| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisa Canu, Giovanni B Frisoni, Federica Agosta, Michela Pievani, Matteo Bonetti, Massimo Filipp. Early and late onset Alzheimer's disease patients have distinct patterns of white matter damage. Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:21074899. |
we investigated patterns of white matter (wm) loss in 18 early onset (eo) and 24 late onset (lo) alzheimer's disease (ad) patients compared with 42 healthy controls (hc), and explored relationships of wm atrophy and apolipoprotein e (apoe) genotype. |
2013-01-24 |
2023-08-12 |
human |
| Jungsu Kim, Adam E M Eltorai, Hong Jiang, Fan Liao, Philip B Verghese, Jaekwang Kim, Floy R Stewart, Jacob M Basak, David M Holtzma. Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis. The Journal of experimental medicine. vol 209. issue 12. 2013-01-22. PMID:23129750. |
the apolipoprotein e (apoe) ε4 allele is the strongest genetic risk factor for alzheimer's disease (ad). |
2013-01-22 |
2023-08-12 |
mouse |
| Miharu Samuraki, Ichiro Matsunari, Wei-Ping Chen, Keisuke Shima, Daisuke Yanase, Nozomi Takeda, Hiroshi Matsuda, Masahito Yamad. Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects. Neurobiology of aging. vol 33. issue 10. 2013-01-21. PMID:22188720. |
apolipoprotein e (apoe) ε4 is known as a genetic risk factor for alzheimer's disease (ad). |
2013-01-21 |
2023-08-12 |
human |
| Pei-Jing Cui, Li Cao, Ying Wang, Yu-Lei Deng, Wei Xu, Gang Wang, Yu Zhang, Lan Zheng, Qing-Zhou Fei, Ting Zhang, Sheng-Di Che. The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 5. 2013-01-21. PMID:22502914. |
several previous studies on the relationship between the insulin-degrading enzyme (ide) gene and alzheimer's disease (ad) have connected certain genetic variants to late-onset ad, in the absence of the apolipoprotein e (apoe)ε4 allele. |
2013-01-21 |
2023-08-12 |
Not clear |
| G C Chiang, W Zhan, N Schuff, M W Weine. White matter alterations in cognitively normal apoE ε2 carriers: insight into Alzheimer resistance? AJNR. American journal of neuroradiology. vol 33. issue 7. 2013-01-18. PMID:22383234. |
white matter alterations in cognitively normal apoe ε2 carriers: insight into alzheimer resistance? |
2013-01-18 |
2023-08-12 |
Not clear |
| Belinda Rahman, Bettina Meiser, Perminder Sachdev, Kristine Barlow-Stewart, Margaret Otlowski, Elvira Zilliacus, Peter Schofiel. To know or not to know: an update of the literature on the psychological and behavioral impact of genetic testing for Alzheimer disease risk. Genetic testing and molecular biomarkers. vol 16. issue 8. 2013-01-14. PMID:22731638. |
alzheimer disease (ad) is a genetically heterogenous disorder; in rare cases autosomal dominantly inherited mutations typically cause early-onset familial ad (eoad), whereas the risk for late-onset ad (load) is generally modulated by genetic variants with relatively low penetrance but high prevalence, with variants in apolipoprotein e (apoe) being a firmly established risk factor. |
2013-01-14 |
2023-08-12 |
Not clear |
| Okko T Pyykkö, Seppo Helisalmi, Anne M Koivisto, Juhani A A Mölsä, Jaana Rummukainen, Ossi Nerg, Irina Alafuzoff, Sakari Savolainen, Hilkka Soininen, Juha E Jääskeläinen, Jaakko Rinne, Ville Leinonen, Mikko Hiltune. APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus. Journal of neurology, neurosurgery, and psychiatry. vol 83. issue 11. 2013-01-11. PMID:22955176. |
to investigate the association of apolipoprotein e (apoe) genotype, especially the apoe4 allele, to (1) idiopathic normal pressure hydrocephalus (inph) and (2) amyloid-β (aβ) plaques in cortical brain biopsies of presumed nph patients with and without a final clinical diagnosis of alzheimer's disease (ad). |
2013-01-11 |
2023-08-12 |
Not clear |
| Iwona Bojar, Angelina Wojcik-Fatla, Alfred Owoc, Andrzej Lewinsk. Polymorphisms of apolipoprotein E gene and cognitive functions of postmenopausal women, measured by battery of computer tests - Central Nervous System Vital Signs. Neuro endocrinology letters. vol 33. issue 4. 2013-01-08. PMID:22936261. |
apolipoprotein e (apoe) gene belongs to the group of genes increasing the risk of the alzheimer's disease (ad) development. |
2013-01-08 |
2023-08-12 |
Not clear |
| Eden Morales-Narváez, Helena Montón, Anna Fomicheva, Arben Merkoç. Signal enhancement in antibody microarrays using quantum dots nanocrystals: application to potential Alzheimer's disease biomarker screening. Analytical chemistry. vol 84. issue 15. 2012-12-18. PMID:22732018. |
apoe was chosen for its potential as a biomarker for alzheimer's disease. |
2012-12-18 |
2023-08-12 |
human |
| Xiaoyan Sun, Joyce Nicholas, Aljoeson Walker, Mark T Wagner, David Bachma. APOE genotype in the diagnosis of Alzheimer's disease in patients with cognitive impairment. American journal of Alzheimer's disease and other dementias. vol 27. issue 5. 2012-12-12. PMID:22815080. |
apoe genotype in the diagnosis of alzheimer's disease in patients with cognitive impairment. |
2012-12-12 |
2023-08-12 |
Not clear |
| Xiaoyan Sun, Joyce Nicholas, Aljoeson Walker, Mark T Wagner, David Bachma. APOE genotype in the diagnosis of Alzheimer's disease in patients with cognitive impairment. American journal of Alzheimer's disease and other dementias. vol 27. issue 5. 2012-12-12. PMID:22815080. |
although an association between the apolipoprotein e (apoe) ε4 allele and increased risk of alzheimer's disease (ad) is established, the utility of apoe genotyping in the clinical diagnosis of ad is still under investigation. |
2012-12-12 |
2023-08-12 |
Not clear |
| Joseph M Castellano, Rashid Deane, Andrew J Gottesdiener, Philip B Verghese, Floy R Stewart, Tim West, Andrew C Paoletti, Tristan R Kasper, Ronald B DeMattos, Berislav V Zlokovic, David M Holtzma. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 38. 2012-12-10. PMID:22927427. |
the apolipoprotein e (apoe)-ε4 allele is the strongest genetic risk factor for late-onset, sporadic alzheimer's disease, likely increasing risk by altering amyloid-β (aβ) accumulation. |
2012-12-10 |
2023-08-12 |
mouse |
| Wan Adriyani W Ruzali, Patrick G Kehoe, Seth Lov. LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: relationship to cerebral amyloid angiopathy and APOE status. Neuroscience letters. vol 525. issue 2. 2012-12-10. PMID:22967844. |
apoe genotype is a risk factor for alzheimer's disease (ad) and cerebral amyloid angiopathy (caa). |
2012-12-10 |
2023-08-12 |
Not clear |
| J Scott Roberts, Clara A Chen, Wendy R Uhlmann, Robert C Gree. Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease. Genetics in medicine : official journal of the American College of Medical Genetics. vol 14. issue 8. 2012-12-07. PMID:22498844. |
effectiveness of a condensed protocol for disclosing apoe genotype and providing risk education for alzheimer disease. |
2012-12-07 |
2023-08-12 |
human |
| Shuai Dong, Lan Chu, Fang Liu, Zhu Xu, Shirong Li, Yifan Zhang, Hao Wang, Lijun Cai, Mingming Da. Roles of the tau gene short tandem repeats in late-onset Alzheimer's disease. The International journal of neuroscience. vol 122. issue 5. 2012-12-06. PMID:22176350. |
this study assessed the roles of tau gene short tandem repeats (strs) nested within intron 1 (rs5820604 and rs10675722) and apolipoprotein e (apoe) gene polymorphisms in 70 late-onset alzheimer's disease (ad) subjects, 70 vascular dementia (vd) subjects, and 70 normal controls (ncs) in guizhou han population. |
2012-12-06 |
2023-08-12 |
human |
| Gwendolen E Haley, Laura Villasana, Catherine Dayger, Matthew J Davis, Jacob Rabe. Apolipoprotein e genotype-dependent paradoxical short-term effects of (56)fe irradiation on the brain. International journal of radiation oncology, biology, physics. vol 84. issue 3. 2012-11-30. PMID:22401921. |
in humans, apolipoprotein e (apoe) is encoded by three major alleles (ε2, ε3, and ε4) and, compared to apoe3, apoe4 increases the risk of developing alzheimer disease and cognitive impairments following various environmental challenges. |
2012-11-30 |
2023-08-12 |
Not clear |
| Richard J Casell. Phenotypic differences between apolipoprotein E genetic subgroups: research and clinical implications. Alzheimer's research & therapy. vol 4. issue 3. 2012-11-29. PMID:22694803. |
with the recent interest in alzheimer's disease course modification and earlier, even preclinical, intervention, questions have arisen regarding the potentially confounding impact of apolipoprotein e (apoe) genotype on study design, therapeutic outcomes, and even clinical practice. |
2012-11-29 |
2023-08-12 |
Not clear |
| Sarah Egert, Gerald Rimbach, Patricia Huebb. ApoE genotype: from geographic distribution to function and responsiveness to dietary factors. The Proceedings of the Nutrition Society. vol 71. issue 3. 2012-11-27. PMID:22564824. |
the apoe ε4 genotype is one of the most important genetic risk factors for age-dependent chronic diseases, including cvd and alzheimer's disease (ad). |
2012-11-27 |
2023-08-12 |
mouse |
| Philip L De Jager, Joshua M Shulman, Lori B Chibnik, Brendan T Keenan, Towfique Raj, Robert S Wilson, Lei Yu, Sue E Leurgans, Dong Tran, Cristin Aubin, Christopher D Anderson, Alessandro Biffi, Jason J Corneveaux, Matthew J Huentelman, Jonathan Rosand, Mark J Daly, Amanda J Myers, Eric M Reiman, David A Bennett, Denis A Evan. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiology of aging. vol 33. issue 5. 2012-11-23. PMID:22054870. |
as expected, we find that the alzheimer's disease (ad) susceptibility locus, apoe, is strongly associated with rate of cognitive decline (p(disc) = 5.6 × 10(-9); p(joint)= 3.7 × 10(-27)). |
2012-11-23 |
2023-08-12 |
human |
| Aaron Bonner-Jackson, Ozioma Okonkwo, Geoffrey Tremon. Apolipoprotein E ε2 and functional decline in amnestic mild cognitive impairment and Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 20. issue 7. 2012-11-13. PMID:21685781. |
recent work has demonstrated the potentially protective effects of the apolipoprotein e (apoe) ε2 allele on cognitive functioning in individuals at risk for developing alzheimer disease. |
2012-11-13 |
2023-08-12 |
Not clear |