| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masharip Atadzhanov, Mwila H Mwaba, Patrice N Mukomena, Shabir Lakhi, Peter Mwaba, Sruti Rayaprolu, James F Meschia, Owen A Ros. Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population. BMC research notes. vol 7. 2014-11-25. PMID:24679048. |
polymorphisms within the apolipoprotein-e (apoe), methylenetetrahydrofolate reductase (mthfr) and angiotensin i-converting enzyme (ace) genes has been associated with cardiovascular and cerebrovascular disorders, alzheimer's disease and other complex diseases in various populations. |
2014-11-25 |
2023-08-12 |
Not clear |
| Hye B Yoo, Hae W Lee, Sue Shin, Sun-Won Park, Jung S Choi, Hee Y Jung, Jungho Cha, Jong-Min Lee, Jun-Young Le. Butyrylcholinesterase K and apolipoprotein ε4 affect cortical thickness and neuropsychiatric symptoms in Alzheimer's disease. Current Alzheimer research. vol 11. issue 2. 2014-11-24. PMID:24479631. |
two major genotypes are known to affect the development and progression of alzheimer's disease (ad) and its response to cholinesterase inhibitors: the apolipoprotein e (apoe) and butyrylcholinesterase genes (bche). |
2014-11-24 |
2023-08-12 |
Not clear |
| Najiba Fekih-Mrissa, Sarra Klai, Meriem Mrad, Malek Mansour, Jamel Zaouali, Nasreddine Gritli, Ridha Mriss. Apolipoprotein E genotypes associated with Alzheimer disease and concomitant stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 23. issue 4. 2014-11-18. PMID:23871727. |
the ɛ4 allele of the apolipoprotein e (apoe) gene is a well-characterized genetic risk factor for alzheimer disease (ad). |
2014-11-18 |
2023-08-12 |
Not clear |
| Eduardo Martínez-Morillo, Henrietta M Nielsen, Ihor Batruch, Andrei P Drabovich, Ilijana Begcevic, Mary F Lopez, Lennart Minthon, Guojun Bu, Niklas Mattsson, Erik Portelius, Oskar Hansson, Eleftherios P Diamandi. Assessment of peptide chemical modifications on the development of an accurate and precise multiplex selected reaction monitoring assay for apolipoprotein e isoforms. Journal of proteome research. vol 13. issue 2. 2014-11-14. PMID:24392642. |
apoe isoforms have been associated with the occurrence and progression of several pathological conditions, such as coronary atherosclerosis and alzheimer's disease. |
2014-11-14 |
2023-08-12 |
Not clear |
| Lance A Johnson, Reid H J Olsen, Louise S Merkens, Andrea DeBarber, Robert D Steiner, Patrick M Sullivan, Nobuyo Maeda, Jacob Rabe. Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. Neurobiology of disease. vol 64. 2014-11-12. PMID:24412220. |
apoe ε4 is a major genetic risk factor for cardiovascular disease (cvd) and alzheimer's disease (ad). |
2014-11-12 |
2023-08-12 |
mouse |
| Richard J Casell. Does an Alzheimer's disease susceptibility gene influence the cognitive effects of cancer therapy? Pediatric blood & cancer. vol 61. issue 10. 2014-11-06. PMID:24106134. |
the apolipoprotein e (apoe) e4 allele is the most prevalent genetic risk factor for alzheimer's disease (ad). |
2014-11-06 |
2023-08-12 |
Not clear |
| Naoto Oikawa, Hiroyuki Hatsuta, Shigeo Murayama, Akemi Suzuki, Katsuhiko Yanagisaw. Influence of APOE genotype and the presence of Alzheimer's pathology on synaptic membrane lipids of human brains. Journal of neuroscience research. vol 92. issue 5. 2014-11-04. PMID:24446209. |
influence of apoe genotype and the presence of alzheimer's pathology on synaptic membrane lipids of human brains. |
2014-11-04 |
2023-08-12 |
human |
| Naoto Oikawa, Hiroyuki Hatsuta, Shigeo Murayama, Akemi Suzuki, Katsuhiko Yanagisaw. Influence of APOE genotype and the presence of Alzheimer's pathology on synaptic membrane lipids of human brains. Journal of neuroscience research. vol 92. issue 5. 2014-11-04. PMID:24446209. |
the apoe genotype is the major risk factor for alzheimer's disease (ad); however, it remains unclarified how the ε4 allele accelerates whereas the ε2 allele suppresses ad development, compared with the more common ε3 allele. |
2014-11-04 |
2023-08-12 |
human |
| Wasim Khan, Vincent Giampietro, Cedric Ginestet, Flavio Dell'Acqua, David Bouls, Steven Newhouse, Richard Dobson, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Christian Büchel, Patricia Conrod, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Anreas Heinz, Bernd Ittermann, Hervé Lemaître, Frauke Nees, Tomas Paus, Zdenka Pausova, Marcella Rietschel, Michael N Smolka, Andreas Ströhle, Jean Gallinat, Eric Westman, Gunther Schumann, Simon Lovestone, Andrew Simmon. No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents. Journal of Alzheimer's disease : JAD. vol 40. issue 1. 2014-10-30. PMID:24326516. |
alleles of the apolipoprotein e (apoe) gene are known to modulate the genetic risk for developing late-onset alzheimer's disease (ad) and have been associated with hippocampal volume differences in ad. |
2014-10-30 |
2023-08-12 |
human |
| J Chapuis, F Hansmannel, M Gistelinck, A Mounier, C Van Cauwenberghe, K V Kolen, F Geller, Y Sottejeau, D Harold, P Dourlen, B Grenier-Boley, Y Kamatani, B Delepine, F Demiautte, D Zelenika, N Zommer, M Hamdane, C Bellenguez, J-F Dartigues, J-J Hauw, F Letronne, A-M Ayral, K Sleegers, A Schellens, L V Broeck, S Engelborghs, P P De Deyn, R Vandenberghe, M O'Donovan, M Owen, J Epelbaum, M Mercken, E Karran, M Bantscheff, G Drewes, G Joberty, D Campion, J-N Octave, C Berr, M Lathrop, P Callaerts, D Mann, J Williams, L Buée, I Dewachter, C Van Broeckhoven, P Amouyel, D Moechars, B Dermaut, J-C Lamber. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Molecular psychiatry. vol 18. issue 11. 2014-10-27. PMID:23399914. |
genome-wide association studies (gwas) have identified a region upstream the bin1 gene as the most important genetic susceptibility locus in alzheimer's disease (ad) after apoe. |
2014-10-27 |
2023-08-12 |
mouse |
| Christian Schmidt, Harry Becker, Inga Zer. Cerebrospinal fluid apolipoprotein E concentration and severity of cognitive impairment in patients with newly diagnosed Alzheimer's disease. American journal of Alzheimer's disease and other dementias. vol 29. issue 1. 2014-10-22. PMID:24277910. |
apolipoprotein e (apoe) plays an important role in the pathogenesis of alzheimer's disease (ad). |
2014-10-22 |
2023-08-12 |
Not clear |
| Chong Wang, Jin-Tai Yu, Hui-Fu Wang, Teng Jiang, Chen-Chen Tan, Xiang-Fei Meng, Holly D Soares, Lan Ta. Meta-analysis of peripheral blood apolipoprotein E levels in Alzheimer's disease. PloS one. vol 9. issue 2. 2014-10-21. PMID:24558469. |
peripheral blood apolipoprotein e (apoe) levels have been proposed as biomarkers of alzheimer's disease (ad), but previous studies on levels of apoe in blood remain inconsistent. |
2014-10-21 |
2023-08-12 |
Not clear |
| Yun Freudenberg-Hua, Jan Freudenberg, Vladimir Vacic, Avinash Abhyankar, Anne-Katrin Emde, Danny Ben-Avraham, Nir Barzilai, Dayna Oschwald, Erika Christen, Jeremy Koppel, Blaine Greenwald, Robert B Darnell, Soren Germer, Gil Atzmon, Peter Davie. Disease variants in genomes of 44 centenarians. Molecular genetics & genomic medicine. vol 2. issue 5. 2014-10-21. PMID:25333069. |
in addition, we found risk variants for late-onset neurodegenerative diseases, such as the apoe ε4 allele that was even present in a homozygous state in one centenarian who did not develop alzheimer's disease. |
2014-10-21 |
2023-08-13 |
Not clear |
| Rui-Chun Lu, Hao Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Ta. TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in Han Chinese. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 3. 2014-10-14. PMID:24166182. |
tmem106b and apoe polymorphisms interact to confer risk for late-onset alzheimer's disease in han chinese. |
2014-10-14 |
2023-08-12 |
Not clear |
| Deborah G Murdock, Yuki Bradford, Nathalie Schnetz-Boutaud, Ping Mayo, Melissa J Allen, Laura N D'Aoust, Xueying Liang, Sabrina L Mitchell, Stephan Zuchner, Gary W Small, John R Gilbert, Margaret A Pericak-Vance, Jonathan L Haine. KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers. PloS one. vol 8. issue 12. 2014-10-12. PMID:24349219. |
kiaa1462, a coronary artery disease associated gene, is a candidate gene for late onset alzheimer disease in apoe carriers. |
2014-10-12 |
2023-08-12 |
Not clear |
| Markus Donix, Alison C Burggren, Maria Scharf, Kira Marschner, Nanthia A Suthana, Prabha Siddarth, Allison K Krupa, Michael Jones, Laurel Martin-Harris, Linda M Ercoli, Karen J Miller, Annett Werner, Rüdiger von Kummer, Cathrin Sauer, Gary W Small, Vjera A Holthoff, Susan Y Bookheime. APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease. Psychiatry research. vol 214. issue 3. 2014-10-10. PMID:24080518. |
apoe associated hemispheric asymmetry of entorhinal cortical thickness in aging and alzheimer's disease. |
2014-10-10 |
2023-08-12 |
human |
| Markus Donix, Alison C Burggren, Maria Scharf, Kira Marschner, Nanthia A Suthana, Prabha Siddarth, Allison K Krupa, Michael Jones, Laurel Martin-Harris, Linda M Ercoli, Karen J Miller, Annett Werner, Rüdiger von Kummer, Cathrin Sauer, Gary W Small, Vjera A Holthoff, Susan Y Bookheime. APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease. Psychiatry research. vol 214. issue 3. 2014-10-10. PMID:24080518. |
among alzheimer's disease patients, this asymmetry might be less dependent on the apoe genotype and a more general marker of incipient disease pathology. |
2014-10-10 |
2023-08-12 |
human |
| Sun-Ho Han, Jun Seok Kim, Youngju Lee, Heesun Choi, Jong-Won Kim, Duk Lyul Na, Eun Gyeong Yang, Myeong-Hee Yu, Daehee Hwang, Cheolju Lee, Inhee Mook-Jun. Both targeted mass spectrometry and flow sorting analysis methods detected the decreased serum apolipoprotein E level in Alzheimer's disease patients. Molecular & cellular proteomics : MCP. vol 13. issue 2. 2014-10-09. PMID:24319058. |
apolipoprotein e (apoe) polymorphism has been appreciated as a valuable predictor of alzheimer disease (ad), and the associated ε4 allele has been recognized as an indicator of susceptibility to this disease. |
2014-10-09 |
2023-08-12 |
Not clear |
| Afef Achouri-Rassas, Sondes Hadj Fredj, Hela Mrabet Khiari, Amina Bibi, Hajer Siala, Amel Mrabet, Taieb Messaou. Association between Alzheimer disease and the -491T allele of regulatory region polymorphism of Apolipoprotein E in a Tunisian population. Neurochemical research. vol 39. issue 2. 2014-10-07. PMID:24326531. |
the apolipoprotein e (apoe) is a well-established risk factor for late-onset alzheimer's disease (ad). |
2014-10-07 |
2023-08-12 |
human |
| U Andreasson, R Lautner, J M Schott, N Mattsson, O Hansson, S-K Herukka, S Helisalmi, M Ewers, H Hampel, A Wallin, L Minthon, J Hardy, K Blennow, H Zetterber. CSF biomarkers for Alzheimer's pathology and the effect size of APOE ɛ4. Molecular psychiatry. vol 19. issue 2. 2014-10-01. PMID:23419830. |
csf biomarkers for alzheimer's pathology and the effect size of apoe ɛ4. |
2014-10-01 |
2023-08-12 |
Not clear |