| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christine Fennema-Notestine, Matthew S Panizzon, Wesley R Thompson, Chi-Hua Chen, Lisa T Eyler, Bruce Fischl, Carol E Franz, Michael D Grant, Amy J Jak, Terry L Jernigan, Michael J Lyons, Michael C Neale, Larry J Seidman, Ming T Tsuang, Hong Xian, Anders M Dale, William S Kreme. Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age. Journal of Alzheimer's disease : JAD. vol 26 Suppl 3. 2012-02-09. PMID:21971450. |
the presence of an apoe ε4 allele (ε4+) increases the risk of developing alzheimer's disease (ad). |
2012-02-09 |
2023-08-12 |
human |
| Simon J Furney, Deborah Kronenberg, Andrew Simmons, Andreas Güntert, Richard J Dobson, Petroula Proitsi, Lars Olof Wahlund, Iwona Kloszewska, Patrizia Mecocci, Hilkka Soininen, Magda Tsolaki, Bruno Vellas, Christian Spenger, Simon Loveston. Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progression. Journal of Alzheimer's disease : JAD. vol 26 Suppl 3. 2012-02-09. PMID:21971479. |
in a total of 205 people with mci, 77 of whom subsequently converted to alzheimer's disease, we find biochemical markers of inflammation to be better predictors of conversion than apoe genotype or clinical measures (area under the curve (auc) 0.65, 0.62, 0.59 respectively). |
2012-02-09 |
2023-08-12 |
human |
| Jungsu Kim, Hong Jiang, Seonha Park, Adam E M Eltorai, Floy R Stewart, Hyejin Yoon, Jacob M Basak, Mary Beth Finn, David M Holtzma. Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 49. 2012-02-02. PMID:22159114. |
the ε4 allele of the apolipoprotein e (apoe) gene is the strongest genetic risk factor for alzheimer's disease (ad). |
2012-02-02 |
2023-08-12 |
mouse |
| Juliana Fagion Lucatelli, Alessandra Chielle Barros, Vanessa Kappel da Silva, Fernanda da Silva Machado, Pâmela Camini Constantin, Ana Amélia Cipriani Dias, Mara Helena Hutz, Fabiana Michelsen de Andrad. Genetic influences on Alzheimer's disease: evidence of interactions between the genes APOE, APOC1 and ACE in a sample population from the South of Brazil. Neurochemical research. vol 36. issue 8. 2012-02-01. PMID:21533863. |
genetic influences on alzheimer's disease: evidence of interactions between the genes apoe, apoc1 and ace in a sample population from the south of brazil. |
2012-02-01 |
2023-08-12 |
Not clear |
| Juliana Fagion Lucatelli, Alessandra Chielle Barros, Vanessa Kappel da Silva, Fernanda da Silva Machado, Pâmela Camini Constantin, Ana Amélia Cipriani Dias, Mara Helena Hutz, Fabiana Michelsen de Andrad. Genetic influences on Alzheimer's disease: evidence of interactions between the genes APOE, APOC1 and ACE in a sample population from the South of Brazil. Neurochemical research. vol 36. issue 8. 2012-02-01. PMID:21533863. |
several genes have been suggested as alzheimer's susceptibility factors, the apolipoprotein e (apoe) gene being an established susceptibility gene and the genes coding angiotensin-converting enzyme (ace) and apolipoprotein c1 (apoc1) being considered possible candidate genes for the disease. |
2012-02-01 |
2023-08-12 |
Not clear |
| Juliana Fagion Lucatelli, Alessandra Chielle Barros, Vanessa Kappel da Silva, Fernanda da Silva Machado, Pâmela Camini Constantin, Ana Amélia Cipriani Dias, Mara Helena Hutz, Fabiana Michelsen de Andrad. Genetic influences on Alzheimer's disease: evidence of interactions between the genes APOE, APOC1 and ACE in a sample population from the South of Brazil. Neurochemical research. vol 36. issue 8. 2012-02-01. PMID:21533863. |
the objective of this study was to investigate the association of ace and apoc1 gene polymorphisms with susceptibility to alzheimer's disease and dementia in general, both alone and combined with the apoe gene. |
2012-02-01 |
2023-08-12 |
Not clear |
| Valtteri Julkunen, Eini Niskanen, Juha Koikkalainen, Sanna-Kaisa Herukka, Maija Pihlajamäki, Merja Hallikainen, Miia Kivipelto, Sebastian Muehlboeck, Alan C Evans, Ritva Vanninen, Hilkka Soinine. Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study. Journal of Alzheimer's disease : JAD. vol 21. issue 4. 2012-01-31. PMID:21504134. |
in this study, we analyzed differences in cortical thickness (cth) between healthy controls (hc), subjects with stable mild cognitive impairment (s-mci), progressive mci (p-mci), and alzheimer's disease (ad), and assessed correlations between cht and clinical disease severity, education, and apolipoprotein e4 (apoe) genotype. |
2012-01-31 |
2023-08-12 |
human |
| Nunzio Pomara, Davide Brun. Potential effects of the APOE epsilon2 allele and of family history of Alzheimer's disease on brain amyloid-β in normal elderly. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 45. 2012-01-25. PMID:22042836. |
potential effects of the apoe epsilon2 allele and of family history of alzheimer's disease on brain amyloid-β in normal elderly. |
2012-01-25 |
2023-08-12 |
Not clear |
| Sebastián Cervantes, Lluís Samaranch, José Manuel Vidal-Taboada, Isabel Lamet, María Jesús Bullido, Ana Frank-García, Francisco Coria, Albert Lleó, Jordi Clarimón, Elena Lorenzo, Elena Alonso, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Onofre Combarros, Marcel Rosich, Elisabet Vilella, Pau Pasto. Genetic variation in APOE cluster region and Alzheimer's disease risk. Neurobiology of aging. vol 32. issue 11. 2012-01-18. PMID:21752496. |
genetic variation in apoe cluster region and alzheimer's disease risk. |
2012-01-18 |
2023-08-12 |
human |
| Sebastián Cervantes, Lluís Samaranch, José Manuel Vidal-Taboada, Isabel Lamet, María Jesús Bullido, Ana Frank-García, Francisco Coria, Albert Lleó, Jordi Clarimón, Elena Lorenzo, Elena Alonso, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Onofre Combarros, Marcel Rosich, Elisabet Vilella, Pau Pasto. Genetic variation in APOE cluster region and Alzheimer's disease risk. Neurobiology of aging. vol 32. issue 11. 2012-01-18. PMID:21752496. |
we report the fine mapping/sequencing results of promoter and regulatory regions of apoe cluster genes (apoe, apoc1, apoc4, apoc2, and tomm40) in alzheimer's disease (ad) risk as well as in the progression from mild cognitive impairment (mci) to ad. |
2012-01-18 |
2023-08-12 |
human |
| V Heise, N Filippini, K P Ebmeier, C E Macka. The APOE ɛ4 allele modulates brain white matter integrity in healthy adults. Molecular psychiatry. vol 16. issue 9. 2012-01-17. PMID:20820167. |
the apolipoprotein e (apoe) ɛ4 allele is the best-established genetic risk factor for sporadic alzheimer's disease, and is also associated with structural gray matter and functional brain changes in healthy young, middle-aged and elderly subjects. |
2012-01-17 |
2023-08-12 |
human |
| E Genin, D Hannequin, D Wallon, K Sleegers, M Hiltunen, O Combarros, M J Bullido, S Engelborghs, P De Deyn, C Berr, F Pasquier, B Dubois, G Tognoni, N Fiévet, N Brouwers, K Bettens, B Arosio, E Coto, M Del Zompo, I Mateo, J Epelbaum, A Frank-Garcia, S Helisalmi, E Porcellini, A Pilotto, P Forti, R Ferri, E Scarpini, G Siciliano, V Solfrizzi, S Sorbi, G Spalletta, F Valdivieso, S Vepsäläinen, V Alvarez, P Bosco, M Mancuso, F Panza, B Nacmias, P Bossù, O Hanon, P Piccardi, G Annoni, D Seripa, D Galimberti, F Licastro, H Soininen, J-F Dartigues, M I Kamboh, C Van Broeckhoven, J C Lambert, P Amouyel, D Campio. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Molecular psychiatry. vol 16. issue 9. 2012-01-17. PMID:21556001. |
apoe and alzheimer disease: a major gene with semi-dominant inheritance. |
2012-01-17 |
2023-08-12 |
Not clear |
| E Genin, D Hannequin, D Wallon, K Sleegers, M Hiltunen, O Combarros, M J Bullido, S Engelborghs, P De Deyn, C Berr, F Pasquier, B Dubois, G Tognoni, N Fiévet, N Brouwers, K Bettens, B Arosio, E Coto, M Del Zompo, I Mateo, J Epelbaum, A Frank-Garcia, S Helisalmi, E Porcellini, A Pilotto, P Forti, R Ferri, E Scarpini, G Siciliano, V Solfrizzi, S Sorbi, G Spalletta, F Valdivieso, S Vepsäläinen, V Alvarez, P Bosco, M Mancuso, F Panza, B Nacmias, P Bossù, O Hanon, P Piccardi, G Annoni, D Seripa, D Galimberti, F Licastro, H Soininen, J-F Dartigues, M I Kamboh, C Van Broeckhoven, J C Lambert, P Amouyel, D Campio. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Molecular psychiatry. vol 16. issue 9. 2012-01-17. PMID:21556001. |
apolipoprotein e (apoe) dependent lifetime risks (ltrs) for alzheimer disease (ad) are currently not accurately known and odds ratios alone are insufficient to assess these risks. |
2012-01-17 |
2023-08-12 |
Not clear |
| E Genin, D Hannequin, D Wallon, K Sleegers, M Hiltunen, O Combarros, M J Bullido, S Engelborghs, P De Deyn, C Berr, F Pasquier, B Dubois, G Tognoni, N Fiévet, N Brouwers, K Bettens, B Arosio, E Coto, M Del Zompo, I Mateo, J Epelbaum, A Frank-Garcia, S Helisalmi, E Porcellini, A Pilotto, P Forti, R Ferri, E Scarpini, G Siciliano, V Solfrizzi, S Sorbi, G Spalletta, F Valdivieso, S Vepsäläinen, V Alvarez, P Bosco, M Mancuso, F Panza, B Nacmias, P Bossù, O Hanon, P Piccardi, G Annoni, D Seripa, D Galimberti, F Licastro, H Soininen, J-F Dartigues, M I Kamboh, C Van Broeckhoven, J C Lambert, P Amouyel, D Campio. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Molecular psychiatry. vol 16. issue 9. 2012-01-17. PMID:21556001. |
together, these results urge a reappraisal of the impact of apoe in alzheimer disease. |
2012-01-17 |
2023-08-12 |
Not clear |
| Panagiotis Alexopoulos, Tanja Richter-Schmidinger, Marco Horn, Sebastian Maus, Martin Reichel, Christos Sidiropoulos, Cosima Rhein, Piotr Lewczuk, Arnd Doerfler, Johannes Kornhube. Hippocampal volume differences between healthy young apolipoprotein E ε2 and ε4 carriers. Journal of Alzheimer's disease : JAD. vol 26. issue 2. 2012-01-17. PMID:21606569. |
the apolipoprotein e (apoe) ε4 allele is the major genetic risk factor for the development of late-onset alzheimer's disease (ad), whereas the presence of the apoe ε2 allele seems to confer protection. |
2012-01-17 |
2023-08-12 |
Not clear |
| Terhi Peuralinna, Maarit Tanskanen, Mira Mäkelä, Tuomo Polvikoski, Anders Paetau, Hannu Kalimo, Raimo Sulkava, John Hardy, Shiao-Lin Lai, Sampath Arepalli, Dena Hernandez, Bryan J Traynor, Andrew Singleton, Pentti J Tienari, Liisa Myllykanga. APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis. Journal of Alzheimer's disease : JAD. vol 26. issue 2. 2012-01-17. PMID:21654062. |
apoe and aβpp gene variation in cortical and cerebrovascular amyloid-β pathology and alzheimer's disease: a population-based analysis. |
2012-01-17 |
2023-08-12 |
human |
| Michelle M Mielke, Jeannie-Marie Leoutsakos, JoAnn T Tschanz, Robert C Green, Yorghos Tripodis, Chris D Corcoran, Maria C Norton, Constantine G Lyketso. Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 26. issue 1. 2012-01-10. PMID:21593560. |
interaction between vascular factors and the apoe ε4 allele in predicting rate of progression in alzheimer's disease. |
2012-01-10 |
2023-08-12 |
human |
| Samuel T Henderson, Judes Poirie. Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study. BMC medical genetics. vol 12. 2012-01-06. PMID:21992747. |
pharmacogenetic analysis of the effects of polymorphisms in apoe, ide and il1b on a ketone body based therapeutic on cognition in mild to moderate alzheimer's disease; a randomized, double-blind, placebo-controlled study. |
2012-01-06 |
2023-08-12 |
human |
| Samuel T Henderson, Judes Poirie. Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study. BMC medical genetics. vol 12. 2012-01-06. PMID:21992747. |
to examine the effect of genetic variation in apoe, ide and il1b on the response to induced ketosis in the alzheimer's disease assessment scale-cognitive subscale (adas-cog) in subjects with mild to moderate alzheimer's disease (ad). |
2012-01-06 |
2023-08-12 |
human |
| O Carmona, C Masuet, O Santiago, P Alía, E Moral, L Alonso-Magdalena, V Casado, T Arbiz. Multiple sclerosis and cognitive decline: is ApoE-4 a surrogate marker? Acta neurologica Scandinavica. vol 124. issue 4. 2011-12-29. PMID:21208197. |
background - the role of the apolipoprotein e (apoe) polymorphism has been well demonstrated in neurodegenerative disorders such as alzheimer. |
2011-12-29 |
2023-08-12 |
Not clear |