| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suping Cai, Yuanyuan Jiang, Yubo Wang, Xiaoming Wu, Junchan Ren, Min Seob Lee, Sunghoon Lee, Liyu Huan. Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28108320. |
apolipoprotein e (apoe) ε4 allele is the genetic risk factor with the most established evidence for sporadic alzheimer's disease. |
2017-12-01 |
2023-08-13 |
Not clear |
| Fan Liao, Hyejin Yoon, Jungsu Ki. Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease. Current opinion in lipidology. vol 28. issue 1. 2017-11-22. PMID:27922847. |
the objective of this article is to review the recent findings about the metabolism of apolipoprotein e (apoe) and amyloid β and other possible mechanisms by which apoe contributes to the pathogenesis of alzheimer's disease. |
2017-11-22 |
2023-08-13 |
Not clear |
| Donald M Lyall, Joey Ward, Stuart J Ritchie, Gail Davies, Breda Cullen, Carlos Celis, Mark E S Bailey, Jana Anderson, Jon Evans, Daniel F Mckay, Andrew M Mcintosh, Naveed Sattar, Daniel J Smith, Ian J Deary, Jill P Pel. Alzheimer disease genetic risk factor APOE e4 and cognitive abilities in 111,739 UK Biobank participants. Age and ageing. vol 45. issue 4. 2017-11-20. PMID:27103599. |
alzheimer disease genetic risk factor apoe e4 and cognitive abilities in 111,739 uk biobank participants. |
2017-11-20 |
2023-08-13 |
human |
| Goran Papenberg, Nina Becker, Beata Ferencz, Moshe Naveh-Benjamin, Erika J Laukka, Lars Bäckman, Yvonne Brehme. Dopamine Receptor Genes Modulate Associative Memory in Old Age. Journal of cognitive neuroscience. vol 29. issue 2. 2017-11-20. PMID:27647283. |
by contrast, genetic risk for alzheimer disease (ad) was associated with worse item and associative memory, indicating adverse effects of apoe ε4 and a genetic risk score for ad (picalm, bin1, clu) on episodic memory in general. |
2017-11-20 |
2023-08-13 |
human |
| Tanya Gwendolyn Nock, Raphaël Chouinard-Watkins, Mélanie Plourd. Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1862. issue 10 Pt A. 2017-11-20. PMID:28733268. |
carriers of an epsilon 4 allele (e4) of apolipoprotein e (apoe) develop alzheimer's disease (ad) earlier than carriers of other apoe alleles. |
2017-11-20 |
2023-08-13 |
mouse |
| Fabricio F Oliveira, Elizabeth S Chen, Marilia C Smith, Paulo H F Bertolucc. Predictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazil. Alzheimer disease and associated disorders. vol 30. issue 3. 2017-11-16. PMID:26523709. |
little is known on how risk factors for alzheimer disease (ad) dementia affect disease progression, much less for populations with low mean schooling, whereas the transcription of apoe may be regulated by nongenetic factors. |
2017-11-16 |
2023-08-13 |
human |
| Jenny Ortega-Rojas, Luis Morales, Esneyder Guerrero, Carlos E Arboleda-Bustos, Adriana Mejia, Diego Forero, Luis Lopez, Rodrigo Pardo, Gonzalo Arboleda, Juan Yunis, Humberto Arboled. Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients. Alzheimer disease and associated disorders. vol 30. issue 4. 2017-11-16. PMID:27023435. |
we evaluated the association of several single-nucleotide polymorphisms in different genes including apoe, tomm40, cr1, pvrl2, sorl1, picalm, and gwa_14q32.13 in a colombian sample of late-onset alzheimer disease (load) patients. |
2017-11-16 |
2023-08-13 |
Not clear |
| Min-Jeong Kim, Sang Won Seo, Sung Tae Kim, Jong-Min Lee, Duk L N. Diffusion Tensor Changes According to Age at Onset and Apolipoprotein E Genotype in Alzheimer Disease. Alzheimer disease and associated disorders. vol 30. issue 4. 2017-11-16. PMID:27227996. |
age at onset is one of the most important factors that affects the clinical course in alzheimer disease (ad), whereas other factors such as apolipoprotein e (apoe) genotype may also play a major role. |
2017-11-16 |
2023-08-13 |
Not clear |
| Dale E Bredesen, Edwin C Amos, Jonathan Canick, Mary Ackerley, Cyrus Raji, Milan Fiala, Jamila Ahdida. Reversal of cognitive decline in Alzheimer's disease. Aging. vol 8. issue 6. 2017-11-16. PMID:27294343. |
these results have far-reaching implications for the treatment of alzheimer's disease, mci, and sci; for personalized programs that may enhance pharmaceutical efficacy; and for personal identification of apoe genotype. |
2017-11-16 |
2023-08-13 |
Not clear |
| M Cacciottolo, X Wang, I Driscoll, N Woodward, A Saffari, J Reyes, M L Serre, W Vizuete, C Sioutas, T E Morgan, M Gatz, H C Chui, S A Shumaker, S M Resnick, M A Espeland, C E Finch, J C Che. Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28140404. |
exposure to particulate matter (pm) in the ambient air and its interactions with apoe alleles may contribute to the acceleration of brain aging and the pathogenesis of alzheimer's disease (ad). |
2017-11-16 |
2023-08-13 |
mouse |
| Carole H Sudre, M Jorge Cardoso, Chris Frost, Josephine Barnes, Frederik Barkhof, Nick Fox, Sébastien Ourseli. APOE ε4 status is associated with white matter hyperintensities volume accumulation rate independent of AD diagnosis. Neurobiology of aging. vol 53. 2017-11-16. PMID:28235680. |
to assess the relationship between carriage of apoe ε4 allele and evolution of white matter hyperintensities (wmhs) volume, we longitudinally studied 339 subjects from the alzheimer's disease neuroimaging initiative cohort with diagnoses ranging from normal controls to probable alzheimer's disease (ad). |
2017-11-16 |
2023-08-13 |
human |
| Liang Gong, Hao Shu, Cancan He, Qing Ye, Feng Bai, Chunming Xie, Zhijun Zhan. Convergent and divergent effects of apolipoprotein E ε4 and ε2 alleles on amygdala functional networks in nondemented older adults. Neurobiology of aging. vol 54. 2017-11-16. PMID:28319835. |
however, this inverse relationship has recently been challenged, and the neural mechanisms underlying the effects of apoe genotype on alzheimer's disease remain unclear. |
2017-11-16 |
2023-08-13 |
human |
| Laila Abdullah, James E Evans, Tanja Emmerich, Gogce Crynen, Ben Shackleton, Andrew P Keegan, Cheryl Luis, Leon Tai, Mary J LaDu, Michael Mullan, Fiona Crawford, Corbin Bachmeie. APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease. Aging. vol 9. issue 3. 2017-11-16. PMID:28333036. |
this study was designed to explore the influence of apolipoprotein e (apoe) on blood phospholipids (pl) in predicting preclinical alzheimer's disease (ad). |
2017-11-16 |
2023-08-13 |
mouse |
| Jin-Yu Zheng, Jian Sun, Chun-Mei Ji, Lin Shen, Zhong-Jun Chen, Peng Xie, Yuan-Zhao Sun, Ru-Tong Y. Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-β/Smad2/STAT3 signaling. Neurobiology of aging. vol 54. 2017-11-16. PMID:28366226. |
astrocytes and apolipoprotein e (apoe) play critical roles in cognitive function, not only under physiological conditions but also in some pathological situations, particularly in the pathological progression of alzheimer's disease (ad). |
2017-11-16 |
2023-08-13 |
mouse |
| Elisa Scheller, Jessica Peter, Lena V Schumacher, Jacob Lahr, Irina Mader, Christoph P Kaller, Stefan Klöppe. APOE moderates compensatory recruitment of neuronal resources during working memory processing in healthy older adults. Neurobiology of aging. vol 56. 2017-11-16. PMID:28528773. |
the apoe ε4 allele increases the risk for sporadic alzheimer's disease and modifies brain activation patterns of numerous cognitive domains. |
2017-11-16 |
2023-08-13 |
Not clear |
| Elisa Scheller, Jessica Peter, Lena V Schumacher, Jacob Lahr, Irina Mader, Christoph P Kaller, Stefan Klöppe. APOE moderates compensatory recruitment of neuronal resources during working memory processing in healthy older adults. Neurobiology of aging. vol 56. 2017-11-16. PMID:28528773. |
using multiple regression models, we identified interactions of apoe variant and age in bilateral hippocampus independently from task performance: ε4 carriers only showed a decrease in activation with increasing age, suggesting high sensitivity of fmri data for detecting changes in alzheimer's disease-relevant brain areas before cognitive decline. |
2017-11-16 |
2023-08-13 |
Not clear |
| Yuan Fu, Jing Zhao, Yuka Atagi, Henrietta M Nielsen, Chia-Chen Liu, Honghua Zheng, Mitsuru Shinohara, Takahisa Kanekiyo, Guojun B. Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan. Molecular neurodegeneration. vol 11. issue 1. 2017-11-09. PMID:27151330. |
alzheimer's disease risk increases significantly in individuals carrying one or two copies of apoe ε4 allele compared to individuals with an ε3/ε3 genotype. |
2017-11-09 |
2023-08-13 |
Not clear |
| Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, Jennifer Lopez-Contreras, Jungsu Kim, Patrick M Sullivan, David M Holtzman, Martin J Sadowsk. APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice. Molecular neurodegeneration. vol 12. issue 1. 2017-11-09. PMID:28143566. |
apoe genotype is the foremost genetic factor modulating β-amyloid (aβ) deposition and risk of sporadic alzheimer's disease (ad). |
2017-11-09 |
2023-08-13 |
mouse |
| Adam P Spira, Yang An, Yu Peng, Mark N Wu, Eleanor M Simonsick, Luigi Ferrucci, Susan M Resnic. APOE Genotype and Nonrespiratory Sleep Parameters in Cognitively Intact Older Adults. Sleep. vol 40. issue 8. 2017-11-08. PMID:28482100. |
the apolipoprotein e (apoe) Ɛ4 allele increases alzheimer's disease (ad) risk and has been linked to a greater risk of sleep-disordered breathing. |
2017-11-08 |
2023-08-13 |
Not clear |
| Katrine Laura Rasmusse. Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review. Atherosclerosis. vol 255. 2017-11-06. PMID:28340945. |
astrocyte-derived apoe is pivotal for cerebral cholesterol metabolism and clearance of β-amyloid, a major pathological hallmark of alzheimer disease. |
2017-11-06 |
2023-08-13 |
Not clear |