| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L Del-Aguila, John C Morris, Carlos Cruchaga, Anne M Fagan, Bruce L Miller, Adam L Boxer, William W Seeley, Oleg Butovsky, Ben A Barres, Steven M Paul, David M Holtzma. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. vol 549. issue 7673. 2018-02-26. PMID:28959956. |
however, whether apoe independently influences tau pathology, the other major proteinopathy of alzheimer disease and other tauopathies, or tau-mediated neurodegeneration, is not clear. |
2018-02-26 |
2023-08-13 |
mouse |
| Feng Lin, Ping Ren, Raymond Y Lo, Benjamin P Chapman, Alanna Jacobs, Timothy M Baran, Anton P Porsteinsson, John J Fox. Insula and Inferior Frontal Gyrus' Activities Protect Memory Performance Against Alzheimer's Disease Pathology in Old Age. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27716674. |
apolipoprotein e (apoe) ɛ4 carriers and patients with amnestic mild cognitive impairment (mci) have high risk of developing alzheimer's disease (ad). |
2018-02-22 |
2023-08-13 |
human |
| Zan Wang, Zhengjia Dai, Hao Shu, Duan Liu, Qihao Guo, Yong He, Zhijun Zhan. Cortical Thickness and Microstructural White Matter Changes Detect Amnestic Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 56. issue 1. 2018-02-21. PMID:27911306. |
both the apolipoprotein e (apoe) ɛ4 allele and amnestic mild cognitive impairment (amci) are considered to be risk factors for alzheimer's disease (ad). |
2018-02-21 |
2023-08-13 |
human |
| Patrick C G Haddick, Jessica L Larson, Nisha Rathore, Tushar R Bhangale, Qui T Phung, Karpagam Srinivasan, David V Hansen, Jennie R Lill, Margaret A Pericak-Vance, Jonathan Haines, Lindsay A Farrer, John S Kauwe, Gerard D Schellenberg, Carlos Cruchaga, Alison M Goate, Timothy W Behrens, Ryan J Watts, Robert R Graham, Joshua S Kaminker, Marcel van der Bru. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. Journal of Alzheimer's disease : JAD. vol 56. issue 3. 2018-02-21. PMID:28106546. |
we conducted a screen to identify variants associated with the age of onset of alzheimer's disease in apoe ɛ4 carriers. |
2018-02-21 |
2023-08-13 |
human |
| Patrick C G Haddick, Jessica L Larson, Nisha Rathore, Tushar R Bhangale, Qui T Phung, Karpagam Srinivasan, David V Hansen, Jennie R Lill, Margaret A Pericak-Vance, Jonathan Haines, Lindsay A Farrer, John S Kauwe, Gerard D Schellenberg, Carlos Cruchaga, Alison M Goate, Timothy W Behrens, Ryan J Watts, Robert R Graham, Joshua S Kaminker, Marcel van der Bru. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. Journal of Alzheimer's disease : JAD. vol 56. issue 3. 2018-02-21. PMID:28106546. |
our study suggests that a common coding region variant of the il-6 receptor results in neuroinflammatory changes that may influence the age of onset of alzheimer's disease in apoe ɛ4 carriers. |
2018-02-21 |
2023-08-13 |
human |
| Lukas Kunz, Martin Reuter, Nikolai Axmacher, Christian Monta. Conscientiousness is Negatively Associated with Grey Matter Volume in Young APOE ɛ4-Carriers. Journal of Alzheimer's disease : JAD. vol 56. issue 3. 2018-02-21. PMID:28106551. |
the etiology of late onset alzheimer's disease (load) depends on multiple factors, among which the apoe ɛ4 allele is the most adverse genetic determinant and conscientiousness represents an influential personality trait. |
2018-02-21 |
2023-08-13 |
human |
| Wasim Khan, Vincent Giampietro, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Christian Büchel, Patricia Conrod, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Anreas Heinz, Bernd Ittermann, Hervé Lemaître, Frauke Nees, Tomas Paus, Zdenka Pausova, Marcella Rietschel, Michael N Smolka, Andreas Ströhle, Jeurgen Gallinat, Bruno Vellas, Hilkka Soininen, Iwona Kloszewska, Magda Tsolaki, Patrizia Mecocci, Christian Spenger, Victor L Villemagne, Colin L Masters, J-Sebastian Muehlboeck, Lars Bäckman, Laura Fratiglioni, Grégoria Kalpouzos, Lars-Olof Wahlund, Gunther Schumann, Simon Lovestone, Steven C R Williams, Eric Westman, Andrew Simmon. A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 56. issue 3. 2018-02-21. PMID:28157104. |
a multi-cohort study of apoe ɛ4 and amyloid-β effects on the hippocampus in alzheimer's disease. |
2018-02-21 |
2023-08-13 |
human |
| Wasim Khan, Vincent Giampietro, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Christian Büchel, Patricia Conrod, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Anreas Heinz, Bernd Ittermann, Hervé Lemaître, Frauke Nees, Tomas Paus, Zdenka Pausova, Marcella Rietschel, Michael N Smolka, Andreas Ströhle, Jeurgen Gallinat, Bruno Vellas, Hilkka Soininen, Iwona Kloszewska, Magda Tsolaki, Patrizia Mecocci, Christian Spenger, Victor L Villemagne, Colin L Masters, J-Sebastian Muehlboeck, Lars Bäckman, Laura Fratiglioni, Grégoria Kalpouzos, Lars-Olof Wahlund, Gunther Schumann, Simon Lovestone, Steven C R Williams, Eric Westman, Andrew Simmon. A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 56. issue 3. 2018-02-21. PMID:28157104. |
the apolipoprotein e (apoe) gene has been consistently shown to modulate the risk of alzheimer's disease (ad). |
2018-02-21 |
2023-08-13 |
human |
| Nain Woo, Su-Kang Kim, Yucheng Sun, Seong Ho Kan. Enhanced capillary electrophoretic screening of Alzheimer based on direct apolipoprotein E genotyping and one-step multiplex PCR. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1072. 2018-02-21. PMID:29202360. |
human apolipoprotein e (apoe) is associated with high cholesterol levels, coronary artery disease, and especially alzheimer's disease. |
2018-02-21 |
2023-08-13 |
human |
| Nain Woo, Su-Kang Kim, Yucheng Sun, Seong Ho Kan. Enhanced capillary electrophoretic screening of Alzheimer based on direct apolipoprotein E genotyping and one-step multiplex PCR. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1072. 2018-02-21. PMID:29202360. |
in this study, we developed an apoe genotyping and one-step multiplex polymerase chain reaction (pcr) based-capillary electrophoresis (ce) method for the enhanced diagnosis of alzheimer's. |
2018-02-21 |
2023-08-13 |
human |
| Nain Woo, Su-Kang Kim, Yucheng Sun, Seong Ho Kan. Enhanced capillary electrophoretic screening of Alzheimer based on direct apolipoprotein E genotyping and one-step multiplex PCR. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1072. 2018-02-21. PMID:29202360. |
the detection limits of the apoe genes were 6.4-62.0pm, which were approximately 100-100,000 times more sensitive than previous alzheimer's diagnosis methods in addition, the combined one-step multiplex pcr and extended vp-based ce method was also successfully applied to the analysis of apoe genotypes in alzheimer's patients and normal samples and confirmed the distribution probability of allele frequencies. |
2018-02-21 |
2023-08-13 |
human |
| Peifen Chang, Xin Li, Chao Ma, Sisi Zhang, Zhen Liu, Kewei Chen, Lin Ai, Jingling Chang, Zhanjun Zhan. The Effects of an APOE Promoter Polymorphism on Human White Matter Connectivity during Non-Demented Aging. Journal of Alzheimer's disease : JAD. vol 55. issue 1. 2018-02-15. PMID:27636845. |
polymorphisms of the apolipoprotein e (apoe) promoter rs405509 are related to alzheimer's disease (ad). |
2018-02-15 |
2023-08-13 |
human |
| Melike Kahya, Eric Vidoni, Jeffrey M Burns, Ashley N Thompson, Kayla Meyer, Catherine F Siengsuko. The Relationship Between Apolipoprotein ε4 Carrier Status and Sleep Characteristics in Cognitively Normal Older Adults. Journal of geriatric psychiatry and neurology. vol 30. issue 5. 2018-02-14. PMID:28747136. |
the apolipoprotein (apoe) ε4 allele, a well-described genetic risk factor for late-onset alzheimer disease (ad), is associated with sleep disturbances even in cognitively normal older adults, although it is not clear whether this association is independent of sleep apnea. |
2018-02-14 |
2023-08-13 |
human |
| Michael Ekstract, Golde I Holtzman, Kye Y Kim, Susan M Willis, Doris T Zalle. Evaluation of a Web-based decision aid for people considering the APOE genetic test for Alzheimer risk. Genetics in medicine : official journal of the American College of Medical Genetics. vol 19. issue 6. 2018-02-13. PMID:27811860. |
evaluation of a web-based decision aid for people considering the apoe genetic test for alzheimer risk. |
2018-02-13 |
2023-08-13 |
Not clear |
| Michael Ekstract, Golde I Holtzman, Kye Y Kim, Susan M Willis, Doris T Zalle. Evaluation of a Web-based decision aid for people considering the APOE genetic test for Alzheimer risk. Genetics in medicine : official journal of the American College of Medical Genetics. vol 19. issue 6. 2018-02-13. PMID:27811860. |
with the increasing interest in apolipoprotein e (apoe) genetic testing to estimate the risk of developing late-onset alzheimer disease, new educational tools are needed to help people make the best decision for themselves about whether to undergo this test. |
2018-02-13 |
2023-08-13 |
Not clear |
| Xiaoke Hao, Xiaohui Yao, Jingwen Yan, Shannon L Risacher, Andrew J Saykin, Daoqiang Zhang, Li She. Identifying Multimodal Intermediate Phenotypes Between Genetic Risk Factors and Disease Status in Alzheimer's Disease. Neuroinformatics. vol 14. issue 4. 2018-02-12. PMID:27277494. |
we applied our proposed method to explore the relation between the well-known ad risk snp apoe rs429358 and three baseline brain imaging modalities (i.e., structural magnetic resonance imaging (mri), fluorodeoxyglucose positron emission tomography (fdg-pet) and f-18 florbetapir pet scans amyloid imaging (av45)) from the alzheimer's disease neuroimaging initiative (adni) database. |
2018-02-12 |
2023-08-13 |
human |
| Anika Saul, Oliver Wirth. Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease. Molecular neurobiology. vol 54. issue 1. 2018-02-09. PMID:26742512. |
endogenous apolipoprotein e (apoe) fragmentation is linked to amyloid pathology in transgenic mouse models of alzheimer's disease. |
2018-02-09 |
2023-08-13 |
mouse |
| Yin-Ying Fan, Qiao-Le Cai, Zhi-Yong Gao, Xue Lin, Qi Huang, Wei Tang, Jia-Hong Li. APOE ε4 allele elevates the expressions of inflammatory factors and promotes Alzheimer's disease progression: A comparative study based on Han and She populations in the Wenzhou area. Brain research bulletin. vol 132. 2018-02-09. PMID:28461186. |
apoe ε4 allele elevates the expressions of inflammatory factors and promotes alzheimer's disease progression: a comparative study based on han and she populations in the wenzhou area. |
2018-02-09 |
2023-08-13 |
Not clear |
| David Mengel, Judith Dams, Jannis Ziemek, Julian Becker, Monika Balzer-Geldsetzer, Rüdiger Hilker, Simon Baudrexel, Elke Kalbe, Nele Schmidt, Karsten Witt, Inga Liepelt-Scarfone, Susanne Gräber, Annette Petrelli, Petra Neuser, Claudia Schulte, Katharina Linse, Alexander Storch, Hans-Ulrich Wittchen, Oliver Riedel, Brit Mollenhauer, Jens Ebentheuer, Claudia Trenkwalder, Thomas Klockgether, Annika Spottke, Ullrich Wüllner, Jörg B Schulz, Kathrin Reetz, Ines Ann Heber, Alfredo Ramirez, Richard Dode. Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease. Parkinsonism & related disorders. vol 29. 2018-02-05. PMID:27321987. |
the apolipoprotein e (apoe) allele ε4 is a known risk factor for alzheimer's disease and has also been suggested to be a risk factor for dementia in pd and even a predictor of impairment in certain cognitive domains. |
2018-02-05 |
2023-08-13 |
Not clear |
| M V Spampinato, B R Langdon, K E Patrick, R O Parker, H Collins, E Pravata\. Gender, apolipoprotein E genotype, and mesial temporal atrophy: 2-year follow-up in patients with stable mild cognitive impairment and with progression from mild cognitive impairment to Alzheimer's disease. Neuroradiology. vol 58. issue 11. 2018-02-05. PMID:27590747. |
this study aimed to examine the relationship between gender, apolipoprotein e (apoe) genotype, and mesial temporal atrophy in mild cognitive impairment (mci) with and without progression to alzheimer's disease (ad). |
2018-02-05 |
2023-08-13 |
Not clear |