| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farid Rajabli, Briseida E Feliciano, Katrina Celis, Kara L Hamilton-Nelson, Patrice L Whitehead, Larry D Adams, Parker L Bussies, Clara P Manrique, Alejandra Rodriguez, Vanessa Rodriguez, Takiyah Starks, Grace E Byfield, Carolina B Sierra Lopez, Jacob L McCauley, Heriberto Acosta, Angel Chinea, Brian W Kunkle, Christiane Reitz, Lindsay A Farrer, Gerard D Schellenberg, Badri N Vardarajan, Jeffery M Vance, Michael L Cuccaro, Eden R Martin, Jonathan L Haines, Goldie S Byrd, Gary W Beecham, Margaret A Pericak-Vanc. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations. PLoS genetics. vol 14. issue 12. 2019-03-04. PMID:30517106. |
ancestral origin of apoe ε4 alzheimer disease risk in puerto rican and african american populations. |
2019-03-04 |
2023-08-13 |
Not clear |
| Farid Rajabli, Briseida E Feliciano, Katrina Celis, Kara L Hamilton-Nelson, Patrice L Whitehead, Larry D Adams, Parker L Bussies, Clara P Manrique, Alejandra Rodriguez, Vanessa Rodriguez, Takiyah Starks, Grace E Byfield, Carolina B Sierra Lopez, Jacob L McCauley, Heriberto Acosta, Angel Chinea, Brian W Kunkle, Christiane Reitz, Lindsay A Farrer, Gerard D Schellenberg, Badri N Vardarajan, Jeffery M Vance, Michael L Cuccaro, Eden R Martin, Jonathan L Haines, Goldie S Byrd, Gary W Beecham, Margaret A Pericak-Vanc. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations. PLoS genetics. vol 14. issue 12. 2019-03-04. PMID:30517106. |
the apoe ε4 allele is the most significant genetic risk factor for late-onset alzheimer disease. |
2019-03-04 |
2023-08-13 |
Not clear |
| Farid Rajabli, Briseida E Feliciano, Katrina Celis, Kara L Hamilton-Nelson, Patrice L Whitehead, Larry D Adams, Parker L Bussies, Clara P Manrique, Alejandra Rodriguez, Vanessa Rodriguez, Takiyah Starks, Grace E Byfield, Carolina B Sierra Lopez, Jacob L McCauley, Heriberto Acosta, Angel Chinea, Brian W Kunkle, Christiane Reitz, Lindsay A Farrer, Gerard D Schellenberg, Badri N Vardarajan, Jeffery M Vance, Michael L Cuccaro, Eden R Martin, Jonathan L Haines, Goldie S Byrd, Gary W Beecham, Margaret A Pericak-Vanc. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations. PLoS genetics. vol 14. issue 12. 2019-03-04. PMID:30517106. |
next, we assessed the ancestral background of apoe alleles ("local" ancestry) and tested if ancestry local to apoe influenced alzheimer disease risk while controlling for global ancestry. |
2019-03-04 |
2023-08-13 |
Not clear |
| Ioannis Dafnis, Letta Argyri, Angeliki Chron. Amyloid-peptide β 42 Enhances the Oligomerization and Neurotoxicity of apoE4: The C-terminal Residues Leu279, Lys282 and Gln284 Modulate the Structural and Functional Properties of apoE4. Neuroscience. vol 394. 2019-03-01. PMID:30367942. |
apolipoprotein e4 (apoe4), one of the three apoe isoforms, is the strongest factor for raising the risk for late-onset alzheimer's disease (ad) and has been proposed to play a major role in ad pathogenesis. |
2019-03-01 |
2023-08-13 |
human |
| Sookjaroen Tangwongchai, Thitiporn Supasitthumrong, Solaphat Hemrunroj, Chavit Tunvirachaisakul, Phenphichcha Chuchuen, Natnicha Houngngam, Thiti Snabboon, Ittipol Tawankanjanachot, Yuthachai Likitchareon, Kamman Phanthumchindad, Michael Mae. In Thai Nationals, the ApoE4 Allele Affects Multiple Domains of Neuropsychological, Biobehavioral, and Social Functioning Thereby Contributing to Alzheimer's Disorder, while the ApoE3 Allele Protects Against Neuropsychiatric Symptoms and Psychosocial Deficits. Molecular neurobiology. vol 55. issue 8. 2019-02-26. PMID:29307083. |
the aim of this study was to examine the associations between apoe alleles (e2, e3, e4) and genotypes and neuropsychological tests, behavioral functions, and dementia symptoms as assessed using consortium to establish a registry for alzheimer's disease (cerad). |
2019-02-26 |
2023-08-13 |
human |
| Chiharu Kai, Yoshikazu Uchiyama, Junji Shiraishi, Hiroshi Fujita, Kunio Do. Computer-aided diagnosis with radiogenomics: analysis of the relationship between genotype and morphological changes of the brain magnetic resonance images. Radiological physics and technology. vol 11. issue 3. 2019-02-22. PMID:29750429. |
our data consisted of magnetic resonance (mr) images of patients with mild cognitive impairment (mci) and alzheimer's disease (ad), as well as their apolipoprotein e (apoe) genotypes. |
2019-02-22 |
2023-08-13 |
Not clear |
| Daniel Felsky, Tina Roostaei, Kwangsik Nho, Shannon L Risacher, Elizabeth M Bradshaw, Vlad Petyuk, Julie A Schneider, Andrew Saykin, David A Bennett, Philip L De Jage. Neuropathological correlates and genetic architecture of microglial activation in elderly human brain. Nature communications. vol 10. issue 1. 2019-02-22. PMID:30679421. |
effect sizes for pam measures are substantial, comparable to that of apoe ε4, the strongest genetic risk factor for alzheimer's disease, and mediation models support an upstream role for microglial activation in alzheimer's disease via accumulation of tau. |
2019-02-22 |
2023-08-13 |
human |
| Rokeya Siddiqui, Shinya Suzu, Mikinori Ueno, Hesham Nasser, Ryota Koba, Farzana Bhuyan, Osamu Noyori, Sofiane Hamidi, Guojun Sheng, Mariko Yasuda-Inoue, Takayuki Hishiki, Sayaka Sukegawa, Eri Miyagi, Klaus Strebel, Shuzo Matsushita, Kunitada Shimotohno, Yasuo Arium. Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages. PLoS pathogens. vol 14. issue 11. 2019-02-19. PMID:30496280. |
different isoforms of apoe have been associated with susceptibility to various diseases including alzheimer's and cardiovascular diseases. |
2019-02-19 |
2023-08-13 |
human |
| Matthew O Goodman, Lori Chibnik, Tianxi Ca. Variance components genetic association test for zero-inflated count outcomes. Genetic epidemiology. vol 43. issue 1. 2019-02-18. PMID:30353568. |
we apply the method to alzheimer's data from the rush university religious orders study and memory and aging project, where as proof of principle we find highly significant associations with the apoe gene, in both the "structural zero" and "count" parameters, when applied to a zero-inflated nps count outcome. |
2019-02-18 |
2023-08-13 |
Not clear |
| Doris T Zalle. "Well, good luck with that": reactions to learning of increased genetic risk for Alzheimer disease. Genetics in medicine : official journal of the American College of Medical Genetics. vol 20. issue 11. 2019-02-13. PMID:29517767. |
apolipoprotein-e (apoe) genetic testing to estimate risk for developing late-onset alzheimer disease is increasingly being offered without prior genetic counseling or preparation. |
2019-02-13 |
2023-08-13 |
Not clear |
| L E Korthauer, L Zhan, O Ajilore, A Leow, I Driscol. Disrupted topology of the resting state structural connectome in middle-aged APOE ε4 carriers. NeuroImage. vol 178. 2019-02-13. PMID:29803958. |
the apolipoprotein e (apoe) ε4 allele is the best characterized genetic risk factor for alzheimer's disease to date. |
2019-02-13 |
2023-08-13 |
Not clear |
| María Belén Ruiz-Roso, Víctor Echeverry-Alzate, Baltasar Ruiz-Roso, José Carlos Quintela, Sandra Ballesteros, Vicente Lahera, Natalia de Las Heras, José Antonio López-Moreno, Beatriz Martín-Fernánde. Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE Nutrients. vol 11. issue 1. 2019-02-12. PMID:30577526. |
low phytanic acid-concentrated dha prevents cognitive deficit and regulates alzheimer disease mediators in an apoe alzheimer's disease (ad) is the main cause of dementia and cognitive impairment. |
2019-02-12 |
2023-08-13 |
Not clear |
| Lorenzo Falsetti, Giovanna Viticchi, Laura Buratti, Francesco Grigioni, Alessandro Capucci, Mauro Silvestrin. Interactions between Atrial Fibrillation, Cardiovascular Risk Factors, and ApoE Genotype in Promoting Cognitive Decline in Patients with Alzheimer's Disease: A Prospective Cohort Study. Journal of Alzheimer's disease : JAD. vol 62. issue 2. 2019-02-08. PMID:29480173. |
interactions between atrial fibrillation, cardiovascular risk factors, and apoe genotype in promoting cognitive decline in patients with alzheimer's disease: a prospective cohort study. |
2019-02-08 |
2023-08-13 |
Not clear |
| Li Juan Zheng, Yun Yan Su, Yun Fei Wang, U Joseph Schoepf, Akos Varga-Szemes, Jonathan Pannell, Xue Liang, Gang Zheng, Guang Ming Lu, Gui Fen Yang, Long Jiang Zhan. Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP/Presenilin-1/2 and APOEε4. Molecular neurobiology. vol 55. issue 4. 2019-02-04. PMID:28502043. |
young healthy adults carrying apoe ε4 and app/presenilin-1/2 displayed different hippocampus functional connectivity patterns, which may underlie the discrepant mechanisms of gene-modulated cognitive dysfunction in alzheimer's disease. |
2019-02-04 |
2023-08-13 |
human |
| Ying-Chih Cheng, Yu-Chen Huang, Hsing-Cheng Li. Effect of Apolipoprotein E ɛ4 Carrier Status on Cognitive Response to Acetylcholinesterase Inhibitors in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis. Dementia and geriatric cognitive disorders. vol 45. issue 5-6. 2019-02-04. PMID:30041236. |
the apolipoprotein e ɛ4 (apoe ɛ4) genotype is the major genetic risk factor for alzheimer's disease (ad). |
2019-02-04 |
2023-08-13 |
Not clear |
| Hanwen Lu, Ling Wu, Jingrui Wang, Zixiao Wang, Xinyao Yi, Jianxiu Wang, Nan Wan. Voltammetric determination of the Alzheimer's disease-related ApoE 4 gene from unamplified genomic DNA extracts by ferrocene-capped gold nanoparticles. Mikrochimica acta. vol 185. issue 12. 2019-02-04. PMID:30426239. |
voltammetric determination of the alzheimer's disease-related apoe 4 gene from unamplified genomic dna extracts by ferrocene-capped gold nanoparticles. |
2019-02-04 |
2023-08-13 |
Not clear |
| Hanwen Lu, Ling Wu, Jingrui Wang, Zixiao Wang, Xinyao Yi, Jianxiu Wang, Nan Wan. Voltammetric determination of the Alzheimer's disease-related ApoE 4 gene from unamplified genomic DNA extracts by ferrocene-capped gold nanoparticles. Mikrochimica acta. vol 185. issue 12. 2019-02-04. PMID:30426239. |
a sensitive method is described for detection of the apoe 4 gene detection which is important for early diagnosis of alzheimer's disease. |
2019-02-04 |
2023-08-13 |
Not clear |
| Hanwen Lu, Ling Wu, Jingrui Wang, Zixiao Wang, Xinyao Yi, Jianxiu Wang, Nan Wan. Voltammetric determination of the Alzheimer's disease-related ApoE 4 gene from unamplified genomic DNA extracts by ferrocene-capped gold nanoparticles. Mikrochimica acta. vol 185. issue 12. 2019-02-04. PMID:30426239. |
graphical abstract schematic presentation of amplified voltammetric detection of alzheimer's disease-related apoe 4 gene from unamplified genomic dna extracts via ferrocene capped gold nanoparticle/streptavidin. |
2019-02-04 |
2023-08-13 |
Not clear |
| Katelyn L Arnemann, Franziska Stöber, Sharada Narayan, Gil D Rabinovici, William J Jagus. Metabolic brain networks in aging and preclinical Alzheimer's disease. NeuroImage. Clinical. vol 17. 2019-01-30. PMID:29527500. |
we explore the effect of two alzheimer's disease risk factors, amyloid-β and apoe ε4 genotype, on metabolic brain networks in cognitively normal older adults (n = 64, ages 69-89) compared to young adults (n = 17, ages 20-30) and patients with alzheimer's disease (n = 22, ages 69-89). |
2019-01-30 |
2023-08-13 |
human |
| Katelyn L Arnemann, Franziska Stöber, Sharada Narayan, Gil D Rabinovici, William J Jagus. Metabolic brain networks in aging and preclinical Alzheimer's disease. NeuroImage. Clinical. vol 17. 2019-01-30. PMID:29527500. |
amyloid-β and the combination of apoe ε4 led to less extensive elevated metabolic correlations compared to other normal older adults, as well as a metabolic brain network more similar to youth and alzheimer's disease. |
2019-01-30 |
2023-08-13 |
human |