| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Na Zhao, Chia-Chen Liu, Wenhui Qiao, Guojun B. Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease. Biological psychiatry. vol 83. issue 4. 2019-05-01. PMID:28434655. |
considering prevalence and relative risk magnitude, the ε4 allele of the apoe gene is the strongest genetic risk factor for late-onset alzheimer's disease (ad). |
2019-05-01 |
2023-08-13 |
Not clear |
| Vladimir N Babenko, Dmitry A Afonnikov, Elena V Ignatieva, Anton V Klimov, Fedor E Gusev, Evgeny I Rogae. Haplotype analysis of APOE intragenic SNPs. BMC neuroscience. vol 19. issue Suppl 1. 2019-04-17. PMID:29745836. |
here, to address the role of apoe haplotypes, we reassessed the diversity of apoe locus in major ethnic groups and in alzheimer's disease neuroimaging initiative (adni) dataset on patients with ad, and subjects with mild cognitive impairment (mci), and control non-demented individuals. |
2019-04-17 |
2023-08-13 |
human |
| Nicholas Brookhouser, Ping Zhang, Richard Caselli, Jean J Kim, David A Brafma. Generation and characterization of two human induced pluripotent stem cell (hiPSC) lines homozygous for the Apolipoprotein e4 (APOE4) risk variant-Alzheimer's disease (ASUi005-A) and healthy non-demented control (ASUi006-A). Stem cell research. vol 32. 2019-04-15. PMID:30296667. |
although the majority of late-onset alzheimer's disease (ad) patients are labeled sporadic, multiple genetic risk variants have been identified, the most powerful and prevalent of which is the e4 variant of the apolipoprotein e (apoe) gene. |
2019-04-15 |
2023-08-13 |
human |
| Z Wang, W Qin, C B Wei, Y Tang, L N Zhao, H M Jin, Y Li, Q Wang, X Q Luan, J C He, J Ji. The microRNA-1908 up-regulation in the peripheral blood cells impairs amyloid clearance by targeting ApoE. International journal of geriatric psychiatry. vol 33. issue 7. 2019-04-10. PMID:29635818. |
to give a new insight into the mechanism of apoe dysregulation and microrna-1908 in alzheimer's disease (ad). |
2019-04-10 |
2023-08-13 |
Not clear |
| Saddia Bano, Muhammad Asif Rasheed, Farrukh Jamil, Muhammad Ibrahim, Sumaira Kanwa. In Silico Identification of Novel Apolipoprotein E4 Inhibitor for Alzheimer's Disease Therapy. Current computer-aided drug design. vol 15. issue 1. 2019-04-08. PMID:30306878. |
apolipoprotein e4 (apoe) is a major genetic factor for developing alzheimer's disease (ad). |
2019-04-08 |
2023-08-13 |
Not clear |
| Nahdia S Jones, G William Rebec. The Synergistic Effects of APOE Genotype and Obesity on Alzheimer's Disease Risk. International journal of molecular sciences. vol 20. issue 1. 2019-04-03. PMID:30586872. |
the synergistic effects of apoe genotype and obesity on alzheimer's disease risk. |
2019-04-03 |
2023-08-13 |
Not clear |
| Cody M Wolfe, Nicholas F Fitz, Kyong Nyon Nam, Iliya Lefterov, Radosveta Koldamov. The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives. International journal of molecular sciences. vol 20. issue 1. 2019-04-03. PMID:30587772. |
the role of apoe and trem2 in alzheimer's disease-current understanding and perspectives. |
2019-04-03 |
2023-08-13 |
Not clear |
| Sven J van der Lee, Frank J Wolters, M Kamran Ikram, Albert Hofman, M Arfan Ikram, Najaf Amin, Cornelia M van Duij. The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study. The Lancet. Neurology. vol 17. issue 5. 2019-03-15. PMID:29555425. |
the effect of apoe and other common genetic variants on the onset of alzheimer's disease and dementia: a community-based cohort study. |
2019-03-15 |
2023-08-13 |
Not clear |
| Sven J van der Lee, Frank J Wolters, M Kamran Ikram, Albert Hofman, M Arfan Ikram, Najaf Amin, Cornelia M van Duij. The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study. The Lancet. Neurology. vol 17. issue 5. 2019-03-15. PMID:29555425. |
in addition to the major genetic determinant of alzheimer's disease, the apoe gene, 23 genetic variants have been associated with the disease. |
2019-03-15 |
2023-08-13 |
Not clear |
| Sven J van der Lee, Frank J Wolters, M Kamran Ikram, Albert Hofman, M Arfan Ikram, Najaf Amin, Cornelia M van Duij. The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study. The Lancet. Neurology. vol 17. issue 5. 2019-03-15. PMID:29555425. |
we assessed the effects of these variants and apoe on cumulative risk and age at onset of alzheimer's disease and all-cause dementia. |
2019-03-15 |
2023-08-13 |
Not clear |
| Santiago Rojas, Anna Brugulat-Serrat, Nuria Bargalló, Carolina Minguillón, Alan Tucholka, Carles Falcon, Andreia Carvalho, Sebastian Morán, Manel Esteller, Nina Gramunt, Karine Fauria, Jordi Camí, José L Molinuevo, Juan D Gisper. Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 38. issue 2. 2019-03-08. PMID:28492093. |
the ɛ4 allele of the apoe gene is the major factor accountable for alzheimer's disease heritability. |
2019-03-08 |
2023-08-13 |
human |
| Yacine Tensaouti, Elizabeth P Stephanz, Tzong-Shiue Yu, Steven G Kerni. ApoE Regulates the Development of Adult Newborn Hippocampal Neurons. eNeuro. vol 5. issue 4. 2019-03-08. PMID:30079373. |
among these genes, apolipoprotein e (apoe) is particularly compelling because the human apoe isoform e4 is a risk factor for the development of alzheimer's disease, where hippocampal neurogenesis is reported to be dysfunctional. |
2019-03-08 |
2023-08-13 |
mouse |
| Brett S East, Gloria Fleming, Kathy Peng, Jonas K Olofsson, Efrat Levy, Paul M Mathews, Donald A Wilso. Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice. Neuroscience. vol 380. 2019-03-07. PMID:29678753. |
the apoe ε4 allele (apoe4) is the single most important genetic risk-factor for alzheimer's disease (ad) while the ε2 allele (apoe2) is associated with a lower risk of ad-related neurodegeneration compared to the most common variant, ε3 (apoe3). |
2019-03-07 |
2023-08-13 |
mouse |
| Shanshan Wang, Jie Zhang, Tengwei Pa. APOE ε4 is associated with higher levels of CSF SNAP-25 in prodromal Alzheimer's disease. Neuroscience letters. vol 685. 2019-03-07. PMID:30144541. |
apoe ε4 is associated with higher levels of csf snap-25 in prodromal alzheimer's disease. |
2019-03-07 |
2023-08-13 |
human |
| Shanshan Wang, Jie Zhang, Tengwei Pa. APOE ε4 is associated with higher levels of CSF SNAP-25 in prodromal Alzheimer's disease. Neuroscience letters. vol 685. 2019-03-07. PMID:30144541. |
the underlying mechanism of apolipoprotein e ε4 (apoe ε4) in the pathogenesis of alzheimer's disease (ad) remains elusive. |
2019-03-07 |
2023-08-13 |
human |
| Nicolas Zink, Wiebke Bensmann, Larissa Arning, Christian Beste, Ann-Kathrin Stoc. Apolipoprotein ε4 is associated with better cognitive control allocation in healthy young adults. NeuroImage. vol 185. 2019-03-06. PMID:30342978. |
such a diametric pattern may also hold true for the ancestral apolipoprotein e (apoe) ε4 allele, which increases the risk for alzheimer's disease and cognitive decline in old age, but may benefit (pre)frontal (executive) functions in young carriers. |
2019-03-06 |
2023-08-13 |
Not clear |
| Felice Contaldi, Federico Capuano, Andrea Fulgione, Riccardo Aiese Cigliano, Walter Sanseverino, Domenico Iannelli, Chiara Medaglia, Rosanna Capparell. The hypothesis that Helicobacter pylori predisposes to Alzheimer's disease is biologically plausible. Scientific reports. vol 7. issue 1. 2019-03-04. PMID:28798312. |
the peptide modulated 77 genes, of which 65 are listed in the alzbase database and include the hallmarks of alzheimer's disease: app, apoe, psen1, and psen2. |
2019-03-04 |
2023-08-13 |
human |
| Winnie Qian, Corinne E Fischer, Tom A Schweizer, David G Muno. Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Current Alzheimer research. vol 15. issue 2. 2019-03-04. PMID:28847281. |
association between psychosis phenotype and apoe genotype on the clinical profiles of alzheimer's disease. |
2019-03-04 |
2023-08-13 |
Not clear |
| Hannah Stocker, Tobias Möllers, Laura Perna, Hermann Brenne. The genetic risk of Alzheimer's disease beyond APOE ε4: systematic review of Alzheimer's genetic risk scores. Translational psychiatry. vol 8. issue 1. 2019-03-04. PMID:30143603. |
the genetic risk of alzheimer's disease beyond apoe ε4: systematic review of alzheimer's genetic risk scores. |
2019-03-04 |
2023-08-13 |
Not clear |
| Hannah Stocker, Tobias Möllers, Laura Perna, Hermann Brenne. The genetic risk of Alzheimer's disease beyond APOE ε4: systematic review of Alzheimer's genetic risk scores. Translational psychiatry. vol 8. issue 1. 2019-03-04. PMID:30143603. |
the ε4 allele of apolipoprotein e (apoe) is the strongest known genetic risk factor of alzheimer's disease (ad) but does not account for the entirety of genetic risk. |
2019-03-04 |
2023-08-13 |
Not clear |