| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tien-Phat V Huynh, Chao Wang, Ainsley C Tran, G Travis Tabor, Thomas E Mahan, Caroline M Francis, Mary Beth Finn, Rebecca Spellman, Melissa Manis, Rudolph E Tanzi, Jason D Ulrich, David M Holtzma. Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. Molecular neurodegeneration. vol 14. issue 1. 2020-06-23. PMID:31623648. |
the apolipoprotein e (apoe) gene is the strongest genetic risk factor for late-onset alzheimer disease (ad). |
2020-06-23 |
2023-08-13 |
mouse |
| Ka Yi G Koo, Tom A Schweizer, Corinne E Fischer, David G Muno. Abnormal Sleep Behaviours Across the Spectrum of Alzheimer's Disease Severity: Influence of APOE Genotypes and Lewy Bodies. Current Alzheimer research. vol 16. issue 3. 2020-06-16. PMID:30605058. |
abnormal sleep behaviours across the spectrum of alzheimer's disease severity: influence of apoe genotypes and lewy bodies. |
2020-06-16 |
2023-08-13 |
Not clear |
| Ka Yi G Koo, Tom A Schweizer, Corinne E Fischer, David G Muno. Abnormal Sleep Behaviours Across the Spectrum of Alzheimer's Disease Severity: Influence of APOE Genotypes and Lewy Bodies. Current Alzheimer research. vol 16. issue 3. 2020-06-16. PMID:30605058. |
the apolipoprotein (apoe) ε4 allele is a well-known risk factor for alzheimer's disease (ad), and sleep disturbances are commonly associated with ad. |
2020-06-16 |
2023-08-13 |
Not clear |
| Shamasree Ghosh, Timir Baran Sil, Subhrajyoti Dolai, Kanchan Gara. High-affinity multivalent interactions between apolipoprotein E and the oligomers of amyloid-β. The FEBS journal. vol 286. issue 23. 2020-06-15. PMID:31287614. |
although the interaction of apoe isoforms with amyloid-β (aβ) peptides plays a critical role in the progression of alzheimer's disease, how they interact with each other remains poorly understood. |
2020-06-15 |
2023-08-13 |
Not clear |
| Vijay K Ramanan, Anna M Castillo, David S Knopman, Jonathan Graff-Radford, Val J Lowe, Ronald C Petersen, Clifford R Jack, Michelle M Mielke, Prashanthi Vemur. Association of Apolipoprotein E ɛ4, Educational Level, and Sex With Tau Deposition and Tau-Mediated Metabolic Dysfunction in Older Adults. JAMA network open. vol 2. issue 10. 2020-06-15. PMID:31642932. |
while amyloidosis is an early event in the alzheimer disease (ad) biomarker cascade, a complex interplay among the apolipoprotein e (apoe) ɛ4 allele, educational levels, and sex may be associated with an individual's resilience to dementia. |
2020-06-15 |
2023-08-13 |
Not clear |
| Yacine Tensaouti, Tzong-Shiue Yu, Steven G Kerni. Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury. PloS one. vol 15. issue 3. 2020-06-15. PMID:32119690. |
it has previously been established that apolipoprotein e (apoe) plays a regulatory role in adult hippocampal neurogenesis, which is of particular interest as the presence of the human apoe isoform apoe4 leads to significant risk for the development of late-onset alzheimer's disease, where impaired neurogenesis has been linked with disease progression. |
2020-06-15 |
2023-08-13 |
mouse |
| Victoria S Marshe, Ilona Gorbovskaya, Sarah Kanji, Maxine Kish, Daniel J Mülle. Clinical implications of APOE genotyping for late-onset Alzheimer's disease (LOAD) risk estimation: a review of the literature. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 1. 2020-06-12. PMID:30382407. |
clinical implications of apoe genotyping for late-onset alzheimer's disease (load) risk estimation: a review of the literature. |
2020-06-12 |
2023-08-13 |
Not clear |
| Allison A Dilliott, Emily C Evans, Sali M K Farhan, Mahdi Ghani, Christine Sato, Ming Zhang, Adam D McIntyre, Henian Cao, Lemuel Racacho, John F Robinson, Michael J Strong, Mario Masellis, Dennis E Bulman, Ekaterina Rogaeva, Sandra E Black, Elizabeth Finger, Andrew Frank, Morris Freedman, Ayman Hassan, Anthony Lang, Christen L Shoesmith, Richard H Swartz, David Tang-Wai, Maria Carmela Tartaglia, John Turnbull, Lorne Zinman, Robert A Hegel. Genetic Variation in the Ontario Neurodegenerative Disease Research Initiative. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 46. issue 5. 2020-06-12. PMID:31217043. |
apolipoprotein e (apoe) e4 is the main genetic risk factor for alzheimer's disease (ad). |
2020-06-12 |
2023-08-13 |
human |
| Angela J Hanson, William A Banks, Lisa F Bettcher, Robert Pepin, Daniel Raftery, Suzanne Craf. Cerebrospinal fluid lipidomics: effects of an intravenous triglyceride infusion and apoE status. Metabolomics : Official journal of the Metabolomic Society. vol 16. issue 1. 2020-06-11. PMID:31832778. |
high-fat diets increase risk for alzheimer's disease, but individuals with the risk gene apoe ε4 (e4) paradoxically have improved memory soon after high fat feeding. |
2020-06-11 |
2023-08-13 |
Not clear |
| Ellen Hubin, Philip B Verghese, Nico van Nuland, Kerensa Broerse. Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation. FEBS letters. vol 593. issue 11. 2020-06-01. PMID:31058310. |
apolipoprotein e (apoe) genotype determines alzheimer's disease (ad) susceptibility, with the apoe ε4 allele being an established risk factor for late-onset ad. |
2020-06-01 |
2023-08-13 |
Not clear |
| Maurizio Gallucci, Carola Dell'Acqua, Cristina Bergamelli, Chiara Fenoglio, Maria Serpente, Daniela Galimberti, Vittorio Fiore, Stefano Medea, Michele Gregianin, Maria Elena Di Battist. A Case with Early Onset Alzheimer's Disease, Frontotemporal Hypometabolism, ApoE Genotype ɛ4/ɛ4 and C9ORF72 Intermediate Expansion: A Treviso Dementia (TREDEM) Registry Case Report. Journal of Alzheimer's disease : JAD. vol 67. issue 3. 2020-05-29. PMID:30714955. |
a case with early onset alzheimer's disease, frontotemporal hypometabolism, apoe genotype ɛ4/ɛ4 and c9orf72 intermediate expansion: a treviso dementia (tredem) registry case report. |
2020-05-29 |
2023-08-13 |
Not clear |
| Shahrnaz Kemal, Robert Vassa. Death by microglia. The Journal of experimental medicine. vol 216. issue 11. 2020-05-29. PMID:31645368. |
the roles of microglia and apoe in tauopathies, such as alzheimer's disease, remain elusive. |
2020-05-29 |
2023-08-13 |
mouse |
| Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, Gregory Louie, M Arthur Moseley, J Will Thompson, Lisa St John-Williams, Jessica D Tenenbaum, Colette Blach, Rui Chang, Roberta D Brinton, Rebecca Baillie, Xianlin Han, John Q Trojanowski, Leslie M Shaw, Ralph Martins, Michael W Weiner, Eugenia Trushina, Jon B Toledo, Peter J Meikle, David A Bennett, Jan Krumsiek, P Murali Doraiswamy, Andrew J Saykin, Rima Kaddurah-Daouk, Gabi Kastenmülle. Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome. Nature communications. vol 11. issue 1. 2020-05-22. PMID:32123170. |
sex and apoe ε4 genotype modify the alzheimer's disease serum metabolome. |
2020-05-22 |
2023-08-13 |
Not clear |
| Wei Theng Sng, Si Ning Yeo, Bernice Xiangting Lin, Tih-Shih Le. Impacts of apolipoprotein E disclosure on healthy Asian older adults: a cohort study. International psychogeriatrics. vol 31. issue 10. 2020-04-29. PMID:30894233. |
the apolipoprotein e (apoe) genotype provides information about alzheimer's disease risk, yet genotype disclosure is discouraged due to concerns about possible distress. |
2020-04-29 |
2023-08-13 |
Not clear |
| Rebecca L Koscik, Derek L Norton, Samantha L Allison, Erin M Jonaitis, Lindsay R Clark, Kimberly D Mueller, Bruce P Hermann, Corinne D Engelman, Carey E Gleason, Mark A Sager, Richard J Chappell, Sterling C Johnso. Characterizing the Effects of Sex, APOE ɛ4, and Literacy on Mid-life Cognitive Trajectories: Application of Information-Theoretic Model Averaging and Multi-model Inference Techniques to the Wisconsin Registry for Alzheimer's Prevention Study. Journal of the International Neuropsychological Society : JINS. vol 25. issue 2. 2020-04-28. PMID:30522545. |
characterizing the effects of sex, apoe ɛ4, and literacy on mid-life cognitive trajectories: application of information-theoretic model averaging and multi-model inference techniques to the wisconsin registry for alzheimer's prevention study. |
2020-04-28 |
2023-08-13 |
Not clear |
| Jessica B Langbaum, Jason Karlawish, J Scott Roberts, Elisabeth M Wood, Angela Bradbury, Nellie High, Trisha L Walsh, David Gordon, Raj Aggarwal, Peter Davis, Carter Stowell, Lane Trisko, Carolyn M Langlois, Eric M Reiman, Pierre N Tario. GeneMatch: A novel recruitment registry using at-home APOE genotyping to enhance referrals to Alzheimer's prevention studies. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 4. 2020-04-27. PMID:30772251. |
genematch: a novel recruitment registry using at-home apoe genotyping to enhance referrals to alzheimer's prevention studies. |
2020-04-27 |
2023-08-13 |
human |
| Eva Díaz-Guerra, Elena P Moreno-Jiménez, Itziar de Rojas, César Rodríguez, Eva Rodríguez-Traver, Esther Arribas-González, María Orera, Isabel Hernández, Agustín Ruiz, Carlos Vicari. A collection of four integration-free iPSC lines derived from diagnosed sporadic Alzheimer's disease patients with different APOE alleles. Stem cell research. vol 39. 2020-04-27. PMID:31401456. |
a collection of four integration-free ipsc lines derived from diagnosed sporadic alzheimer's disease patients with different apoe alleles. |
2020-04-27 |
2023-08-13 |
Not clear |
| Eva Díaz-Guerra, Elena P Moreno-Jiménez, Itziar de Rojas, César Rodríguez, Eva Rodríguez-Traver, Esther Arribas-González, María Orera, Isabel Hernández, Agustín Ruiz, Carlos Vicari. A collection of four integration-free iPSC lines derived from diagnosed sporadic Alzheimer's disease patients with different APOE alleles. Stem cell research. vol 39. 2020-04-27. PMID:31401456. |
genetic polymorphism of apolipoprotein e (apoe) confers differential susceptibility to late-onset alzheimer's disease (load). |
2020-04-27 |
2023-08-13 |
Not clear |
| Eric M Reiman, Joseph F Arboleda-Velasquez, Yakeel T Quiroz, Matthew J Huentelman, Thomas G Beach, Richard J Caselli, Yinghua Chen, Yi Su, Amanda J Myers, John Hardy, Jean Paul Vonsattel, Steven G Younkin, David A Bennett, Philip L De Jager, Eric B Larson, Paul K Crane, C Dirk Keene, M Ilyas Kamboh, Julia K Kofler, Linda Duque, John R Gilbert, Harry E Gwirtsman, Joseph D Buxbaum, Dennis W Dickson, Matthew P Frosch, Bernardino F Ghetti, Kathryn L Lunetta, Li-San Wang, Bradley T Hyman, Walter A Kukull, Tatiana Foroud, Jonathan L Haines, Richard P Mayeux, Margaret A Pericak-Vance, Julie A Schneider, John Q Trojanowski, Lindsay A Farrer, Gerard D Schellenberg, Gary W Beecham, Thomas J Montine, Gyungah R Ju. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature communications. vol 11. issue 1. 2020-04-23. PMID:32015339. |
finding and targeting the factors by which apoe and its variants influence alzheimer's disease could have a major impact on the understanding, treatment and prevention of the disease. |
2020-04-23 |
2023-08-13 |
Not clear |
| T L Stephen, M Cacciottolo, D Balu, T E Morgan, M J LaDu, C E Finch, C J Pik. APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31113487. |
apoe genotype and sex affect microglial interactions with plaques in alzheimer's disease mice. |
2020-04-21 |
2023-08-13 |
mouse |