| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leigh Goedeke, Carlos Fernández-Hernand. MicroRNAs: a connection between cholesterol metabolism and neurodegeneration. Neurobiology of disease. vol 72 Pt A. 2015-07-28. PMID:24907491. |
specifically, genes involved in cholesterol biosynthesis (24-dehydrocholesterol reductase, dhcr24) and cholesterol efflux (atp-binding cassete transporter, abca1, and apolipoprotein e, apoe) have been associated with developing alzheimer's disease. |
2015-07-28 |
2023-08-13 |
Not clear |
| Leigh Goedeke, Carlos Fernández-Hernand. MicroRNAs: a connection between cholesterol metabolism and neurodegeneration. Neurobiology of disease. vol 72 Pt A. 2015-07-28. PMID:24907491. |
indeed, apoe was the first gene variation found to increase the risk of alzheimer's disease and remains the risk gene with the greatest known impact. |
2015-07-28 |
2023-08-13 |
Not clear |
| Vo Van Giau, Eva Bagyinszky, Seong Soo A An, Sang Yun Ki. Role of apolipoprotein E in neurodegenerative diseases. Neuropsychiatric disease and treatment. vol 11. 2015-07-27. PMID:26213471. |
this review will summarize the updated research progress on apoe functions and its role in alzheimer's disease, parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, type iii hyperlipoproteinemia, vascular dementia, and ischemic stroke. |
2015-07-27 |
2023-08-13 |
Not clear |
| N Iu Bachyns'ka, I F Rozheliuk, V O Kholyn, I M Pishel', Iu I Leono. [ApoE gene polymorphism as a predictor of therapeutic response to treatment acetylcholinesterase inhibitor for elderly patients with Alzheimer's and vascular dementia types]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 67. issue 2 Pt 2. 2015-07-22. PMID:25796815. |
[apoe gene polymorphism as a predictor of therapeutic response to treatment acetylcholinesterase inhibitor for elderly patients with alzheimer's and vascular dementia types]. |
2015-07-22 |
2023-08-13 |
Not clear |
| N Iu Bachyns'ka, I F Rozheliuk, V O Kholyn, I M Pishel', Iu I Leono. [ApoE gene polymorphism as a predictor of therapeutic response to treatment acetylcholinesterase inhibitor for elderly patients with Alzheimer's and vascular dementia types]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 67. issue 2 Pt 2. 2015-07-22. PMID:25796815. |
effectiveness of donepezil hydrochloride treatment for elderly patients with alzheimer's and vascular dementia types depending on the apoe genotype. |
2015-07-22 |
2023-08-13 |
Not clear |
| Kenji Sakai, Delphine Boche, Roxana Carare, David Johnston, Clive Holmes, Seth Love, James A R Nicol. Aβ immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy. Acta neuropathologica. vol 128. issue 6. 2015-07-21. PMID:25195061. |
aβ immunotherapy for alzheimer's disease: effects on apoe and cerebral vasculopathy. |
2015-07-21 |
2023-08-13 |
Not clear |
| Ianna Lacerda Sampaio Braga, Patricia Natalia Silva, Tatiane Katsue Furuya, Leonardo Caires Santos, Belisa Caldana Pires, Diego Robles Mazzotti, Paulo Henrique Bertolucci, Maysa Seabra Cendoroglo, Marília Cardoso Smit. Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease. American journal of Alzheimer's disease and other dementias. vol 30. issue 2. 2015-07-17. PMID:24951635. |
effect of apoe and chrna7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of alzheimer's disease. |
2015-07-17 |
2023-08-13 |
Not clear |
| Angela J Hanson, Suzanne Craft, William A Bank. The APOE genotype: modification of therapeutic responses in Alzheimer's disease. Current pharmaceutical design. vol 21. issue 1. 2015-07-15. PMID:25330331. |
the apoe genotype: modification of therapeutic responses in alzheimer's disease. |
2015-07-15 |
2023-08-13 |
Not clear |
| Katrin Morgen, Alfredo Ramirez, Lutz Frölich, Heike Tost, Michael M Plichta, Heike Kölsch, Fabian Rakebrandt, Otto Rienhoff, Frank Jessen, Oliver Peters, Holger Jahn, Christian Luckhaus, Michael Hüll, Hermann-Josef Gertz, Johannes Schröder, Harald Hampel, Stefan J Teipel, Johannes Pantel, Isabella Heuser, Jens Wiltfang, Eckart Rüther, Johannes Kornhuber, Wolfgang Maier, Andreas Meyer-Lindenber. Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 5 Suppl. 2015-07-13. PMID:24613704. |
genetic interaction of picalm and apoe is associated with brain atrophy and cognitive impairment in alzheimer's disease. |
2015-07-13 |
2023-08-12 |
Not clear |
| Katrin Morgen, Alfredo Ramirez, Lutz Frölich, Heike Tost, Michael M Plichta, Heike Kölsch, Fabian Rakebrandt, Otto Rienhoff, Frank Jessen, Oliver Peters, Holger Jahn, Christian Luckhaus, Michael Hüll, Hermann-Josef Gertz, Johannes Schröder, Harald Hampel, Stefan J Teipel, Johannes Pantel, Isabella Heuser, Jens Wiltfang, Eckart Rüther, Johannes Kornhuber, Wolfgang Maier, Andreas Meyer-Lindenber. Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 5 Suppl. 2015-07-13. PMID:24613704. |
evidence has emerged indicating that the ε4 allele of apoe and picalm interact in conferring risk of alzheimer's disease (ad). |
2015-07-13 |
2023-08-12 |
Not clear |
| Christian D Furman, Lori A Earnshaw, David J Doukas, Lindsay A Farrer, Robert P Friedlan. A case of inappropriate apolipoprotein e testing in Alzheimer's disease due to lack of an informed consent discussion. American journal of Alzheimer's disease and other dementias. vol 29. issue 7. 2015-07-13. PMID:24615498. |
apolipoprotein e (apoe) genetic testing is used to assist in the diagnosis of alzheimer's disease (ad). |
2015-07-13 |
2023-08-12 |
Not clear |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Qiao-Quan Zhang, Lei Cao, Meng-Shan Tan, Li-Ze Gu, Hui-Fu Wang, Zheng-Zheng Ding, Ying-Dong Zhang, Jin-Tai Y. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:25047746. |
triggering receptor expressed on myeloid cells 2 (trem2) gene is a recently identified susceptibility gene for alzheimer's disease (ad), as its low-frequency variants increase the risk of this disease with an odds ratio similar to that of an apoe ɛ4 allele. |
2015-07-07 |
2023-08-13 |
mouse |
| Robert G Knight, Helen S L Tsui, Wickliffe C Abraham, C Murray Skeaff, Jennifer A McMahon, Nicholas J Cutfiel. Lack of effect of the apolipoprotein E ε4 genotype on cognition during healthy aging. Journal of clinical and experimental neuropsychology. vol 36. issue 7. 2015-07-06. PMID:25026037. |
the apolipoprotein e (apoe) ε4 genotype is associated with an increased risk of alzheimer's disease. |
2015-07-06 |
2023-08-13 |
Not clear |
| Jiu Chen, Hao Shu, Zan Wang, Duan Liu, Yongmei Shi, Xiangrong Zhang, Zhijun Zhan. The interaction of APOE genotype by age in amnestic mild cognitive impairment: a voxel-based morphometric study. Journal of Alzheimer's disease : JAD. vol 43. issue 2. 2015-07-06. PMID:25114090. |
the apolipoprotein e (apoe) gene has been confirmed as the major genetic risk factor for the conversion of amnestic mild cognitive impairment (amci) to alzheimer's disease (ad). |
2015-07-06 |
2023-08-13 |
Not clear |
| Silke Matura, David Prvulovic, Marius Butz, Daniel Hartmann, Beate Sepanski, Katja Linnemann, Viola Oertel-Knöchel, Tarik Karakaya, Fabian Fußer, Johannes Pantel, Vincent van de Ve. Recognition memory is associated with altered resting-state functional connectivity in people at genetic risk for Alzheimer's disease. The European journal of neuroscience. vol 40. issue 7. 2015-06-29. PMID:24989884. |
the apolipoprotein e ε4 (apoe ε4) allele not only represents the strongest single genetic risk factor for sporadic alzheimer's disease, but also imposes independent effects on brain function in healthy individuals where it has been shown to promote subtle memory deficits and altered intrinsic functional brain network connectivity. |
2015-06-29 |
2023-08-13 |
human |
| Wen-Zheng Chu, Li Gong, Ying-Qiu Xu, Guo-Hua Cai, Kuo-Chen Cho. Apolipoprotein E gene variants of Alzheimer's disease and vascular dementia patients in a community population of Nanking. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 10. issue 8. 2015-06-19. PMID:24678786. |
to explore apolipoprotein e gene variants distribution among the patients of alzheimer's disease and vascular dementia for the elderly community population in nanking, the polymerase chain reaction and restriction fragment length polymorphism techniques were employed to analyze the gene frequency of apolipoprotein e (apoe) for 113 cases with alzheimer's disease (ad), 85 cases with vascular dementia (vad), 147 cases with questionable dementia (qd), and 396 dementia-free controls. |
2015-06-19 |
2023-08-12 |
Not clear |
| Wen-Zheng Chu, Li Gong, Ying-Qiu Xu, Guo-Hua Cai, Kuo-Chen Cho. Apolipoprotein E gene variants of Alzheimer's disease and vascular dementia patients in a community population of Nanking. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 10. issue 8. 2015-06-19. PMID:24678786. |
these results suggest that apoe ε4 gene may be responsible for up to 45% of the genetic component of alzheimer's disease, and may act as a discriminator between ad and vad as well. |
2015-06-19 |
2023-08-12 |
Not clear |
| Mark L Cohen, Chae Kim, Tracy Haldiman, Mohamed ElHag, Prachi Mehndiratta, Termsarasab Pichet, Frances Lissemore, Michelle Shea, Yvonne Cohen, Wei Chen, Janis Blevins, Brian S Appleby, Krystyna Surewicz, Witold K Surewicz, Martha Sajatovic, Curtis Tatsuoka, Shulin Zhang, Ping Mayo, Mariusz Butkiewicz, Jonathan L Haines, Alan J Lerner, Jiri G Safa. Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β. Brain : a journal of neurology. vol 138. issue Pt 4. 2015-06-16. PMID:25688081. |
using novel biophysical methods, we analysed levels, particle size, and conformational characteristics of amyloid-β in the posterior cingulate cortex, hippocampus and cerebellum of 48 cases of alzheimer's disease with distinctly different disease durations, and correlated the data with apoe gene polymorphism. |
2015-06-16 |
2023-08-13 |
Not clear |
| Mark L Cohen, Chae Kim, Tracy Haldiman, Mohamed ElHag, Prachi Mehndiratta, Termsarasab Pichet, Frances Lissemore, Michelle Shea, Yvonne Cohen, Wei Chen, Janis Blevins, Brian S Appleby, Krystyna Surewicz, Witold K Surewicz, Martha Sajatovic, Curtis Tatsuoka, Shulin Zhang, Ping Mayo, Mariusz Butkiewicz, Jonathan L Haines, Alan J Lerner, Jiri G Safa. Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β. Brain : a journal of neurology. vol 138. issue Pt 4. 2015-06-16. PMID:25688081. |
rapidly progressive alzheimer's disease that is associated with a low frequency of apoe e4 allele demonstrates considerably expanded conformational heterogeneity of amyloid-β42, with higher levels of distinctly structured amyloid-β42 particles composed of 30-100 monomers, and fewer particles composed of < 30 monomers. |
2015-06-16 |
2023-08-13 |
Not clear |
| Farid Radmanesh, William J Devan, Christopher D Anderson, Jonathan Rosand, Guido J Falcon. Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data. European journal of human genetics : EJHG. vol 22. issue 10. 2015-06-11. PMID:24448547. |
two common single-nucleotide polymorphisms (snps) in apoe, rs429358 and rs7412, determine the three epsilon alleles that are established genetic risk factors for late-onset alzheimer's disease (ad), cerebral amyloid angiopathy, and intracerebral hemorrhage (ich). |
2015-06-11 |
2023-08-12 |
human |