| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunyu Zhang, Riletemuer Hu, Guohua Zhang, Yan Zhe, Baolige Hu, Juan He, Zhiguang Wang, Xiaokun Q. A Weighted Genetic Risk Score Based on Four APOE-Independent Alzheimer's Disease Risk Loci May Supplement APOE E4 for Better Disease Prediction. Journal of molecular neuroscience : MN. vol 69. issue 3. 2020-04-20. PMID:31346968. |
a weighted genetic risk score based on four apoe-independent alzheimer's disease risk loci may supplement apoe e4 for better disease prediction. |
2020-04-20 |
2023-08-13 |
human |
| Eun-Gyung Lee, Jessica Tulloch, Sunny Chen, Lesley Leong, Aleen D Saxton, Brian Kraemer, Martin Darvas, C Dirk Keene, Andrew Shutes-David, Kaitlin Todd, Steve Millard, Chang-En Y. Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease. PloS one. vol 15. issue 1. 2020-04-20. PMID:31978088. |
redefining transcriptional regulation of the apoe gene and its association with alzheimer's disease. |
2020-04-20 |
2023-08-13 |
human |
| Eun-Gyung Lee, Jessica Tulloch, Sunny Chen, Lesley Leong, Aleen D Saxton, Brian Kraemer, Martin Darvas, C Dirk Keene, Andrew Shutes-David, Kaitlin Todd, Steve Millard, Chang-En Y. Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease. PloS one. vol 15. issue 1. 2020-04-20. PMID:31978088. |
the apolipoprotein e gene (apoe) is the strongest genetic risk factor for late-onset alzheimer's disease (ad), yet the expression of apoe is not clearly understood. |
2020-04-20 |
2023-08-13 |
human |
| Dhiraj Kumar, Pravir Kuma. An In-Silico Investigation of Key Lysine Residues and Their Selection for Clearing off Aβ and Holo-AβPP Through Ubiquitination. Interdisciplinary sciences, computational life sciences. vol 11. issue 4. 2020-04-16. PMID:30194628. |
herein, (1) we identified the aggregation prone sequence in aβ40 and aβ42 as 'hhqklvffae' and 'sgyevhhqklvffaedvg/kgaiiglmvggv' respectively with critical lysine (k) at 16 and 28 for stabilizing the aggregates; (2) elucidated the interaction pattern of aβpp with other alzheimer's related proteins bace1, apoe, snca, apbb1, casp8, nae1, adam10, and psen1 to describe the pathophysiology; (3) found apoe as commonly interacting factor between amyloid beta and tau for governing ad pathogenesis; (4) reported k224, k351, k363, k377, k601, k662, k751, and k763 as potential putative lysine for facilitating aβpp clearance through ubiquitination thereby arresting aβ formation; and (5) observed conserved glutamine (q), glutamic acid (e), and alpha-helical conformation as few crucial factors for lysine selectivity in the ubiquitination of aβpp. |
2020-04-16 |
2023-08-13 |
Not clear |
| Leon M Aksman, Marzia A Scelsi, Andre F Marquand, Daniel C Alexander, Sebastien Ourselin, Andre Altman. Modeling longitudinal imaging biomarkers with parametric Bayesian multi-task learning. Human brain mapping. vol 40. issue 13. 2020-04-13. PMID:31168892. |
we demonstrate this using alzheimer's disease neuroimaging initiative (adni) data, where we model longitudinal trajectories of mri-derived cortical volumes in neurodegeneration, with coupling based on apoe genotype, cerebrospinal fluid (csf) and amyloid pet-based biomarkers. |
2020-04-13 |
2023-08-13 |
human |
| Morteza Abyadeh, Kurosh Djafarian, Fatemeh Heydarinejad, Shahab Alizadeh, Sakineh Shab-Bida. Association between Apolipoprotein E Gene Polymorphism and Alzheimer's Disease in an Iranian Population: A Meta-Analysis. Journal of molecular neuroscience : MN. vol 69. issue 4. 2020-04-13. PMID:31444704. |
the development of alzheimer's disease (ad) has been strongly linked to the apolipoprotein e (apoe) polymorphism. |
2020-04-13 |
2023-08-13 |
Not clear |
| Melissa Lamar, Lei Yu, Leah H Rubin, Bryan D James, Lisa L Barnes, Jose Marcelo Farfel, Chris Gaiteri, Aron S Buchman, David A Bennett, Julie A Schneide. APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 2. 2020-04-10. PMID:30321502. |
apolipoprotein e (apoe) is a susceptibility gene for late-onset alzheimer's disease neuropathology; less is known about the relationship between apoe and cerebrovascular disease (cvd) neuropathology. |
2020-04-10 |
2023-08-13 |
Not clear |
| b' Greta P\\xc5\\xa1emeneckien\\xc4\\x97, K\\xc4\\x99stutis Petrikonis, And Daiva Rastenyt\\xc4\\x9. Polymorphisms of Proinflammatory Cytokines in Relation to APOE Epsilon 4 and Risk of Alzheimer\'s Disease in the Lithuanian Population. Medicina (Kaunas, Lithuania). vol 55. issue 10. 2020-04-06. PMID:31618972.' |
polymorphisms of proinflammatory cytokines in relation to apoe epsilon 4 and risk of alzheimer's disease in the lithuanian population. |
2020-04-06 |
2023-08-13 |
Not clear |
| Zhuqing Shi, Hongjie Yu, Yishuo Wu, Madison Ford, Chelsea Perschon, Chihsiung Wang, Siqun L Zheng, Jianfeng X. Genetic risk score modifies the effect of APOE on risk and age onset of Alzheimer's disease. Clinical genetics. vol 95. issue 2. 2020-03-30. PMID:30460685. |
genetic risk score modifies the effect of apoe on risk and age onset of alzheimer's disease. |
2020-03-30 |
2023-08-13 |
Not clear |
| Zhuqing Shi, Hongjie Yu, Yishuo Wu, Madison Ford, Chelsea Perschon, Chihsiung Wang, Siqun L Zheng, Jianfeng X. Genetic risk score modifies the effect of APOE on risk and age onset of Alzheimer's disease. Clinical genetics. vol 95. issue 2. 2020-03-30. PMID:30460685. |
single nucleotide polymorphism (snp)-based genetic risk score (grs) and apoe genotype are both important in risk prediction of alzheimer's disease (ad); however, the interaction between grs and apoe has not been extensively investigated. |
2020-03-30 |
2023-08-13 |
Not clear |
| Alexander M Kulminski, Yury Loika, Irina Culminskaya, Jian Huang, Konstantin G Arbeev, Olivia Bagley, Mary F Feitosa, Joseph M Zmuda, Kaare Christensen, Anatoliy I Yashi. Independent associations of TOMM40 and APOE variants with body mass index. Aging cell. vol 18. issue 1. 2020-03-30. PMID:30462377. |
while a stronger role of the apoe than tomm40 variants in alzheimer's disease was suggested, comparative contribution of the tomm40-apoe variants in the regulation of body weight remains elusive. |
2020-03-30 |
2023-08-13 |
Not clear |
| Hailin Liu, Shengwei Liu, Xiaocui Tian, Qian Wang, Jiangyan Rao, Yucun Wang, Fei Xiang, Hang Zheng, Lu Xu, Zhi Don. Bexarotene Attenuates Focal Cerebral Ischemia-Reperfusion Injury via the Suppression of JNK/Caspase-3 Signaling Pathway. Neurochemical research. vol 44. issue 12. 2020-03-30. PMID:31680194. |
apolipoprotein e (apoe) is implicated not only in chronic degenerative neurological diseases, such as alzheimer's disease, but also in acute brain disorders, including traumatic brain injury. |
2020-03-30 |
2023-08-13 |
mouse |
| Guy C Brow. The endotoxin hypothesis of neurodegeneration. Journal of neuroinflammation. vol 16. issue 1. 2020-03-23. PMID:31519175. |
endotoxin binds directly to apoe, and the apoe4 variant both sensitises to endotoxin and predisposes to alzheimer's disease. |
2020-03-23 |
2023-08-13 |
mouse |
| Tina Bilousova, Mikhail Melnik, Emily Miyoshi, Bianca L Gonzalez, Wayne W Poon, Harry V Vinters, Carol A Miller, Maria M Corrada, Claudia Kawas, Asa Hatami, Ricardo Albay, Charles Glabe, Karen H Gyly. Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4. The American journal of pathology. vol 189. issue 8. 2020-03-11. PMID:31108099. |
apolipoprotein e (apoe) colocalizes with amyloid-β (aβ) in alzheimer disease (ad) plaques and in synapses, and evidence suggests that direct interactions between apoe and aβ are important for apoe's effects in ad. |
2020-03-11 |
2023-08-13 |
human |
| Claus Rieker, Eugenia Migliavacca, Angélique Vaucher, Gilles Baud, Julien Marquis, Aline Charpagne, Nagabhooshan Hegde, Laurence Guignard, Michael McLachlan, Amy M Poole. Apolipoprotein E4 Expression Causes Gain of Toxic Function in Isogenic Human Induced Pluripotent Stem Cell-Derived Endothelial Cells. Arteriosclerosis, thrombosis, and vascular biology. vol 39. issue 9. 2020-03-10. PMID:31315437. |
the apoe (apolipoprotein) allele epsilon 4 is a major genetic risk factor for alzheimer disease, cardiovascular disorders, and stroke, indicating that it significantly impacts cerebral and vascular systems. |
2020-03-10 |
2023-08-13 |
human |
| R Guerreiro, T Orme, A C Naj, A B Kuzma, G D Schellenberg, J Bra. Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers? Neuropathology and applied neurobiology. vol 45. issue 2. 2020-03-03. PMID:30229991. |
is apoe ε4 required for alzheimer's disease to develop in trem2 p.r47h variant carriers? |
2020-03-03 |
2023-08-13 |
Not clear |
| Kathleen M McAvoy, Hameetha Rajamohamed Sait, Galina Marsh, Michael Peterson, Taylor L Reynolds, Jake Gagnon, Sarah Geisler, Prescott Leach, Chris Roberts, Ellen Cahir-McFarland, Richard M Ransohoff, Andrea Crott. Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo. PloS one. vol 14. issue 8. 2020-03-03. PMID:31408457. |
bin1 is the most important risk locus for late onset alzheimer's disease (load), after apoe. |
2020-03-03 |
2023-08-13 |
mouse |
| Yi-Chun Chen, Ya-Jen Chiu, Chih-Hsin Lin, Wen-Chuin Hsu, Jia-Lu Wu, Chen-Hsiang Huang, Chia-Wei Lin, Ching-Fa Yao, Hei-Jen Huang, Yen-Shi Lo, Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-L. Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30689566. |
indole compound nc009-1 augments apoe and trka in alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement. |
2020-03-02 |
2023-08-13 |
mouse |
| Eloise Hudry, Jacob Klickstein, Claudia Cannavo, Rosemary Jackson, Alona Muzikansky, Sheetal Gandhi, David Urick, Taylie Sargent, Lauren Wrobleski, Allyson D Roe, Steven S Hou, Kishore V Kuchibhotla, Rebecca A Betensky, Tara Spires-Jones, Bradley T Hyma. Opposing Roles of apolipoprotein E in aging and neurodegeneration. Life science alliance. vol 2. issue 1. 2020-02-26. PMID:30760557. |
removal of apoe not only impairs cognitive functions but also reduces neuritic amyloid plaques in mouse models of alzheimer's disease (ad). |
2020-02-26 |
2023-08-13 |
mouse |
| Masaya Tachibana, Marie-Louise Holm, Chia-Chen Liu, Mitsuru Shinohara, Tomonori Aikawa, Hiroshi Oue, Yu Yamazaki, Yuka A Martens, Melissa E Murray, Patrick M Sullivan, Kathrin Weyer, Simon Glerup, Dennis W Dickson, Guojun Bu, Takahisa Kanekiy. APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1. The Journal of clinical investigation. vol 129. issue 3. 2020-02-24. PMID:30741718. |
carrying the ε4 allele of the apoe gene encoding apolipoprotein e (apoe4) markedly increases the risk for late-onset alzheimer's disease (ad), in which apoe4 exacerbates the brain accumulation and subsequent deposition of amyloid-β (aβ) peptides. |
2020-02-24 |
2023-08-13 |
mouse |