| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabricio Ferreira de Oliveira, Fernando Vieira Pereira, Glaucia Akiko Kamikado Pivi, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucc. Effects of APOE haplotypes and measures of cardiovascular risk over gender-dependent cognitive and functional changes in one year in Alzheimer's disease. The International journal of neuroscience. vol 128. issue 5. 2018-08-13. PMID:29064737. |
effects of apoe haplotypes and measures of cardiovascular risk over gender-dependent cognitive and functional changes in one year in alzheimer's disease. |
2018-08-13 |
2023-08-13 |
Not clear |
| Kwangsik Nho, Sungeun Kim, Emrin Horgusluoglu, Shannon L Risacher, Li Shen, Dokyoon Kim, Seunggeun Lee, Tatiana Foroud, Leslie M Shaw, John Q Trojanowski, Paul S Aisen, Ronald C Petersen, Clifford R Jack, Michael W Weiner, Robert C Green, Arthur W Toga, Andrew J Sayki. Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease. BMC medical genomics. vol 10. issue Suppl 1. 2018-07-23. PMID:28589856. |
association analysis of rare variants near the apoe region with csf and neuroimaging biomarkers of alzheimer's disease. |
2018-07-23 |
2023-08-13 |
Not clear |
| Kwangsik Nho, Sungeun Kim, Emrin Horgusluoglu, Shannon L Risacher, Li Shen, Dokyoon Kim, Seunggeun Lee, Tatiana Foroud, Leslie M Shaw, John Q Trojanowski, Paul S Aisen, Ronald C Petersen, Clifford R Jack, Michael W Weiner, Robert C Green, Arthur W Toga, Andrew J Sayki. Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease. BMC medical genomics. vol 10. issue Suppl 1. 2018-07-23. PMID:28589856. |
the apoe ε4 allele is the most significant common genetic risk factor for late-onset alzheimer's disease (load). |
2018-07-23 |
2023-08-13 |
Not clear |
| Perry G Ridge, Celeste M Karch, Simon Hsu, Ivan Arano, Craig C Teerlink, Mark T W Ebbert, Josue D Gonzalez Murcia, James M Farnham, Anna R Damato, Mariet Allen, Xue Wang, Oscar Harari, Victoria M Fernandez, Rita Guerreiro, Jose Bras, John Hardy, Ronald Munger, Maria Norton, Celeste Sassi, Andrew Singleton, Steven G Younkin, Dennis W Dickson, Todd E Golde, Nathan D Price, Nilüfer Ertekin-Taner, Carlos Cruchaga, Alison M Goate, Christopher Corcoran, JoAnn Tschanz, Lisa A Cannon-Albright, John S K Kauw. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome medicine. vol 9. issue 1. 2018-07-13. PMID:29183403. |
while age and the apoe ε4 allele are major risk factors for alzheimer's disease (ad), a small percentage of individuals with these risk factors exhibit ad resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline. |
2018-07-13 |
2023-08-13 |
Not clear |
| Veronica Tisato, Giovanni Zuliani, Marco Vigliano, Giovanna Longo, Eugenia Franchini, Paola Secchiero, Giorgio Zauli, Elvezia Maria Paraboschi, Ajay Vikram Singh, Maria Luisa Serino, Beatrice Ortolani, Amedeo Zurlo, Cristina Bosi, Antonio Greco, Davide Seripa, Rosanna Asselta, Donato Gemmat. Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases. PloS one. vol 13. issue 3. 2018-07-13. PMID:29518107. |
in this light, we explored the role of common single nucleotide polymorphisms (snps) in the main iron homeostasis genes and in the main lipoprotein transporter gene (apoe) in a cohort of 765 patients with dementia of different origin: alzheimer's disease (ad) n = 276; vascular dementia (vad), n = 255; mild cognitive impairment (mci), n = 234; and in normal controls (n = 1086). |
2018-07-13 |
2023-08-13 |
Not clear |
| Lucy Liu, Kevin R MacKenzie, Nagireddy Putluri, Mirjana Maletić-Savatić, Hugo J Belle. The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell metabolism. vol 26. issue 5. 2018-07-09. PMID:28965825. |
we show that human apoe can substitute for a fly glial apolipoprotein and that apoe4, an alzheimer's disease susceptibility allele, is impaired in lipid transport and promotes neurodegeneration, providing insights into disease mechanisms. |
2018-07-09 |
2023-08-13 |
mouse |
| Erica Dresselhaus, James M Duerr, Fabien Vincent, Emily K Sylvain, Mercedes Beyna, Lorraine F Lanyon, Erik LaChapelle, Martin Pettersson, Kelly R Bales, Gayathri Ramaswam. Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion. PloS one. vol 13. issue 3. 2018-07-06. PMID:29579087. |
despite the important role of apolipoprotein e (apoe) secretion from astrocytes in brain lipid metabolism and the strong association of apoe4, one of the human apoe isoforms, with sporadic and late onset forms of alzheimer's disease (ad) little is known about the regulation of astrocytic apoe. |
2018-07-06 |
2023-08-13 |
human |
| Nicholas Brookhouser, Ping Zhang, Richard Caselli, Jean J Kim, David A Brafma. Generation and characterization of human induced pluripotent stem cell (hiPSC) lines from an Alzheimer's disease (ASUi001-A) and non-demented control (ASUi002-A) patient homozygous for the Apolipoprotein e4 (APOE4) risk variant. Stem cell research. vol 24. 2018-07-03. PMID:29034886. |
although the majority of late-onset alzheimer's disease (ad) patients are labeled sporadic, multiple genetic risk variants have been identified, the most powerful and prevalent of which is the e4 variant of the apolipoprotein e (apoe) gene. |
2018-07-03 |
2023-08-13 |
human |
| Marcus O W Grimm, Daniel M Michaelson, Tobias Hartman. Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention. Journal of lipid research. vol 58. issue 11. 2018-06-21. PMID:28528321. |
omega-3 fatty acids, lipids, and apoe lipidation in alzheimer's disease: a rationale for multi-nutrient dementia prevention. |
2018-06-21 |
2023-08-13 |
Not clear |
| Ningnannan Zhang, Huaigui Liu, Wen Qin, Bing Liu, Tianzi Jiang, Chunshui Y. APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 10. 2018-06-14. PMID:27620974. |
genetic variations of apoe and kibra have been associated with human memory and alzheimer's disease. |
2018-06-14 |
2023-08-13 |
Not clear |
| Xiao Luo, Tiantian Qiu, Yunlu Jia, Peiyu Huang, Xiaojun Xu, Xinfeng Yu, Zhujing Shen, Yerfan Jiaerken, Xiaojun Guan, Jiong Zhou, Minming Zhan. Intrinsic functional connectivity alterations in cognitively intact elderly APOE ε4 carriers measured by eigenvector centrality mapping are related to cognition and CSF biomarkers: a preliminary study. Brain imaging and behavior. vol 11. issue 5. 2018-06-11. PMID:27714554. |
apolipoprotein e (apoe) ε4 allele is the best established genetic risk factor for sporadic alzheimer's disease (ad). |
2018-06-11 |
2023-08-13 |
Not clear |
| Adam P Mecca, Nicole M Barcelos, Shuo Wang, Anna Brück, Nabeel Nabulsi, Beata Planeta-Wilson, Jennifer Nadelmann, Amanda L Benincasa, Jim Ropchan, Yiyun Huang, Joel Gelernter, Peter H Van Ness, Richard E Carson, Christopher H van Dyc. Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease. Neurobiology of aging. vol 61. 2018-06-04. PMID:29111487. |
cortical β-amyloid burden, gray matter, and memory in adults at varying apoe ε4 risk for alzheimer's disease. |
2018-06-04 |
2023-08-13 |
human |
| Sandra den Hoedt, Carola I F Janssen, Giuseppe Astarita, Daniele Piomelli, Frank P J Leijten, Simone M Crivelli, Adrie J M Verhoeven, Helga E de Vries, Jochen Walter, Pilar Martinez-Martinez, Eric J G Sijbrands, Amanda J Kiliaan, Monique T Mulde. Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:28035926. |
apolipoprotein e (apoe) is known for its role in lipid trafficking and the ɛ4 allele is a risk factor for late onset alzheimer's disease (ad). |
2018-05-30 |
2023-08-13 |
human |
| Michelle M Mielke, Norman J Haughey, Dingfen Han, Yang An, Veera Venkata Ratnam Bandaru, Constantine G Lyketsos, Luigi Ferrucci, Susan M Resnic. The Association Between Plasma Ceramides and Sphingomyelins and Risk of Alzheimer's Disease Differs by Sex and APOE in the Baltimore Longitudinal Study of Aging. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:28035934. |
the association between plasma ceramides and sphingomyelins and risk of alzheimer's disease differs by sex and apoe in the baltimore longitudinal study of aging. |
2018-05-30 |
2023-08-13 |
Not clear |
| Ayano Mise, Yuta Yoshino, Kiyohiro Yamazaki, Yuki Ozaki, Tomoko Sao, Taku Yoshida, Takaaki Mori, Yoko Mori, Shinichiro Ochi, Jun-Ichi Iga, Shu-Ichi Uen. TOMM40 and APOE Gene Expression and Cognitive Decline in Japanese Alzheimer's Disease Subjects. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:28984592. |
tomm40 and apoe gene expression and cognitive decline in japanese alzheimer's disease subjects. |
2018-05-30 |
2023-08-13 |
human |
| Ayano Mise, Yuta Yoshino, Kiyohiro Yamazaki, Yuki Ozaki, Tomoko Sao, Taku Yoshida, Takaaki Mori, Yoko Mori, Shinichiro Ochi, Jun-Ichi Iga, Shu-Ichi Uen. TOMM40 and APOE Gene Expression and Cognitive Decline in Japanese Alzheimer's Disease Subjects. Journal of Alzheimer's disease : JAD. vol 60. issue 3. 2018-05-30. PMID:28984592. |
tomm40 is located on chromosome 19, is in linkage disequilibrium with apolipoprotein e (apoe), andis reported in several genome-wide association studies to be associated with alzheimer's disease (ad). |
2018-05-30 |
2023-08-13 |
human |
| Ramón López-Higes, Inmaculada C Rodríguez-Rojo, José M Prados, Pedro Montejo, David Del-Río, María Luisa Delgado-Losada, Mercedes Montenegro, David López-Sanz, Ana Barabas. APOE ε4 Modulation of Training Outcomes in Several Cognitive Domains in a Sample of Cognitively Intact Older Adults. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550244. |
most research points to the ɛ4 allele of the apolipoprotein e (apoe) gene as the most recognizable genetic risk factor associated with alzheimer's disease pathogenesis. |
2018-05-22 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Robert Williamson, Simon M Laws, Victor L Villemagne, Pierrick Bourgeat, Christopher Fowler, Stephanie Rainey-Smith, Olivier Salvado, Ralph N Martins, Christopher C Rowe, Colin L Masters, Paul Maruf. Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550258. |
the association between the apolipoprotein e (apoe) ɛ4 allele and high risk of developing alzheimer's disease (ad) dementia before the age of 80 has been recognized for over 30 years. |
2018-05-22 |
2023-08-13 |
Not clear |
| Jill K Morris, Roxanne Adeline Z Uy, Eric D Vidoni, Heather M Wilkins, Ashley E Archer, John P Thyfault, John M Miles, Jeffrey M Burn. Effect of APOE ε4 Genotype on Metabolic Biomarkers in Aging and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550261. |
effect of apoe ε4 genotype on metabolic biomarkers in aging and alzheimer's disease. |
2018-05-22 |
2023-08-13 |
human |
| Enrica Cavedo, Simone Lista, Katrine Rojkova, Patrizia A Chiesa, Marion Houot, Katharina Brueggen, Janusch Blautzik, Arun L W Bokde, Bruno Dubois, Frederik Barkhof, Petra J W Pouwels, Stefan Teipel, Harald Hampe. Disrupted white matter structural networks in healthy older adult APOE ε4 carriers - An international multicenter DTI study. Neuroscience. vol 357. 2018-05-22. PMID:28596117. |
the ε4 allelic variant of the apolipoprotein e gene (apoe ε4) is the best-established genetic risk factor for late-onset alzheimer's disease (ad). |
2018-05-22 |
2023-08-13 |
human |