| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katrine Laura Rasmusse. Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review. Atherosclerosis. vol 255. 2017-11-06. PMID:28340945. |
plasma levels of apoe and other lipids and lipoproteins are under strong genetic influence by the apoe polymorphism, and the ε4 allele is a strong genetic risk factor for alzheimer disease. |
2017-11-06 |
2023-08-13 |
Not clear |
| Luke W Bonham, Rahul S Desikan, Jennifer S Yokoyam. The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27357286. |
the relationship between complement factor c3, apoe ε4, amyloid and tau in alzheimer's disease. |
2017-10-25 |
2023-08-13 |
Not clear |
| Luke W Bonham, Rahul S Desikan, Jennifer S Yokoyam. The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27357286. |
our results support a conceptual model of the ad pathogenic cascade where a synergistic relationship between the complement cascade (c3) and apoe ε4 results in elevated alzheimer's neurodegeneration and in turn, amyloid further regulates the effect of the complement cascade on downstream tau pathology. |
2017-10-25 |
2023-08-13 |
Not clear |
| Kirstie L McDermott, G Peggy McFall, Shea J Andrews, Kaarin J Anstey, Roger A Dixo. Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles. The journals of gerontology. Series B, Psychological sciences and social sciences. vol 72. issue 6. 2017-10-24. PMID:28025282. |
apolipoprotein e (apoe) ɛ4 and clusterin (clu) c alleles are risk factors for alzheimer's disease (ad) and episodic memory (em) decline. |
2017-10-24 |
2023-08-13 |
Not clear |
| Scott C Neu, Judy Pa, Walter Kukull, Duane Beekly, Amanda Kuzma, Prabhakaran Gangadharan, Li-San Wang, Klaus Romero, Stephen P Arneric, Alberto Redolfi, Daniele Orlandi, Giovanni B Frisoni, Rhoda Au, Sherral Devine, Sanford Auerbach, Ana Espinosa, Mercè Boada, Agustín Ruiz, Sterling C Johnson, Rebecca Koscik, Jiun-Jie Wang, Wen-Chuin Hsu, Yao-Liang Chen, Arthur W Tog. Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis. JAMA neurology. vol 74. issue 10. 2017-10-18. PMID:28846757. |
it is unclear whether female carriers of the apolipoprotein e (apoe) ε4 allele are at greater risk of developing alzheimer disease (ad) than men, and the sex-dependent association of mild cognitive impairment (mci) and apoe has not been established. |
2017-10-18 |
2023-08-13 |
Not clear |
| Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O'Loughlin, Yang Xu, Zain Fanek, David J Greco, Scott T Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L Heppner, Vladimir Litvak, David M Holtzman, Hans Lassmann, Howard L Weiner, Jordi Ochando, Christian Haass, Oleg Butovsk. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. vol 47. issue 3. 2017-10-18. PMID:28930663. |
we identified a specific apolipoprotein e (apoe)-dependent molecular signature in microglia from models of amyotrophic lateral sclerosis (als), multiple sclerosis (ms), and alzheimer's disease (ad) and in microglia surrounding neuritic β-amyloid (aβ)-plaques in the brains of people with ad. |
2017-10-18 |
2023-08-13 |
mouse |
| P Dourlen, F J Fernandez-Gomez, C Dupont, B Grenier-Boley, C Bellenguez, H Obriot, R Caillierez, Y Sottejeau, J Chapuis, A Bretteville, F Abdelfettah, C Delay, N Malmanche, H Soininen, M Hiltunen, M-C Galas, P Amouyel, N Sergeant, L Buée, J-C Lambert, B Dermau. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Molecular psychiatry. vol 22. issue 6. 2017-10-17. PMID:27113998. |
a recent genome-wide association meta-analysis for alzheimer's disease (ad) identified 19 risk loci (in addition to apoe) in which the functional genes are unknown. |
2017-10-17 |
2023-08-13 |
mouse |
| Henrietta M Nielsen, Kewei Chen, Wendy Lee, Yinghua Chen, Robert J Bauer, Eric Reiman, Richard Caselli, Guojun B. Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism. Alzheimer's research & therapy. vol 9. issue 1. 2017-10-17. PMID:28137305. |
carriers of the apoe ε4 allele are at increased risk of developing alzheimer's disease (ad), and have been shown to have reduced cerebral metabolic rate of glucose (cmrgl) in the same brain areas frequently affected in ad. |
2017-10-17 |
2023-08-13 |
Not clear |
| Hussein N Yassine, Varun Rawat, Wendy J Mack, Joseph F Quinn, Karin Yurko-Mauro, Eileen Bailey-Hall, Paul S Aisen, Helena C Chui, Lon S Schneide. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease. Alzheimer's research & therapy. vol 8. 2017-10-16. PMID:27358067. |
the effect of apoe genotype on the delivery of dha to cerebrospinal fluid in alzheimer's disease. |
2017-10-16 |
2023-08-13 |
Not clear |
| Hussein N Yassine, Varun Rawat, Wendy J Mack, Joseph F Quinn, Karin Yurko-Mauro, Eileen Bailey-Hall, Paul S Aisen, Helena C Chui, Lon S Schneide. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease. Alzheimer's research & therapy. vol 8. 2017-10-16. PMID:27358067. |
apolipoprotein e (apoe) ɛ4 and low cerebrospinal fluid (csf) amyloid-β42 (aβ42) levels are predictors for developing alzheimer's disease (ad). |
2017-10-16 |
2023-08-13 |
Not clear |
| Hussein N Yassine, Varun Rawat, Wendy J Mack, Joseph F Quinn, Karin Yurko-Mauro, Eileen Bailey-Hall, Paul S Aisen, Helena C Chui, Lon S Schneide. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease. Alzheimer's research & therapy. vol 8. 2017-10-16. PMID:27358067. |
our objective in the present study was to examine whether apoe ɛ4 genotype and low csf aβ42 levels were associated with reduced delivery of dha to csf in the alzheimer's disease cooperative study-sponsored dha clinical trial. |
2017-10-16 |
2023-08-13 |
Not clear |
| Joanne S Allard, Oyonumo Ntekim, Steven P Johnson, Julius S Ngwa, Vernon Bond, Dynell Pinder, Richard F Gillum, Thomas V Fungwe, John Kwagyan, Thomas O Obisesa. APOEε4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study. Experimental gerontology. vol 87. issue Pt A. 2017-10-16. PMID:27864047. |
possession of the apolipoprotein e (apoe) gene ε4 allele is the most prevalent genetic risk factor for late onset alzheimer's disease (ad). |
2017-10-16 |
2023-08-13 |
Not clear |
| Frank Schraml, Kewei Chen, Napatkamon Ayutyanont, Roontiva Auttawut, Jessica B S Langbaum, Wendy Lee, Xiaofen Liu, Dan Bandy, Stephanie Q Reeder, Gene E Alexander, Richard J Caselli, Adam S Fleisher, Eric M Reima. Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose. PloS one. vol 8. issue 6. 2017-10-12. PMID:23840615. |
association between an alzheimer's disease-related index and apoe ε4 gene dose. |
2017-10-12 |
2023-08-12 |
Not clear |
| Claire Lancaster, Naji Tabet, Jennifer Ruste. The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline. Neurobiology of aging. vol 48. 2017-10-12. PMID:27661410. |
possession of an apolipoprotein e (apoe) e4 allele is an established risk factor for alzheimer's disease, whereas the less commonly studied e2 variant is premised to offer some protection. |
2017-10-12 |
2023-08-13 |
human |
| Charlotte Jendresen, Vibeke Årskog, Michael R Daws, Lars N G Nilsso. The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. Journal of neuroinflammation. vol 14. issue 1. 2017-10-11. PMID:28320424. |
triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) are genetically linked to alzheimer's disease. |
2017-10-11 |
2023-08-13 |
human |
| Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucc. Longitudinal lipid profile variations and clinical change in Alzheimer's disease dementia. Neuroscience letters. vol 646. 2017-10-10. PMID:28274859. |
in this longitudinal study, 192 consecutive outpatients with late-onset alzheimer's disease dementia were stratified according to apoe haplotypes, and followed for one year to investigate associations of lipid profile variations and lipophilic statin therapy with changes in cognition, caregiver burden, basic and instrumental functionality. |
2017-10-10 |
2023-08-13 |
Not clear |
| Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucc. Longitudinal lipid profile variations and clinical change in Alzheimer's disease dementia. Neuroscience letters. vol 646. 2017-10-10. PMID:28274859. |
in conclusion, apoe haplotypes seem to influence the protective effects of lipid profile variations for patients with alzheimer's disease dementia, but current evidence is insufficient to propose lipid-lowering drugs as specific anti-dementia therapy. |
2017-10-10 |
2023-08-13 |
Not clear |
| Alejandro Cáceres, José E Vargas, Juan R Gonzále. APOE and MS4A6A interact with GnRH signaling in Alzheimer's disease: Enrichment of epistatic effects. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 4. 2017-10-06. PMID:27337227. |
apoe and ms4a6a interact with gnrh signaling in alzheimer's disease: enrichment of epistatic effects. |
2017-10-06 |
2023-08-13 |
Not clear |
| Lei Yu, Michael W Lutz, Robert S Wilson, Daniel K Burns, Allen D Roses, Ann M Saunders, Jingyun Yang, Chris Gaiteri, Philip L De Jager, Lisa L Barnes, David A Bennet. APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. PloS one. vol 12. issue 7. 2017-10-06. PMID:28672022. |
apoe ε4-tomm40 '523 haplotypes and the risk of alzheimer's disease in older caucasian and african americans. |
2017-10-06 |
2023-08-13 |
human |
| Lingling Zheng, Jianzhong Duan, Xiaoling Duan, Weitao Zhou, Chunjiang Chen, Yanhua Li, Jie Chen, Weihui Zhou, Yan-Jiang Wang, Tingyu Li, Weihong Son. Association of Apolipoprotein E (ApoE) Polymorphism with Alzheimer's Disease in Chinese Population. Current Alzheimer research. vol 13. issue 8. 2017-10-02. PMID:27033052. |
association of apolipoprotein e (apoe) polymorphism with alzheimer's disease in chinese population. |
2017-10-02 |
2023-08-13 |
human |