| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher C Stewart, Patricia A Boyle, Bryan D James, Lei Yu, S Duke Han, David A Bennet. Associations of APOE ε4 With Health and Financial Literacy Among Community-Based Older Adults Without Dementia. The journals of gerontology. Series B, Psychological sciences and social sciences. vol 73. issue 5. 2019-08-09. PMID:27174891. |
we therefore examined associations of health and financial literacy with the apoe ε4 allele, the chief genetic risk factor for alzheimer's disease, among older adults without dementia. |
2019-08-09 |
2023-08-13 |
Not clear |
| Jessica Tulloch, Lesley Leong, Sunny Chen, C Dirk Keene, Steven P Millard, Andrew Shutes-David, Oscar L Lopez, Julia Kofler, Jeffrey A Kaye, Randy Woltjer, Peter T Nelson, Janna H Neltner, Gregory A Jicha, Douglas Galasko, Eliezer Masliah, James B Leverenz, Chang-En Yu, Debby Tsuan. APOE DNA methylation is altered in Lewy body dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 7. 2019-08-09. PMID:29544979. |
inheritance of the ε4 allele of apolipoprotein e (apoe) increases a person's risk of developing both alzheimer's disease (ad) and lewy body dementia (lbd), yet the underlying mechanisms behind this risk are incompletely understood. |
2019-08-09 |
2023-08-13 |
Not clear |
| Tobias Skillbäck, Ronald Lautner, Niklas Mattsson, Jonathan M Schott, Ingmar Skoog, Katarina Nägga, Lena Kilander, Anders Wimo, Bengt Winblad, Maria Eriksdotter, Kaj Blennow, Henrik Zetterber. Apolipoprotein E genotypes and longevity across dementia disorders. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 7. 2019-08-09. PMID:29548722. |
the ε4 allele of the apolipoprotein e (apoe) gene is a prominent risk factor for alzheimer's disease (ad), but its implication in other dementias is less well studied. |
2019-08-09 |
2023-08-13 |
Not clear |
| Niklas Mattsson, Colin Groot, Willemijn J Jansen, Susan M Landau, Victor L Villemagne, Sebastiaan Engelborghs, Mark M Mintun, Alberto Lleo, José Luis Molinuevo, William J Jagust, Giovanni B Frisoni, Adrian Ivanoiu, Gaël Chételat, Catarina Resende de Oliveira, Karen M Rodrigue, Johannes Kornhuber, Anders Wallin, Aleksandra Klimkowicz-Mrowiec, Ramesh Kandimalla, Julius Popp, Pauline P Aalten, Dag Aarsland, Daniel Alcolea, Ina S Almdahl, Inês Baldeiras, Mark A van Buchem, Enrica Cavedo, Kewei Chen, Ann D Cohen, Stefan Förster, Juan Fortea, Kristian S Frederiksen, Yvonne Freund-Levi, Kiran Dip Gill, Olymbia Gkatzima, Timo Grimmer, Harald Hampel, Sanna-Kaisa Herukka, Peter Johannsen, Koen van Laere, Mony J de Leon, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M Møllergård, John C Morris, Barbara Mroczko, Arto Nordlund, Sudesh Prabhakar, Oliver Peters, Lorena Rami, Eloy Rodríguez-Rodríguez, Catherine M Roe, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W Seo, Hilkka Soininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E Teunissen, Frans R J Verhey, Stephanie J B Vos, Linda J C van Waalwijk van Doorn, Gunhild Waldemar, Åsa K Wallin, Jens Wiltfang, Rik Vandenberghe, David J Brooks, Tormod Fladby, Christopher C Rowe, Alexander Drzezga, Marcel M Verbeek, Marie Sarazin, David A Wolk, Adam S Fleisher, William E Klunk, Duk L Na, Pascual Sánchez-Juan, Dong Young Lee, Agneta Nordberg, Magda Tsolaki, Vincent Camus, Juha O Rinne, Anne M Fagan, Henrik Zetterberg, Kaj Blennow, Gil D Rabinovici, Oskar Hansson, Bart N M van Berckel, Wiesje M van der Flier, Philip Scheltens, Pieter Jelle Visser, Rik Ossenkoppel. Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 7. 2019-08-09. PMID:29601787. |
apolipoprotein e (apoe) ε4 is the major genetic risk factor for alzheimer's disease (ad), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (aβ) pathology. |
2019-08-09 |
2023-08-13 |
human |
| Raffaele Cacciaglia, José Luis Molinuevo, Carles Falcón, Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Nina Gramunt, Manel Esteller, Sebastián Morán, Carolina Minguillón, Karine Fauria, Juan Domingo Gisper. Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 7. 2019-08-09. PMID:29605385. |
apolipoprotein e (apoe)-ε4 is the major genetic risk factor for alzheimer's disease. |
2019-08-09 |
2023-08-13 |
Not clear |
| Jan Te Nijenhuis, Kyu Yeong Choi, Yu Yong Choi, Jang Jae Lee, Eun Hyun Seo, Hoowon Kim, Kun Ho Le. Differences Between APOE Carriers and Non-APOE Carriers on Neurocognitive Tests: Jensen Effects? American journal of Alzheimer's disease and other dementias. vol 33. issue 6. 2019-08-07. PMID:29607654. |
being a carrier of the apolipoprotein e (apoe) ε4 allele is a clear risk factor for development of alzheimer's disease (ad). |
2019-08-07 |
2023-08-13 |
Not clear |
| Niklas Mattsson, Rik Ossenkoppele, Ruben Smith, Olof Strandberg, Tomas Ohlsson, Jonas Jögi, Sebastian Palmqvist, Erik Stomrud, Oskar Hansso. Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer's disease: a cohort study. Alzheimer's research & therapy. vol 10. issue 1. 2019-08-06. PMID:30086796. |
greater tau load and reduced cortical thickness in apoe ε4-negative alzheimer's disease: a cohort study. |
2019-08-06 |
2023-08-13 |
Not clear |
| Niklas Mattsson, Rik Ossenkoppele, Ruben Smith, Olof Strandberg, Tomas Ohlsson, Jonas Jögi, Sebastian Palmqvist, Erik Stomrud, Oskar Hansso. Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer's disease: a cohort study. Alzheimer's research & therapy. vol 10. issue 1. 2019-08-06. PMID:30086796. |
the objective of this preliminary study was therefore to test if tau load and brain structure differ by apoe ε4 in alzheimer's disease. |
2019-08-06 |
2023-08-13 |
Not clear |
| Hanna-Leena Hietaranta-Luoma, Maaria Tringham, Heli Karjalainen, Laura Tanner, Kirsi Vähäkangas, Anna-Maija Pietilä, Kari Åkerman, Hannu Puolijoki, Raija Tahvonen, Anu Hopi. A Long-Term Follow-Up Study on Disclosing Genetic Risk Information (APOE) to Promote Healthy Lifestyles in Finland. Lifestyle genomics. vol 11. issue 3-6. 2019-08-05. PMID:31234179. |
the information disclosed was the carrier status of the apolipoprotein e (apoe)alleles, which differentially contribute to the genetic risk for cardiovascular disease (cvd) and alzheimer's disease. |
2019-08-05 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Md Tanvir Kabir, Abdullah Al Mamun, Mohamed M Abdel-Daim, George E Barreto, Ghulam Md Ashra. APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis. Molecular neurobiology. vol 56. issue 4. 2019-08-02. PMID:30032423. |
apoe and alzheimer's disease: evidence mounts that targeting apoe4 may combat alzheimer's pathogenesis. |
2019-08-02 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Md Tanvir Kabir, Abdullah Al Mamun, Mohamed M Abdel-Daim, George E Barreto, Ghulam Md Ashra. APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis. Molecular neurobiology. vol 56. issue 4. 2019-08-02. PMID:30032423. |
this review also highlighted utmost apoe targeting therapeutic tactics that are crucial for controlling alzheimer's pathogenesis. |
2019-08-02 |
2023-08-13 |
Not clear |
| Sonia Moreno-Grau, Octavio Rodríguez-Gómez, Ángela Sanabria, Alba Pérez-Cordón, Domingo Sánchez-Ruiz, Carla Abdelnour, Sergi Valero, Isabel Hernández, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Silvia Gil, Miguel Ángel Santos-Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Marina Guitart, Anna Gailhajanet, Itziar de Rojas, Óscar Sotolongo-Grau, Susana Ruiz, Nuria Aguilera, Judith Papasey, Elvira Martín, Esther Peleja, Francisco Lomeña, Francisco Campos, Assumpta Vivas, Marta Gómez-Chiari, Miguel Ángel Tejero, Joan Giménez, Manuel Serrano-Ríos, Adelina Orellana, Lluís Tárraga, Agustín Ruiz, Mercè Boad. Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy Brain Initiative (FACEHBI) study baseline results. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 5. 2019-07-30. PMID:29156223. |
exploring apoe genotype effects on alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: the fundacioace healthy brain initiative (facehbi) study baseline results. |
2019-07-30 |
2023-08-13 |
Not clear |
| Yuemiao Yin, Zhao Wan. ApoE and Neurodegenerative Diseases in Aging. Advances in experimental medicine and biology. vol 1086. 2019-07-23. PMID:30232753. |
apoe expression regulation and apoe gene polymorphism have an important connection with neurological or neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease (pd), ischemic stroke, and other diseases. |
2019-07-23 |
2023-08-13 |
human |
| Qingnan Zhao, Yaqi Shen, Yanli Zhao, Lining Si, Shan Jiang, Yu Qi. Val66Met Polymorphism in BDNF Has No Sexual and APOE ε4 Status-Based Dimorphic Effects on Susceptibility to Alzheimer's Disease: Evidence From an Updated Meta-Analysis of Case-Control Studies and High-Throughput Genotyping Cohorts. American journal of Alzheimer's disease and other dementias. vol 33. issue 1. 2019-07-17. PMID:28984138. |
val66met polymorphism in bdnf has no sexual and apoe ε4 status-based dimorphic effects on susceptibility to alzheimer's disease: evidence from an updated meta-analysis of case-control studies and high-throughput genotyping cohorts. |
2019-07-17 |
2023-08-13 |
Not clear |
| John L Robinson, Edward B Lee, Sharon X Xie, Lior Rennert, EunRan Suh, Colin Bredenberg, Carrie Caswell, Vivianna M Van Deerlin, Ning Yan, Ahmed Yousef, Howard I Hurtig, Andrew Siderowf, Murray Grossman, Corey T McMillan, Bruce Miller, John E Duda, David J Irwin, David Wolk, Lauren Elman, Leo McCluskey, Alice Chen-Plotkin, Daniel Weintraub, Steven E Arnold, Johannes Brettschneider, Virginia M-Y Lee, John Q Trojanowsk. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a journal of neurology. vol 141. issue 7. 2019-07-17. PMID:29878075. |
our data imply that increased age and apoe ɛ4 status are risk factors for co-pathologies independent of neurodegenerative disease; that neurodegenerative disease severity influences co-pathology as evidenced by the prevalence of co-pathology in high alzheimer's disease and neocortical lewy body disease, but not intermediate alzheimer's disease or limbic lewy body disease; and that tau and α-synuclein strains may also modify co-pathologies since tauopathies and synucleinopathies had differing co-pathologies and burdens. |
2019-07-17 |
2023-08-13 |
Not clear |
| Motoko Shinohara, Mitsuru Shinohara, Jing Zhao, Yuan Fu, Chia-Chen Liu, Takahisa Kanekiyo, Guojun B. 5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway. International journal of molecular sciences. vol 20. issue 6. 2019-07-17. PMID:30934555. |
apolipoprotein e (apoe) is linked to the risk for alzheimer's disease (ad) and thus has been suggested to be an important therapeutic target. |
2019-07-17 |
2023-08-13 |
mouse |
| Stephen P Salloway, Reisa Sperling, Nick C Fox, Marwan N Sabbagh, Lawrence S Honig, Anton P Porsteinsson, Hany Rofael, Nzeera Ketter, Daniel Wang, Enchi Liu, Stephen Carr, Ronald S Black, H Robert Brashea. Long-Term Follow Up of Patients with Mild-to-Moderate Alzheimer's Disease Treated with Bapineuzumab in a Phase III, Open-Label, Extension Study. Journal of Alzheimer's disease : JAD. vol 64. issue 3. 2019-07-15. PMID:29914022. |
a 3-year extension of two phase iii parent studies of intravenous (iv) bapineuzumab in patients with mild-to-moderate alzheimer's disease dementia (apolipoprotein (apoe) ɛ4 carriers and noncarriers) is summarized. |
2019-07-15 |
2023-08-13 |
Not clear |
| Eero A Haapala, Jussi Paananen, Mikko Hiltunen, Timo A Lakk. Associations of Genetic Susceptibility to Alzheimer's Disease with Adiposity and Cardiometabolic Risk Factors among Children in a 2-Year Follow-up Study. Journal of Alzheimer's disease : JAD. vol 64. issue 2. 2019-07-15. PMID:29914036. |
we investigated the associations of genetic risk score (grs) for alzheimer's disease and apolipoprotein e (apoe) ɛ variant with cardiometabolic risk factors during 2-year follow-up in children and whether body fat percentage (bf%) modify these associations. |
2019-07-15 |
2023-08-13 |
Not clear |
| Shruti Mishra, Tyler M Blazey, David M Holtzman, Carlos Cruchaga, Yi Su, John C Morris, Tammie L S Benzinger, Brian A Gordo. Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype. Brain : a journal of neurology. vol 141. issue 6. 2019-07-08. PMID:29672664. |
longitudinal brain imaging in preclinical alzheimer disease: impact of apoe ε4 genotype. |
2019-07-08 |
2023-08-13 |
human |
| Shruti Mishra, Tyler M Blazey, David M Holtzman, Carlos Cruchaga, Yi Su, John C Morris, Tammie L S Benzinger, Brian A Gordo. Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype. Brain : a journal of neurology. vol 141. issue 6. 2019-07-08. PMID:29672664. |
while prior work reliably demonstrates that the apoe ɛ4 allele has deleterious group level effects on alzheimer disease pathology, the homogeneity of its influence across the lifespan and spatially in the brain remains unknown. |
2019-07-08 |
2023-08-13 |
human |