| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T G Jensen, A D Roses, A L Jørgense. Apolipoprotein E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low density lipoprotein receptor. Neuroscience letters. vol 180. issue 2. 1995-05-04. PMID:7700578. |
alzheimer's disease with late onset is associated with inheritance of isoform 4 of the polymorphic apolipoprotein e (apoe). |
1995-05-04 |
2023-08-12 |
monkey |
| P L Richey, S L Siedlak, M A Smith, G Perr. Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis. Biochemical and biophysical research communications. vol 208. issue 2. 1995-04-24. PMID:7695621. |
apolipoprotein e (apoe) genotype is a significant risk factor for the development of alzheimer disease (ad) and the apoe protein is associated with senile plaques (sp) and neurofibrillary tangles (nft), the pathological lesions of ad. |
1995-04-24 |
2023-08-12 |
Not clear |
| J Hardy, R Crook, G Prihar, G Roberts, R Raghavan, R Perr. Senile dementia of the Lewy body type has an apolipoprotein E epsilon 4 allele frequency intermediate between controls and Alzheimer's disease. Neuroscience letters. vol 182. issue 1. 1995-04-18. PMID:7891871. |
we have examined the apolipoprotein e (apoe) allele distributions in alzheimer's disease, parkinson's disease, senile dementia of the lewy body type and neurologically normal controls. |
1995-04-18 |
2023-08-12 |
Not clear |
| D Y Huang, M Goedert, R Jakes, K H Weisgraber, C C Garner, A M Saunders, M A Pericak-Vance, D E Schmechel, A D Roses, W J Strittmatte. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neuroscience letters. vol 182. issue 1. 1995-04-18. PMID:7891887. |
isoform-specific interactions of apoe with the microtubule-associated proteins map2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of alzheimer's disease. |
1995-04-18 |
2023-08-12 |
Not clear |
| E M Castano, F Prelli, T Wisniewski, A Golabek, R A Kumar, C Soto, B Frangion. Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. The Biochemical journal. vol 306 ( Pt 2). 1995-04-13. PMID:7534068. |
the apolipoprotein e (apoe) gene locus has recently been associated with late-onset alzheimer's disease. |
1995-04-13 |
2023-08-12 |
Not clear |
| E M Castano, F Prelli, T Wisniewski, A Golabek, R A Kumar, C Soto, B Frangion. Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. The Biochemical journal. vol 306 ( Pt 2). 1995-04-13. PMID:7534068. |
however, apoe produced only a minimal effect on a beta-(1-40q), found in the dutch variant of alzheimer's disease. |
1995-04-13 |
2023-08-12 |
Not clear |
| E M Castano, F Prelli, T Wisniewski, A Golabek, R A Kumar, C Soto, B Frangion. Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. The Biochemical journal. vol 306 ( Pt 2). 1995-04-13. PMID:7534068. |
these in vitro observations support the hypothesis that apoe acts as a pathological chaperone, promoting the beta-pleated-sheet conformation of soluble a beta into amyloid fibres, and provide a possible explanation for the association of the apoe4 genetic isoform with alzheimer's disease. |
1995-04-13 |
2023-08-12 |
Not clear |
| G W Small, J C Mazziotta, M T Collins, L R Baxter, M E Phelps, M A Mandelkern, A Kaplan, A La Rue, C F Adamson, L Chan. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. JAMA. vol 273. issue 12. 1995-04-12. PMID:7884953. |
cerebral parietal hypometabolism and left-right asymmetry occur early in the course of alzheimer disease (ad), and the apolipoprotein e type 4 allele (apoe epsilon 4) is a risk factor for familial ad. |
1995-04-12 |
2023-08-12 |
Not clear |
| A Tamaok. [Apolipoprotein E4 and late-onset Alzheimer's disease]. Nihon rinsho. Japanese journal of clinical medicine. vol 52. issue 12. 1995-03-16. PMID:7853720. |
the apoe immunoreactivity was associated with amyloid both in senile plaques and cerebral blood vessels and neurofibrillary tangles (nfts) in alzheimer's disease (ad). |
1995-03-16 |
2023-08-12 |
Not clear |
| H Yamaguchi, K Ishiguro, S Sugihara, Y Nakazato, T Kawarabayashi, X Sun, S Hira. Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition. Acta neuropathologica. vol 88. issue 5. 1995-03-09. PMID:7847069. |
the localization of apolipoprotein e (apoe) has been examined immunohistochemically in the autopsied brains of middle-aged and old-aged control subjects, with and without amyloid beta protein (a beta) deposits, and of alzheimer's disease patients. |
1995-03-09 |
2023-08-12 |
human |
| H Yamaguchi, K Ishiguro, S Sugihara, Y Nakazato, T Kawarabayashi, X Sun, S Hira. Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition. Acta neuropathologica. vol 88. issue 5. 1995-03-09. PMID:7847069. |
in the cerebellar molecular layer, small dots of apoe immunoreactivity, which were prominent in the alzheimer's disease subjects, were observed in addition to immunoreactivity in diffuse plaques. |
1995-03-09 |
2023-08-12 |
human |
| A D Roses, A M Saunder. APOE is a major susceptibility gene for Alzheimer's disease. Current opinion in biotechnology. vol 5. issue 6. 1995-03-03. PMID:7765750. |
apoe is a major susceptibility gene for alzheimer's disease. |
1995-03-03 |
2023-08-12 |
Not clear |
| A D Roses, A M Saunder. APOE is a major susceptibility gene for Alzheimer's disease. Current opinion in biotechnology. vol 5. issue 6. 1995-03-03. PMID:7765750. |
the initial report on apoe as a susceptibility gene for late-onset alzheimer's disease was presented a little more than two years ago. |
1995-03-03 |
2023-08-12 |
Not clear |
| K A Crutcher, M A Clay, S A Scott, X Tian, M Tolar, J A Harmon. Neurite degeneration elicited by apolipoprotein E peptides. Experimental neurology. vol 130. issue 1. 1995-02-14. PMID:7821387. |
apolipoprotein e (apoe) has been localized to the neurofibrillary tangles and beta-amyloid-containing plaques found in the cortex of patients with alzheimer's disease (ad) (14, 28), suggesting that apoe may play a role in this disorder. |
1995-02-14 |
2023-08-12 |
chicken |
| C Berr, J J Hauw, P Delaère, C Duyckaerts, P Amouye. Apolipoprotein E allele epsilon 4 is linked to increased deposition of the amyloid beta-peptide (A-beta) in cases with or without Alzheimer's disease. Neuroscience letters. vol 178. issue 2. 1995-02-13. PMID:7824200. |
this observation contrasted with the expected association between alzheimer's disease and apoe epsilon 4 allele. |
1995-02-13 |
2023-08-12 |
human |
| C F Lippa, T W Smith, A M Saunders, R Crook, D Pulaski-Salo, P Davies, J Hardy, A D Roses, D Dickso. Apolipoprotein E genotype and Lewy body disease. Neurology. vol 45. issue 1. 1995-02-10. PMID:7824144. |
to determine whether apolipoprotein e (apoe) genotype affects neuropathology in lewy body disease (lbd), we examined 18 cases of lbd that did not have concurrent alzheimer's disease by the cerad criteria. |
1995-02-10 |
2023-08-12 |
Not clear |
| S Sorbi, B Nacmias, P Forleo, S Latorraca, I Gobbini, L Bracco, S Piacentini, L Amaducc. ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease. Neuroscience letters. vol 177. issue 1-2. 1995-02-10. PMID:7824157. |
apoe allele frequencies in italian sporadic and familial alzheimer's disease. |
1995-02-10 |
2023-08-12 |
human |
| S Sorbi, B Nacmias, P Forleo, S Latorraca, I Gobbini, L Bracco, S Piacentini, L Amaducc. ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease. Neuroscience letters. vol 177. issue 1-2. 1995-02-10. PMID:7824157. |
recent studies have provided evidence of association of apolipoprotein e (apoe) epsilon 4 allele and late onset familial and sporadic alzheimer's disease (ad). |
1995-02-10 |
2023-08-12 |
human |
| T Lehtimäki, T Pirttilä, P D Mehta, H M Wisniewski, H Frey, T Nikkar. Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease. Human genetics. vol 95. issue 1. 1995-02-03. PMID:7814023. |
apolipoprotein e (apoe) polymorphism and its influence on apoe concentrations in the cerebrospinal fluid in finnish patients with alzheimer's disease. |
1995-02-03 |
2023-08-12 |
Not clear |
| T Lehtimäki, T Pirttilä, P D Mehta, H M Wisniewski, H Frey, T Nikkar. Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease. Human genetics. vol 95. issue 1. 1995-02-03. PMID:7814023. |
the apoe phenotype of 83 patients with probable alzheimer's disease (ad) and of 164 non-demented controls was determined by isoelectric focusing and western blotting. |
1995-02-03 |
2023-08-12 |
Not clear |