| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Perneczky, P Alexopoulos, S Wagenpfeil, H Bickel, A Kur. Head circumference, apolipoprotein E genotype and cognition in the Bavarian School Sisters Study. European psychiatry : the journal of the Association of European Psychiatrists. vol 27. issue 3. 2012-07-25. PMID:21398096. |
the apolipoprotein e (apoe) ɛ4 allele is correlated with an earlier onset of alzheimer's disease symptoms; larger head circumference has been associated with an individual resilience against cognitive impairment. |
2012-07-25 |
2023-08-12 |
Not clear |
| Afef Achouri Rassas, Hela Mrabet Khiari, Sondes Hadj Fredj, Safa Sahnoun, Hend Batti, Nouria Oudiaa Zakraoui, Aroua Cherif, Nadia Anane, Nadia Ben Ali, Taieb Messaoud, Amel Mrabe. High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 33. issue 1. 2012-07-19. PMID:21710128. |
high apoe epsilon 4 allele frequencies associated with alzheimer disease in a tunisian population. |
2012-07-19 |
2023-08-12 |
Not clear |
| Afef Achouri Rassas, Hela Mrabet Khiari, Sondes Hadj Fredj, Safa Sahnoun, Hend Batti, Nouria Oudiaa Zakraoui, Aroua Cherif, Nadia Anane, Nadia Ben Ali, Taieb Messaoud, Amel Mrabe. High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 33. issue 1. 2012-07-19. PMID:21710128. |
the goal of the study was to examine the apolipoprotein e (apoe) genotypes in a tunisian sample of patients with alzheimer disease (ad) and normal controls, and to compare the results with the findings from the literature. |
2012-07-19 |
2023-08-12 |
Not clear |
| X Elcoroaristizabal Martín, M Fernández Martínez, L Galdos Alcelay, A Molano Salazar, R Bereincua Gandarias, S Inglés Borda, F Gómez Busto, J M Uterga Valiente, B Indakoetxea Juanbeltz, M A Gómez Beldarraín, M M de Pancorb. Progression from amnesic mild cognitive impairment to Alzheimer's disease: ESR1 and ESR2 polymorphisms and APOE gene. Dementia and geriatric cognitive disorders. vol 32. issue 5. 2012-07-11. PMID:22311091. |
progression from amnesic mild cognitive impairment to alzheimer's disease: esr1 and esr2 polymorphisms and apoe gene. |
2012-07-11 |
2023-08-12 |
Not clear |
| O J G Schiepers, S E Harris, A J Gow, A Pattie, C E Brett, J M Starr, I J Dear. APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921. Molecular psychiatry. vol 17. issue 3. 2012-06-29. PMID:21263443. |
carriers of the apoe e4 allele have an increased risk of developing alzheimer's disease. |
2012-06-29 |
2023-08-12 |
human |
| O J G Schiepers, S E Harris, A J Gow, A Pattie, C E Brett, J M Starr, I J Dear. APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921. Molecular psychiatry. vol 17. issue 3. 2012-06-29. PMID:21263443. |
thus, possession of the apoe e4 allele may not only predispose to alzheimer's disease, but also appears to be a risk factor for non-pathological decline in verbal memory and abstract reasoning in the ninth decade of life. |
2012-06-29 |
2023-08-12 |
human |
| Mary Wiese, Adam Antebi, Hui Zhen. Regulation of neuronal APL-1 expression by cholesterol starvation. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363792. |
while mutations in app lead to the development of familial alzheimer's disease (fad), sporadic ad has only one clear genetic modifier: the ε4 allele of the apolipoprotein e (apoe) gene. |
2012-06-29 |
2023-08-12 |
caenorhabditis_elegans |
| Stephen Arold, Patrick Sullivan, Tina Bilousova, Edmond Teng, Carol A Miller, Wayne W Poon, Harry V Vinters, Lindsey B Cornwell, Tommy Saing, Gregory M Cole, Karen Hoppens Gyly. Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. Acta neuropathologica. vol 123. issue 1. 2012-06-25. PMID:22020632. |
apolipoprotein e level and cholesterol are associated with reduced synaptic amyloid beta in alzheimer's disease and apoe tr mouse cortex. |
2012-06-25 |
2023-08-12 |
mouse |
| Yan Fu, Fang He, Nelson Leung Sang Tang, Cindy Woon Chi Tam, Victor Wing Cheong Lui, Helen Fung Kum Chiu, Linda Chiu Wa La. NEDD9 gene polymorphism influences the risk of Alzheimer disease and cognitive function in Chinese older persons. Alzheimer disease and associated disorders. vol 26. issue 1. 2012-06-20. PMID:21399483. |
the scores of cantonese version of the mini-mental state examination and alzheimer's disease assessment subscale-cognitive subscale were associated with n polymorphism after adjusting for sex, age, education year, and apoe ε4 status (linear regression model, p<0.05). |
2012-06-20 |
2023-08-12 |
Not clear |
| J S Roberts, K D Christensen, R C Gree. Using Alzheimer's disease as a model for genetic risk disclosure: implications for personal genomics. Clinical genetics. vol 80. issue 5. 2012-06-15. PMID:21696382. |
apolipoprotein e (apoe) testing for risk of alzheimer's disease (ad) provides a paradigm in which to examine the process and impact of disclosing genetic susceptibility for a prevalent, severe and incurable neurological condition. |
2012-06-15 |
2023-08-12 |
human |
| Natalya V Ponomareva, Andrey Y Goltsov, Svetlana S Kunijeva, Nadejda S Scheglova, Daria D Malina, Andrey A Mitrofanov, Tatiana I Boikova, Evgeny I Rogae. Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:22206848. |
the epsilon4 allele of the apolipoprotein e gene (apoe), as well as aging increase the risk of alzheimer's and vascular diseases. |
2012-06-15 |
2023-08-12 |
human |
| Yuangui Zhu, Evelyn Nwabuisi-Heath, Sonya B Dumanis, Leon M Tai, Chunjiang Yu, G William Rebeck, Mary Jo LaD. APOE genotype alters glial activation and loss of synaptic markers in mice. Glia. vol 60. issue 4. 2012-06-12. PMID:22228589. |
the ε4 allele of the apolipoprotein e (apoe) gene is the strongest genetic risk factor for late-onset alzheimer's disease (ad), and affects clinical outcomes of chronic and acute brain damages. |
2012-06-12 |
2023-08-12 |
mouse |
| Gloria C Chiang, Philip S Insel, Duygu Tosun, Norbert Schuff, Diana Truran-Sacrey, Sky T Raptentsetsang, Paul M Thompson, Eric M Reiman, Clifford R Jack, Nick C Fox, William J Jagust, Danielle J Harvey, Laurel A Beckett, Anthony Gamst, Paul S Aisen, Ron C Petersen, Michael W Weine. Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 7. issue 5. 2012-06-06. PMID:21889115. |
apolipoprotein ɛ4 (apoe ɛ4), a genetic risk factor for alzheimer's disease, is also known to be associated with hippocampal volume loss. |
2012-06-06 |
2023-08-12 |
Not clear |
| Aleksandra Maruszak, Beata Pepłońska, Krzysztof Safranow, Małgorzata Chodakowska-Żebrowska, Maria Barcikowska, Cezary Zekanowsk. TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity. Journal of Alzheimer's disease : JAD. vol 28. issue 2. 2012-05-24. PMID:22008263. |
recently, it has been reported that tomm40 variable-length poly-t sequence polymorphism (rs10524523) in combination with apoe alleles (e2, e3, e4) significantly influences late-onset alzheimer's disease (load) age of onset. |
2012-05-24 |
2023-08-12 |
Not clear |
| Alex Ward, Sheila Crean, Catherine J Mercaldi, Jenna M Collins, Dylan Boyd, Michael N Cook, H Michael Arrigh. Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis. Neuroepidemiology. vol 38. issue 1. 2012-05-18. PMID:22179327. |
prevalence of apolipoprotein e4 genotype and homozygotes (apoe e4/4) among patients diagnosed with alzheimer's disease: a systematic review and meta-analysis. |
2012-05-18 |
2023-08-12 |
Not clear |
| Alex Ward, Sheila Crean, Catherine J Mercaldi, Jenna M Collins, Dylan Boyd, Michael N Cook, H Michael Arrigh. Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis. Neuroepidemiology. vol 38. issue 1. 2012-05-18. PMID:22179327. |
the purpose of this study is to summarize and evaluate published estimates for the prevalence of apoe e4 carrier status among the population diagnosed with alzheimer's disease (ad) by geographic region and country. |
2012-05-18 |
2023-08-12 |
Not clear |
| Lynn M Bekris, Franziska Lutz, Chang-En Y. Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE. Journal of human genetics. vol 57. issue 1. 2012-05-17. PMID:22089642. |
genetic variation within the apolipoprotein e gene (apoe) locus is associated with late-onset alzheimer's disease risk and quantitative traits as well as apoe expression in multiple tissues. |
2012-05-17 |
2023-08-12 |
human |
| Yusuke Takata, Masayuki Kikukawa, Haruo Hanyu, Shunichi Koyama, Soichiro Shimizu, Takahiko Umahara, Hirofumi Sakurai, Toshihiko Iwamoto, Kazuma Ohyashiki, Junko H Ohyashik. Association between ApoE phenotypes and telomere erosion in Alzheimer's disease. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 67. issue 4. 2012-05-15. PMID:22016362. |
association between apoe phenotypes and telomere erosion in alzheimer's disease. |
2012-05-15 |
2023-08-12 |
Not clear |
| Maartje I Kester, Nicolaas A Verwey, Evert J van Elk, Marinus A Blankenstein, Philip Scheltens, Wiesje M van der Flie. Progression from MCI to AD: predictive value of CSF Aβ42 is modified by APOE genotype. Neurobiology of aging. vol 32. issue 8. 2012-05-14. PMID:19748159. |
to study csf biomarkers amyloid-beta 1-42 (aβ42) and total tau (tau) in relation to apoe genotype in their ability to predict progression from mild cognitive impairment (mci) to alzheimer's disease (ad). |
2012-05-14 |
2023-08-12 |
Not clear |
| Taher Darreh-Shori, Negar Modiri, Kaj Blennow, Souad Baza, Chelenk Kamil, Hiba Ahmed, Niels Andreasen, Agneta Nordber. The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase. Neurobiology of aging. vol 32. issue 7. 2012-05-07. PMID:19713000. |
the apolipoprotein e (apoe) ε4 allele has consistently been established as an alzheimer's disease (ad) risk factor, but its pathological contribution to ad is obscure. |
2012-05-07 |
2023-08-12 |
Not clear |