| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giacomo Koch, Francesco Di Lorenzo, Stefano Loizzo, Caterina Motta, Sara Travaglione, Monica Baiula, Roberto Rimondini, Viviana Ponzo, Sonia Bonnì, Sofia Toniolo, Fabrizio Sallustio, Marco Bozzali, Carlo Caltagirone, Gabriele Campana, Alessandro Martoran. CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29062035. |
in alzheimer's disease (ad) patients, apopoliprotein (apoe) polymorphism is the main genetic factor associated with more aggressive clinical course. |
2019-07-01 |
2023-08-13 |
human |
| Jianjia Fan, Rui Qi Zhao, Cameron Parro, Wenchen Zhao, Hsien-Ya Chou, Jerome Robert, Tarek Z Deeb, Carina Raynoschek, Samantha Barichievy, Ola Engkvist, Marcello Maresca, Ryan Hicks, Johan Meuller, Stephen J Moss, Nicholas J Brandon, Michael W Wood, Iva Kulic, Cheryl L Wellingto. Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway. Journal of lipid research. vol 59. issue 5. 2019-06-27. PMID:29563219. |
apoe is the primary lipid carrier within the cns and the strongest genetic risk factor for late onset alzheimer's disease (ad). |
2019-06-27 |
2023-08-13 |
mouse |
| M Maltais, P de Souto Barreto, Y Rolland, B Vella. The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults. The Journal of frailty & aging. vol 8. issue 2. 2019-06-27. PMID:30997917. |
apolipoprotein (apoe ε4) status has been associated with various cardiovascular diseases and alzheimer's disease. |
2019-06-27 |
2023-08-13 |
Not clear |
| Sonia Sanz Muñoz, Brett Garner, Lezanne Oo. Understanding the Role of ApoE Fragments in Alzheimer's Disease. Neurochemical research. vol 44. issue 6. 2019-06-11. PMID:30225748. |
understanding the role of apoe fragments in alzheimer's disease. |
2019-06-11 |
2023-08-13 |
human |
| Hao Shu, Yongmei Shi, Gang Chen, Zan Wang, Duan Liu, Chunxian Yue, B Douglas Ward, Wenjun Li, Zhan Xu, Guangyu Chen, Qi-Hao Guo, Jun Xu, Shi-Jiang Li, Zhijun Zhan. Distinct neural correlates of episodic memory among apolipoprotein E alleles in cognitively normal elderly. Brain imaging and behavior. vol 13. issue 1. 2019-06-10. PMID:29396739. |
the apolipoprotein e (apoe) ε4 and ε2 alleles are acknowledged genetic factors modulating alzheimer's disease (ad) risk and episodic memory (em) deterioration in an opposite manner. |
2019-06-10 |
2023-08-13 |
human |
| E Ferri, C Gussago, M Casati, D Mari, P D Rossi, S Ciccone, M Cesari, B Arosi. Apolipoprotein E gene in physiological and pathological aging. Mechanisms of ageing and development. vol 178. 2019-06-07. PMID:30658061. |
since the ε4 variant is associated with alzheimer's disease (ad), it might represent an opportunity for exploring the relationship of apoe with physiological and pathological aging. |
2019-06-07 |
2023-08-13 |
Not clear |
| Jin Lu, Jianliang Fu, Yuan Zhong, Quanjun Yang, Jinlu Huang, Jie Li, Yan Huo, Yuwu Zhao, Lili Wan, Cheng Gu. Association between ABCA1 gene polymorphisms and the therapeutic response to donepezil therapy in Han Chinese patients with Alzheimer's disease. Brain research bulletin. vol 140. 2019-06-04. PMID:29605487. |
it is reported that abca1, which plays a key role in cholesterol transport and apolipoprotein e (apoe) metabolism in the brain, is related to alzheimer's disease. |
2019-06-04 |
2023-08-13 |
Not clear |
| Jiaxuan Liu, Wei Zhao, Erin B Ware, Stephen T Turner, Thomas H Mosley, Jennifer A Smit. DNA methylation in the APOE genomic region is associated with cognitive function in African Americans. BMC medical genomics. vol 11. issue 1. 2019-05-29. PMID:29739406. |
genetic variations in apolipoprotein e (apoe) and proximal genes (pvrl2, tomm40, and apoc1) are associated with cognitive function and dementia, particularly alzheimer's disease. |
2019-05-29 |
2023-08-13 |
Not clear |
| Madeleine L Werhane, Kelsey R Thomas, Emily C Edmonds, Katherine J Bangen, My Tran, Alexandra L Clark, Daniel A Nation, Paul E Gilbert, Mark W Bondi, Lisa Delano-Woo. Differential Effect of APOE ɛ4 Status and Elevated Pulse Pressure on Functional Decline in Cognitively Normal Older Adults. Journal of Alzheimer's disease : JAD. vol 62. issue 4. 2019-05-28. PMID:29562507. |
since few studies have characterized how these risk factors affect everyday functioning, we investigated the relationship between apoe ɛ4 genotype and elevated pulse pressure (pp) on functional change in cognitively normal participants from the alzheimer's disease neuroimaging initiative (adni). |
2019-05-28 |
2023-08-13 |
human |
| Faissal Stipho, Robert Jackson, Marwan N Sabbag. Pathologically Confirmed Alzheimer's Disease in APOE ɛ2 Homozygotes is Rare but Does Occur. Journal of Alzheimer's disease : JAD. vol 62. issue 4. 2019-05-28. PMID:29562509. |
pathologically confirmed alzheimer's disease in apoe ɛ2 homozygotes is rare but does occur. |
2019-05-28 |
2023-08-13 |
Not clear |
| Anna Pierzchlińska, Monika Białecka, Mateusz Kurzawski, Jarosław Sławe. The impact of Apolipoprotein E alleles on cognitive performance in patients with Parkinson's disease. Neurologia i neurochirurgia polska. vol 52. issue 4. 2019-05-23. PMID:29776682. |
apoe gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which apoe4 is a confirmed risk factor for alzheimer's disease. |
2019-05-23 |
2023-08-13 |
human |
| Ting Xie, Samina Akbar, Maria G Stathopoulou, Thierry Oster, Christine Masson, Frances T Yen, Sophie Visvikis-Sies. Epistatic interaction of apolipoprotein E and lipolysis-stimulated lipoprotein receptor genetic variants is associated with Alzheimer's disease. Neurobiology of aging. vol 69. 2019-05-21. PMID:29858039. |
the ε4 allele of the apolipoprotein e (apoe) gene common polymorphism is the strongest genetic risk factor for alzheimer's disease (ad). |
2019-05-21 |
2023-08-13 |
human |
| Matthew Pontifex, David Vauzour, Anne-Marie Minihan. The effect of APOE genotype on Alzheimer's disease risk is influenced by sex and docosahexaenoic acid status. Neurobiology of aging. vol 69. 2019-05-21. PMID:29909178. |
the effect of apoe genotype on alzheimer's disease risk is influenced by sex and docosahexaenoic acid status. |
2019-05-21 |
2023-08-13 |
Not clear |
| Neha Sinha, Chelsie N Berg, Nicholas J Tustison, Ashlee Shaw, Diane Hill, Michael A Yassa, Mark A Gluc. APOE ε4 status in healthy older African Americans is associated with deficits in pattern separation and hippocampal hyperactivation. Neurobiology of aging. vol 69. 2019-05-21. PMID:29909179. |
african americans are 1.4 times more likely than european americans to carry the apolipoprotein e (apoe) ε4 allele, a risk factor for alzheimer's disease (ad). |
2019-05-21 |
2023-08-13 |
Not clear |
| Paul A Parcon, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Richard A Jones, Ling Liu, Robert J Shmookler Reis, Steven W Barger, Robert E Mrak, W Sue T Griffi. Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 2. 2019-05-20. PMID:28945989. |
alzheimer apolipoprotein e (apoe) ɛ4/ɛ4 carriers have earlier disease onset and more protein aggregates than patients with other apoe genotypes. |
2019-05-20 |
2023-08-13 |
Not clear |
| James D Stefaniak, Li Su, Elijah Mak, Nasim Sheikh-Bahaei, Katie Wells, Karen Ritchie, Adam Waldman, Craig W Ritchie, John T O'Brie. Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 2. 2019-05-20. PMID:29156222. |
cerebral small vessel disease (csvd) is associated with late-onset alzheimer's disease (load) and might contribute to the relationship between apolipoprotein e ε4 (apoe ε4) and load, in older people. |
2019-05-20 |
2023-08-13 |
Not clear |
| Emilie T Reas, Gail A Laughlin, Jaclyn Bergstrom, Donna Kritz-Silverstein, Elizabeth Barrett-Connor, Linda K McEvo. Effects of APOE on cognitive aging in community-dwelling older adults. Neuropsychology. vol 33. issue 3. 2019-05-20. PMID:30730162. |
the apolipoprotein e (apoe) gene is an established risk factor for sporadic alzheimer's disease, with elevated risk for ε4-carriers and reduced risk for ε2-carriers. |
2019-05-20 |
2023-08-13 |
Not clear |
| Yi Tang, Ya-Mei Li, Ming Zhang, Yan-Qiu Chen, Qin Su. ε3/4 genotype of the apolipoprotein E is associated with higher risk of Alzheimer's disease in patients with type 2 diabetes mellitus. Gene. vol 703. 2019-05-17. PMID:30890475. |
the association of apoe polymorphism and alzheimer's disease (ad) in t2dm patients remains largely unknown. |
2019-05-17 |
2023-08-13 |
Not clear |
| Changjun Yin, Susanne Ackermann, Zhe Ma, Sarajo K Mohanta, Chuankai Zhang, Yuanfang Li, Sandor Nietzsche, Martin Westermann, Li Peng, Desheng Hu, Sai Vineela Bontha, Prasad Srikakulapu, Michael Beer, Remco T A Megens, Sabine Steffens, Markus Hildner, Luke D Halder, Hans-Henning Eckstein, Jaroslav Pelisek, Jochen Herms, Sigrun Roeber, Thomas Arzberger, Anna Borodovsky, Livia Habenicht, Christoph J Binder, Christian Weber, Peter F Zipfel, Christine Skerka, Andreas J R Habenich. ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nature medicine. vol 25. issue 3. 2019-05-13. PMID:30692699. |
apolipoprotein-e (apoe) has been implicated in alzheimer's disease, atherosclerosis, and other unresolvable inflammatory conditions but a common mechanism of action remains elusive. |
2019-05-13 |
2023-08-13 |
mouse |
| Prabha Siddarth, Alison C Burggren, David A Merrill, Linda M Ercoli, Zanjbeel Mahmood, Jorge R Barrio, Gary W Smal. Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding. PloS one. vol 13. issue 12. 2019-05-06. PMID:30517207. |
the translocase of outer mitochondrial membrane 40 (tomm40), which lies in linkage disequilibrium with the apolipoprotein e (apoe) gene, has been implicated in alzheimer's disease (ad). |
2019-05-06 |
2023-08-13 |
Not clear |