| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miharu Samuraki, Ichiro Matsunari, Wei-Ping Chen, Keisuke Shima, Daisuke Yanase, Nozomi Takeda, Hiroshi Matsuda, Masahito Yamad. Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects. Neurobiology of aging. vol 33. issue 10. 2013-01-21. PMID:22188720. |
apolipoprotein e (apoe) ε4 is known as a genetic risk factor for alzheimer's disease (ad). |
2013-01-21 |
2023-08-12 |
human |
| Pei-Jing Cui, Li Cao, Ying Wang, Yu-Lei Deng, Wei Xu, Gang Wang, Yu Zhang, Lan Zheng, Qing-Zhou Fei, Ting Zhang, Sheng-Di Che. The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 5. 2013-01-21. PMID:22502914. |
several previous studies on the relationship between the insulin-degrading enzyme (ide) gene and alzheimer's disease (ad) have connected certain genetic variants to late-onset ad, in the absence of the apolipoprotein e (apoe)ε4 allele. |
2013-01-21 |
2023-08-12 |
Not clear |
| G C Chiang, W Zhan, N Schuff, M W Weine. White matter alterations in cognitively normal apoE ε2 carriers: insight into Alzheimer resistance? AJNR. American journal of neuroradiology. vol 33. issue 7. 2013-01-18. PMID:22383234. |
white matter alterations in cognitively normal apoe ε2 carriers: insight into alzheimer resistance? |
2013-01-18 |
2023-08-12 |
Not clear |
| Belinda Rahman, Bettina Meiser, Perminder Sachdev, Kristine Barlow-Stewart, Margaret Otlowski, Elvira Zilliacus, Peter Schofiel. To know or not to know: an update of the literature on the psychological and behavioral impact of genetic testing for Alzheimer disease risk. Genetic testing and molecular biomarkers. vol 16. issue 8. 2013-01-14. PMID:22731638. |
alzheimer disease (ad) is a genetically heterogenous disorder; in rare cases autosomal dominantly inherited mutations typically cause early-onset familial ad (eoad), whereas the risk for late-onset ad (load) is generally modulated by genetic variants with relatively low penetrance but high prevalence, with variants in apolipoprotein e (apoe) being a firmly established risk factor. |
2013-01-14 |
2023-08-12 |
Not clear |
| Okko T Pyykkö, Seppo Helisalmi, Anne M Koivisto, Juhani A A Mölsä, Jaana Rummukainen, Ossi Nerg, Irina Alafuzoff, Sakari Savolainen, Hilkka Soininen, Juha E Jääskeläinen, Jaakko Rinne, Ville Leinonen, Mikko Hiltune. APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus. Journal of neurology, neurosurgery, and psychiatry. vol 83. issue 11. 2013-01-11. PMID:22955176. |
to investigate the association of apolipoprotein e (apoe) genotype, especially the apoe4 allele, to (1) idiopathic normal pressure hydrocephalus (inph) and (2) amyloid-β (aβ) plaques in cortical brain biopsies of presumed nph patients with and without a final clinical diagnosis of alzheimer's disease (ad). |
2013-01-11 |
2023-08-12 |
Not clear |
| Iwona Bojar, Angelina Wojcik-Fatla, Alfred Owoc, Andrzej Lewinsk. Polymorphisms of apolipoprotein E gene and cognitive functions of postmenopausal women, measured by battery of computer tests - Central Nervous System Vital Signs. Neuro endocrinology letters. vol 33. issue 4. 2013-01-08. PMID:22936261. |
apolipoprotein e (apoe) gene belongs to the group of genes increasing the risk of the alzheimer's disease (ad) development. |
2013-01-08 |
2023-08-12 |
Not clear |
| Eden Morales-Narváez, Helena Montón, Anna Fomicheva, Arben Merkoç. Signal enhancement in antibody microarrays using quantum dots nanocrystals: application to potential Alzheimer's disease biomarker screening. Analytical chemistry. vol 84. issue 15. 2012-12-18. PMID:22732018. |
apoe was chosen for its potential as a biomarker for alzheimer's disease. |
2012-12-18 |
2023-08-12 |
human |
| Xiaoyan Sun, Joyce Nicholas, Aljoeson Walker, Mark T Wagner, David Bachma. APOE genotype in the diagnosis of Alzheimer's disease in patients with cognitive impairment. American journal of Alzheimer's disease and other dementias. vol 27. issue 5. 2012-12-12. PMID:22815080. |
apoe genotype in the diagnosis of alzheimer's disease in patients with cognitive impairment. |
2012-12-12 |
2023-08-12 |
Not clear |
| Xiaoyan Sun, Joyce Nicholas, Aljoeson Walker, Mark T Wagner, David Bachma. APOE genotype in the diagnosis of Alzheimer's disease in patients with cognitive impairment. American journal of Alzheimer's disease and other dementias. vol 27. issue 5. 2012-12-12. PMID:22815080. |
although an association between the apolipoprotein e (apoe) ε4 allele and increased risk of alzheimer's disease (ad) is established, the utility of apoe genotyping in the clinical diagnosis of ad is still under investigation. |
2012-12-12 |
2023-08-12 |
Not clear |
| Joseph M Castellano, Rashid Deane, Andrew J Gottesdiener, Philip B Verghese, Floy R Stewart, Tim West, Andrew C Paoletti, Tristan R Kasper, Ronald B DeMattos, Berislav V Zlokovic, David M Holtzma. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 38. 2012-12-10. PMID:22927427. |
the apolipoprotein e (apoe)-ε4 allele is the strongest genetic risk factor for late-onset, sporadic alzheimer's disease, likely increasing risk by altering amyloid-β (aβ) accumulation. |
2012-12-10 |
2023-08-12 |
mouse |
| Wan Adriyani W Ruzali, Patrick G Kehoe, Seth Lov. LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: relationship to cerebral amyloid angiopathy and APOE status. Neuroscience letters. vol 525. issue 2. 2012-12-10. PMID:22967844. |
apoe genotype is a risk factor for alzheimer's disease (ad) and cerebral amyloid angiopathy (caa). |
2012-12-10 |
2023-08-12 |
Not clear |
| J Scott Roberts, Clara A Chen, Wendy R Uhlmann, Robert C Gree. Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease. Genetics in medicine : official journal of the American College of Medical Genetics. vol 14. issue 8. 2012-12-07. PMID:22498844. |
effectiveness of a condensed protocol for disclosing apoe genotype and providing risk education for alzheimer disease. |
2012-12-07 |
2023-08-12 |
human |
| Shuai Dong, Lan Chu, Fang Liu, Zhu Xu, Shirong Li, Yifan Zhang, Hao Wang, Lijun Cai, Mingming Da. Roles of the tau gene short tandem repeats in late-onset Alzheimer's disease. The International journal of neuroscience. vol 122. issue 5. 2012-12-06. PMID:22176350. |
this study assessed the roles of tau gene short tandem repeats (strs) nested within intron 1 (rs5820604 and rs10675722) and apolipoprotein e (apoe) gene polymorphisms in 70 late-onset alzheimer's disease (ad) subjects, 70 vascular dementia (vd) subjects, and 70 normal controls (ncs) in guizhou han population. |
2012-12-06 |
2023-08-12 |
human |
| Gwendolen E Haley, Laura Villasana, Catherine Dayger, Matthew J Davis, Jacob Rabe. Apolipoprotein e genotype-dependent paradoxical short-term effects of (56)fe irradiation on the brain. International journal of radiation oncology, biology, physics. vol 84. issue 3. 2012-11-30. PMID:22401921. |
in humans, apolipoprotein e (apoe) is encoded by three major alleles (ε2, ε3, and ε4) and, compared to apoe3, apoe4 increases the risk of developing alzheimer disease and cognitive impairments following various environmental challenges. |
2012-11-30 |
2023-08-12 |
Not clear |
| Richard J Casell. Phenotypic differences between apolipoprotein E genetic subgroups: research and clinical implications. Alzheimer's research & therapy. vol 4. issue 3. 2012-11-29. PMID:22694803. |
with the recent interest in alzheimer's disease course modification and earlier, even preclinical, intervention, questions have arisen regarding the potentially confounding impact of apolipoprotein e (apoe) genotype on study design, therapeutic outcomes, and even clinical practice. |
2012-11-29 |
2023-08-12 |
Not clear |
| Sarah Egert, Gerald Rimbach, Patricia Huebb. ApoE genotype: from geographic distribution to function and responsiveness to dietary factors. The Proceedings of the Nutrition Society. vol 71. issue 3. 2012-11-27. PMID:22564824. |
the apoe ε4 genotype is one of the most important genetic risk factors for age-dependent chronic diseases, including cvd and alzheimer's disease (ad). |
2012-11-27 |
2023-08-12 |
mouse |
| Philip L De Jager, Joshua M Shulman, Lori B Chibnik, Brendan T Keenan, Towfique Raj, Robert S Wilson, Lei Yu, Sue E Leurgans, Dong Tran, Cristin Aubin, Christopher D Anderson, Alessandro Biffi, Jason J Corneveaux, Matthew J Huentelman, Jonathan Rosand, Mark J Daly, Amanda J Myers, Eric M Reiman, David A Bennett, Denis A Evan. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiology of aging. vol 33. issue 5. 2012-11-23. PMID:22054870. |
as expected, we find that the alzheimer's disease (ad) susceptibility locus, apoe, is strongly associated with rate of cognitive decline (p(disc) = 5.6 × 10(-9); p(joint)= 3.7 × 10(-27)). |
2012-11-23 |
2023-08-12 |
human |
| Aaron Bonner-Jackson, Ozioma Okonkwo, Geoffrey Tremon. Apolipoprotein E ε2 and functional decline in amnestic mild cognitive impairment and Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 20. issue 7. 2012-11-13. PMID:21685781. |
recent work has demonstrated the potentially protective effects of the apolipoprotein e (apoe) ε2 allele on cognitive functioning in individuals at risk for developing alzheimer disease. |
2012-11-13 |
2023-08-12 |
Not clear |
| Ximena S Rossello, Urule Igbavboa, Gary A Weisman, Grace Y Sun, W Gibson Woo. AP-2β regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes. Brain research. vol 1444. 2012-11-13. PMID:22325097. |
two key players involved in alzheimer's disease (ad) are amyloid beta protein (aβ) and apolipoprotein e (apoe). |
2012-11-13 |
2023-08-12 |
mouse |
| E Gozalpour, K Kamali, K Mohammd, Hr Khorram Khorshid, M Ohadi, M Karimloo, A Mirabzadeh, A Fotouh. Association between Alzheimer's Disease and Apolipoprotein E Polymorphisms. Iranian journal of public health. vol 39. issue 2. 2012-11-01. PMID:23112999. |
apolipoprotein e (apoe), which its ε4 allele has been reported as a risk factor in late onset alzheimer's disease (ad), is the main cholesterol carrier in the brain. |
2012-11-01 |
2023-08-12 |
Not clear |