| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liv Tybjærg Nordestgaard, Anne Tybjærg-Hansen, Katrine Laura Rasmussen, Børge G Nordestgaard, Ruth Frikke-Schmid. Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals. BMC medicine. vol 16. issue 1. 2018-05-21. PMID:29534716. |
like the ε4 allele of the apolipoprotein e gene (apoe), the clusterin gene (clu) is a risk locus for alzheimer's disease, and may play additional roles in atherosclerosis pathogenesis. |
2018-05-21 |
2023-08-13 |
Not clear |
| Anindit Chhibber, Liqin Zha. ERβ and ApoE isoforms interact to regulate BDNF-5-HT Alzheimer's research & therapy. vol 9. issue 1. 2018-05-17. PMID:28934977. |
erβ and apoe isoforms interact to regulate bdnf-5-ht depression has been reported to be commonly manifested in patients with alzheimer's disease (ad) and is considered a risk factor for ad. |
2018-05-17 |
2023-08-13 |
human |
| Ge Li, Jane B Shofer, Eric C Petrie, Chang-En Yu, Charles W Wilkinson, Dianne P Figlewicz, Andrew Shutes-David, Jing Zhang, Thomas J Montine, Murray A Raskind, Joseph F Quinn, Douglas R Galasko, Elaine R Peskin. Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults. Alzheimer's research & therapy. vol 9. issue 1. 2018-05-15. PMID:28673336. |
cerebrospinal fluid biomarkers for alzheimer's and vascular disease vary by age, gender, and apoe genotype in cognitively normal adults. |
2018-05-15 |
2023-08-13 |
Not clear |
| Ge Li, Jane B Shofer, Eric C Petrie, Chang-En Yu, Charles W Wilkinson, Dianne P Figlewicz, Andrew Shutes-David, Jing Zhang, Thomas J Montine, Murray A Raskind, Joseph F Quinn, Douglas R Galasko, Elaine R Peskin. Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults. Alzheimer's research & therapy. vol 9. issue 1. 2018-05-15. PMID:28673336. |
this study sought to evaluate gender and apoe genotype-related differences in the concentrations of cerebrospinal fluid (csf) biomarkers for alzheimer's disease (ad) and cerebrovascular injury across the life span of cognitively normal adults. |
2018-05-15 |
2023-08-13 |
Not clear |
| Lan Zhou, Qian Gao, Meng Nie, Jing-Li Gu, Wei Hao, Lin Wang, Ji-Min Ca. Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE Scientific reports. vol 6. 2018-05-08. PMID:27824104. |
degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in apoe alzheimer's disease (ad) patients suffer sleep disorders and circadian rhythm disturbances (crds). |
2018-05-08 |
2023-08-13 |
Not clear |
| Qian Chu, Jolene K Diedrich, Joan M Vaughan, Cynthia J Donaldson, Michael F Nunn, Kuo-Fen Lee, Alan Saghatelia. HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective. Journal of the American Chemical Society. vol 138. issue 30. 2018-05-03. PMID:27379525. |
humans have three different apoe alleles, apoe ε2, apoe ε3, and apoe ε4, and genetic studies identified apoe4 as the strongest genetic risk factor for alzheimer's disease (ad). |
2018-05-03 |
2023-08-13 |
human |
| Diana J Moreno, Sebastián Pino, Ángela Ríos, Francisco Lopera, Henry Ostos, Marc Via, Gabriel Bedoy. Genetic Ancestry and Susceptibility to Late-Onset Alzheimer Disease (LOAD) in the Admixed Colombian Population. Alzheimer disease and associated disorders. vol 31. issue 3. 2018-05-01. PMID:28369008. |
differences in the prevalence of dementia among populations and in the effect of apolipoprotein e (apoe) on the emergence of alzheimer disease (ad), which is the main type of dementia, have been reported. |
2018-05-01 |
2023-08-13 |
Not clear |
| Christopher R Nicholas, Siobhan M Hoscheidt, Lindsay R Clark, Annie M Racine, Sara E Berman, Rebecca L Koscik, N Maritza Dowling, Sanjay Asthana, Bradley T Christian, Mark A Sager, Sterling C Johnso. Positive affect predicts cerebral glucose metabolism in late middle-aged adults. Social cognitive and affective neuroscience. vol 12. issue 6. 2018-04-13. PMID:28402542. |
after controlling for age, sex, perceived health status, depressive symptoms, anti-depressant use, family history of alzheimer's disease, apoe ε4 status and interval between visits, positive affect was associated with greater cerebral glucose metabolism across para-/limbic, frontal, temporal and parietal regions. |
2018-04-13 |
2023-08-13 |
human |
| Matteo De Marco, Annamaria Vallelunga, Francesca Meneghello, Susheel Varma, Alejandro F Frangi, Annalena Venner. ApoE ε4 Allele Related Alterations in Hippocampal Connectivity in Early Alzheimer's Disease Support Memory Performance. Current Alzheimer research. vol 14. issue 7. 2018-04-10. PMID:28176662. |
apoe ε4 allele related alterations in hippocampal connectivity in early alzheimer's disease support memory performance. |
2018-04-10 |
2023-08-13 |
Not clear |
| Per Johansson, Erik G Almqvist, Maria Bjerke, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensso. Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 59. issue 3. 2018-04-10. PMID:28697566. |
apolipoprotein e (apoe) has been extensively studied in alzheimer's disease (ad), but little is known of apolipoprotein a-i (apoa-i) in cerebrospinal fluid (csf). |
2018-04-10 |
2023-08-13 |
Not clear |
| Heather M Wilkins, Scott J Koppel, Rebecca Bothwell, Jonathan Mahnken, Jeffrey M Burns, Russell H Swerdlo. Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients. Redox biology. vol 12. 2018-04-03. PMID:28448944. |
platelet cytochrome oxidase and citrate synthase activities in apoe ε4 carrier and non-carrier alzheimer's disease patients. |
2018-04-03 |
2023-08-13 |
human |
| G William Rebec. The role of APOE on lipid homeostasis and inflammation in normal brains. Journal of lipid research. vol 58. issue 8. 2018-03-28. PMID:28258087. |
the role of apoe in the risk of alzheimer's disease (ad) has largely focused on its effects on ad pathological processes. |
2018-03-28 |
2023-08-13 |
Not clear |
| Alen Zollo, Zoe Allen, Helle F Rasmussen, Filomena Iannuzzi, Yichen Shi, Agnete Larsen, Thorsten J Maier, Carmela Matron. Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele. Neural plasticity. vol 2017. 2018-03-26. PMID:28634550. |
sortilin-related receptor expression in human neural stem cells derived from alzheimer's disease patients carrying the apoe epsilon 4 allele. |
2018-03-26 |
2023-08-13 |
human |
| Kyong Nyon Nam, Cody M Wolfe, Nicholas F Fitz, Florent Letronne, Emilie L Castranio, Anais Mounier, Jonathan Schug, Iliya Lefterov, Radosveta Koldamov. Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29038051. |
alzheimer's disease (ad) is a multifactorial neurodegenerative disorder that is influenced by genetic and environmental risk factors, such as inheritance of ε4 allele of apoe (apoe4), sex and diet. |
2018-03-26 |
2023-08-13 |
mouse |
| Bhagyalakshmi Mallapura Shankarappa, Lakshmi Narayanan Kota, Meera Purushottam, Kavita Nagpal, Odity Mukherjee, Biju Viswanath, Mathew Varghese, Srikala Bharath, Sanjeev Jai. Effect of CLU and PICALM polymorphisms on AD risk: A study from south India. Asian journal of psychiatry. vol 27. 2018-03-20. PMID:28558900. |
to study the association of apolipoprotein e (apoe), clusterin (clu) and phosphatidylinositol binding clathrin assembly protein (picalm) polymorphisms in alzheimer's disease (ad) subjects compared to cognitively normal control subjects in an indian population. |
2018-03-20 |
2023-08-13 |
human |
| Lisa M James, Brian E Engdahl, Apostolos P Georgopoulo. Apolipoprotein E: the resilience gene. Experimental brain research. vol 235. issue 6. 2018-03-19. PMID:28299413. |
the apolipoprotein e (apoe) gene has been implicated in various conditions, most notably alzheimer's disease and coronary artery disease. |
2018-03-19 |
2023-08-13 |
human |
| Nicholas Brookhouser, Ping Zhang, Richard Caselli, Jean J Kim, David A Brafma. Generation and characterization of human induced pluripotent stem cell (hiPSC) lines from an Alzheimer's disease (ASUi003-A) and non-demented control (ASUi004-A) patient homozygous for the Apolipoprotein e4 (APOE4) risk variant. Stem cell research. vol 25. 2018-03-19. PMID:29246571. |
although the majority of late-onset alzheimer's disease (ad) patients are labeled sporadic, multiple genetic risk variants have been identified, the most powerful and prevalent of which is the e4 variant of the apolipoprotein e (apoe) gene. |
2018-03-19 |
2023-08-13 |
human |
| Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Ka. Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. Oncotarget. vol 8. issue 15. 2018-03-05. PMID:28199971. |
genome-wide association studies and meta-analyses implicated that increased risk of developing alzheimer's diseases (ad) has been associated with the abca7, apoe, bin1, cass4, cd2ap, cd33, celf1, clu, cr1, dsg2, epha1, fermt2, hla-drb1, hla-drb4, inpp5d, mef2c, ms4a4a, ms4a4e, ms4a6e, nme8, picalm, pld3, ptk2b, rin3, slc24a4, sorl1, and zcwpw1 genes. |
2018-03-05 |
2023-08-13 |
human |
| Martha Ruiz, Isis Arias, Gloria Rolón, Enio Hernández, Pilar Garavito, Carlos Silvera-Redond. APOE gene polymorphism analysis in Barranquilla, Colombia. Biomedica : revista del Instituto Nacional de Salud. vol 36. issue 1. 2018-02-26. PMID:27622438. |
the genetic variability present in the apoe gene polymorphism is considered an important factor associated with predisposition to diseases affecting lipid metabolism, as well as heart diseases and alzheimer's disease, among others. |
2018-02-26 |
2023-08-13 |
Not clear |
| Simone Hollands, Yen Ying Lim, Simon M Laws, Victor L Villemagne, Robert H Pietrzak, Karra Harrington, Tenielle Porter, Peter Snyder, David Ames, Christopher Fowler, Stephanie R Rainey-Smith, Ralph N Martins, Olivier Salvado, Joanne Robertson, Christopher C Rowe, Colin L Masters, Paul Maruf. APOEɛ4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults. Journal of Alzheimer's disease : JAD. vol 57. issue 2. 2018-02-26. PMID:28234254. |
in cognitively normal (cn) older adults, carriage of the apolipoprotein e (apoe) ɛ4 allele is associated with increased risk for dementia of the alzheimer type (ad-dementia). |
2018-02-26 |
2023-08-13 |
Not clear |