, Orestes Vicente Forlenz. Apolipoprotein E genotype is not associated with cognitive impairment in older adults with bipolar disorder. Bipolar disorders. vol 18. issue 1. 2016-09-26. PMID:26877211. |
the ε4 allele (apoe*4) of apolipoprotein e (apoe) is a well-established risk factor for dementia in alzheimer's disease (ad). |
2016-09-26 |
2023-08-13 |
Not clear |
| Tanmoy Kumar Maiti, Subhas Konar, Shyamal Bir, Piyush Kalakoti, Papireddy Bollam, Anil Nand. Role of apolipoprotein E polymorphism as a prognostic marker in traumatic brain injury and neurodegenerative disease: a critical review. Neurosurgical focus. vol 39. issue 5. 2016-09-22. PMID:26646927. |
apoe polymorphism plays a significant role in pathogenesis of neurodegeneration, particularly in alzheimer's disease. |
2016-09-22 |
2023-08-13 |
Not clear |
| Michael W Lutz, Donna Crenshaw, Kathleen A Welsh-Bohmer, Daniel K Burns, Allen D Rose. New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics. Current neurology and neuroscience reports. vol 16. issue 5. 2016-09-22. PMID:27039903. |
genetic variants identified through large-scale genome-wide association studies have not substantially improved the accuracy provided by apoe genotype to identify people at high risk of late-onset alzheimer's disease (load). |
2016-09-22 |
2023-08-13 |
human |
| Yifat Segev, Adva Livne, Meshi Mints, Kobi Rosenblu. Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer's Disease. Frontiers in behavioral neuroscience. vol 10. 2016-09-22. PMID:27656136. |
concurrence of high fat diet and apoe gene induces allele specific metabolic and mental stress changes in a mouse model of alzheimer's disease. |
2016-09-22 |
2023-08-13 |
mouse |
| Luke W Bonham, Ethan G Geier, Chun C Fan, Josiah K Leong, Lilah Besser, Walter A Kukull, John Kornak, Ole A Andreassen, Gerard D Schellenberg, Howard J Rosen, William P Dillon, Christopher P Hess, Bruce L Miller, Anders M Dale, Rahul S Desikan, Jennifer S Yokoyam. Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease. Annals of clinical and translational neurology. vol 3. issue 9. 2016-09-20. PMID:27648456. |
age-dependent effects of apoe ε4 in preclinical alzheimer's disease. |
2016-09-20 |
2023-08-13 |
Not clear |
| Luke W Bonham, Ethan G Geier, Chun C Fan, Josiah K Leong, Lilah Besser, Walter A Kukull, John Kornak, Ole A Andreassen, Gerard D Schellenberg, Howard J Rosen, William P Dillon, Christopher P Hess, Bruce L Miller, Anders M Dale, Rahul S Desikan, Jennifer S Yokoyam. Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease. Annals of clinical and translational neurology. vol 3. issue 9. 2016-09-20. PMID:27648456. |
the ε4 allele of apolipoprotein e (apoe) is the strongest known common genetic risk factor for alzheimer's disease (ad) and alters age of onset in retrospective studies. |
2016-09-20 |
2023-08-13 |
Not clear |
| G Jun, C A Ibrahim-Verbaas, M Vronskaya, J-C Lambert, J Chung, A C Naj, B W Kunkle, L-S Wang, J C Bis, C Bellenguez, D Harold, K L Lunetta, A L Destefano, B Grenier-Boley, R Sims, G W Beecham, A V Smith, V Chouraki, K L Hamilton-Nelson, M A Ikram, N Fievet, N Denning, E R Martin, H Schmidt, Y Kamatani, M L Dunstan, O Valladares, A R Laza, D Zelenika, A Ramirez, T M Foroud, S-H Choi, A Boland, T Becker, W A Kukull, S J van der Lee, F Pasquier, C Cruchaga, D Beekly, A L Fitzpatrick, O Hanon, M Gill, R Barber, V Gudnason, D Campion, S Love, D A Bennett, N Amin, C Berr, Magda Tsolaki, J D Buxbaum, O L Lopez, V Deramecourt, N C Fox, L B Cantwell, L Tárraga, C Dufouil, J Hardy, P K Crane, G Eiriksdottir, D Hannequin, R Clarke, D Evans, T H Mosley, L Letenneur, C Brayne, W Maier, P De Jager, V Emilsson, J-F Dartigues, H Hampel, M I Kamboh, R F A G de Bruijn, C Tzourio, P Pastor, E B Larson, J I Rotter, M C O'Donovan, T J Montine, M A Nalls, S Mead, E M Reiman, P V Jonsson, C Holmes, P H St George-Hyslop, M Boada, P Passmore, J R Wendland, R Schmidt, K Morgan, A R Winslow, J F Powell, M Carasquillo, S G Younkin, J Jakobsdóttir, J S K Kauwe, K C Wilhelmsen, D Rujescu, M M Nöthen, A Hofman, L Jones, J L Haines, B M Psaty, C Van Broeckhoven, P Holmans, L J Launer, R Mayeux, M Lathrop, A M Goate, V Escott-Price, S Seshadri, M A Pericak-Vance, P Amouyel, J Williams, C M van Duijn, G D Schellenberg, L A Farre. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25778476. |
apoe ɛ4, the most significant genetic risk factor for alzheimer disease (ad), may mask effects of other loci. |
2016-09-16 |
2023-08-13 |
human |
| G Jun, C A Ibrahim-Verbaas, M Vronskaya, J-C Lambert, J Chung, A C Naj, B W Kunkle, L-S Wang, J C Bis, C Bellenguez, D Harold, K L Lunetta, A L Destefano, B Grenier-Boley, R Sims, G W Beecham, A V Smith, V Chouraki, K L Hamilton-Nelson, M A Ikram, N Fievet, N Denning, E R Martin, H Schmidt, Y Kamatani, M L Dunstan, O Valladares, A R Laza, D Zelenika, A Ramirez, T M Foroud, S-H Choi, A Boland, T Becker, W A Kukull, S J van der Lee, F Pasquier, C Cruchaga, D Beekly, A L Fitzpatrick, O Hanon, M Gill, R Barber, V Gudnason, D Campion, S Love, D A Bennett, N Amin, C Berr, Magda Tsolaki, J D Buxbaum, O L Lopez, V Deramecourt, N C Fox, L B Cantwell, L Tárraga, C Dufouil, J Hardy, P K Crane, G Eiriksdottir, D Hannequin, R Clarke, D Evans, T H Mosley, L Letenneur, C Brayne, W Maier, P De Jager, V Emilsson, J-F Dartigues, H Hampel, M I Kamboh, R F A G de Bruijn, C Tzourio, P Pastor, E B Larson, J I Rotter, M C O'Donovan, T J Montine, M A Nalls, S Mead, E M Reiman, P V Jonsson, C Holmes, P H St George-Hyslop, M Boada, P Passmore, J R Wendland, R Schmidt, K Morgan, A R Winslow, J F Powell, M Carasquillo, S G Younkin, J Jakobsdóttir, J S K Kauwe, K C Wilhelmsen, D Rujescu, M M Nöthen, A Hofman, L Jones, J L Haines, B M Psaty, C Van Broeckhoven, P Holmans, L J Launer, R Mayeux, M Lathrop, A M Goate, V Escott-Price, S Seshadri, M A Pericak-Vance, P Amouyel, J Williams, C M van Duijn, G D Schellenberg, L A Farre. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25778476. |
we re-analyzed genome-wide association study (gwas) data from the international genomics of alzheimer's project (igap) consortium in apoe ɛ4+ (10 352 cases and 9207 controls) and apoe ɛ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (snp) and apoe ɛ4 status. |
2016-09-16 |
2023-08-13 |
human |
| Shannon L Risacher, Sungeun Kim, Kwangsik Nho, Tatiana Foroud, Li Shen, Ronald C Petersen, Clifford R Jack, Laurel A Beckett, Paul S Aisen, Robert A Koeppe, William J Jagust, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Andrew J Sayki. APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 12. 2016-09-08. PMID:25960448. |
apoe effect on alzheimer's disease biomarkers in older adults with significant memory concern. |
2016-09-08 |
2023-08-13 |
Not clear |
| Shannon L Risacher, Sungeun Kim, Kwangsik Nho, Tatiana Foroud, Li Shen, Ronald C Petersen, Clifford R Jack, Laurel A Beckett, Paul S Aisen, Robert A Koeppe, William J Jagust, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Andrew J Sayki. APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 12. 2016-09-08. PMID:25960448. |
this study assessed apolipoprotein e (apoe) ε4 carrier status effects on alzheimer's disease imaging and cerebrospinal fluid (csf) biomarkers in cognitively normal older adults with significant memory concerns (smc). |
2016-09-08 |
2023-08-13 |
Not clear |