| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raj K Kalapatapu, Kevin L Delucch. APOE e4 genotype and cigarette smoking in adults with normal cognition and mild cognitive impairment: a retrospective baseline analysis of a national dataset. The American journal of drug and alcohol abuse. vol 39. issue 4. 2013-10-21. PMID:23808899. |
apoe e4 genotype is known to be a risk factor for alzheimer's disease and atherosclerosis. |
2013-10-21 |
2023-08-12 |
Not clear |
| Agnieszka Ługowska, Małgorzata Musielak, Ewa Jamroz, Antoni Pyrkosz, Tomasz Kmieć, Anna Tylki-Szymańska, Małgorzata Bednarska-Makaru. Apolipoprotein E genotype and LRP1 polymorphisms in patients with different clinical types of metachromatic leukodystrophy. Gene. vol 526. issue 2. 2013-10-18. PMID:23701968. |
taking into consideration the fact that apoe4 leads to the loss of sulfatides in csf of alzheimer's disease patients, we examined if apoe isoforms display any impact on clinical outcome in patients with different forms of mld in whom sulfatides accumulate. |
2013-10-18 |
2023-08-12 |
Not clear |
| Drew Christie, Jane Shofer, Steven P Millard, Ellen Li, Mary Ann Demichele-Sweet, Elise A Weamer, M Ilyas Kamboh, Oscar L Lopez, Robert A Sweet, Debby Tsuan. Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype. Behavioral and brain functions : BBF. vol 8. 2013-10-17. PMID:23270420. |
genetic association between apoe*4 and neuropsychiatric symptoms in patients with probable alzheimer's disease is dependent on the psychosis phenotype. |
2013-10-17 |
2023-08-12 |
Not clear |
| Angelique P A Vermeiren, Hans Bosma, Pieter-Jelle Visser, Maurice P Zeegers, Caroline Graff, Michael Ewers, Giovanni B Frisoni, Lutz Frölich, Harald Hampel, Roy W Jones, Patrick G Kehoe, Hermine Lenoir, Lennart Minthon, Flavio M Nobili, Marcel Olde Rikkert, Anne-Sophie Rigaud, Philip Scheltens, Hilkka Soininen, Luiza Spiru, Magda Tsolaki, Lars-Olof Wahlund, Bruno Vellas, Gordon Wilcock, Lyzel S Elias-Sonnenschein, Frans R J Verhe. The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA Study. Journal of Alzheimer's disease : JAD. vol 35. issue 2. 2013-10-17. PMID:23380990. |
we assessed the interaction between the apoe ε4 allele and education level in the etiology of alzheimer's disease (ad) among memory clinic patients from the multicenter descripa study. |
2013-10-17 |
2023-08-12 |
human |
| Meiyao Wang, Illarion V Turk. Mass spectrometry quantification revealed accumulation of C-terminal fragment of apolipoprotein E in the Alzheimer's frontal cortex. PloS one. vol 8. issue 4. 2013-10-17. PMID:23593485. |
polymorphic variation in the apolipoprotein e (apoe) gene is the major genetic susceptibility factor for late-onset alzheimer's disease (ad) and likely contributes to neuropathology through various pathways. |
2013-10-17 |
2023-08-12 |
human |
| Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzma. In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Molecular neurodegeneration. vol 8. 2013-09-20. PMID:23601557. |
the link between apolipoprotein e (apoe) and alzheimer's disease is likely due in large part to the impact of apoe on the metabolism of amyloid β (aβ) within the brain. |
2013-09-20 |
2023-08-12 |
mouse |
| Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzma. In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Molecular neurodegeneration. vol 8. 2013-09-20. PMID:23601557. |
manipulation of apoe levels and lipidation within the brain has been proposed as a therapeutic target for the treatment of alzheimer's disease. |
2013-09-20 |
2023-08-12 |
mouse |
| Manuel Fernández-Martínez, Xabier Elcoroaristizabal Martín, Elisa Blanco Martín, Luis Galdos Alcelay, Iratxe Ugarriza Serrano, Fernando Gómez Busto, Maite Alvarez-Álvarez, Ana Molano Salazar, Rocio Bereincua Gandarias, Sandra Inglés Borda, Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Ángeles Gómez Beldarraín, Josefa Moraza López, Myriam Barandiarán Amillano, Marian M de Pancorb. Oestrogen receptor polymorphisms are an associated risk factor for mild cognitive impairment and Alzheimer disease in women APOE {varepsilon}4 carriers: a case-control study. BMJ open. vol 3. issue 9. 2013-09-20. PMID:24052609. |
oestrogen receptor polymorphisms are an associated risk factor for mild cognitive impairment and alzheimer disease in women apoe {varepsilon}4 carriers: a case-control study. |
2013-09-20 |
2023-08-12 |
Not clear |
| Manuel Fernández-Martínez, Xabier Elcoroaristizabal Martín, Elisa Blanco Martín, Luis Galdos Alcelay, Iratxe Ugarriza Serrano, Fernando Gómez Busto, Maite Alvarez-Álvarez, Ana Molano Salazar, Rocio Bereincua Gandarias, Sandra Inglés Borda, Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Ángeles Gómez Beldarraín, Josefa Moraza López, Myriam Barandiarán Amillano, Marian M de Pancorb. Oestrogen receptor polymorphisms are an associated risk factor for mild cognitive impairment and Alzheimer disease in women APOE {varepsilon}4 carriers: a case-control study. BMJ open. vol 3. issue 9. 2013-09-20. PMID:24052609. |
examine the role of single nucleotide polymorphisms (snps) in the oestrogen receptor (er) genes: rs9340799, rs2234693, rs2228480 (in the esr1 gene) and rs4986938 (in the esr2 gene) as a risk factor for amnesic mild cognitive impairment (mcia) and alzheimer's disease (ad) and its possible association with the apolipoprotein e (apoe) gene. |
2013-09-20 |
2023-08-12 |
Not clear |
| Valerio Leoni, Claudio Cacci. Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. Biochemical pharmacology. vol 86. issue 1. 2013-09-19. PMID:23541982. |
apoe, 24ohc, tau and soluble app were correlated in alzheimer disease (ad) samples. |
2013-09-19 |
2023-08-12 |
Not clear |
| Mitsuru Shinohara, Ronald C Petersen, Dennis W Dickson, Guojun B. Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation. Acta neuropathologica. vol 125. issue 4. 2013-09-16. PMID:23371365. |
to reveal the underlying mechanisms responsible for the regional vulnerability to amyloid-β (aβ) accumulation prior to the development of alzheimer's disease, we studied distribution of aβ, apolipoprotein e (apoe), synaptic markers, and other molecules involved in aβ metabolism in multiple brain areas of non-demented individuals. |
2013-09-16 |
2023-08-12 |
Not clear |
| Herve Rhinn, Ryousuke Fujita, Liang Qiang, Rong Cheng, Joseph H Lee, Asa Abeliovic. Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease. Nature. vol 500. issue 7460. 2013-09-13. PMID:23883936. |
integrative genomics identifies apoe ε4 effectors in alzheimer's disease. |
2013-09-13 |
2023-08-12 |
human |
| Allen D Roses, Michael W Lutz, Donna G Crenshaw, Iris Grossman, Ann M Saunders, W Kirby Gottschal. TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 9. issue 2. 2013-08-26. PMID:23333464. |
a number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (tomm40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein e (apoe), with age of onset of alzheimer's disease (ad). |
2013-08-26 |
2023-08-12 |
human |
| C J Brainerd, V F Reyna, R C Petersen, G E Smith, A E Kenney, C J Gross, E S Taub, B L Plassman, G G Fishe. The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study. Neuropsychology. vol 27. issue 1. 2013-08-21. PMID:23356599. |
the ε4 allele of the apolipoprotein e (apoe) genotype is the most widely accepted genetic risk factor for alzheimer's dementia (ad), but findings on whether it is a risk factor for the ad prodrome, mild cognitive impairment (mci), have been inconsistent. |
2013-08-21 |
2023-08-12 |
Not clear |
| Aleksandra Klimkowicz-Mrowiec, Pawel Wolkow, Malgorzata Sado, Anna Dziubek, Joanna Pera, Tomasz Dziedzic, Andrzej Szczudlik, Agnieszka Slowi. Influence of rs1080985 single nucleotide polymorphism of the CYP2D6 gene on response to treatment with donepezil in patients with alzheimer's disease. Neuropsychiatric disease and treatment. vol 9. 2013-08-16. PMID:23950644. |
there is also evidence that the common apolipoprotein e (apoe) polymorphism may affect the response to treatment with donepezil in alzheimer's disease. |
2013-08-16 |
2023-08-12 |
Not clear |
| S Mariani, M Ventriglia, I Simonelli, G Spalletta, S Bucossi, M Siotto, F Assogna, J M Melgari, F Vernieri, R Squitt. Effects of hemochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and Alzheimer's and Parkinson's diseases. Frontiers in aging neuroscience. vol 5. 2013-08-12. PMID:23935582. |
we have carried out a molecular analysis investigating the interaction between iron specific gene variants [transferrin (tf, p589s), hemochromatosis (hfe) c282y and (h63d)], iron biochemical variables [iron, tf, ceruloplasmin (cp), cp:tf ratio and % of tf saturation (% tf-sat)] and apolipoprotein e (apoe) gene variants in 139 alzheimer's disease (ad), 27 mild cognitive impairment (mci), 78 parkinson's disease (pd) patients and 139 healthy controls to investigate mechanisms of iron regulation or toxicity. |
2013-08-12 |
2023-08-12 |
Not clear |
| David M Holtzman, Joachim Herz, Guojun B. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harbor perspectives in medicine. vol 2. issue 3. 2013-08-08. PMID:22393530. |
apolipoprotein e (apoe) genotype is the major genetic risk factor for alzheimer disease (ad); the ε4 allele increases risk and the ε2 allele is protective. |
2013-08-08 |
2023-08-12 |
Not clear |
| Sun Mi Kim, Min Ji Kim, Hak Young Rhee, Chang-Woo Ryu, Eui Jong Kim, Esben Thade Petersen, Geon-Ho Jahn. Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele. Neuroradiology. vol 55. issue 1. 2013-08-07. PMID:22828738. |
regional cerebral perfusion in patients with alzheimer's disease and mild cognitive impairment: effect of apoe epsilon4 allele. |
2013-08-07 |
2023-08-12 |
human |
| Sun Mi Kim, Min Ji Kim, Hak Young Rhee, Chang-Woo Ryu, Eui Jong Kim, Esben Thade Petersen, Geon-Ho Jahn. Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele. Neuroradiology. vol 55. issue 1. 2013-08-07. PMID:22828738. |
the objective of this study was to evaluate the effect of apolipoprotein e (apoe) epsilon 4 allele on regional cerebral perfusion (rcbf) changes using arterial spin labeling (asl) magnetic resonance imaging (mri) in subjects who are carriers or noncarriers of this risk factor for alzheimer disease (ad). |
2013-08-07 |
2023-08-12 |
human |
| Paul C R Hopkin. Neurodegeneration in a Drosophila model for the function of TMCC2, an amyloid protein precursor-interacting and apolipoprotein E-binding protein. PloS one. vol 8. issue 2. 2013-08-05. PMID:23409049. |
we previously identified tmcc2 as a protein that interacted differentially with normal versus alzheimer's disease-risk forms of both apolipoprotein e (apoe) and the amyloid protein precursor (app). |
2013-08-05 |
2023-08-12 |
human |