| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicolas Henry, Eva-Maria Krammer, Florian Stengel, Quentin Adams, François Van Liefferinge, Ellen Hubin, Rui Chaves, Rouslan Efremov, Ruedi Aebersold, Guy Vandenbussche, Martine Prévost, Vincent Raussens, Stéphanie Dero. Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach. PLoS computational biology. vol 14. issue 6. 2018-11-27. PMID:29933361. |
apolipoprotein e (apoe) is a forefront actor in the transport of lipids and the maintenance of cholesterol homeostasis, and is also strongly implicated in alzheimer's disease. |
2018-11-27 |
2023-08-13 |
Not clear |
| Jennifer N K Nyarko, Maa O Quartey, Paul R Pennington, Ryan M Heistad, Doris Dea, Judes Poirier, Glen B Baker, Darrell D Moussea. Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease. Neuroscience. vol 373. 2018-11-26. PMID:29331531. |
profiles of β-amyloid peptides and key secretases in brain autopsy samples differ with sex and apoe ε4 status: impact for risk and progression of alzheimer disease. |
2018-11-26 |
2023-08-13 |
Not clear |
| Jennifer N K Nyarko, Maa O Quartey, Paul R Pennington, Ryan M Heistad, Doris Dea, Judes Poirier, Glen B Baker, Darrell D Moussea. Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease. Neuroscience. vol 373. 2018-11-26. PMID:29331531. |
the apoe ε4 allele was originally reported to contribute to risk of alzheimer's disease (ad) in women, yet male and female ad patient-derived data are routinely pooled. |
2018-11-26 |
2023-08-13 |
Not clear |
| Ewa Niechwiej-Szwedo, Anthony Tapper, David Gonzalez, Ryan M Bradley, Robin Dunca. Saccade latency delays in young apolipoprotein E (APOE) epsilon 4 carriers. Behavioural brain research. vol 353. 2018-11-26. PMID:30003976. |
the apolipoprotein e (apoe) epsilon 4 isoform has been associated with a significantly greater risk of developing late onset alzheimer's disease (ad). |
2018-11-26 |
2023-08-13 |
Not clear |
| Dana A Kelly, Michael Seidenberg, Katherine Reiter, Kristy A Nielson, John L Woodard, J Carson Smith, Sally Durgerian, Stephen M Ra. Differential 5-year brain atrophy rates in cognitively declining and stable APOE-ε4 elders. Neuropsychology. vol 32. issue 6. 2018-11-14. PMID:29911873. |
the apolipoprotein e (apoe) ε4 allele is the most important genetic risk factor for late-onset alzheimer's disease. |
2018-11-14 |
2023-08-13 |
Not clear |
| Xiaoke Hao, Chanxiu Li, Lei Du, Xiaohui Yao, Jingwen Yan, Shannon L Risacher, Andrew J Saykin, Li Shen, Daoqiang Zhan. Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer's Disease. Scientific reports. vol 7. 2018-11-07. PMID:28291242. |
we perform an empirical study using the alzheimer's disease neuroimaging initiative (adni) cohort to discover the relationships among snps from ad risk gene apoe, imaging qts extracted from structural magnetic resonance imaging scans, and cognitive and diagnostic outcomes. |
2018-11-07 |
2023-08-13 |
Not clear |
| Ryo Iketani, Keiko Ohno, Yohei Kawasaki, Kunihiro Matsumoto, Hiroshi Yamada, Satoshi Kishin. Apolipoprotein E Gene Polymorphisms Affect the Efficacy of Thiazolidinediones for Alzheimer's Disease: A Systematic Review and Meta-Analysis. Biological & pharmaceutical bulletin. vol 41. issue 7. 2018-10-24. PMID:29962398. |
although several studies have evaluated the efficacy of thiazolidinediones (tzd) for the treatment of alzheimer's disease (ad), investigation of the impact of apolipoprotein e (apoe) gene polymorphisms on the efficacy of tzd remains insufficient. |
2018-10-24 |
2023-08-13 |
human |
| Ryo Iketani, Keiko Ohno, Yohei Kawasaki, Kunihiro Matsumoto, Hiroshi Yamada, Satoshi Kishin. Apolipoprotein E Gene Polymorphisms Affect the Efficacy of Thiazolidinediones for Alzheimer's Disease: A Systematic Review and Meta-Analysis. Biological & pharmaceutical bulletin. vol 41. issue 7. 2018-10-24. PMID:29962398. |
mean differences (md) of alzheimer's disease assessment scale-cognitive subscale (adas-cog) total score with 95% confidence intervals (ci) were calculated for subgroups stratified by apoe genotype. |
2018-10-24 |
2023-08-13 |
human |
| Marina Felipe Grossi, Maria das Graças Carvalho, Josianne Nicácio Silveira, Gisele Santos Gonçalves, Karina Braga Gomes, Maria Aparecida Bicalho, Ieda de Fátima Oliveira Silv. OxLDL plasma levels in patients with Alzheimer's disease. Arquivos de neuro-psiquiatria. vol 76. issue 4. 2018-10-17. PMID:29742249. |
the objective of this study was to characterize the conventional lipid profile, oxldl levels and apoe polymorphism in patients with alzheimer's disease (ad) and in elderly individuals without cognitive impairment. |
2018-10-17 |
2023-08-13 |
Not clear |
| Binbin Wang, Suying Bao, Zhigang Zhang, Xueya Zhou, Jing Wang, Yanhui Fan, Yan Zhang, Yan Li, Luhua Chen, Yizhen Jia, Jiang Li, Miaoxin Li, Wenhua Zheng, Nan Mu, Liqiu Wang, Zhe Yu, Dana S M Wong, Yalun Zhang, Joseph Kwan, Henry Ka-Fung Mak, Amirthagowri Ambalavanan, Sirui Zhou, Wangwei Cai, Jin Zheng, Shishu Huang, Guy A Rouleau, Wanling Yang, Ekaterina Rogaeva, Xu Ma, Peter St George-Hyslop, Leung Wing Chu, You-Qiang Son. A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population. Neurobiology of aging. vol 68. 2018-10-16. PMID:29656768. |
a rare variant in mlkl confers susceptibility to apoe ɛ4-negative alzheimer's disease in hong kong chinese population. |
2018-10-16 |
2023-08-13 |
Not clear |
| C Lopez Lopez, A Caputo, F Liu, M E Riviere, M-L Rouzade-Dominguez, R G Thomas, J B Langbaum, R Lenz, E M Reiman, A Graf, P N Tario. The Alzheimer's Prevention Initiative Generation Program: Evaluating CNP520 Efficacy in the Prevention of Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 4. issue 4. 2018-10-11. PMID:29181489. |
the generation program comprises two pivotal phase ii/iii studies with similar designs to assess the efficacy and safety of investigational treatments in a cognitively unimpaired population at increased risk for developing alzheimer's disease based on age and apolipoprotein e (apoe) genotype (i.e., presence of the apoe ε4 allele). |
2018-10-11 |
2023-08-13 |
Not clear |
| Julius S Ngwa, Thomas V Fungwe, Oyonumo Ntekim, Joanne S Allard, Sheree M Johnson, Chimene Castor, Lennox Graham, Sheeba Nadarajah, Richard F Gillum, Thomas O Obisesa. Associations of Pulse and Blood Pressure with Hippocampal Volume by APOE and Cognitive Phenotype: The Alzheimer's Disease Neuroimaging Initiative (ADNI). Dementia and geriatric cognitive disorders. vol 45. issue 1-2. 2018-10-05. PMID:29694964. |
associations of pulse and blood pressure with hippocampal volume by apoe and cognitive phenotype: the alzheimer's disease neuroimaging initiative (adni). |
2018-10-05 |
2023-08-13 |
Not clear |
| Francis E Cambronero, Dandan Liu, Jacquelyn E Neal, Elizabeth E Moore, Katherine A Gifford, James G Terry, Sangeeta Nair, Kimberly R Pechman, Katie E Osborn, Timothy J Hohman, Susan P Bell, J David Sweatt, Thomas J Wang, Joshua A Beckman, John Jeffrey Carr, Angela L Jefferso. APOE genotype modifies the association between central arterial stiffening and cognition in older adults. Neurobiology of aging. vol 67. 2018-10-04. PMID:29656011. |
this study tested the interaction between arterial stiffening and an alzheimer's disease genetic risk factor (apolipoprotein e [apoe] genotype) on cognition among older adults. |
2018-10-04 |
2023-08-13 |
human |
| Li Zhou, Hai-Yan Li, Ji-Hui Wang, Zhe-Zhi Deng, Yi-Long Shan, Sha Tan, Yi-Hua Shi, Ming-Xing Zhang, San-Xin Liu, Bing-Jun Zhang, Ming-Fan Hong, Zheng-Qi Lu, Xu-Ming Huan. Correlation of gene polymorphisms of CD36 and ApoE with susceptibility of Alzheimer disease: A case-control study. Medicine. vol 97. issue 38. 2018-10-03. PMID:30235742. |
correlation of gene polymorphisms of cd36 and apoe with susceptibility of alzheimer disease: a case-control study. |
2018-10-03 |
2023-08-13 |
human |
| Li Zhou, Hai-Yan Li, Ji-Hui Wang, Zhe-Zhi Deng, Yi-Long Shan, Sha Tan, Yi-Hua Shi, Ming-Xing Zhang, San-Xin Liu, Bing-Jun Zhang, Ming-Fan Hong, Zheng-Qi Lu, Xu-Ming Huan. Correlation of gene polymorphisms of CD36 and ApoE with susceptibility of Alzheimer disease: A case-control study. Medicine. vol 97. issue 38. 2018-10-03. PMID:30235742. |
this research was aimed to explore correlation of gene polymorphisms of cd36 and apoe with susceptibility of alzheimer disease (ad).this study was a case-control study. |
2018-10-03 |
2023-08-13 |
human |
| Kurt D Christensen, Wendy R Uhlmann, J Scott Roberts, Erin Linnenbringer, Peter J Whitehouse, Charmaine D M Royal, Thomas O Obisesan, L Adrienne Cupples, Melissa B Butson, Grace-Ann Fasaye, Susan Hiraki, Clara A Chen, Uwe Siebert, Robert Cook-Deegan, Robert C Gree. A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone. Genetics in medicine : official journal of the American College of Medical Genetics. vol 20. issue 1. 2018-10-02. PMID:28726810. |
subanalyses were inconclusive for apoe ɛ4-positive participants, although mean anxiety and depression scores were still well below cutoffs for clinical concern.conclusiontelephone disclosure of apoe results and risk for alzheimer disease is generally safe and helps providers meet demands for services, even when results identify an increased risk for disease. |
2018-10-02 |
2023-08-13 |
human |
| Rebecca Christine Knickmeyer, M Elizabeth Ros. Imaging and rare APOE alleles: Alzheimer disease as a developmental disorder. Neurology. vol 87. issue 6. 2018-09-26. PMID:27412139. |
imaging and rare apoe alleles: alzheimer disease as a developmental disorder. |
2018-09-26 |
2023-08-13 |
Not clear |
| Jiajia Zhang, Caiyuan Hao, Jinxiang Jiang, Yangjian Feng, Xi Chen, Ying Zheng, Jiawei Liu, Zhilin Zhang, Cheng Long, Li Yan. The mechanisms underlying olfactory deficits in apolipoprotein E-deficient mice: focus on olfactory epithelium and olfactory bulb. Neurobiology of aging. vol 62. 2018-09-26. PMID:29107844. |
apoe induction is beneficial for alzheimer's disease (ad) treatment, whereas apoe deficiency results in impaired olfaction, but the timing and underlying molecular and cellular mechanisms of these effects remain unclear. |
2018-09-26 |
2023-08-13 |
mouse |
| Tal Nuriel, Sergio L Angulo, Usman Khan, Archana Ashok, Qiuying Chen, Helen Y Figueroa, Sheina Emrani, Li Liu, Mathieu Herman, Geoffrey Barrett, Valerie Savage, Luna Buitrago, Efrain Cepeda-Prado, Christine Fung, Eliana Goldberg, Steven S Gross, S Abid Hussaini, Herman Moreno, Scott A Small, Karen E Duf. Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology. Nature communications. vol 8. issue 1. 2018-09-11. PMID:29133888. |
the ε4 allele of apolipoprotein e (apoe) is the dominant genetic risk factor for late-onset alzheimer's disease (ad). |
2018-09-11 |
2023-08-13 |
mouse |
| Yvonne Shao, McKenzie Shaw, Kaitlin Todd, Maria Khrestian, Giana D'Aleo, P John Barnard, Jeff Zahratka, Jagan Pillai, Chang-En Yu, C Dirk Keene, James B Leverenz, Lynn M Bekri. DNA methylation of TOMM40-APOE-APOC2 in Alzheimer's disease. Journal of human genetics. vol 63. issue 4. 2018-09-05. PMID:29371683. |
the apolipoprotein e (apoe) ε4 allele is the major genetic risk factor for alzheimer's disease (ad). |
2018-09-05 |
2023-08-13 |
human |