| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin D Boros, Kelsey M Greathouse, Marla Gearing, Jeremy H Herskowit. Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging. Neurobiology of aging. vol 73. 2019-12-19. PMID:30339964. |
linear models defined relationships between spines and age, mini-mental state examination, apolipoprotein e (apoe) ε4 allele status, and alzheimer's disease (ad) pathology. |
2019-12-19 |
2023-08-13 |
human |
| Nahid Zokaei, Giedrė Čepukaitytė, Alexander G Board, Clare E Mackay, Masud Husain, Anna Christina Nobr. Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories. Neurobiology of aging. vol 73. 2019-12-19. PMID:30342272. |
short- and long-term memory performance as a function of apolipoprotein-e (apoe) genotype was examined in older, healthy individuals using sensitive and comparable tasks to provide a more detailed description of influences of the ε4 allele (highest genetic risk factor for alzheimer's disease) on memory. |
2019-12-19 |
2023-08-13 |
Not clear |
| Xiaopu Zhou, Yu Chen, Kin Y Mok, Timothy C Y Kwok, Vincent C T Mok, Qihao Guo, Fanny C Ip, Yuewen Chen, Nandita Mullapudi, Paola Giusti-Rodríguez, Patrick F Sullivan, John Hardy, Amy K Y Fu, Yun Li, Nancy Y I. Non-coding variability at the APOE locus contributes to the Alzheimer's risk. Nature communications. vol 10. issue 1. 2019-12-13. PMID:31346172. |
non-coding variability at the apoe locus contributes to the alzheimer's risk. |
2019-12-13 |
2023-08-13 |
human |
| Ya-Ting Chang, Etsuro Mori, Maki Suzuki, Manabu Ikeda, Chi-Wei Huang, Jun-Jun Lee, Wen-Neng Chang, Chiung-Chih Chan. APOE-MS4A genetic interactions are associated with executive dysfunction and network abnormality in clinically mild Alzheimer's disease. NeuroImage. Clinical. vol 21. 2019-12-11. PMID:30528368. |
although single nucleotide polymorphisms of membrane-spanning 4a (ms4a) (rs670139) and several other susceptibility genes have shown interaction effects on the risk of alzheimer's disease (ad), little is known about the interaction effects of apolipoprotein e (apoe) with ms4a (rs670139) on cognitive performances, and the underlying pathogenesis is unclear. |
2019-12-11 |
2023-08-13 |
Not clear |
| Tenielle Porter, Samantha C Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Yen Ying Lim, David Ames, Colin L Masters, Ralph N Martins, Stephanie Rainey-Smith, Christopher C Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L Villemagne, Simon M Law. Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease. Neurobiology of aging. vol 76. 2019-12-06. PMID:30716541. |
klotho allele status is not associated with aβ and apoe ε4-related cognitive decline in preclinical alzheimer's disease. |
2019-12-06 |
2023-08-13 |
Not clear |
| Aiqian Zhang, Qingnan Zhao, Dabao Xu, Shan Jian. Brain APOE expression quantitative trait loci-based association study identified one susceptibility locus for Alzheimer's disease by interacting with APOE ε4. Scientific reports. vol 8. issue 1. 2019-11-25. PMID:29795290. |
brain apoe expression quantitative trait loci-based association study identified one susceptibility locus for alzheimer's disease by interacting with apoe ε4. |
2019-11-25 |
2023-08-13 |
Not clear |
| Gemma Lombardi, Cristina Polito, Valentina Berti, Silvia Bagnoli, Benedetta Nacmias, Alberto Pupi, Sandro Sorb. Contribution of Bilingualism to Cognitive Reserve of an Italian Literature Professor at High Risk for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 66. issue 4. 2019-11-25. PMID:30475769. |
we describe a case of a bilingual italian man affected by mild cognitive impairment with high cognitive reserve that, despite the presence of multiple risk factors (apoe ɛ4/ɛ4 genotype, older age, untreated obstructive sleep apnea syndrome, ad-like biomarker alterations) did not convert to alzheimer's disease up to 5 years follow-up. |
2019-11-25 |
2023-08-13 |
Not clear |
| Tang, Jiang, Gu, Jin, Lin, Qian, Wang, Zhan. [The relation between alpha1-antichymotrypsin gene polymorphism and epsilon4 allele of apolipoprotein E gene in Alzheimer disease in Chinese] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 16. issue 2. 2019-11-20. PMID:10200363. |
[the relation between alpha1-antichymotrypsin gene polymorphism and epsilon4 allele of apolipoprotein e gene in alzheimer disease in chinese] objective: to detect the relation between alpha1-antichymotrpsin(aact)gene polymorphism and epsilon4 allele of apolipoprotein e (apoe) gene in alzheimer disease (ad) in chinese. |
2019-11-20 |
2023-08-12 |
Not clear |
| Ekaterina Rogaeva, Anurag Tandon, Peter H. St George-Hyslo. Genetic markers in the diagnosis of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 3. issue 3. 2019-11-20. PMID:12214050. |
abbreviations: ad, alzheimer's disease; abetapp, amyloid beta protein precursor; bace, beta-site abetapp cleaving enzyme; ps1, presenilin-1; ps2, presenilin-2; apoe, apolipoprotein e; lrp, low density lipoprotein receptor-related protein; snps, single-nucleotide polymorphisms; a2m, alpha-2-macroglobulin. |
2019-11-20 |
2023-08-12 |
Not clear |
| Mitsuru Shinohara, Takahisa Kanekiyo, Longyu Yang, Duane Linthicum, Motoko Shinohara, Yuan Fu, Laura Price, Jessica L Frisch-Daiello, Xianlin Han, John D Fryer, Guojun B. APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations. Annals of neurology. vol 79. issue 5. 2019-11-20. PMID:26933942. |
apolipoprotein e (apoe), a major cholesterol carrier in the brain, is associated with a strong risk for alzheimer disease. |
2019-11-20 |
2023-08-13 |
Not clear |
| Alzheimer disease: Elevated neurogranin levels reveal early synaptic damage in APOE* ɛ4 carriers. Nature reviews. Neurology. vol 12. issue 8. 2019-11-20. PMID:27364747. |
alzheimer disease: elevated neurogranin levels reveal early synaptic damage in apoe* ɛ4 carriers. |
2019-11-20 |
2023-08-13 |
Not clear |
| Gina M Finan, Ronald Realubit, Sungkwon Chung, Dieter Lütjohann, Nan Wang, John R Cirrito, Charles Karan, Tae-Wan Ki. Bioactive Compound Screen for Pharmacological Enhancers of Apolipoprotein E in Primary Human Astrocytes. Cell chemical biology. vol 23. issue 12. 2019-11-20. PMID:27889409. |
pharmacological enhancement of apolipoprotein e (apoe), a cholesterol-transporting apolipoprotein, has been proposed as a promising therapeutic approach for alzheimer's disease. |
2019-11-20 |
2023-08-13 |
human |
| Maowen Ba, Min Kong, Xiaofeng Li, Kok Pin Ng, Pedro Rosa-Neto, Serge Gauthie. Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer's disease? Translational neurodegeneration. vol 5. 2019-11-20. PMID:27891223. |
is apoe ɛ 4 a good biomarker for amyloid pathology in late onset alzheimer's disease? |
2019-11-20 |
2023-08-13 |
Not clear |
| Joanna E Pankiewicz, Martin J Sadowsk. APOE genotype and Alzheimer's immunotherapy. Oncotarget. vol 8. issue 25. 2019-11-20. PMID:28537920. |
apoe genotype and alzheimer's immunotherapy. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xiaochen Huang, Shengqi Dong, Jie Zhen, Huiqiang Zhang, Tong Lin, Yuhong Zeng, Nicholas Van Halm-Lutterodt, Linhong Yua. The Role of ApoE Polymorphism in the Relationship between Serum Steroid Hormone Levels and Cognition in Older Chinese Adults: A Cross-Sectional Study. Frontiers in endocrinology. vol 9. 2019-11-20. PMID:29559956. |
epidemiology studies have indicated an association of apolipoprotein e (apoe) genetic polymorphism and circulating steroid hormone levels with the risk of alzheimer's disease. |
2019-11-20 |
2023-08-13 |
Not clear |
| Gaoang Ren, Wei Bao, Zhiping Zeng, Weidong Zhang, Ce Shang, Maosi Wang, Ying Su, Xiao-Kun Zhang, Hu Zho. Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce β-Amyloid Plaques in Alzheimer's Disease Mouse Model. Molecular pharmaceutics. vol 16. issue 2. 2019-11-18. PMID:29995422. |
bexarotene, an agonist of retinoid x receptor alpha (rxrα), has been shown to increase the expression of apoe, abca1, and abcg1 by activating rxr/lxr and rxr/ppar heterodimers, resulting in amyloid β (aβ)-protein clearance in the brain of an alzheimer's disease (ad) mouse model and reversal of mouse cognitive deficits. |
2019-11-18 |
2023-08-13 |
mouse |
| Tenielle Porter, Samantha C Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Yen Ying Lim, Qiao-Xin Li, David Ames, Colin L Masters, Stephanie Rainey-Smith, Christopher C Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L Villemagne, Simon M Law. Utility of an Alzheimer's Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer's Disease: A Prospective Longitudinal Study. Journal of Alzheimer's disease : JAD. vol 66. issue 3. 2019-11-14. PMID:30412495. |
with the exception of apoe, genetic variants associated with increased alzheimer's disease (ad) risk are characterized by small effect sizes. |
2019-11-14 |
2023-08-13 |
Not clear |
| Rebeca Geffin, Micheline McCarth. Aging and Apolipoprotein E in HIV Infection. Journal of neurovirology. vol 24. issue 5. 2019-11-11. PMID:29987582. |
in addition, apolipoprotein e (apoe), one of the most influential host risk factors for developing alzheimer's disease, has been implicated in the development of hand. |
2019-11-11 |
2023-08-13 |
Not clear |
| Chinthalapally V Rao, Mudassir Farooqui, Adam S Asch, Hiroshi Y Yamad. Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model. Cell cycle (Georgetown, Tex.). vol 17. issue 19-20. 2019-11-08. PMID:30231670. |
abbreviations: alzheimer's disease (ad); late-onset alzheimer's disease (load); early-onset alzheimer's disease (eoad); shugoshin-1 (sgo1); chromosome instability (cin); apolipoprotein (apoe); central nervous system (cns); amyloid precursor protein (app); n-methyl-d-aspartate (nmda); hazard ratio (hr); cyclin-dependent kinase (cdk); chronic atrial intestinal dysrhythmia (caid); beta-secretase 1 (bace); phosphor-histone h3 (p-h3); research and development (r&d); non-steroidal anti-inflammatory drugs (nsaids); brain blood barrier (bbb). |
2019-11-08 |
2023-08-13 |
mouse |
| O Scheyer, A Rahman, H Hristov, C Berkowitz, R S Isaacson, R Diaz Brinton, L Moscon. Female Sex and Alzheimer's Risk: The Menopause Connection. The journal of prevention of Alzheimer's disease. vol 5. issue 4. 2019-11-08. PMID:30298180. |
along with advanced age and apolipoprotein e (apoe)-4 genotype, female sex is a major risk factor for developing late-onset alzheimer's disease (ad). |
2019-11-08 |
2023-08-13 |
Not clear |