| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J LaDu, M T Falduto, A M Manelli, C A Reardon, G S Getz, D E Frai. Isoform-specific binding of apolipoprotein E to beta-amyloid. The Journal of biological chemistry. vol 269. issue 38. 1994-10-20. PMID:8089103. |
apolipoprotein e (apoe), particularly the e4 allele, is genetically linked to the incidence of alzheimer's disease. |
1994-10-20 |
2023-08-12 |
human |
| M J LaDu, M T Falduto, A M Manelli, C A Reardon, G S Getz, D E Frai. Isoform-specific binding of apolipoprotein E to beta-amyloid. The Journal of biological chemistry. vol 269. issue 38. 1994-10-20. PMID:8089103. |
apoe is present in the extracellular senile plaques and intracellular neurofibrillary tangles associated with alzheimer's disease. |
1994-10-20 |
2023-08-12 |
human |
| b' M Akaaboune, M Villanova, B W Festoff, M Verdi\\xc3\\xa8re-Sahuqu\\xc3\\xa9, D Hanta\\xc3\\xa. Apolipoprotein E expression at neuromuscular junctions in mouse, rat and human skeletal muscle. FEBS letters. vol 351. issue 2. 1994-10-10. PMID:8082773.' |
apolipoprotein e (apoe)-epsilon 4 allele has been associated with late onset familial alzheimer's disease (ad). |
1994-10-10 |
2023-08-12 |
mouse |
| A D Rose. Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. Journal of neuropathology and experimental neurology. vol 53. issue 5. 1994-10-10. PMID:8083686. |
apolipoprotein e affects the rate of alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on apoe genotype and duration of disease. |
1994-10-10 |
2023-08-12 |
Not clear |
| C M van Duijn, P de Knijff, M Cruts, A Wehnert, L M Havekes, A Hofman, C Van Broeckhove. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nature genetics. vol 7. issue 1. 1994-10-04. PMID:8075646. |
several studies have reported an association of the apolipoprotein e allele epsilon 4 (apoe*4) to familial and sporadic late-onset alzheimer's disease (load). |
1994-10-04 |
2023-08-12 |
human |
| C M van Duijn, P de Knijff, M Cruts, A Wehnert, L M Havekes, A Hofman, C Van Broeckhove. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nature genetics. vol 7. issue 1. 1994-10-04. PMID:8075646. |
here we report on the relationship between apoe*4 and early-onset alzheimer's disease (eoad) in a dutch population-based study. |
1994-10-04 |
2023-08-12 |
human |
| S H Han, C Hulette, A M Saunders, G Einstein, M Pericak-Vance, W J Strittmatter, A D Roses, D E Schmeche. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Experimental neurology. vol 128. issue 1. 1994-09-23. PMID:8070517. |
apolipoprotein e (apoe, protein; apoe, gene) is a susceptibility gene for late-onset familial and sporadic alzheimer's disease (ad). |
1994-09-23 |
2023-08-12 |
Not clear |
| R Benjamin, A Leake, F K McArthur, P G Ince, J M Candy, J A Edwardson, C M Morris, E Bjertnes. Protective effect of apoE epsilon 2 in Alzheimer's disease. Lancet (London, England). vol 344. issue 8920. 1994-09-15. PMID:7914580. |
protective effect of apoe epsilon 2 in alzheimer's disease. |
1994-09-15 |
2023-08-12 |
Not clear |
| L Lannfelt, L Lilius, M Nastase, M Viitanen, L Fratiglioni, G Eggertsen, L Berglund, B Angelin, J Linder, B Winbla. Lack of association between apolipoprotein E allele epsilon 4 and sporadic Alzheimer's disease. Neuroscience letters. vol 169. issue 1-2. 1994-09-01. PMID:8047277. |
apolipoprotein e (apoe) is a protein involved in the transport of lipids and a component of alzheimer's disease (ad) plaques. |
1994-09-01 |
2023-08-12 |
Not clear |
| C Van Broeckhoven, H Backhovens, M Cruts, J J Martin, R Crook, H Houlden, J Hard. APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease. Neuroscience letters. vol 169. issue 1-2. 1994-09-01. PMID:8047278. |
apoe genotype does not modulate age of onset in families with chromosome 14 encoded alzheimer's disease. |
1994-09-01 |
2023-08-12 |
Not clear |
| C Van Broeckhoven, H Backhovens, M Cruts, J J Martin, R Crook, H Houlden, J Hard. APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease. Neuroscience letters. vol 169. issue 1-2. 1994-09-01. PMID:8047278. |
a recent study has demonstrated an association of the apolipoprotein e allele epsilon 4 (apoe*4) to familial and sporadic late-onset alzheimer's disease (ad). |
1994-09-01 |
2023-08-12 |
Not clear |
| D A Sanan, K H Weisgraber, S J Russell, R W Mahley, D Huang, A Saunders, D Schmechel, T Wisniewski, B Frangione, A D Rose. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. The Journal of clinical investigation. vol 94. issue 2. 1994-08-25. PMID:8040342. |
late-onset and sporadic alzheimer's disease are associated with the apolipoprotein e (apoe) type 4 allele expressing the protein isoform apoe4. |
1994-08-25 |
2023-08-12 |
cattle |
| R N Butle. ApoE: new risk factor for Alzheimer's. Geriatrics. vol 49. issue 8. 1994-08-19. PMID:8039724. |
apoe: new risk factor for alzheimer's. |
1994-08-19 |
2023-08-12 |
Not clear |
| A Poduri, M Gearing, G W Rebeck, S S Mirra, J Tigges, B T Hyma. Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys. The American journal of pathology. vol 144. issue 6. 1994-07-05. PMID:8203459. |
recent studies of late onset familial and sporadic alzheimer's disease (ad) show a genetic disequilibrium between inheritance of the epsilon 4 allele of the apolipoprotein e (apoe) gene and development of ad. |
1994-07-05 |
2023-08-12 |
mouse |
| C Talbot, C Lendon, N Craddock, S Shears, J C Morris, A Goat. Protection against Alzheimer's disease with apoE epsilon 2. Lancet (London, England). vol 343. issue 8910. 1994-06-28. PMID:7910910. |
protection against alzheimer's disease with apoe epsilon 2. |
1994-06-28 |
2023-08-12 |
Not clear |
| B P Nathan, S Bellosta, D A Sanan, K H Weisgraber, R W Mahley, R E Pita. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science (New York, N.Y.). vol 264. issue 5160. 1994-06-01. PMID:8171342. |
apolipoprotein e4 (apoe4), one of the three common isoforms of apoe, has been implicated in alzheimer's disease. |
1994-06-01 |
2023-08-12 |
Not clear |
| C E Yu, H Payami, J M Olson, M Boehnke, E M Wijsman, H T Orr, W A Kukull, K A Goddard, E Nemens, J A Whit. The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. American journal of human genetics. vol 54. issue 4. 1994-04-13. PMID:8128960. |
evidence of linkage of apoe and apocii to fad was examined by maximum-likelihood methods, using three models and assuming autosomal dominant inheritance: (1) age-dependent penetrance, (2) extremely low (1%) penetrance, and (3) age-dependent penetrance corrected for sporadic alzheimer disease (ad). |
1994-04-13 |
2023-08-12 |
human |
| M E Gåfvels, M Caird, D Britt, C L Jackson, D Patterson, J F Straus. Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23. Somatic cell and molecular genetics. vol 19. issue 6. 1994-04-11. PMID:8128315. |
expression in brain may be related to high levels of apoe expression in that organ, an observation of potential relevance to the recently hypothesized role for apoe in late onset alzheimer disease. |
1994-04-11 |
2023-08-12 |
mouse |
| J S Whitson, M P Mims, W J Strittmatter, T Yamaki, J D Morrisett, S H Appe. Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E. Biochemical and biophysical research communications. vol 199. issue 1. 1994-04-01. PMID:8123007. |
thus, interaction between these proteins does not directly increase a beta neurotoxicity, and the role of apoe in alzheimer's disease remains to be elucidated. |
1994-04-01 |
2023-08-12 |
Not clear |
| M L Peacock, J K Fin. ApoE epsilon 4 allelic association with Alzheimer's disease: independent confirmation using denaturing gradient gel electrophoresis. Neurology. vol 44. issue 2. 1994-03-17. PMID:8309587. |
apoe epsilon 4 allelic association with alzheimer's disease: independent confirmation using denaturing gradient gel electrophoresis. |
1994-03-17 |
2023-08-12 |
human |