| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren C Tindale, Stephen Leach, Kevin Ushey, Denise Daley, Angela R Brooks-Wilso. Rare and common variants in the Apolipoprotein E gene in healthy oldest old. Neurobiology of aging. vol 35. issue 3. 2014-09-29. PMID:24126160. |
the apoe exons and promoter were resequenced in dna samples from 376 healthy oldest old aged ≥ 85 yrs with no self-reported history of cancer, cardiovascular disease, diabetes, major pulmonary disease or alzheimer disease ("super-seniors") and 376 population-based controls aged 41-54. |
2014-09-29 |
2023-08-12 |
Not clear |
| Fabricio Ferreira de Oliveira, Paulo Henrique Ferreira Bertolucci, Elizabeth Suchi Chen, Marilia de Arruda Cardoso Smit. Pharmacological modulation of cognitive and behavioral symptoms in patients with dementia due to Alzheimer's disease. Journal of the neurological sciences. vol 336. issue 1-2. 2014-09-29. PMID:24189208. |
to evaluate correlations of pharmacological treatment with cognitive and behavioral symptoms in patients with dementia due to alzheimer's disease with low schooling, subjects were assessed for demographic features, neuropsychiatric symptoms, cognitive decline, functionality, caregiver burden, apoe haplotypes and pharmacological treatment. |
2014-09-29 |
2023-08-12 |
human |
| Lei Yu, Patricia A Boyle, Sue Leurgans, Julie A Schneider, David A Bennet. Disentangling the effects of age and APOE on neuropathology and late life cognitive decline. Neurobiology of aging. vol 35. issue 4. 2014-09-29. PMID:24199961. |
we examined the extent to which the hallmark pathologies of alzheimer's disease, lewy body disease, and cerebrovascular diseases account for the association of age and apoe with decline in episodic memory versus nonepisodic cognitive abilities. |
2014-09-29 |
2023-08-12 |
human |
| Xiaofan Xue, Milan Zhang, Yicong Lin, Erhe Xu, Jianping Ji. Association between the SORL1 rs2070045 polymorphism and late-onset Alzheimer's disease: interaction with the ApoE genotype in the Chinese Han population. Neuroscience letters. vol 559. 2014-09-28. PMID:24309291. |
association between the sorl1 rs2070045 polymorphism and late-onset alzheimer's disease: interaction with the apoe genotype in the chinese han population. |
2014-09-28 |
2023-08-12 |
human |
| Motoi Nishimura, Mamoru Satoh, Satomi Nishimura, Shoko Kakinuma, Kenichi Sato, Setsu Sawai, Sachio Tsuchida, Takeshi Kazama, Kazuyuki Matsushita, Sayaka Kado, Yoshio Kodera, Fumio Nomur. Human apolipoprotein e resequencing by proteomic analysis and its application to serotyping. PloS one. vol 9. issue 1. 2014-09-17. PMID:24454848. |
apolipoprotein e (apoe) typing is considered important because of the association between apoe and alzheimer's disease and familial dyslipidemia and is currently performed by genetic testing (apoe genotyping). |
2014-09-17 |
2023-08-12 |
human |
| Leon M Tai, Shipra Mehra, Varsha Shete, Steve Estus, G William Rebeck, Guojun Bu, Mary Jo LaD. Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Molecular neurodegeneration. vol 9. 2014-09-12. PMID:24386905. |
the apoe4 allele of apolipoprotein e (apoe) is the greatest genetic risk factor for alzheimer's disease (ad) compared to apoe2 and apoe3. |
2014-09-12 |
2023-08-12 |
human |
| Christopher W Medway, Samer Abdul-Hay, Tynickwa Mims, Li Ma, Gina Bisceglio, Fanggeng Zou, Shane Pankratz, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Joanna Siuda, Zbigniew K Wszolek, Owen A Ross, Minerva Carrasquillo, Dennis W Dickson, Neill Graff-Radford, Ronald C Petersen, Nilüfer Ertekin-Taner, Kevin Morgan, Guojun Bu, Steven G Younki. ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. Molecular neurodegeneration. vol 9. 2014-09-12. PMID:24607147. |
apoe variant p.v236e is associated with markedly reduced risk of alzheimer's disease. |
2014-09-12 |
2023-08-12 |
human |
| Christopher W Medway, Samer Abdul-Hay, Tynickwa Mims, Li Ma, Gina Bisceglio, Fanggeng Zou, Shane Pankratz, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Joanna Siuda, Zbigniew K Wszolek, Owen A Ross, Minerva Carrasquillo, Dennis W Dickson, Neill Graff-Radford, Ronald C Petersen, Nilüfer Ertekin-Taner, Kevin Morgan, Guojun Bu, Steven G Younki. ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. Molecular neurodegeneration. vol 9. 2014-09-12. PMID:24607147. |
recent genome-wide association studies (gwas) of late-onset alzheimer's disease (load) have identified single nucleotide polymorphisms (snps) which show significant association at the well-known apoe locus and at nineteen additional loci. |
2014-09-12 |
2023-08-12 |
human |
| Qin Zhou, Dantao Peng, Xinrui Yuan, Zeping Lv, Shenghang Pang, Wenyu Jiang, Chuyu Yang, Xiaohong Shi, Guofang Pang, Yige Yang, Haiqun Xie, Wandong Zhang, Caiyou Hu, Ze Yan. APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease. Neural regeneration research. vol 9. issue 6. 2014-09-10. PMID:25206869. |
apoe and apoc1 gene polymorphisms are associated with cognitive impairment progression in chinese patients with late-onset alzheimer's disease. |
2014-09-10 |
2023-08-13 |
Not clear |
| Qin Zhou, Dantao Peng, Xinrui Yuan, Zeping Lv, Shenghang Pang, Wenyu Jiang, Chuyu Yang, Xiaohong Shi, Guofang Pang, Yige Yang, Haiqun Xie, Wandong Zhang, Caiyou Hu, Ze Yan. APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease. Neural regeneration research. vol 9. issue 6. 2014-09-10. PMID:25206869. |
current evidence shows that apolipoprotein e (apoe), apolipoprotein ci (apoc1) and low density lipoprotein receptor-related protein (lrp) variations are related to late-onset alzheimer's disease. |
2014-09-10 |
2023-08-13 |
Not clear |
| Qin Zhou, Dantao Peng, Xinrui Yuan, Zeping Lv, Shenghang Pang, Wenyu Jiang, Chuyu Yang, Xiaohong Shi, Guofang Pang, Yige Yang, Haiqun Xie, Wandong Zhang, Caiyou Hu, Ze Yan. APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease. Neural regeneration research. vol 9. issue 6. 2014-09-10. PMID:25206869. |
we performed a 30-month longitudinal cohort study to investigate the relationship between alzheimer's disease and apoe, apoc1, and lrp. |
2014-09-10 |
2023-08-13 |
Not clear |
| Qin Zhou, Dantao Peng, Xinrui Yuan, Zeping Lv, Shenghang Pang, Wenyu Jiang, Chuyu Yang, Xiaohong Shi, Guofang Pang, Yige Yang, Haiqun Xie, Wandong Zhang, Caiyou Hu, Ze Yan. APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease. Neural regeneration research. vol 9. issue 6. 2014-09-10. PMID:25206869. |
in conclusion, apoe ε4 plays an important role in augmenting cognitive decline, and apoc1 h2 may act synergistically with apoe ε4 in increasing the risk of cognitive decline in chinese patients with late-onset alzheimer's disease. |
2014-09-10 |
2023-08-13 |
Not clear |
| John M Ringman, Michael C Sachs, Yan Zhou, Sarah E Monsell, Jeffrey L Saver, Harry V Vinter. Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease. JAMA neurology. vol 71. issue 7. 2014-09-08. PMID:24797962. |
clinical predictors of severe cerebral amyloid angiopathy and influence of apoe genotype in persons with pathologically verified alzheimer disease. |
2014-09-08 |
2023-08-13 |
Not clear |
| Shawn M Newlander, Alan Chu, Usha S Sinha, Po H Lu, George Bartzoki. Methodological improvements in voxel-based analysis of diffusion tensor images: applications to study the impact of apolipoprotein E on white matter integrity. Journal of magnetic resonance imaging : JMRI. vol 39. issue 2. 2014-09-06. PMID:23589355. |
to identify regional differences in apparent diffusion coefficient (adc) and fractional anisotropy (fa) using customized preprocessing before voxel-based analysis (vba) in 14 normal subjects with the specific genes that decrease (apolipoprotein [apo] e ε2) and that increase (apoe ε4) the risk of alzheimer's disease. |
2014-09-06 |
2023-08-12 |
human |
| Hisashi Fujioka, Clyde F Phelix, Robert P Friedland, Xiongwei Zhu, Elizabeth A Perry, Rudy J Castellani, George Perr. Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: implications for differences in racial susceptibility to Alzheimer's disease. Journal of health care for the poor and underserved. vol 24. issue 4 Suppl. 2014-09-05. PMID:24241262. |
apolipoprotein e 4 (apoe 4) has been linked to pathogenesis of alzheimer's disease and has been suggested to be maintained through evolutionary pressure via a protective role in malaria infection. |
2014-09-05 |
2023-08-12 |
human |
| Felix Carbonell, Arnaud Charil, Alex P Zijdenbos, Alan C Evans, Barry J Bedel. β-Amyloid is associated with aberrant metabolic connectivity in subjects with mild cognitive impairment. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 7. 2014-09-02. PMID:24736891. |
mild cognitive impairment subjects from the alzheimer's disease neuroimaging initiative (adni) study were categorized into β-amyloid-low and β-amyloid-high groups, based on quantitative analysis of [18f]florbetapir pet scans, and apoe ɛ4 non-carriers and carriers based on genotyping. |
2014-09-02 |
2023-08-13 |
human |
| Wenjuan Zhao, Jiguo Zhang, Elizabeth G Davis, G William Rebec. Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector. Frontiers in aging neuroscience. vol 6. 2014-09-01. PMID:25177293. |
this system allowed us to examine aβ metabolism in vivo, and test the effects of both aging and apoe genotype, two of the strongest risk factors for alzheimer's disease. |
2014-09-01 |
2023-08-13 |
mouse |
| Anne-Sophie Carl. Sortilin, a novel APOE receptor implicated in Alzheimer disease. Prion. vol 7. issue 5. 2014-08-29. PMID:24121631. |
sortilin, a novel apoe receptor implicated in alzheimer disease. |
2014-08-29 |
2023-08-12 |
mouse |
| Anne-Sophie Carl. Sortilin, a novel APOE receptor implicated in Alzheimer disease. Prion. vol 7. issue 5. 2014-08-29. PMID:24121631. |
three apoe alleles exist in the human population with ε4 being an alzheimer disease (ad) risk gene and ε2 being protective relative to the common ε3 variant. |
2014-08-29 |
2023-08-12 |
mouse |
| Christian Montag, Lukas Kunz, Nikolai Axmacher, Rayna Sariyska, Bernd Lachmann, Martin Reute. Common genetic variation of the APOE gene and personality. BMC neuroscience. vol 15. 2014-08-27. PMID:24884737. |
a recent study yielded first evidence that personality plays an important role in explaining the influence of a prominent apoe polymorphism on cognitive decline and alzheimer's disease (ad) in elderly humans. |
2014-08-27 |
2023-08-13 |
human |