| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew B Wolf, Richard J Caselli, Eric M Reiman, Jon Vall. APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease. Neurobiology of aging. vol 34. issue 4. 2013-08-01. PMID:23159550. |
apoe and neuroenergetics: an emerging paradigm in alzheimer's disease. |
2013-08-01 |
2023-08-12 |
Not clear |
| Andrew B Wolf, Richard J Caselli, Eric M Reiman, Jon Vall. APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease. Neurobiology of aging. vol 34. issue 4. 2013-08-01. PMID:23159550. |
apoe is the major known genetic risk factor for late-onset alzheimer's disease. |
2013-08-01 |
2023-08-12 |
Not clear |
| Giancarlo Zito, Renato Polimanti, Valentina Panetta, Mariacarla Ventriglia, Carlo Salustri, Maria Cristina Siotto, Filomena Moffa, Claudia Altamura, Fabrizio Vernieri, Domenico Lupoi, Emanuele Cassetta, Paolo M Rossini, Rosanna Squitt. Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in Alzheimer's disease and vascular dementia. Rejuvenation research. vol 16. issue 1. 2013-08-01. PMID:23216585. |
antioxidant status and apoe genotype as susceptibility factors for neurodegeneration in alzheimer's disease and vascular dementia. |
2013-08-01 |
2023-08-12 |
Not clear |
| Giancarlo Zito, Renato Polimanti, Valentina Panetta, Mariacarla Ventriglia, Carlo Salustri, Maria Cristina Siotto, Filomena Moffa, Claudia Altamura, Fabrizio Vernieri, Domenico Lupoi, Emanuele Cassetta, Paolo M Rossini, Rosanna Squitt. Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in Alzheimer's disease and vascular dementia. Rejuvenation research. vol 16. issue 1. 2013-08-01. PMID:23216585. |
to address this issue, we evaluated the effects of antioxidant status and apoe genotype on neurodegeneration in patients with dementia of the alzheimer type (ad), with vascular dementia (vad), and in elderly healthy controls. |
2013-08-01 |
2023-08-12 |
Not clear |
| María M Corrada, Annlia Paganini-Hill, Daniel J Berlau, Claudia H Kawa. Apolipoprotein E genotype, dementia, and mortality in the oldest old: the 90+ Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 9. issue 1. 2013-07-25. PMID:23123227. |
although the apolipoprotein e (apoe) ε4 allele is a major genetic risk factor for alzheimer's disease (ad), it is not clear whether this relationship persists among the oldest old. |
2013-07-25 |
2023-08-12 |
human |
| Philip B Verghese, Joseph M Castellano, Kanchan Garai, Yinong Wang, Hong Jiang, Aarti Shah, Guojun Bu, Carl Frieden, David M Holtzma. ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 19. 2013-07-19. PMID:23620513. |
apolipoprotein e gene (apoe) alleles may shift the onset of alzheimer's disease (ad) through apoe protein isoforms changing the probability of amyloid-β (aβ) accumulation. |
2013-07-19 |
2023-08-12 |
mouse |
| Chia-Chen Liu, Chia-Chan Liu, Takahisa Kanekiyo, Huaxi Xu, Guojun B. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nature reviews. Neurology. vol 9. issue 2. 2013-07-08. PMID:23296339. |
apoe polymorphic alleles are the main genetic determinants of alzheimer disease (ad) risk: individuals carrying the ε4 allele are at increased risk of ad compared with those carrying the more common ε3 allele, whereas the ε2 allele decreases risk. |
2013-07-08 |
2023-08-12 |
Not clear |
| Hyun Jeong Han, Byeong C Kim, Jun-Young Lee, Seung-Ho Ryu, Hae Ri Na, Soo Jin Yoon, Hyun Young Park, Joon Hyun Shin, Soo-Jin Cho, Hyon-Ah Yi, Mun Seong Choi, Jae-Hyeok Heo, Kyung Won Park, Kwang K Kim, Seong Hye Cho. Response to rivastigmine transdermal patch or memantine plus rivastigmine patch is affected by apolipoprotein E genotype in Alzheimer patients. Dementia and geriatric cognitive disorders. vol 34. issue 3-4. 2013-07-02. PMID:23051684. |
the apolipoprotein e (apoe) genotype in response to pharmacological treatments in patients with alzheimer's disease (ad) remains a matter of controversy. |
2013-07-02 |
2023-08-12 |
Not clear |
| Sonny Ly, Robin Altman, Jitka Petrlova, Yu Lin, Silvia Hilt, Thomas Huser, Ted A Laurence, John C Vos. Binding of apolipoprotein E inhibits the oligomer growth of amyloid-β peptide in solution as determined by fluorescence cross-correlation spectroscopy. The Journal of biological chemistry. vol 288. issue 17. 2013-06-24. PMID:23430745. |
apoe plays a pivotal role in the aggregation and clearance of aβ peptides in the brain, and the ε4 allele of apoe is the most significant known genetic modulator of alzheimer risk. |
2013-06-24 |
2023-08-12 |
Not clear |
| Sonny Ly, Robin Altman, Jitka Petrlova, Yu Lin, Silvia Hilt, Thomas Huser, Ted A Laurence, John C Vos. Binding of apolipoprotein E inhibits the oligomer growth of amyloid-β peptide in solution as determined by fluorescence cross-correlation spectroscopy. The Journal of biological chemistry. vol 288. issue 17. 2013-06-24. PMID:23430745. |
understanding the interaction between apoe and aβ will provide insight into the mechanism by which different apoe isoforms determine alzheimer disease risk. |
2013-06-24 |
2023-08-12 |
Not clear |
| Carlos Cruchaga, John S K Kauwe, Petra Nowotny, Kelly Bales, Eve H Pickering, Kevin Mayo, Sarah Bertelsen, Anthony Hinrichs, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Human molecular genetics. vol 21. issue 20. 2013-06-21. PMID:22821396. |
cerebrospinal fluid apoe levels: an endophenotype for genetic studies for alzheimer's disease. |
2013-06-21 |
2023-08-12 |
Not clear |
| Carlos Cruchaga, John S K Kauwe, Petra Nowotny, Kelly Bales, Eve H Pickering, Kevin Mayo, Sarah Bertelsen, Anthony Hinrichs, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Human molecular genetics. vol 21. issue 20. 2013-06-21. PMID:22821396. |
the apolipoprotein e (apoe) genotype is the major genetic risk factor for alzheimer's disease (ad). |
2013-06-21 |
2023-08-12 |
Not clear |
| Rachel E Bennett, Thomas J Esparza, Hal A Lewis, Eddie Kim, Christine L Mac Donald, Patrick M Sullivan, David L Brod. Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice. Journal of neuropathology and experimental neurology. vol 72. issue 5. 2013-06-10. PMID:23584199. |
by analogy to effects of apoe4 on the risk of alzheimer disease (ad), the apoe genotype may influence β-amyloid (aβ) and tau deposition after tbi. |
2013-06-10 |
2023-08-12 |
mouse |
| Feng Xu, Michael P Vitek, Carol A Colton, Mary Lou Previti, Judianne Davis, William E Van Nostran. Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice. Journal of Alzheimer's disease : JAD. vol 31. issue 2. 2013-06-04. PMID:22635103. |
human apolipoprotein (apoe) genotype influences the development of alzheimer's disease and cerebral amyloid angiopathy (caa), where the ε4 allele increases and the ε2 allele decreases the risk for developing disease. |
2013-06-04 |
2023-08-12 |
mouse |
| Virawudh Soontornniyomkij, David J Moore, Ben Gouaux, Benchawanna Soontornniyomkij, Erick T Tatro, Anya Umlauf, Eliezer Masliah, Andrew J Levine, Elyse J Singer, Harry V Vinters, Benjamin B Gelman, Susan Morgello, Mariana Cherner, Igor Grant, Cristian L Achi. Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers. AIDS (London, England). vol 26. issue 18. 2013-06-03. PMID:23018443. |
the apolipoprotein e (apoe) ε4 allele enhances cerebral accumulation of β-amyloid (aβ) and is a major risk factor for sporadic alzheimer's disease. |
2013-06-03 |
2023-08-12 |
Not clear |
| Luz E Botero, Andrés E Toro, Alber J Patiño, Guillermo Salazar, Juan C Rodríguez, Juan C Suárez-Escudero, Gustavo A Alarcón, Ana Corcimaru, Cristina Osorio, Joseph S Y Jeong, Oscar Alzat. Diabetes mellitus in patients with Alzheimer's disease: clinical description and correlation with the APOE genotype in a sample population from the province of Antioquia, Colombia. Biomedica : revista del Instituto Nacional de Salud. vol 32. issue 2. 2013-05-28. PMID:23242298. |
diabetes mellitus in patients with alzheimer's disease: clinical description and correlation with the apoe genotype in a sample population from the province of antioquia, colombia. |
2013-05-28 |
2023-08-12 |
Not clear |
| b' Mart\\xc3\\xad Colom-Cadena, Ellen Gelpi, Mar\\xc3\\xada J Mart\\xc3\\xad, Sara Charif, Oriol Dols-Icardo, Rafael Blesa, Jordi Clarim\\xc3\\xb3n, Alberto Lle\\xc3\\xb. MAPT H1 haplotype is associated with enhanced \\xce\\xb1-synuclein deposition in dementia with Lewy bodies. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22819391.' |
dlb h1/h1 (n = 12) and h2 carriers (n = 10) did not differ in demographics, clinical variables, concomitant alzheimer's pathology, or apoe genotype. |
2013-05-24 |
2023-08-12 |
Not clear |
| Yifat Segev, Daniel M Michaelson, Kobi Rosenblu. ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22883908. |
the main risk factor for sporadic alzheimer's disease (sad) is aging, and the main genetic risk factor reducing the age of sad onset is the expression of apolipoprotein e (apoe)4. |
2013-05-24 |
2023-08-12 |
mouse |
| Patrick Holton, Mina Ryten, Michael Nalls, Daniah Trabzuni, Michael E Weale, Dena Hernandez, Helen Crehan, J Raphael Gibbs, Richard Mayeux, Jonathan L Haines, Lindsay A Farrer, Margaret A Pericak-Vance, Gerard D Schellenberg, Manuel Ramirez-Restrepo, Anzhelika Engel, Amanda J Myers, Jason J Corneveaux, Matthew J Huentelman, Allissa Dillman, Mark R Cookson, Eric M Reiman, Andrew Singleton, John Hardy, Rita Guerreir. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Annals of human genetics. vol 77. issue 2. 2013-05-23. PMID:23360175. |
recent genome wide association studies have identified clu, cr1, abca7 bin1, picalm and ms4a6a/ms4a6e in addition to the long established apoe, as loci for alzheimer's disease. |
2013-05-23 |
2023-08-12 |
Not clear |
| Åsa Johansson, Stefan Enroth, Magnus Palmblad, André M Deelder, Jonas Bergquist, Ulf Gyllenste. Identification of genetic variants influencing the human plasma proteome. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 12. 2013-05-23. PMID:23487758. |
these snps represent both regulatory snps and nonsynonymous changes defining well-studied disease alleles such as the ε4 allele of apolipoprotein e (apoe), which has been shown to increase risk of alzheimer's disease. |
2013-05-23 |
2023-08-12 |
human |