| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Monge-Argilés, R Gasparini-Berenguer, M Gutierrez-Agulló, C Muñoz-Ruiz, J Sánchez-Payá, C Leiva-Santan. Influence of APOE Genotype on Alzheimer's Disease CSF Biomarkers in a Spanish Population. BioMed research international. vol 2016. 2016-12-22. PMID:27092308. |
influence of apoe genotype on alzheimer's disease csf biomarkers in a spanish population. |
2016-12-22 |
2023-08-13 |
Not clear |
| J A Monge-Argilés, R Gasparini-Berenguer, M Gutierrez-Agulló, C Muñoz-Ruiz, J Sánchez-Payá, C Leiva-Santan. Influence of APOE Genotype on Alzheimer's Disease CSF Biomarkers in a Spanish Population. BioMed research international. vol 2016. 2016-12-22. PMID:27092308. |
to evaluate the association between apolipoprotein e (apoe) genotype and cerebrospinal fluid (csf) levels of alzheimer's disease (ad) biomarkers and to study the influence of apoe genotype on the development of ad in a spanish population. |
2016-12-22 |
2023-08-13 |
Not clear |
| Elena Vallino Costassa, Michele Fiorini, Gianluigi Zanusso, Simone Peletto, Pierluigi Acutis, Elisa Baioni, Cristiana Maurella, Fabrizio Tagliavini, Marcella Catania, Marina Gallo, Monica Lo Faro, Maria Novella Chieppa, Daniela Meloni, Antonio D'Angelo, Orlando Paciello, Roberta Ghidoni, Elisa Tonoli, Cristina Casalone, Cristiano Coron. Characterization of Amyloid-β Deposits in Bovine Brains. Journal of Alzheimer's disease : JAD. vol 51. issue 3. 2016-12-19. PMID:26890772. |
exploration of the genetic variability of apoe, psen1, and psen2 genes involved in alzheimer's disease pathogenesis revealed several previously unreported polymorphisms. |
2016-12-19 |
2023-08-13 |
human |
| Vicent Bonet-Costa, Vicente Herranz-Pérez, MariCarmen Blanco-Gandía, Cristina Mas-Bargues, Marta Inglés, Patricia Garcia-Tarraga, Marta Rodriguez-Arias, Jose Miñarro, Consuelo Borras, Jose Manuel Garcia-Verdugo, Jose Viñ. Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 51. issue 3. 2016-12-19. PMID:26890773. |
amyloid-β (aβ) clearance from brain, which is decreased in alzheimer's disease, is facilitated by apolipoprotein e (apoe). |
2016-12-19 |
2023-08-13 |
mouse |
| Timothy J Hohman, Jessica N Cooke-Bailey, Christiane Reitz, Gyungah Jun, Adam Naj, Gary W Beecham, Zhi Liu, Regina M Carney, Jeffrey M Vance, Michael L Cuccaro, Ruchita Rajbhandary, Badri Narayan Vardarajan, Li-San Wang, Otto Valladares, Chiao-Feng Lin, Eric B Larson, Neill R Graff-Radford, Denis Evans, Philip L De Jager, Paul K Crane, Joseph D Buxbaum, Jill R Murrell, Towfique Raj, Nilufer Ertekin-Taner, Mark W Logue, Clinton T Baldwin, Robert C Green, Lisa L Barnes, Laura B Cantwell, M Daniele Fallin, Rodney C P Go, Patrick Griffith, Thomas O Obisesan, Jennifer J Manly, Kathryn L Lunetta, M Ilyas Kamboh, Oscar L Lopez, David A Bennett, John Hardy, Hugh C Hendrie, Kathleen S Hall, Alison M Goate, Rosalyn Lang, Goldie S Byrd, Walter A Kukull, Tatiana M Foroud, Lindsay A Farrer, Eden R Martin, Margaret A Pericak-Vance, Gerard D Schellenberg, Richard Mayeux, Jonathan L Haines, Tricia A Thornton-Well. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 3. 2016-12-15. PMID:26092349. |
recently, the largest genome-wide association study in aas to date confirmed that six of the alzheimer's disease (ad)-related genetic variants originally discovered in ea cohorts are also risk variants in aa; however, the risk attributable to many of the loci (e.g., apoe, abca7) differed substantially from previous studies in ea. |
2016-12-15 |
2023-08-13 |
Not clear |
| Hao Shu, Yongmei Shi, Gang Chen, Zan Wang, Duan Liu, Chunxian Yue, B Douglas Ward, Wenjun Li, Zhan Xu, Guangyu Chen, Qihao Guo, Jun Xu, Shi-Jiang Li, Zhijun Zhan. Opposite Neural Trajectories of Apolipoprotein E ϵ4 and ϵ2 Alleles with Aging Associated with Different Risks of Alzheimer's Disease. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 4. 2016-12-13. PMID:25336599. |
the apolipoprotein e (apoe) ϵ4 allele is a confirmed genetic risk factor and the apoe ϵ2 allele is a protective factor related to late-onset alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
human |
| Afef Achouri-Rassas, Nadia Ben Ali, Aroua Cherif, Saloua Fray, Hajer Siala, Nouria Oudiaa Zakraoui, Sondes Hadj-Fredj, Mariem Kechaou, Nadia Anane, Slim Echebi, Taieb Messaoud, Samir Bela. Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 3. 2016-12-13. PMID:26456241. |
association between ace polymorphism, cognitive phenotype and apoe e4 allele in a tunisian population with alzheimer disease. |
2016-12-13 |
2023-08-13 |
Not clear |
| Xiao Luo, Tiantian Qiu, Xiaojun Xu, Peiyu Huang, Quanquan Gu, Zhujing Shen, Xinfeng Yu, YunLu Jia, Xiaojun Guan, Ruirui Song, Minming Zhan. Decreased Inter-Hemispheric Functional Connectivity in Cognitively Intact Elderly APOE ɛ4 Carriers: A Preliminary Study. Journal of Alzheimer's disease : JAD. vol 50. issue 4. 2016-12-13. PMID:26836191. |
the apolipoprotein e (apoe) ɛ4 allele is the best-known genetic risk factor for developing sporadic alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
Not clear |
| Mohamad El Haj, Pascal Antoine, Philippe Amouyel, Jean-Charles Lambert, Florence Pasquier, Dimitrios Kapogianni. Apolipoprotein E (APOE) ε4 and episodic memory decline in Alzheimer's disease: A review. Ageing research reviews. vol 27. 2016-12-13. PMID:26876367. |
apolipoprotein e (apoe) ε4 and episodic memory decline in alzheimer's disease: a review. |
2016-12-13 |
2023-08-13 |
Not clear |
| Mohamad El Haj, Pascal Antoine, Philippe Amouyel, Jean-Charles Lambert, Florence Pasquier, Dimitrios Kapogianni. Apolipoprotein E (APOE) ε4 and episodic memory decline in Alzheimer's disease: A review. Ageing research reviews. vol 27. 2016-12-13. PMID:26876367. |
a growing body of research has examined the relationship between episodic memory decline, the cognitive hallmark of alzheimer's disease (ad), and the presence of apolipoprotein e ε4 (apoe ε4) allele, a major genetic risk factor for the disease. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jesus J Gomar, Concepcion Conejero-Goldberg, Edward D Huey, Peter Davies, Terry E Goldber. Lack of neural compensatory mechanisms of BDNF val66met met carriers and APOE E4 carriers in healthy aging, mild cognitive impairment, and Alzheimer's disease. Neurobiology of aging. vol 39. 2016-12-13. PMID:26923413. |
lack of neural compensatory mechanisms of bdnf val66met met carriers and apoe e4 carriers in healthy aging, mild cognitive impairment, and alzheimer's disease. |
2016-12-13 |
2023-08-13 |
human |
| Maximilian Wiesmann, Valerio Zerbi, Diane Jansen, Roy Haast, Dieter Lütjohann, Laus M Broersen, Arend Heerschap, Amanda J Kiliaa. A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice. Neural plasticity. vol 2016. 2016-12-13. PMID:27034849. |
apoe ε4 (apoe4) polymorphism is the main genetic determinant of sporadic alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
mouse |
| Anna Limon-Sztencel, Beata S Lipska-Ziętkiewicz, Magdalena Chmara, Bartosz Wasag, Leszek Bidzan, Beata R Godlewska, Janusz Limo. The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms. Alzheimer's research & therapy. vol 8. issue 1. 2016-12-13. PMID:27193889. |
the algorithm for alzheimer risk assessment based on apoe promoter polymorphisms. |
2016-12-13 |
2023-08-13 |
Not clear |
| Anna Limon-Sztencel, Beata S Lipska-Ziętkiewicz, Magdalena Chmara, Bartosz Wasag, Leszek Bidzan, Beata R Godlewska, Janusz Limo. The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms. Alzheimer's research & therapy. vol 8. issue 1. 2016-12-13. PMID:27193889. |
over the past two decades, the apoe gene and its polymorphisms have been among the most studied risk factors of alzheimer disease (ad) development; yet, there are discrepancies between various studies regarding their impact. |
2016-12-13 |
2023-08-13 |
Not clear |
| Takayoshi Tokutake, Kensaku Kasuga, Norikazu Hara, Takeshi Ikeuch. [Multifunctional Roles of APOE in Alzheimer's Disease Pathogenesis]. Brain and nerve = Shinkei kenkyu no shinpo. vol 68. issue 7. 2016-12-13. PMID:27395454. |
[multifunctional roles of apoe in alzheimer's disease pathogenesis]. |
2016-12-13 |
2023-08-13 |
Not clear |
| Takayoshi Tokutake, Kensaku Kasuga, Norikazu Hara, Takeshi Ikeuch. [Multifunctional Roles of APOE in Alzheimer's Disease Pathogenesis]. Brain and nerve = Shinkei kenkyu no shinpo. vol 68. issue 7. 2016-12-13. PMID:27395454. |
numerous epidemiological studies have shown that the apolipoprotein e gene (apoe) is a strong genetic risk factor for alzheimer's disease (ad) among people from various ethnic backgrounds. |
2016-12-13 |
2023-08-13 |
Not clear |
| Amanda Heslegrave, Wendy Heywood, Ross Paterson, Nadia Magdalinou, Johan Svensson, Per Johansson, Annika Öhrfelt, Kaj Blennow, John Hardy, Jonathan Schott, Kevin Mills, Henrik Zetterber. Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:26754172. |
the discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (trem2) are risk factors for alzheimer's disease (ad), with only the apolipoprotein e (apoe) ε4 gene allele conferring a higher risk, has led to increased interest in immune biology in the brain. |
2016-11-08 |
2023-08-13 |
Not clear |
| Gerald Novak, Nick Fox, Shona Clegg, Casper Nielsen, Steven Einstein, Yuan Lu, Iulia Cristina Tudor, Keith Gregg, Jianing Di, Peter Collins, Bradley T Wyman, Eric Yuen, Michael Grundman, H Robert Brashear, Enchi Li. Changes in Brain Volume with Bapineuzumab in Mild to Moderate Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 49. issue 4. 2016-10-28. PMID:26639957. |
bapineuzumab, an anti-amyloid-β monoclonal antibody, was evaluated in two placebo-controlled trials in apoe*ɛ4 carriers and noncarriers, respectively, with alzheimer's disease. |
2016-10-28 |
2023-08-13 |
Not clear |
| Eun Hyun Seo, Sang Hoon Kim, Sang Hag Park, Seong-Ho Kang, Il Han Cho. Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment. Journal of Korean medical science. vol 31. issue 2. 2016-10-28. PMID:26839485. |
this study aimed to investigate the independent and interactive influences of apolipoprotein e (apoe) ε4 and beta-amyloid (aβ) on multiple cognitive domains in a large group of cognitively normal (cn) individuals and patients with mild cognitive impairment (mci) and alzheimer's disease (ad). |
2016-10-28 |
2023-08-13 |
human |
| Eun Hyun Seo, Sang Hoon Kim, Sang Hag Park, Seong-Ho Kang, Il Han Cho. Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment. Journal of Korean medical science. vol 31. issue 2. 2016-10-28. PMID:26839485. |
participants were included if clinical and cognitive assessments, amyloid imaging, and apoe genotype were all available from the alzheimer's disease neuroimaging initiative database (cn = 324, mci = 502, ad = 182). |
2016-10-28 |
2023-08-13 |
human |