| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lingling Zheng, Jianzhong Duan, Xiaoling Duan, Weitao Zhou, Chunjiang Chen, Yanhua Li, Jie Chen, Weihui Zhou, Yan-Jiang Wang, Tingyu Li, Weihong Son. Association of Apolipoprotein E (ApoE) Polymorphism with Alzheimer's Disease in Chinese Population. Current Alzheimer research. vol 13. issue 8. 2017-10-02. PMID:27033052. |
apolipoprotein e (apoe) plays a vital role in cholesterol metabolism and its allele polymorphisms have been associated with several diseases including alzheimer's disease (ad). |
2017-10-02 |
2023-08-13 |
human |
| Gerardo Salvato, Eva Z Patai, Tayla McCloud, Anna C Nobr. Apolipoprotein ɛ4 breaks the association between declarative long-term memory and memory-based orienting of spatial attention in middle-aged individuals. Cortex; a journal devoted to the study of the nervous system and behavior. vol 82. 2017-10-02. PMID:27395443. |
apolipoprotein (apoe) ɛ4 genotype has been identified as a risk factor for late-onset alzheimer disease (ad). |
2017-10-02 |
2023-08-13 |
Not clear |
| Chin Hong Tan, Bradley T Hyman, Jacinth J X Tan, Christopher P Hess, William P Dillon, Gerard D Schellenberg, Lilah M Besser, Walter A Kukull, Karolina Kauppi, Linda K McEvoy, Ole A Andreassen, Anders M Dale, Chun Chieh Fan, Rahul S Desika. Polygenic hazard scores in preclinical Alzheimer disease. Annals of neurology. vol 82. issue 3. 2017-10-02. PMID:28940650. |
phs predicted longitudinal clinical decline among older individuals with moderate to high consortium to establish a registry for alzheimer's disease (amyloid) and braak (tau) scores at autopsy, even among apoe ɛ4 noncarriers. |
2017-10-02 |
2023-08-13 |
Not clear |
| Chin Hong Tan, Bradley T Hyman, Jacinth J X Tan, Christopher P Hess, William P Dillon, Gerard D Schellenberg, Lilah M Besser, Walter A Kukull, Karolina Kauppi, Linda K McEvoy, Ole A Andreassen, Anders M Dale, Chun Chieh Fan, Rahul S Desika. Polygenic hazard scores in preclinical Alzheimer disease. Annals of neurology. vol 82. issue 3. 2017-10-02. PMID:28940650. |
beyond apoe, phs may help identify asymptomatic individuals at highest risk for developing alzheimer neurodegeneration. |
2017-10-02 |
2023-08-13 |
Not clear |
| Eleanna Kara, Jordan D Marks, Zhanyun Fan, Jacob A Klickstein, Allyson D Roe, Kelly A Krogh, Susanne Wegmann, Masato Maesako, Christina C Luo, Ravi Mylvaganam, Oksana Berezovska, Eloise Hudry, Bradley T Hyma. Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay. The Journal of biological chemistry. vol 292. issue 36. 2017-09-29. PMID:28684412. |
apolipoprotein e (apoe) has an important role in the pathogenesis of alzheimer's disease with its three isoforms having distinct effects on disease risk. |
2017-09-29 |
2023-08-13 |
Not clear |
| Jill K Morris, Eric D Vidoni, Heather M Wilkins, Ashley E Archer, Nicole C Burns, Rainer T Karcher, Rasinio S Graves, Russell H Swerdlow, John P Thyfault, Jeffrey M Burn. Impaired fasting glucose is associated with increased regional cerebral amyloid. Neurobiology of aging. vol 44. 2017-09-28. PMID:27318141. |
the alzheimer's disease risk gene apolipoprotein e epsilon 4 (apoe ε4) is associated with increased cerebral amyloid. |
2017-09-28 |
2023-08-13 |
human |
| Shorena Janelidze, Joakim Hertze, Katarina Nägga, Karin Nilsson, Christer Nilsson, Malin Wennström, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Oskar Hansso. Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype. Neurobiology of aging. vol 51. 2017-09-28. PMID:28061383. |
however, this measure was not changed during preclinical or prodromal alzheimer's disease and was not associated with amyloid positron emission tomography or apoe genotype. |
2017-09-28 |
2023-08-13 |
Not clear |
| A Cecile Jw Janssens, Eline M Bunnik, Wylie Burke, Maartje Hn Scherme. Uninformed consent in nutrigenomic research. European journal of human genetics : EJHG. vol 25. issue 7. 2017-09-28. PMID:28488677. |
a well-known example is the apoe gene, which is implicated in cholesterol regulation and is a major risk factor for alzheimer's disease. |
2017-09-28 |
2023-08-13 |
human |
| Lauren C Tindale, Stephen Leach, John J Spinelli, Angela R Brooks-Wilso. Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old. Oncotarget. vol 8. issue 13. 2017-09-26. PMID:28206976. |
apoe, hp, and cryl1 have all been associated with alzheimer's disease, the pathology of which involves lipid and cholesterol pathways. |
2017-09-26 |
2023-08-13 |
Not clear |
| J I Vélez, F Lopera, D Sepulveda-Falla, H R Patel, A S Johar, A Chuah, C Tobón, D Rivera, A Villegas, Y Cai, K Peng, R Arkell, F X Castellanos, S J Andrews, M F Silva Lara, P K Creagh, S Easteal, J de Leon, M L Wong, J Licinio, C A Mastronardi, M Arcos-Burgo. APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease. Molecular psychiatry. vol 21. issue 7. 2017-09-25. PMID:26619808. |
apoe*e2 allele delays age of onset in psen1 e280a alzheimer's disease. |
2017-09-25 |
2023-08-13 |
Not clear |
| Hongwon Kim, Junsang Yoo, Jaein Shin, Yujung Chang, Junghyun Jung, Dong-Gyu Jo, Janghwan Kim, Wonhee Jang, Christopher J Lengner, Byung-Soo Kim, Jongpil Ki. Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron. Brain : a journal of neurology. vol 140. issue 8. 2017-09-21. PMID:28899010. |
modelling apoe ɛ3/4 allele-associated sporadic alzheimer's disease in an induced neuron. |
2017-09-21 |
2023-08-13 |
mouse |
| Hongwon Kim, Junsang Yoo, Jaein Shin, Yujung Chang, Junghyun Jung, Dong-Gyu Jo, Janghwan Kim, Wonhee Jang, Christopher J Lengner, Byung-Soo Kim, Jongpil Ki. Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron. Brain : a journal of neurology. vol 140. issue 8. 2017-09-21. PMID:28899010. |
here, we report the generation of induced neuron-based model of sporadic alzheimer's disease in mice and humans, and used this system to explore the pathogenic mechanisms resulting from the sporadic alzheimer's disease risk factor apolipoprotein e (apoe) ɛ3/4 allele. |
2017-09-21 |
2023-08-13 |
mouse |
| Hongwon Kim, Junsang Yoo, Jaein Shin, Yujung Chang, Junghyun Jung, Dong-Gyu Jo, Janghwan Kim, Wonhee Jang, Christopher J Lengner, Byung-Soo Kim, Jongpil Ki. Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron. Brain : a journal of neurology. vol 140. issue 8. 2017-09-21. PMID:28899010. |
importantly, we demonstrate that apoe ɛ3/4 patient induced neuron culture models can faithfully recapitulate molecular signatures seen in apoe ɛ3/4-associated sporadic alzheimer's disease patients. |
2017-09-21 |
2023-08-13 |
mouse |
| Hongwon Kim, Junsang Yoo, Jaein Shin, Yujung Chang, Junghyun Jung, Dong-Gyu Jo, Janghwan Kim, Wonhee Jang, Christopher J Lengner, Byung-Soo Kim, Jongpil Ki. Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron. Brain : a journal of neurology. vol 140. issue 8. 2017-09-21. PMID:28899010. |
moreover, analysis of the gene network derived from apoe ɛ3/4 patient induced neurons reveals a strong interaction between apoe ɛ3/4 and another alzheimer's disease risk factor, desmoglein 2 (dsg2). |
2017-09-21 |
2023-08-13 |
mouse |
| Hongwon Kim, Junsang Yoo, Jaein Shin, Yujung Chang, Junghyun Jung, Dong-Gyu Jo, Janghwan Kim, Wonhee Jang, Christopher J Lengner, Byung-Soo Kim, Jongpil Ki. Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron. Brain : a journal of neurology. vol 140. issue 8. 2017-09-21. PMID:28899010. |
these data provide a direct connection between apoe ɛ3/4 and another alzheimer's disease susceptibility gene and demonstrate in proof of principle the utility of induced neuron-based modelling of alzheimer's disease for therapeutic discovery. |
2017-09-21 |
2023-08-13 |
mouse |
| Elliott J Mufson, Michael Malek-Ahmadi, Noelle Snyder, Jake Ausdemore, Kewei Chen, Sylvia E Pere. Braak stage and trajectory of cognitive decline in noncognitively impaired elders. Neurobiology of aging. vol 43. 2017-09-19. PMID:27255819. |
these data suggest that age and apoe ε4 status, rather than alzheimer's disease-related pathology, play a more prominent role in the trajectory of cognitive decline over time in this elderly nondemented population. |
2017-09-19 |
2023-08-13 |
human |
| Anthony J Hinrich, Francine M Jodelka, Jennifer L Chang, Daniella Brutman, Angela M Bruno, Clark A Briggs, Bryan D James, Grace E Stutzmann, David A Bennett, Steven A Miller, Frank Rigo, Robert A Marr, Michelle L Hasting. Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides. EMBO molecular medicine. vol 8. issue 4. 2017-09-13. PMID:26902204. |
given its role in cognition and its association with the alzheimer's disease (ad) risk gene, apoe, apoer2 has been proposed to be involved in ad, though a role for the receptor in the disease is not clear. |
2017-09-13 |
2023-08-13 |
mouse |
| Donald R Royall, Safa Al-Rubaye, Ram Bishnoi, Raymond F Palme. Few serum proteins mediate APOE's association with dementia. PloS one. vol 12. issue 3. 2017-09-07. PMID:28291794. |
in this analysis, we explore serum proteins as potential mediators of apoe's specific association with δ in a large, ethnically diverse longitudinal cohort, the texas alzheimer's research and care consortium (tarcc). |
2017-09-07 |
2023-08-13 |
Not clear |
| Kristin L Ayers, Uyenlinh L Mirshahi, Amr H Wardeh, Michael F Murray, Ke Hao, Benjamin S Glicksberg, Shuyu Li, David J Carey, Rong Che. A loss of function variant in CASP7 protects against Alzheimer's disease in homozygous APOE ε4 allele carriers. BMC genomics. vol 17 Suppl 2. 2017-09-05. PMID:27358062. |
a loss of function variant in casp7 protects against alzheimer's disease in homozygous apoe ε4 allele carriers. |
2017-09-05 |
2023-08-13 |
Not clear |
| Franca Rosa Guerini, Elisabetta Farina, Andrea Saul Costa, Francesca Baglio, Francesca Lea Saibene, Nicolò Margaritella, Elena Calabrese, Milena Zanzottera, Elisabetta Bolognesi, Raffaello Nemni, Mario Cleric. ApoE and SNAP-25 Polymorphisms Predict the Outcome of Multidimensional Stimulation Therapy Rehabilitation in Alzheimer's Disease. Neurorehabilitation and neural repair. vol 30. issue 9. 2017-08-25. PMID:27075583. |
apoe and snap-25 polymorphisms predict the outcome of multidimensional stimulation therapy rehabilitation in alzheimer's disease. |
2017-08-25 |
2023-08-13 |
Not clear |