| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W J Strittmatter, A D Rose. Apolipoprotein E and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 11. 1995-06-29. PMID:7761390. |
inheritance of specific apolipoprotein e (apoe) alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic alzheimer disease. |
1995-06-29 |
2023-08-12 |
human |
| W J Strittmatter, A D Rose. Apolipoprotein E and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 11. 1995-06-29. PMID:7761390. |
these and other isoform-specific interactions of apoe give rise to testable hypotheses for the mechanism(s) of pathogenesis of alzheimer disease. |
1995-06-29 |
2023-08-12 |
human |
| W J Strittmatter, A D Rose. Apolipoprotein E and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 11. 1995-06-29. PMID:7761390. |
the identification of apoe in the cytoplasm of human neurons and the characterization of isoform-specific binding of apoe to the microtubule-associated proteins tau and map-2 present the possibility that apoe may affect microtubule function in the alzheimer brain. |
1995-06-29 |
2023-08-12 |
human |
| A D Roses, A M Saunders, E H Corder, M A Pericak-Vance, S H Han, G Einstein, C Hulette, D E Schmechel, M Holsti, D Huan. Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease. Arzneimittel-Forschung. vol 45. issue 3A. 1995-06-29. PMID:7763336. |
the apoe gene is not a disease locus, with specific mutations causing alzheimer disease. |
1995-06-29 |
2023-08-12 |
Not clear |
| T Yamada, A Kondo, J Takamatsu, J Tateishi, I Got. Apolipoprotein E mRNA in the brains of patients with Alzheimer's disease. Journal of the neurological sciences. vol 129. issue 1. 1995-06-22. PMID:7751846. |
to clarify the role of apolipoprotein e (apoe) in the pathophysiology of alzheimer's disease (ad), we used an rt-pcr method to investigate apoe and glial fibrillary acidic protein (gfap) mrna expression in the brain. |
1995-06-22 |
2023-08-12 |
Not clear |
| C M van Duijn, P de Knijff, A Wehnert, J De Voecht, J B Bronzova, L M Havekes, A Hofman, C Van Broeckhove. The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Annals of neurology. vol 37. issue 5. 1995-06-16. PMID:7755355. |
it was suggested that in contrast to the e4 allele, the e2 allele of the apolipoprotein e gene (apoe*2) has a protective effect for late-onset alzheimer's disease and early-onset alzheimer's disease (eoad). |
1995-06-16 |
2023-08-12 |
human |
| E Sobel, J Louhija, R Sulkava, Z Davanipour, K Kontula, H Miettinen, M Tikkanen, K Kainulainen, R Tilvi. Lack of association of apolipoprotein E allele epsilon 4 with late-onset Alzheimer's disease among Finnish centenarians. Neurology. vol 45. issue 5. 1995-06-15. PMID:7746404. |
no association between alzheimer's disease (ad) and apolipoprotein e type epsilon 4 (apoe epsilon 4) phenotype was found among centenarians in finland (n = 179). |
1995-06-15 |
2023-08-12 |
human |
| B Nacmias, S Latorraca, P Piersanti, P Forleo, S Piacentini, L Bracco, L Amaducci, S Sorb. ApoE genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val-->Ile mutated families. Neuroscience letters. vol 183. issue 1-2. 1995-06-14. PMID:7746463. |
apoe genotype and familial alzheimer's disease: a possible influence on age of onset in app717 val-->ile mutated families. |
1995-06-14 |
2023-08-12 |
Not clear |
| B Nacmias, S Latorraca, P Piersanti, P Forleo, S Piacentini, L Bracco, L Amaducci, S Sorb. ApoE genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val-->Ile mutated families. Neuroscience letters. vol 183. issue 1-2. 1995-06-14. PMID:7746463. |
recent studies have shown a genetic association of the apolipoprotein e (apoe) epsilon 4 allele with late onset familial and sporadic alzheimer's disease (ad). |
1995-06-14 |
2023-08-12 |
Not clear |
| B Nacmias, S Latorraca, P Piersanti, P Forleo, S Piacentini, L Bracco, L Amaducci, S Sorb. ApoE genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val-->Ile mutated families. Neuroscience letters. vol 183. issue 1-2. 1995-06-14. PMID:7746463. |
in this study we analysed the possible association of the genetic polymorphism of the apoe gene with age of onset in italian familial alzheimer's disease (fad) families including two early onset familial alzheimer's (eofad) families with the app717 val-->ile mutation in the amyloid precursor protein (app) gene on chromosome 21. |
1995-06-14 |
2023-08-12 |
Not clear |
| H Basun, M Grut, B Winblad, L Lannfel. Apolipoprotein epsilon 4 allele and disease progression in patients with late-onset Alzheimer's disease. Neuroscience letters. vol 183. issue 1-2. 1995-06-14. PMID:7746480. |
a random sample of 60 late-onset alzheimer's disease (ad) cases from a population-based study were apolipoprotein e (apoe) genotyped and clinically examined with a 3-year interval. |
1995-06-14 |
2023-08-12 |
Not clear |
| P Seeman, F Laccone, J Reiss, G Stopp. Absence of mutations in the apolipoprotein E (APOE) gene of patients with Alzheimer disease. Human mutation. vol 5. issue 1. 1995-05-30. PMID:7728146. |
absence of mutations in the apolipoprotein e (apoe) gene of patients with alzheimer disease. |
1995-05-30 |
2023-08-12 |
Not clear |
| M I Kambo. Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease. Human biology. vol 67. issue 2. 1995-05-30. PMID:7729825. |
the most dramatic and unexpected finding in this regard was made in early 1993, when it was reported that the presence of the apoe*4 allele is a significant risk factor for the development of late-onset familial alzheimer's disease, a debilitating brain disorder. |
1995-05-30 |
2023-08-12 |
Not clear |
| M I Kambo. Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease. Human biology. vol 67. issue 2. 1995-05-30. PMID:7729825. |
since then, a number of studies have confirmed this provocative association and also have found that the apoe*4 allele is a major risk factor for alzheimer's disease regardless of age at onset or family history. |
1995-05-30 |
2023-08-12 |
Not clear |
| M I Kambo. Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease. Human biology. vol 67. issue 2. 1995-05-30. PMID:7729825. |
apoe appears to contribute directly to the pathogenesis of alzheimer's disease because it has been immunochemically localized in three defining lesions of the disease (extracellular amyloid plaques, intracellular neurofibrillary tangles, and vascular amyloid deposits). |
1995-05-30 |
2023-08-12 |
Not clear |
| M I Kambo. Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease. Human biology. vol 67. issue 2. 1995-05-30. PMID:7729825. |
in this article i review current data about the association between apoe polymorphism and alzheimer's disease and possible physiological mechanisms behind this association. |
1995-05-30 |
2023-08-12 |
Not clear |
| B T Hyman, H L West, G W Rebeck, S V Buldyrev, R N Mantegna, M Ukleja, S Havlin, H E Stanle. Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 8. 1995-05-25. PMID:7724603. |
the discovery that the epsilon 4 allele of the apolipoprotein e (apoe) gene is a putative risk factor for alzheimer disease (ad) in the general population has highlighted the role of genetic influences in this extremely common and disabling illness. |
1995-05-25 |
2023-08-12 |
Not clear |
| M J LaDu, T M Pederson, D E Frail, C A Reardon, G S Getz, M T Faldut. Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid. The Journal of biological chemistry. vol 270. issue 16. 1995-05-23. PMID:7721816. |
apolipoprotein e (apoe), particularly the e4 allele, is genetically linked to the incidence of alzheimer's disease. |
1995-05-23 |
2023-08-12 |
human |
| K Blennow, C Hesse, P Fredma. Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer's disease. Neuroreport. vol 5. issue 18. 1995-05-04. PMID:7696597. |
apolipoprotein e (apoe) has been implicated in the pathogenesis of alzheimer's disease (ad). |
1995-05-04 |
2023-08-12 |
Not clear |
| T G Jensen, A D Roses, A L Jørgense. Apolipoprotein E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low density lipoprotein receptor. Neuroscience letters. vol 180. issue 2. 1995-05-04. PMID:7700578. |
alzheimer's disease with late onset is associated with inheritance of isoform 4 of the polymorphic apolipoprotein e (apoe). |
1995-05-04 |
2023-08-12 |
monkey |