| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Liu, Lan Tan, Hui-Fu Wang, Yong Liu, Xiao-Ke Hao, Chen-Chen Tan, Teng Jiang, Bing Liu, Dao-Qiang Zhang, Jin-Tai Y. Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26298664. |
we used the alzheimer's disease neuroimaging initiative (adni) database to examine the influence of apoe ε4 dose on clinical and neuroimaging biomarkers across the ad spectrum (from cognitive normal to ad patients with severe cognitive impairment). |
2018-01-16 |
2023-08-13 |
human |
| Courtney Lane-Donovan, Joachim Her. ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease. Trends in endocrinology and metabolism: TEM. vol 28. issue 4. 2018-01-12. PMID:28057414. |
apoe, apoe receptors, and the synapse in alzheimer's disease. |
2018-01-12 |
2023-08-13 |
mouse |
| Sophie Stukas, Lita Freeman, Michael Lee, Anna Wilkinson, Alice Ossoli, Boris Vaisman, Stephen Demosky, Jeniffer Chan, Veronica Hirsch-Reinshagen, Alan T Remaley, Cheryl L Wellingto. LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice. Journal of lipid research. vol 55. issue 8. 2018-01-11. PMID:24950691. |
apoe is directly involved in the pathological progression of alzheimer's disease, including facilitating β-amyloid (aβ) clearance from the brain, a function that requires its lipidation by abca1. |
2018-01-11 |
2023-08-13 |
mouse |
| Florence F Roussotte, Katherine L Narr, Gary W Small, Paul M Thompso. The C677T variant in MTHFR modulates associations between blood-based and cerebrospinal fluid biomarkers of neurodegeneration. Neuroreport. vol 27. issue 12. 2018-01-11. PMID:27380243. |
this report suggests the value of genotyping patients at the c677t functional variant when using plasma apoe levels as a preclinical biomarker for alzheimer's disease. |
2018-01-11 |
2023-08-13 |
human |
| Jing Zhao, Mary D Davis, Yuka A Martens, Mitsuru Shinohara, Neill R Graff-Radford, Steven G Younkin, Zbigniew K Wszolek, Takahisa Kanekiyo, Guojun B. APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes. Human molecular genetics. vol 26. issue 14. 2018-01-11. PMID:28444230. |
the ε4 allele of the apoe gene encoding apolipoprotein e (apoe) is a strong genetic risk factor for aging-related cognitive decline as well as late-onset alzheimer's disease (ad) compared to the common ε3 allele. |
2018-01-11 |
2023-08-13 |
mouse |
| Bruce Teter, Mary Jo LaDu, Patrick M Sullivan, Sally A Frautschy, Greg M Col. Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain. Neuroreport. vol 27. issue 11. 2018-01-09. PMID:27281274. |
the apolipoprotein e (apoe) isotype apoe4 is a prevalent genetic risk factor for alzheimer's disease (ad) that can modulate systemic and central inflammation, independent of amyloid accumulation. |
2018-01-09 |
2023-08-13 |
mouse |
| Nina Rostgaard, Peter Roos, Esben Budtz-Jørgensen, Peter Johannsen, Gunhild Waldemar, Anne Nørremølle, Suzanne G Lindquist, Susanne Gydesen, Jeremy M Brown, John Collinge, Adrian M Isaacs, Troels T Nielsen, Jørgen E Nielse. TMEM106B and ApoE polymorphisms in CHMP2B-mediated frontotemporal dementia (FTD-3). Neurobiology of aging. vol 59. 2018-01-08. PMID:28888721. |
the role of apolipoprotein e (apoe) in ftd is uncertain, though an established risk factor in alzheimer's disease. |
2018-01-08 |
2023-08-13 |
Not clear |
| C Ma, Y Zhang, X Li, J Zhang, K Chen, Y Liang, Y Chen, Z Liu, Z Zhan. Is there a significant interaction effect between apolipoprotein E rs405509 T/T and ε4 genotypes on cognitive impairment and gray matter volume? European journal of neurology. vol 23. issue 9. 2018-01-04. PMID:27259692. |
evidence demonstrates that the t allele of the single-nucleotide polymorphism rs405509 in the apolipoprotein e (apoe) promoter is a risk factor for alzheimer's disease. |
2018-01-04 |
2023-08-13 |
Not clear |
| Argonde C van Harten, Wesley Jongbloed, Charlotte E Teunissen, Philip Scheltens, Rob Veerhuis, Wiesje M van der Flie. CSF ApoE predicts clinical progression in nondemented APOEε4 carriers. Neurobiology of aging. vol 57. 2018-01-03. PMID:28571653. |
possible associations between cerebrospinal fluid (csf) and plasma apolipoprotein e (apoe) concentration and early clinical and pathophysiological manifestation of alzheimer's disease were studied in a large and well-defined population of nondemented patients. |
2018-01-03 |
2023-08-13 |
Not clear |
| Argonde C van Harten, Wesley Jongbloed, Charlotte E Teunissen, Philip Scheltens, Rob Veerhuis, Wiesje M van der Flie. CSF ApoE predicts clinical progression in nondemented APOEε4 carriers. Neurobiology of aging. vol 57. 2018-01-03. PMID:28571653. |
development of alzheimer's disease in apoeε4 noncarriers may be unrelated to apoe concentration. |
2018-01-03 |
2023-08-13 |
Not clear |
| Catherine F Slattery, Jiaying Zhang, Ross W Paterson, Alexander J M Foulkes, Amelia Carton, Kirsty Macpherson, Laura Mancini, David L Thomas, Marc Modat, Nicolas Toussaint, David M Cash, John S Thornton, Susie M D Henley, Sebastian J Crutch, Daniel C Alexander, Sebastien Ourselin, Nick C Fox, Hui Zhang, Jonathan M Schot. ApoE influences regional white-matter axonal density loss in Alzheimer's disease. Neurobiology of aging. vol 57. 2018-01-03. PMID:28578156. |
apoe influences regional white-matter axonal density loss in alzheimer's disease. |
2018-01-03 |
2023-08-13 |
Not clear |
| Angana Ray, Navjeet Ahalawat, Jagannath Monda. Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E. Biophysical journal. vol 113. issue 12. 2018-01-02. PMID:29262361. |
atomistic insights into structural differences between e3 and e4 isoforms of apolipoprotein e. among various isoforms of apolipoprotein e (apoe), the e4 isoform (apoe4) is considered to be the strongest risk factor for alzheimer's disease, whereas the e3 isoform (apoe3) is neutral to the disease. |
2018-01-02 |
2023-08-13 |
Not clear |
| Timothy J Hohman, Logan Dumitrescu, Amy Oksol, Madison Wagener, Katherine A Gifford, Angela L Jefferso. APOE allele frequencies in suspected non-amyloid pathophysiology (SNAP) and the prodromal stages of Alzheimer's Disease. PloS one. vol 12. issue 11. 2017-12-26. PMID:29190651. |
apoe allele frequencies in suspected non-amyloid pathophysiology (snap) and the prodromal stages of alzheimer's disease. |
2017-12-26 |
2023-08-13 |
human |
| Tien-Phat V Huynh, Fan Liao, Caroline M Francis, Grace O Robinson, Javier Remolina Serrano, Hong Jiang, Joseph Roh, Mary Beth Finn, Patrick M Sullivan, Thomas J Esparza, Floy R Stewart, Thomas E Mahan, Jason D Ulrich, Tracy Cole, David M Holtzma. Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. Neuron. vol 96. issue 5. 2017-12-20. PMID:29216448. |
the apolipoprotein e (apoe) gene is the strongest genetic risk factor for late-onset alzheimer disease. |
2017-12-20 |
2023-08-13 |
mouse |
| G Siegel, F H M E Mockenhaupt, A-L Behnke, E Ermilov, K Winkler, A R Pries, M Malmsten, R Hetzer, R Saunders, B Lindma. Lipoprotein binding to anionic biopolyelectrolytes and the effect of glucose on nanoplaque formation in arteriosclerosis and Alzheimer's disease. Advances in colloid and interface science. vol 232. 2017-12-18. PMID:26969281. |
furthermore, it has been demonstrated that distinct apoe isoforms on the blood lipids further both arteriosclerotic and alzheimer nanoplaque formation and therefore impair flow-mediated vascular reactivity as well. |
2017-12-18 |
2023-08-13 |
human |
| Alison C Burggren, Zanjbeel Mahmood, Theresa M Harrison, Prabha Siddarth, Karen J Miller, Gary W Small, David A Merrill, Susan Y Bookheime. Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ε4 variant. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 7. 2017-12-18. PMID:28183529. |
the translocase of outer mitochondrial membrane 40 (tomm40), which lies in linkage disequilibrium with apolipoprotein e (apoe), has received attention more recently as a promising gene in alzheimer's disease (ad) risk. |
2017-12-18 |
2023-08-13 |
Not clear |
| Masao Ueki, Yoshinori Kawasaki, Gen Tamiy. Detecting genetic association through shortest paths in a bidirected graph. Genetic epidemiology. vol 41. issue 6. 2017-12-18. PMID:28626864. |
when applied to real gwas data from the alzheimer's disease neuroimaging initiative (adni), our method detected two groups of snps: one in a region containing the apolipoprotein e (apoe) gene, and another in a region close to the semaphorin 5a (sema5a) gene. |
2017-12-18 |
2023-08-13 |
Not clear |
| Marie-Thérèse Traversy, Milène Vandal, Cyntia Tremblay, Marine Tournissac, Ariane Giguère-Rancourt, A David Bennett, Frédéric Calo. Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene. Psychoneuroendocrinology. vol 77. 2017-12-07. PMID:28088659. |
apolipoprotein e epsilon-4 (apoeε4 or apoe4), an allelic variation of the apoe gene, not only increases the risk of developing the late-onset form of alzheimer's disease (ad), but also influences the outcome of treatment. |
2017-12-07 |
2023-08-13 |
mouse |
| Paraskevi Prasinou, Ioannis Dafnis, Giorgia Giacometti, Carla Ferreri, Angeliki Chroni, Chryssostomos Chatgilialogl. Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells. Biochimica et biophysica acta. Biomembranes. vol 1859. issue 10. 2017-12-05. PMID:28688796. |
human apoe has three common isoforms, the apoe4 being associated with alzheimer's disease. |
2017-12-05 |
2023-08-13 |
human |
| Xiaoyan Sun, Chuanhui Dong, Bonnie Levin, Elizabeth Crocco, David Loewenstein, Henrik Zetterberg, Kaj Blennow, Clinton B Wrigh. APOE ε4 carriers may undergo synaptic damage conferring risk of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 11. 2017-12-01. PMID:27321472. |
pathogenesis of alzheimer's disease (ad) in apolipoprotein e ε4 (apoe ε4) carriers remains unclear. |
2017-12-01 |
2023-08-13 |
Not clear |