| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth E Blue, Andréa R V R Horimoto, Shubhabrata Mukherjee, Ellen M Wijsman, Timothy A Thornto. Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 12. 2020-09-02. PMID:31606368. |
although the relationship between apoe and alzheimer's disease (ad) is well established in populations of european descent, the effects of apoe and ancestry on ad risk in diverse populations is not well understood. |
2020-09-02 |
2023-08-13 |
Not clear |
| C E Murray, A King, C Troakes, A Hodges, T Lashle. APOE ε4 is also required in TREM2 R47H variant carriers for Alzheimer's disease to develop. Neuropathology and applied neurobiology. vol 45. issue 2. 2020-09-01. PMID:29411406. |
apoe ε4 is also required in trem2 r47h variant carriers for alzheimer's disease to develop. |
2020-09-01 |
2023-08-13 |
Not clear |
| Linhui Xie, Pradeep Varathan, Kwangsik Nho, Andrew J Saykin, Paul Salama, Jingwen Ya. Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modularity-constrained Lasso. PloS one. vol 15. issue 6. 2020-08-31. PMID:32555747. |
large-scale genome wide association studies (gwass) have led to discovery of many genetic risk factors in alzheimer's disease (ad), such as apoe, tomm40 and clu. |
2020-08-31 |
2023-08-13 |
Not clear |
| Carr J Smith, J Wesson Ashford, Thomas A Perfett. Putative Survival Advantages in Young Apolipoprotein ɛ4 Carriers are Associated with Increased Neural Stress. Journal of Alzheimer's disease : JAD. vol 68. issue 3. 2020-08-27. PMID:30814349. |
inheritance of a single copy of the apolipoprotein e (apoe) ɛ4 allele increases risk of alzheimer's disease (ad) by 3-4-fold, with homozygosity associated with a 12-16-fold increase in risk, relative to ɛ3 allele homozygosity. |
2020-08-27 |
2023-08-13 |
human |
| M Tzioras, C Davies, A Newman, R Jackson, T Spires-Jone. Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease. Neuropathology and applied neurobiology. vol 45. issue 4. 2020-08-21. PMID:30394574. |
invited review: apoe at the interface of inflammation, neurodegeneration and pathological protein spread in alzheimer's disease. |
2020-08-21 |
2023-08-13 |
Not clear |
| Min Liu, Manish D Paranjpe, Xin Zhou, Phan Q Duy, Manu S Goyal, Tammie L S Benzinger, Jie Lu, Rongfu Wang, Yun Zho. Sex modulates the ApoE ε4 effect on brain tau deposition measured by Theranostics. vol 9. issue 17. 2020-08-20. PMID:31410194. |
sex modulates the apoe ε4 effect on brain tau deposition measured by the strongest genetic risk factor for alzheimer's disease (ad) is the apolipoprotein e type 4 allele (apoe ε4). |
2020-08-20 |
2023-08-13 |
Not clear |
| Jie Gao, Russell Littman, Graciel Diamante, Xu Xiao, In Sook Ahn, Xia Yang, Tracy A Cole, Peter Tontono. Therapeutic IDOL Reduction Ameliorates Amyloidosis and Improves Cognitive Function in APP/PS1 Mice. Molecular and cellular biology. vol 40. issue 8. 2020-08-19. PMID:31964754. |
brain lipoprotein receptors have been shown to regulate the metabolism of apoe and β-amyloid (aβ) and are potential therapeutic targets for alzheimer's disease (ad). |
2020-08-19 |
2023-08-13 |
mouse |
| Emily S Bower, Jacquelyn Szajer, Claire Murph. Effect of Worry Level on Recall Memory for Odors in ApoE-ε4 Carriers and Non-Carriers. Journal of the International Neuropsychological Society : JINS. vol 25. issue 5. 2020-08-11. PMID:30987686. |
increased levels of worry, age, and presence of the apolipoprotein-e (apoe)-ε4 allele are associated with the risk of developing cognitive declines and alzheimer's disease (ad). |
2020-08-11 |
2023-08-13 |
Not clear |
| Ya-Ting Chang, Shih-Wei Hsu, Shu-Hua Huang, Chi-Wei Huang, Wen-Neng Chang, Chia-Yi Lien, Jun-Jun Lee, Chen-Chang Lee, Chiung-Chih Chan. ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer's disease. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31831047. |
since both apoe and abca7 protein expression may independently reduce neuritic plaque burden and reorganize fibrillar amyloid burden-mediated disruption of functional connectivity in the default mode network, we aimed to investigate the effect of the apoe-abca7 interaction on default mode network in alzheimer's disease. |
2020-08-06 |
2023-08-13 |
Not clear |
| Min-Tzu Lo, Karolina Kauppi, Chun-Chieh Fan, Nilotpal Sanyal, Emilie T Reas, V S Sundar, Wen-Chung Lee, Rahul S Desikan, Linda K McEvoy, Chi-Hua Che. Identification of genetic heterogeneity of Alzheimer's disease across age. Neurobiology of aging. vol 84. 2020-08-04. PMID:30979435. |
the risk of apoe for alzheimer's disease (ad) is modified by age. |
2020-08-04 |
2023-08-13 |
Not clear |
| G Peggy McFall, Lars Bäckman, Roger A Dixo. Nuances in Alzheimer's Genetic Risk Reveal Differential Predictions of Non-demented Memory Aging Trajectories: Selective Patterns by APOE Genotype and Sex. Current Alzheimer research. vol 16. issue 4. 2020-08-03. PMID:30873923. |
nuances in alzheimer's genetic risk reveal differential predictions of non-demented memory aging trajectories: selective patterns by apoe genotype and sex. |
2020-08-03 |
2023-08-13 |
Not clear |
| G Peggy McFall, Lars Bäckman, Roger A Dixo. Nuances in Alzheimer's Genetic Risk Reveal Differential Predictions of Non-demented Memory Aging Trajectories: Selective Patterns by APOE Genotype and Sex. Current Alzheimer research. vol 16. issue 4. 2020-08-03. PMID:30873923. |
apolipoprotein e (apoe) is a prominent genetic risk factor for alzheimer's disease (ad) and a frequent target for associations with non-demented and cognitively impaired aging. |
2020-08-03 |
2023-08-13 |
Not clear |
| Frank de Wolf, Mohsen Ghanbari, Silvan Licher, Kevin McRae-McKee, Luuk Gras, Gerrit Jan Weverling, Paulien Wermeling, Sanaz Sedaghat, M Kamran Ikram, Reem Waziry, Wouter Koudstaal, Jaco Klap, Stefan Kostense, Albert Hofman, Roy Anderson, Jaap Goudsmit, M Arfan Ikra. Plasma tau, neurofilament light chain and amyloid-β levels and risk of dementia; a population-based cohort study. Brain : a journal of neurology. vol 143. issue 4. 2020-07-31. PMID:32206776. |
associations between biomarker plasma levels and incident all-cause and alzheimer's disease dementia during follow-up were assessed using cox proportional-hazard regression models adjusted for age, sex, education, cardiovascular risk factors and apoe ε4 status. |
2020-07-31 |
2023-08-13 |
human |
| Juho-Pekka Karjalainen, Nina Mononen, Nina Hutri-Kähönen, Miikael Lehtimäki, Markus Juonala, Mika Ala-Korpela, Mika Kähönen, Olli Raitakari, Terho Lehtimäk. The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study. Scientific reports. vol 9. issue 1. 2020-07-27. PMID:30679475. |
apolipoprotein e (apoe) is the key regulator of plasma lipids, mediating altered functionalities in lipoprotein metabolism - affecting the risk of coronary artery (cad) and alzheimer's diseases, as well as longevity. |
2020-07-27 |
2023-08-13 |
human |
| S Shen, W Zhou, X Chen, J Zhan. Sex differences in the association of APOE ε4 genotype with longitudinal hippocampal atrophy in cognitively normal older people. European journal of neurology. vol 26. issue 11. 2020-07-20. PMID:31102429. |
the aim of this study was to determine the effects of apolipoprotein e ε4 (apoe ε4) genotype and sex together on longitudinal change in adjusted hippocampal volume [hippocampal volume:intracranial volume ratio (hpvr)] across the alzheimer's disease (ad) continuum. |
2020-07-20 |
2023-08-13 |
Not clear |
| Sherilyn Thibeau, Kirstie McDermott, G Peggy McFall, Kenneth Rockwood, Roger A Dixo. Frailty effects on non-demented cognitive trajectories are moderated by sex and Alzheimer's genetic risk. Alzheimer's research & therapy. vol 11. issue 1. 2020-07-15. PMID:31221191. |
in a longitudinal sample of non-demented older adults, we examine whether (a) the level and/or change in frailty predicts trajectories across three cognitive domains (memory, speed, and executive function (ef)) and (b) prediction patterns are modified by sex or alzheimer's genetic risk (apolipoprotein e (apoe)). |
2020-07-15 |
2023-08-13 |
Not clear |
| Lisa Vermunt, Sietske A M Sikkes, Ardo van den Hout, Ron Handels, Isabelle Bos, Wiesje M van der Flier, Silke Kern, Pierre-Jean Ousset, Paul Maruff, Ingmar Skoog, Frans R J Verhey, Yvonne Freund-Levi, Magda Tsolaki, Åsa K Wallin, Marcel Olde Rikkert, Hilkka Soininen, Luisa Spiru, Henrik Zetterberg, Kaj Blennow, Philip Scheltens, Graciela Muniz-Terrera, Pieter Jelle Visse. Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 7. 2020-07-10. PMID:31164314. |
duration of preclinical, prodromal, and dementia stages of alzheimer's disease in relation to age, sex, and apoe genotype. |
2020-07-10 |
2023-08-13 |
Not clear |
| Lisa Vermunt, Sietske A M Sikkes, Ardo van den Hout, Ron Handels, Isabelle Bos, Wiesje M van der Flier, Silke Kern, Pierre-Jean Ousset, Paul Maruff, Ingmar Skoog, Frans R J Verhey, Yvonne Freund-Levi, Magda Tsolaki, Åsa K Wallin, Marcel Olde Rikkert, Hilkka Soininen, Luisa Spiru, Henrik Zetterberg, Kaj Blennow, Philip Scheltens, Graciela Muniz-Terrera, Pieter Jelle Visse. Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 7. 2020-07-10. PMID:31164314. |
we estimated the age-specific duration of the preclinical, prodromal, and dementia stages of alzheimer's disease (ad) and the influence of sex, setting, apolipoprotein e (apoe) genotype, and cerebrospinal fluid tau on disease duration. |
2020-07-10 |
2023-08-13 |
Not clear |
| Yu-Wen Alvin Huang, Bo Zhou, Amber M Nabet, Marius Wernig, Thomas C Südho. Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 37. 2020-06-25. PMID:31331998. |
humans express three genetic apoe variants, apoe2, apoe3, and apoe4, which exhibit distinct apoe receptor-binding properties and differentially affect alzheimer's disease (ad), such that apoe2 protects against, and apoe4 predisposes to ad. |
2020-06-25 |
2023-08-13 |
human |
| Rachel L Nosheny, Philip S Insel, Niklas Mattsson, Duygu Tosun, Shannon Buckley, Diana Truran, N Schuff, Paul S Aisen, Michael W Weine. Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults. Neurobiology of aging. vol 82. 2020-06-25. PMID:31437719. |
in 80 cu participants from the alzheimer's disease neuroimaging initiative, we determined effects of aβ and age on longitudinal, regional atrophy rates, while accounting for confounding variables including sex, apoe ε4 genotype, white matter lesions, and cerebrospinal fluid total and phosphorylated tau levels. |
2020-06-25 |
2023-08-13 |
human |