| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark L Cohen, Chae Kim, Tracy Haldiman, Mohamed ElHag, Prachi Mehndiratta, Termsarasab Pichet, Frances Lissemore, Michelle Shea, Yvonne Cohen, Wei Chen, Janis Blevins, Brian S Appleby, Krystyna Surewicz, Witold K Surewicz, Martha Sajatovic, Curtis Tatsuoka, Shulin Zhang, Ping Mayo, Mariusz Butkiewicz, Jonathan L Haines, Alan J Lerner, Jiri G Safa. Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β. Brain : a journal of neurology. vol 138. issue Pt 4. 2015-06-16. PMID:25688081. |
rapidly progressive alzheimer's disease that is associated with a low frequency of apoe e4 allele demonstrates considerably expanded conformational heterogeneity of amyloid-β42, with higher levels of distinctly structured amyloid-β42 particles composed of 30-100 monomers, and fewer particles composed of < 30 monomers. |
2015-06-16 |
2023-08-13 |
Not clear |
| Farid Radmanesh, William J Devan, Christopher D Anderson, Jonathan Rosand, Guido J Falcon. Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data. European journal of human genetics : EJHG. vol 22. issue 10. 2015-06-11. PMID:24448547. |
two common single-nucleotide polymorphisms (snps) in apoe, rs429358 and rs7412, determine the three epsilon alleles that are established genetic risk factors for late-onset alzheimer's disease (ad), cerebral amyloid angiopathy, and intracerebral hemorrhage (ich). |
2015-06-11 |
2023-08-12 |
human |
| Christian Schmidt, Martin Wolff, Nicolas von Ahsen, Katharina Lange, Tim Friede, Inga Zer. CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 21. issue 10. 2015-06-03. PMID:24998857. |
snp in ace, apoe, bin1, clu, cr1, cst3, exoc3l2, gwa14q32.13, il8, ldlr, picalm, and tnk1 were determined in 40 alzheimer's disease patients who were observed for 2 to 3 years. |
2015-06-03 |
2023-08-13 |
Not clear |
| Joanna E Pankiewicz, Maitea Guridi, Jungsu Kim, Ayodeji A Asuni, Sandrine Sanchez, Patrick M Sullivan, David M Holtzman, Martin J Sadowsk. Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:24972680. |
blocking the apoe/aβ interaction ameliorates aβ-related pathology in apoe ε2 and ε4 targeted replacement alzheimer model mice. |
2015-05-29 |
2023-08-13 |
mouse |
| Dahyun Yi, Dong Y Lee, Bo K Sohn, Young M Choe, Eun H Seo, Min S Byun, Jong I Wo. Beta-amyloid associated differential effects of APOE ε4 on brain metabolism in cognitively normal elderly. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 22. issue 10. 2015-05-28. PMID:24495404. |
although apolipoprotein (apoe) ε4 allele is a well-established risk factor for late-onset alzheimer disease (ad), the mechanism of its effects on ad pathogenesis is not fully understood. |
2015-05-28 |
2023-08-12 |
Not clear |
| Lv Shi, Xin Du, Hong Zhou, Changlu Tao, Yuntao Liu, Fantao Meng, Gao Wu, Ying Xiong, Chun Xia, Yu Wang, Guoqiang Bi, Jiang-Ning Zho. Cumulative effects of the ApoE genotype and gender on the synaptic proteome and oxidative stress in the mouse brain. The international journal of neuropsychopharmacology. vol 17. issue 11. 2015-05-26. PMID:24810422. |
elderly females, particularly those carrying the apolipoprotein e (apoe)-ε4 allele, have a higher risk of developing alzheimer's disease (ad). |
2015-05-26 |
2023-08-13 |
mouse |
| Maria Stefania Spagnuolo, Bernardetta Maresca, Valeria La Marca, Albino Carrizzo, Carlo Veronesi, Chiara Cupidi, Tommaso Piccoli, Raffaele Giovanni Maletta, Amalia Cecilia Bruni, Paolo Abrescia, Luisa Ciglian. Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk. ACS chemical neuroscience. vol 5. issue 9. 2015-05-26. PMID:25058565. |
hence, the risk of developing alzheimer's disease might not only be linked to the different apoe isoforms, but also rely on the level of critical ligands, such as haptoglobin. |
2015-05-26 |
2023-08-13 |
Not clear |
| Xiao Da, Jon B Toledo, Jarcy Zee, David A Wolk, Sharon X Xie, Yangming Ou, Amanda Shacklett, Paraskevi Parmpi, Leslie Shaw, John Q Trojanowski, Christos Davatziko. Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers. NeuroImage. Clinical. vol 4. 2015-05-19. PMID:24371799. |
this study evaluates the individual, as well as relative and joint value of indices obtained from magnetic resonance imaging (mri) patterns of brain atrophy (quantified by the spare-ad index), cerebrospinal fluid (csf) biomarkers, apoe genotype, and cognitive performance (adas-cog) in progression from mild cognitive impairment (mci) to alzheimer's disease (ad) within a variable follow-up period up to 6 years, using data from the alzheimer's disease neuroimaging initiative-1 (adni-1). |
2015-05-19 |
2023-08-12 |
human |
| Mark W Bondi, Emily C Edmonds, Amy J Jak, Lindsay R Clark, Lisa Delano-Wood, Carrie R McDonald, Daniel A Nation, David J Libon, Rhoda Au, Douglas Galasko, David P Salmo. Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates. Journal of Alzheimer's disease : JAD. vol 42. issue 1. 2015-05-11. PMID:24844687. |
resulting cluster groups were then compared and further examined for apoe allelic frequencies, cerebrospinal fluid (csf) alzheimer's disease (ad) biomarker levels, and clinical outcomes. |
2015-05-11 |
2023-08-13 |
human |
| Niklas Mattsson, Philip S Insel, Michael Donohue, Susan Landau, William J Jagust, Leslie M Shaw, John Q Trojanowski, Henrik Zetterberg, Kaj Blennow, Michael W Weine. Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease. Brain : a journal of neurology. vol 138. issue Pt 3. 2015-04-20. PMID:25541191. |
cerebrospinal fluid and positron emission tomography amyloid-β were measured at baseline in 769 persons [161 healthy controls, 68 subjective memory complaints, 419 mild cognitive impairment and 121 alzheimer's disease dementia, mean age 72 years (standard deviation 7 years), 47% females] and used to predict diagnosis, apoe ε4 carriage status, cerebral blood flow, cerebrospinal fluid total-tau and phosphorylated-tau levels (cross-sectionally); and hippocampal volume, fluorodeoxyglucose positron emission tomography results and alzheimer's disease assessment scale-cognitive subscale scores (longitudinally). |
2015-04-20 |
2023-08-13 |
Not clear |
| Orwa Aboud, Paul A Parcon, K Mark DeWall, Ling Liu, Robert E Mrak, W Sue T Griffi. Aging, Alzheimer's, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50. Frontiers in cellular neuroscience. vol 9. 2015-04-10. PMID:25859183. |
aging, alzheimer's, and apoe genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-p50. |
2015-04-10 |
2023-08-13 |
human |
| Orwa Aboud, Paul A Parcon, K Mark DeWall, Ling Liu, Robert E Mrak, W Sue T Griffi. Aging, Alzheimer's, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50. Frontiers in cellular neuroscience. vol 9. 2015-04-10. PMID:25859183. |
however, few studies address these issues in human brain from those who either age without dementia and overt neuropathology, or succumb to alzheimer's; especially as such propensity may be influenced by apoe genotype. |
2015-04-10 |
2023-08-13 |
human |
| Orwa Aboud, Paul A Parcon, K Mark DeWall, Ling Liu, Robert E Mrak, W Sue T Griffi. Aging, Alzheimer's, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50. Frontiers in cellular neuroscience. vol 9. 2015-04-10. PMID:25859183. |
we studied the expression and distribution of the dynein subunit dynactin-p50, the β amyloid precursor protein (βapp), and hyperphosphorylated tau (p-tau) in tissues and tissue sections of brains from non-demented, neuropathology-free patients and from alzheimer patients, with either apoe ε3,3 or apoe ε4,4. |
2015-04-10 |
2023-08-13 |
human |
| Orwa Aboud, Paul A Parcon, K Mark DeWall, Ling Liu, Robert E Mrak, W Sue T Griffi. Aging, Alzheimer's, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50. Frontiers in cellular neuroscience. vol 9. 2015-04-10. PMID:25859183. |
tissues from alzheimer patients with apoe ε3,3 had less p-tau, more βapp, dynactin-p50, and synaptophysin than did tissues from alzheimer patients carrying apoe ε4,4. |
2015-04-10 |
2023-08-13 |
human |
| P Lestaevel, F Airault, R Racine, H Bensoussan, B Dhieux, O Delissen, L Manens, J Aigueperse, P Voisin, M Souid. Influence of environmental enrichment and depleted uranium on behaviour, cholesterol and acetylcholine in apolipoprotein E-deficient mice. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:23749703. |
alzheimer's disease is associated with genetic risk factors, of which the apolipoprotein e (apoe) is the most prevalent, and is affected by environmental factors that include education early in life and exposure to metals. |
2015-04-06 |
2023-08-12 |
mouse |
| T Luck, S G Riedel-Heller, M Luppa, B Wiese, M Köhler, F Jessen, H Bickel, S Weyerer, M Pentzek, H-H König, J Prokein, A Ernst, M Wagner, E Mösch, J Werle, A Fuchs, C Brettschneider, M Scherer, W Maie. Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late life: analysis of gene-environment interaction for the risk of dementia and Alzheimer's disease dementia. Psychological medicine. vol 44. issue 6. 2015-03-31. PMID:23883793. |
as physical activity may modify the effect of the apolipoprotein e (apoe) ε4 allele on the risk of dementia and alzheimer's disease (ad) dementia, we tested for such a gene-environment interaction in a sample of general practice patients aged ⩾75 years. |
2015-03-31 |
2023-08-12 |
Not clear |
| Orwa Aboud, Robert E Mrak, Frederick A Boop, W Sue T Griffi. Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252240. |
to determine if epilepsy-related changes reflect those in another neurological condition, analogous tissue samples harvested from 10 autopsy-verified alzheimer brains, and from 10 neurologically and neuropathologically normal control patients were analyzed using immunofluorescence histochemistry, western immunoblot, and real-time pcr to determine genotype effects on neuronal number and size, neuronal and glial expressions of amyloid β (aβ) precursor protein (βapp), aβ, apolipoprotein e (apoe), s100b, interleukin-1α and β, and α and β secretases; and on markers of neuronal stress, including dna/rna damage and caspase 3 expression. |
2015-03-31 |
2023-08-12 |
Not clear |
| Tamuno Alfred, Yoav Ben-Shlomo, Rachel Cooper, Rebecca Hardy, Cyrus Cooper, Ian J Deary, Jane Elliott, David Gunnell, Sarah E Harris, Mika Kivimaki, Meena Kumari, Richard M Martin, Chris Power, Avan Aihie Sayer, John M Starr, Diana Kuh, Ian N M Da. Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme. Age (Dordrecht, Netherlands). vol 36. issue 4. 2015-03-31. PMID:25073452. |
the apoe ε2/3/4 genotype has been associated with low-density lipoprotein cholesterol (ldl-c) and alzheimer disease. |
2015-03-31 |
2023-08-13 |
Not clear |
| Jiya Sun, Fuhai Song, Jiajia Wang, Guangchun Han, Zhouxian Bai, Bin Xie, Xuemei Feng, Jianping Jia, Yong Duan, Hongxing Le. Hidden risk genes with high-order intragenic epistasis in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24762948. |
meta-analysis of data from genome-wide association studies (gwas) of alzheimer's disease (ad) has confirmed the high risk of apoe and identified twenty other risk genes/loci with moderate effect size. |
2015-03-30 |
2023-08-13 |
Not clear |
| Ying Liu, Jin-Tai Yu, Hui-Fu Wang, Pei-Ran Han, Chen-Chen Tan, Chong Wang, Xiang-Fei Meng, Shannon L Risacher, Andrew J Saykin, Lan Ta. APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis. Journal of neurology, neurosurgery, and psychiatry. vol 86. issue 2. 2015-03-27. PMID:24838911. |
apoe genotype and neuroimaging markers of alzheimer's disease: systematic review and meta-analysis. |
2015-03-27 |
2023-08-13 |
Not clear |