| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C L Berkowitz, L Mosconi, A Rahman, O Scheyer, H Hristov, R S Isaacso. Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach. The journal of prevention of Alzheimer's disease. vol 5. issue 4. 2019-11-08. PMID:30298183. |
clinical application of apoe in alzheimer's prevention: a precision medicine approach. |
2019-11-08 |
2023-08-13 |
Not clear |
| Jessica Tulloch, Lesley Leong, Zachary Thomson, Sunny Chen, Eun-Gyung Lee, C Dirk Keene, Steven P Millard, Chang-En Y. Glia-specific APOE epigenetic changes in the Alzheimer's disease brain. Brain research. vol 1698. 2019-11-04. PMID:30081037. |
glia-specific apoe epigenetic changes in the alzheimer's disease brain. |
2019-11-04 |
2023-08-13 |
human |
| Jessica Tulloch, Lesley Leong, Zachary Thomson, Sunny Chen, Eun-Gyung Lee, C Dirk Keene, Steven P Millard, Chang-En Y. Glia-specific APOE epigenetic changes in the Alzheimer's disease brain. Brain research. vol 1698. 2019-11-04. PMID:30081037. |
the apolipoprotein e gene (apoe) is the strongest genetic risk factor for developing alzheimer's disease (ad). |
2019-11-04 |
2023-08-13 |
human |
| Maxime M Bos, Raymond Noordam, Gerard J Blauw, P Eline Slagboom, Patrick C N Rensen, Diana van Heems. The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors? The journals of gerontology. Series A, Biological sciences and medical sciences. vol 74. issue 1. 2019-10-31. PMID:30321297. |
in literature, especially the apoe ɛ4 isoform has been associated with an increased risk of mortality and age-related diseases such as alzheimer's disease (ad), cardiovascular diseases (cvd), as compared to the "neutral" apoe ɛ3 isoform. |
2019-10-31 |
2023-08-13 |
Not clear |
| Long Wu, Xin Zhang, Liqin Zha. Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 30. 2019-10-28. PMID:29967007. |
human apoe isoforms differentially modulate brain glucose and ketone body metabolism: implications for alzheimer's disease risk reduction and early intervention. |
2019-10-28 |
2023-08-13 |
mouse |
| Long Wu, Xin Zhang, Liqin Zha. Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 30. 2019-10-28. PMID:29967007. |
humans possess three genetic isoforms of apolipoprotein e (apoe)-apoe2, apoe3, and apoe4-that confer differential risk for alzheimer's disease (ad); however, the underlying mechanisms are poorly understood. |
2019-10-28 |
2023-08-13 |
mouse |
| M Clare O'Donoghue, Susannah E Murphy, Giovanna Zamboni, Anna C Nobre, Clare E Macka. APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review. Cortex; a journal devoted to the study of the nervous system and behavior. vol 104. 2019-10-17. PMID:29800787. |
apoe genotype and cognition in healthy individuals at risk of alzheimer's disease: a review. |
2019-10-17 |
2023-08-13 |
Not clear |
| Timothy J Hohman, Logan Dumitrescu, Lisa L Barnes, Madhav Thambisetty, Gary Beecham, Brian Kunkle, Katherine A Gifford, William S Bush, Lori B Chibnik, Shubhabrata Mukherjee, Philip L De Jager, Walter Kukull, Paul K Crane, Susan M Resnick, C Dirk Keene, Thomas J Montine, Gerard D Schellenberg, Jonathan L Haines, Henrik Zetterberg, Kaj Blennow, Eric B Larson, Sterling C Johnson, Marilyn Albert, David A Bennett, Julie A Schneider, Angela L Jefferso. Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA neurology. vol 75. issue 8. 2019-10-17. PMID:29801024. |
the strongest genetic risk factor for alzheimer disease (ad), the apolipoprotein e (apoe) gene, has a stronger association among women compared with men. |
2019-10-17 |
2023-08-13 |
Not clear |
| Yanal A Shafagoj, Randa G Naffa, Mohammed S El-Khateeb, Yazeed L Abdulla, Aseem A Al-Qaddoumi, Faisal A Khatib, Yousef F Al-Motassem, Eman M Al-Khatee. APOE Gene polymorphism among Jordanian Alzheimer`s patients with relation to lipid profile. Neurosciences (Riyadh, Saudi Arabia). vol 23. issue 1. 2019-10-16. PMID:29455218. |
apoe gene polymorphism among jordanian alzheimer`s patients with relation to lipid profile. |
2019-10-16 |
2023-08-13 |
Not clear |
| Yanal A Shafagoj, Randa G Naffa, Mohammed S El-Khateeb, Yazeed L Abdulla, Aseem A Al-Qaddoumi, Faisal A Khatib, Yousef F Al-Motassem, Eman M Al-Khatee. APOE Gene polymorphism among Jordanian Alzheimer`s patients with relation to lipid profile. Neurosciences (Riyadh, Saudi Arabia). vol 23. issue 1. 2019-10-16. PMID:29455218. |
to investigate the frequencies of the apolipoprotein e (apoe) alleles and genotypes and study their relationship with the lipid profile in jordanian patients with late-onset alzheimer`s disease (ad). |
2019-10-16 |
2023-08-13 |
Not clear |
| Martina Zverova, Eva Kitzlerova, Zdenek Fisar, Roman Jirak, Jana Hroudova, Hana Benakova, Petra Lelkova, Pavel Martasek, Jiri Raboc. Interplay between the APOE Genotype and Possible Plasma Biomarkers in Alzheimer's Disease. Current Alzheimer research. vol 15. issue 10. 2019-10-16. PMID:29852871. |
interplay between the apoe genotype and possible plasma biomarkers in alzheimer's disease. |
2019-10-16 |
2023-08-13 |
Not clear |
| Masataka Kikuchi, Akihiro Nakay. [Apolipoprotein E4, a Genetic Risk Factor for Alzheimer's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 71. issue 10. 2019-10-09. PMID:31588049. |
apolipoprotein e (apoe) is reported to be a strong genetic risk factor for alzheimer's disease (ad), broadly contributing to the ad pathologies observed in most populations. |
2019-10-09 |
2023-08-13 |
Not clear |
| Alexander M Kulminski, Jian Huang, Jiayi Wang, Liang He, Yury Loika, Irina Culminskay. Apolipoprotein E region molecular signatures of Alzheimer's disease. Aging cell. vol 17. issue 4. 2019-10-07. PMID:29797398. |
although the apoe region is the strongest genetic risk factor for alzheimer's diseases (ads), its pathogenic role remains poorly understood. |
2019-10-07 |
2023-08-13 |
human |
| Xue Liang, Zhenyu Yin, Renyuan Liu, Hui Zhao, Sichu Wu, Jiaming Lu, Zhao Qing, Yongyue Wei, Qingxian Yang, Bin Zhu, Yun Xu, Bing Zhan. The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ε4 in Nondemented Elderly Subjects. Neuro-degenerative diseases. vol 18. issue 5-6. 2019-10-02. PMID:30673663. |
(1) to investigate atrophy patterns of hippocampal subfield volume and alzheimer's disease (ad)-signature cortical thickness in mild cognitive impairment (mci) patients; (2) to explore the association between the neuropsychological (np) and the brain structure in the mci and older normal cognition group; (3) to determine whether these associations were modified by the apolipoprotein e (apoe) ε4 gene and cognitive status. |
2019-10-02 |
2023-08-13 |
human |
| Kurt A Jellinge. Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 4. 2019-09-30. PMID:29222591. |
intravitam pet and post-mortem studies revealed more pronounced cortical atrophy, elevated cortical and limbic lewy pathologies (with apoe ε4), apart from higher prevalence of alzheimer pathology in dlb than pdd. |
2019-09-30 |
2023-08-13 |
human |
| Rachel F Buckley, Elizabeth C Mormino, Rebecca E Amariglio, Michael J Properzi, Jennifer S Rabin, Yen Ying Lim, Kathryn V Papp, Heidi I L Jacobs, Samantha Burnham, Bernard J Hanseeuw, Vincent Doré, Annette Dobson, Colin L Masters, Michael Waller, Christopher C Rowe, Paul Maruff, Michael C Donohue, Dorene M Rentz, Dylan Kirn, Trey Hedden, Jasmeer Chhatwal, Aaron P Schultz, Keith A Johnson, Victor L Villemagne, Reisa A Sperlin. Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 9. 2019-09-27. PMID:29803541. |
sex, amyloid, and apoe ε4 and risk of cognitive decline in preclinical alzheimer's disease: findings from three well-characterized cohorts. |
2019-09-27 |
2023-08-13 |
Not clear |
| Dustin Chernick, Stephanie Ortiz-Valle, Angela Jeong, Suresh K Swaminathan, Karunya K Kandimalla, G William Rebeck, Ling L. High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia. Journal of neurochemistry. vol 147. issue 5. 2019-09-27. PMID:30028014. |
the apolipoprotein e (apoe) ε4 allele is the primary genetic risk factor for late-onset alzheimer's disease (ad). |
2019-09-27 |
2023-08-13 |
mouse |
| Ida Juul Rasmussen, Anne Tybjærg-Hansen, Katrine Laura Rasmussen, Børge G Nordestgaard, Ruth Frikke-Schmid. Blood-brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals. European journal of epidemiology. vol 34. issue 6. 2019-09-27. PMID:30830563. |
to test whether genetic variants in picalm, bin1, cd2ap, and rin3-suggested to be involved in blood-brain barrier amyloid-β transcytosis pathways-associate with alzheimer's disease, all dementia, suggested vascular dementia, and stroke, and whether such associations are independent of the strong ε4 apoe risk allele. |
2019-09-27 |
2023-08-13 |
Not clear |
| Ida Juul Rasmussen, Anne Tybjærg-Hansen, Katrine Laura Rasmussen, Børge G Nordestgaard, Ruth Frikke-Schmid. Blood-brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals. European journal of epidemiology. vol 34. issue 6. 2019-09-27. PMID:30830563. |
genetic variants in picalm, bin1, cd2ap, and rin3 are associated with increased risk of alzheimer's disease, all dementia, and suggested vascular dementia independent of the strong apoe ε4 allele. |
2019-09-27 |
2023-08-13 |
Not clear |
| Maria Tensil, Johannes B Hessler, Maria Gutsmiedl, Lina Riedl, Timo Grimmer, Janine Diehl-Schmi. Sex Differences in Neuropsychological Test Performance in Alzheimer's Disease and the Influence of the ApoE Genotype. Alzheimer disease and associated disorders. vol 32. issue 2. 2019-09-25. PMID:29189302. |
sex differences in neuropsychological test performance in alzheimer's disease and the influence of the apoe genotype. |
2019-09-25 |
2023-08-13 |
Not clear |