| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenzhang Wang, Xiongwei Zh. HDL mimetic peptides affect apolipoprotein E metabolism: equal supplement or functional enhancer?: An Editorial for 'High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia' on page 647. Journal of neurochemistry. vol 147. issue 5. 2019-09-25. PMID:30474860. |
ε4 allele of apoe is the strongest genetic risk factor for late onset alzheimer's disease (ad). |
2019-09-25 |
2023-08-13 |
mouse |
| Fan Liao, Aimin Li, Monica Xiong, Nga Bien-Ly, Hong Jiang, Yin Zhang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton, Grace O Robinson, Javier Remolina Serrano, Adam P Silverman, Jing L Guo, Jennifer Getz, Kirk Henne, Cheryl Eg Leyns, Gilbert Gallardo, Jason D Ulrich, Patrick M Sullivan, Eli Paul Lerner, Eloise Hudry, Zachary K Sweeney, Mark S Dennis, Bradley T Hyman, Ryan J Watts, David M Holtzma. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of clinical investigation. vol 128. issue 5. 2019-09-11. PMID:29600961. |
the apolipoprotein e e4 allele of the apoe gene is the strongest genetic factor for late-onset alzheimer disease (load). |
2019-09-11 |
2023-08-13 |
mouse |
| Fan Liao, Aimin Li, Monica Xiong, Nga Bien-Ly, Hong Jiang, Yin Zhang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton, Grace O Robinson, Javier Remolina Serrano, Adam P Silverman, Jing L Guo, Jennifer Getz, Kirk Henne, Cheryl Eg Leyns, Gilbert Gallardo, Jason D Ulrich, Patrick M Sullivan, Eli Paul Lerner, Eloise Hudry, Zachary K Sweeney, Mark S Dennis, Bradley T Hyman, Ryan J Watts, David M Holtzma. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of clinical investigation. vol 128. issue 5. 2019-09-11. PMID:29600961. |
there is compelling evidence that apoe influences alzheimer disease (ad) in large part by affecting amyloid β (aβ) aggregation and clearance; however, the molecular mechanism underlying these findings remains largely unknown. |
2019-09-11 |
2023-08-13 |
mouse |
| Olga Pletnikova, Yusuke Kageyama, Gay Rudow, Katherine D LaClair, Marilyn Albert, Barbara J Crain, Jing Tian, David Fowler, Juan C Troncos. The spectrum of preclinical Alzheimer's disease pathology and its modulation by ApoE genotype. Neurobiology of aging. vol 71. 2019-09-11. PMID:30099348. |
the spectrum of preclinical alzheimer's disease pathology and its modulation by apoe genotype. |
2019-09-11 |
2023-08-13 |
human |
| Niklas Mattsson, Oscar Eriksson, Olof Lindberg, Michael Schöll, Björn Lampinen, Markus Nilsson, Philip S Insel, Ronald Lautner, Olof Strandberg, Danielle van Westen, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Oskar Hansso. Effects of APOE ε4 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal Alzheimer's disease. Neurobiology of aging. vol 71. 2019-09-11. PMID:30107289. |
effects of apoe ε4 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal alzheimer's disease. |
2019-09-11 |
2023-08-13 |
Not clear |
| Niklas Mattsson, Oscar Eriksson, Olof Lindberg, Michael Schöll, Björn Lampinen, Markus Nilsson, Philip S Insel, Ronald Lautner, Olof Strandberg, Danielle van Westen, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Oskar Hansso. Effects of APOE ε4 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal Alzheimer's disease. Neurobiology of aging. vol 71. 2019-09-11. PMID:30107289. |
apolipoprotein (apoe) ε4 is a major genetic risk factor for alzheimer's disease (ad), but its importance for the clinical and biological heterogeneity in ad is unclear, particularly at the prodromal stage. |
2019-09-11 |
2023-08-13 |
Not clear |
| Javier Oltra-Cucarella, Miriam Sánchez-SanSegundo, Rosario Ferrer-Cascale. Cognition or genetics? Predicting Alzheimer's disease with practice effects, APOE genotype, and brain metabolism. Neurobiology of aging. vol 71. 2019-09-11. PMID:30172222. |
predicting alzheimer's disease with practice effects, apoe genotype, and brain metabolism. |
2019-09-11 |
2023-08-13 |
Not clear |
| Javier Oltra-Cucarella, Miriam Sánchez-SanSegundo, Rosario Ferrer-Cascale. Cognition or genetics? Predicting Alzheimer's disease with practice effects, APOE genotype, and brain metabolism. Neurobiology of aging. vol 71. 2019-09-11. PMID:30172222. |
as practice effects are common in neuropsychological assessment, this study analyzed their utility to identify individuals with amnestic mild cognitive impairment (amci) at the greatest risk for alzheimer's disease (ad-risk) and compared practice effects with apoe and brain metabolism biomarkers. |
2019-09-11 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Pawel Kalinowski, Robert H Pietrzak, Simon M Laws, Samantha C Burnham, David Ames, Victor L Villemagne, Christopher J Fowler, Stephanie R Rainey-Smith, Ralph N Martins, Christopher C Rowe, Colin L Masters, Paul T Maruf. Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease. JAMA neurology. vol 75. issue 4. 2019-09-10. PMID:29356823. |
older age, high levels of β-amyloid (aβ), and the presence of the apolipoprotein e (apoe) ε4 allele are risk factors for alzheimer disease (ad). |
2019-09-10 |
2023-08-13 |
Not clear |
| Dahyun Yi, Younghwa Lee, Min Soo Byun, Jun Ho Lee, Kang Ko, Bo Kyung Sohn, Young Min Choe, Hyo Jung Choi, Hyewon Baek, Chul-Ho Sohn, Yu Kyeong Kim, Dong Young Le. Synergistic interaction between APOE and family history of Alzheimer's disease on cerebral amyloid deposition and glucose metabolism. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-09. PMID:30134963. |
synergistic interaction between apoe and family history of alzheimer's disease on cerebral amyloid deposition and glucose metabolism. |
2019-09-09 |
2023-08-13 |
Not clear |
| Lucas Kraft, Louise C Serpell, John R Atac. A Biophysical Approach to the Identification of Novel ApoE Chemical Probes. Biomolecules. vol 9. issue 2. 2019-08-30. PMID:30700058. |
alzheimer's disease (ad) is the most common type of dementia and, after age, the greatest risk factor for developing ad is the allelic variation of apolipoprotein e (apoe), with homozygote carriers of the apoe4 allele having an up to 12-fold greater risk of developing ad than noncarriers. |
2019-08-30 |
2023-08-13 |
Not clear |
| Paraskevi L Tsiolaki, Aikaterini D Katsafana, Fotis A Baltoumas, Nikolaos N Louros, Vassiliki A Iconomido. Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study. International journal of molecular sciences. vol 20. issue 9. 2019-08-30. PMID:31071995. |
interestingly, the lipid-free apoe form has been shown to be co-localized with the amyloidogenic aβ peptide in amyloid plaques in alzheimer's disease, whereas in particular, the apoe4 isoform is a crucial risk factor for late-onset alzheimer's disease. |
2019-08-30 |
2023-08-13 |
human |
| Paraskevi L Tsiolaki, Aikaterini D Katsafana, Fotis A Baltoumas, Nikolaos N Louros, Vassiliki A Iconomido. Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study. International journal of molecular sciences. vol 20. issue 9. 2019-08-30. PMID:31071995. |
additional computational work concerning the apoe-Αβ complex also designates apoe amyloidogenic regions as important binding sites for oligomeric Αβ; taking an important step forward in the field of alzheimer's anti-aggregation drug development. |
2019-08-30 |
2023-08-13 |
human |
| Michaël E Belloy, Valerio Napolioni, Michael D Greiciu. A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward. Neuron. vol 101. issue 5. 2019-08-26. PMID:30844401. |
a quarter century of apoe and alzheimer's disease: progress to date and the path forward. |
2019-08-26 |
2023-08-13 |
human |
| Ian Fyf. Alzheimer disease: APOE ε4 affects cognitive decline but does not block benefits of healthy lifestyle. Nature reviews. Neurology. vol 14. issue 3. 2019-08-22. PMID:29422646. |
alzheimer disease: apoe ε4 affects cognitive decline but does not block benefits of healthy lifestyle. |
2019-08-22 |
2023-08-13 |
Not clear |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
interplay between innate immunity and alzheimer disease: apoe and trem2 in the spotlight. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
apoe (which encodes apolipoprotein e) is the strongest genetic risk factor for alzheimer disease, and apoe was recently shown to affect the disease in part through its immunomodulatory function. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
here, we review the rapidly growing literature on the role of disease-associated microglia, trem2 and apoe in the pathogenesis of alzheimer disease and present an integrated view of innate immune function in alzheimer disease. |
2019-08-15 |
2023-08-13 |
Not clear |
| Kumar B Rajan, Lisa L Barnes, Robert S Wilson, Jennifer Weuve, Elizabeth A McAninch, Denis A Evan. Blood pressure and risk of incident Alzheimer's disease dementia by antihypertensive medications and APOE ε4 allele. Annals of neurology. vol 83. issue 5. 2019-08-13. PMID:29637601. |
blood pressure and risk of incident alzheimer's disease dementia by antihypertensive medications and apoe ε4 allele. |
2019-08-13 |
2023-08-13 |
Not clear |
| Georgette L Suidan, Gayathri Ramaswam. Targeting Apolipoprotein E for Alzheimer's Disease: An Industry Perspective. International journal of molecular sciences. vol 20. issue 9. 2019-08-12. PMID:31052389. |
humans have three common apoe isoforms, apoe2, apoe3 and apoe4, that show a strong genotype effect on the risk and age of onset for sporadic and late onset forms of alzheimer's disease (ad). |
2019-08-12 |
2023-08-13 |
Not clear |