| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zoltán Bochdanovits, Javier Simón-Sánchez, Marianne Jonker, Witte J Hoogendijk, Aad van der Vaart, Peter Heutin. Accurate prediction of a minimal region around a genetic association signal that contains the causal variant. European journal of human genetics : EJHG. vol 22. issue 2. 2015-01-20. PMID:23736218. |
we apply our method to two genome-wide association data sets and localize both the functional variant rep1 in the α-synuclein gene that conveys susceptibility to parkinson's disease and the apoe gene responsible for the association signal in the alzheimer's disease data set. |
2015-01-20 |
2023-08-12 |
Not clear |
| Jun Li, Fuchang Zhang, Yunliang Wang, Yan Wang, Wei Qin, Qinghe Xing, Xueqing Qian, Tingwei Guo, Xiaocai Gao, Lin He, Jianjun Ga. Association between ε2/3/4, promoter polymorphism (-491A/T, -427T/C, and -219T/G) at the apolipoprotein E gene, and mental retardation in children from an iodine deficiency area, China. BioMed research international. vol 2014. 2015-01-20. PMID:24790992. |
several common single-nucleotide polymorphisms (snps) at apolipoprotein e (apoe) have been linked with late onset sporadic alzheimer's disease and declining normative cognitive ability in elder people, but we are unclear about their relationship with cognition in children. |
2015-01-20 |
2023-08-13 |
Not clear |
| Judes Poirier, Justin Miron, Cynthia Picard, Patrick Gormley, Louise Théroux, John Breitner, Doris De. Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease. Neurobiology of aging. vol 35 Suppl 2. 2015-01-20. PMID:24973118. |
the discovery that the apolipoprotein e (apoe) ε4 allele is genetically linked to both sporadic and familial late-onset alzheimer's disease (ad) raises the possibility that a dysfunction of the lipid transport system could seriously affect lipid homeostasis in the brain of ad subjects. |
2015-01-20 |
2023-08-13 |
human |
| Emily N Manning, Josephine Barnes, David M Cash, Jonathan W Bartlett, Kelvin K Leung, Sebastien Ourselin, Nick C Fo. APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD. PloS one. vol 9. issue 5. 2015-01-15. PMID:24878738. |
to investigate whether apoe ε4 carriers have higher hippocampal atrophy rates than non-carriers in alzheimer's disease (ad), mild cognitive impairment (mci) and controls, and if so, whether higher hippocampal atrophy rates are still observed after adjusting for concurrent whole-brain atrophy rates. |
2015-01-15 |
2023-08-13 |
Not clear |
| Motoi Nishimura, Mamoru Satoh, Kazuyuki Matsushita, Fumio Nomur. How proteomic ApoE serotyping could impact Alzheimer's disease risk assessment: genetic testing by proteomics. Expert review of proteomics. vol 11. issue 4. 2015-01-14. PMID:24992828. |
how proteomic apoe serotyping could impact alzheimer's disease risk assessment: genetic testing by proteomics. |
2015-01-14 |
2023-08-13 |
human |
| Motoi Nishimura, Mamoru Satoh, Kazuyuki Matsushita, Fumio Nomur. How proteomic ApoE serotyping could impact Alzheimer's disease risk assessment: genetic testing by proteomics. Expert review of proteomics. vol 11. issue 4. 2015-01-14. PMID:24992828. |
because the type of apoe expressed is related to sporadic alzheimer's disease risk and familial hyperlipidemia, many clinical studies have utilized apoe typing in recent years. |
2015-01-14 |
2023-08-13 |
human |
| Viana Manrique Suárez, Yuriem Fernández, Elena del Carmen Ruiz López, David Higginson Clarke, Maria Antonieta Bobes, Ana Maria Riverón, Lilia López-Cánova. Apolipoprotein E alleles in Cuban patients with mild cognitive impairment. American journal of Alzheimer's disease and other dementias. vol 29. issue 3. 2015-01-12. PMID:24370622. |
apolipoprotein e (apoe) ε4 genotype is the most clearly documented risk factor for alzheimer's disease (ad). |
2015-01-12 |
2023-08-12 |
Not clear |
| Sarah E Monsell, Lilah M Besser, Katherine B Heller, Harvey Checkoway, Irene Litvan, Walter A Kukul. Clinical and pathologic presentation in Parkinson's disease by apolipoprotein e4 allele status. Parkinsonism & related disorders. vol 20. issue 5. 2015-01-07. PMID:24582705. |
apolipoprotein (apoe) e4 allele status has been linked to clinical presentation and progression in alzheimer's disease; however, evidence for a role of apoe e4 in parkinson's disease (pd) remains largely inconclusive. |
2015-01-07 |
2023-08-12 |
Not clear |
| James R Hall, April R Wiechmann, Leigh A Johnson, Melissa Edwards, Robert C Barber, Rebecca Cunningham, Meharvan Singh, Sid E O'Bryan. The impact of APOE status on relationship of biomarkers of vascular risk and systemic inflammation to neuropsychiatric symptoms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 40. issue 4. 2015-01-06. PMID:24577461. |
the impact of apoe status on relationship of biomarkers of vascular risk and systemic inflammation to neuropsychiatric symptoms in alzheimer's disease. |
2015-01-06 |
2023-08-12 |
Not clear |
| Jihan Xia, Bingjun Hu, Yulian Mu, Leilei Xin, Shulin Yang, Kui L. Molecular cloning and characterization of the promoter region of the porcine apolipoprotein E gene. Molecular biology reports. vol 41. issue 5. 2015-01-05. PMID:24464129. |
apolipoprotein e (apoe), a component of lipoproteins plays an important role in the transport and metabolism of cholesterol, and is associated with hyperlipoproteinemia and alzheimer's disease. |
2015-01-05 |
2023-08-12 |
human |
| Wenjin Wei, Xiupeng Xu, Hailin Li, Yaxuan Zhang, Dongfeng Han, Yingyi Wang, Wei Yan, Xiefeng Wang, Junxia Zhang, Ning Liu, Yongping Yo. The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease: a meta-analysis. Neuromolecular medicine. vol 16. issue 2. 2015-01-05. PMID:24497179. |
previous studies have reported an association between human sirtuins' single-nucleotide polymorphisms (snps) and alzheimer's disease (ad) susceptibility in the apolipoprotein e (apoe) ε4-negative population, although the findings are inconsistent. |
2015-01-05 |
2023-08-12 |
human |
| Xia Wang, Xiaomei Shang, Jing Luan, Shicui Zhan. Identification, expression and function of apolipoprotein E in annual fish Nothobranchius guentheri: implication for an aging marker. Biogerontology. vol 15. issue 3. 2015-01-02. PMID:24573419. |
variation in apoe gene has been reported to be associated with longevity in humans as well as with aged diseases such as atherosclerosis, alzheimer's disease, and parkinson's disease. |
2015-01-02 |
2023-08-12 |
human |
| Liang Wang, Jonathan Day, Catherine M Roe, Matthew R Brier, Jewell B Thomas, Tammie L Benzinger, John C Morris, Beau M Ance. The effect of APOE ε4 allele on cholinesterase inhibitors in patients with Alzheimer disease: evaluation of the feasibility of resting state functional connectivity magnetic resonance imaging. Alzheimer disease and associated disorders. vol 28. issue 2. 2015-01-02. PMID:24830360. |
the effect of apoe ε4 allele on cholinesterase inhibitors in patients with alzheimer disease: evaluation of the feasibility of resting state functional connectivity magnetic resonance imaging. |
2015-01-02 |
2023-08-13 |
human |
| Liang Wang, Jonathan Day, Catherine M Roe, Matthew R Brier, Jewell B Thomas, Tammie L Benzinger, John C Morris, Beau M Ance. The effect of APOE ε4 allele on cholinesterase inhibitors in patients with Alzheimer disease: evaluation of the feasibility of resting state functional connectivity magnetic resonance imaging. Alzheimer disease and associated disorders. vol 28. issue 2. 2015-01-02. PMID:24830360. |
this work is to determine whether apolipoprotein e (apoe) genotype modulates the effect of cholinesterase inhibitor (chei) treatment on resting state functional connectivity magnetic resonance imaging (rs-fcmri) in patients with alzheimer disease (ad). |
2015-01-02 |
2023-08-13 |
human |
| Leon M Tai, Kevin P Koster, Jia Luo, Sue H Lee, Yue-Ting Wang, Nicole C Collins, Manel Ben Aissa, Gregory R J Thatcher, Mary Jo LaD. Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. The Journal of biological chemistry. vol 289. issue 44. 2014-12-31. PMID:25217640. |
previous data demonstrate that bexarotene (bex), retinoid x receptor (rxr) agonist, reduces soluble and insoluble amyloid-β (aβ) in alzheimer disease (ad)-transgenic mice either by increasing the levels of mouse apolipoprotein e (apoe) or increasing abca1/abcg1-induced apoe lipoprotein association/lipidation. |
2014-12-31 |
2023-08-13 |
mouse |
| Paul O'Callaghan, Fredrik Noborn, Dag Sehlin, Jin-ping Li, Lars Lannfelt, Ulf Lindahl, Xiao Zhan. Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 21. issue 2. 2014-12-30. PMID:24491019. |
the increased risk of alzheimer's disease (ad) associated with specific apolipoprotein e (apoe) isoforms appears to relate to altered amyloid-β (aβ) homeostasis. |
2014-12-30 |
2023-08-12 |
Not clear |
| Nuria Garatachea, Enzo Emanuele, Miguel Calero, Noriyuki Fuku, Yasumichi Arai, Yukiko Abe, Haruka Murakami, Motohiko Miyachi, Thomas Yvert, Zoraida Verde, Ma Ascensión Zea, Letizia Venturini, Catalina Santiago, Alejandro Santos-Lozano, Gabriel Rodríguez-Romo, Giovanni Ricevuti, Nobuyoshi Hirose, Alberto Rábano, Alejandro Luci. ApoE gene and exceptional longevity: Insights from three independent cohorts. Experimental gerontology. vol 53. 2014-12-29. PMID:24534555. |
the apoe gene is associated with the risk of alzheimer or cardiovascular disease but its influence on exceptional longevity (el) is uncertain. |
2014-12-29 |
2023-08-12 |
human |
| Mariana Medina-Sánchez, Sandrine Miserere, Eden Morales-Narváez, Arben Merkoç. On-chip magneto-immunoassay for Alzheimer's biomarker electrochemical detection by using quantum dots as labels. Biosensors & bioelectronics. vol 54. 2014-12-24. PMID:24287417. |
apoe was evaluated for its potential as biomarker for alzheimer's disease detection, achieving a limit of detection (lod) of ~12.5 ng ml(-1) with a linear range from 10 to 200 ng ml(-1) and high accuracy for diluted human plasma. |
2014-12-24 |
2023-08-12 |
human |
| Mengyuan Liu, Ying Zhang, Ya Ruth Huo, Shuling Liu, Shuai Liu, Junwei Wang, Change Wang, Jinhuan Wang, Yong J. Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China. Dementia and geriatric cognitive disorders extra. vol 4. issue 3. 2014-12-24. PMID:25538729. |
influence of the rs1080985 single nucleotide polymorphism of the cyp2d6 gene and apoe polymorphism on the response to donepezil treatment in patients with alzheimer's disease in china. |
2014-12-24 |
2023-08-13 |
Not clear |
| Mengyuan Liu, Ying Zhang, Ya Ruth Huo, Shuling Liu, Shuai Liu, Junwei Wang, Change Wang, Jinhuan Wang, Yong J. Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China. Dementia and geriatric cognitive disorders extra. vol 4. issue 3. 2014-12-24. PMID:25538729. |
recent data have indicated that the rs1080985 single nucleotide polymorphism (snp) of the cytochrome p450 (cyp) 2d6 and the common apolipoprotein e (apoe) gene may affect the response to donepezil in patients with alzheimer's disease (ad). |
2014-12-24 |
2023-08-13 |
Not clear |