| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Uchihara, C Duyckaerts, Y He, K Kobayashi, D Seilhean, P Amouyel, J J Hau. ApoE immunoreactivity and microglial cells in Alzheimer's disease brain. Neuroscience letters. vol 195. issue 1. 1995-12-18. PMID:7478253. |
apoe immunoreactivity and microglial cells in alzheimer's disease brain. |
1995-12-18 |
2023-08-12 |
Not clear |
| T Uchihara, C Duyckaerts, Y He, K Kobayashi, D Seilhean, P Amouyel, J J Hau. ApoE immunoreactivity and microglial cells in Alzheimer's disease brain. Neuroscience letters. vol 195. issue 1. 1995-12-18. PMID:7478253. |
the spatial relationship of apolipoprotein e (apoe)-like immunoreactivity (ir) to amyloid beta-peptide (a beta), astrocytes and microglial cells in the brain of alzheimer's disease was studied by double immunolabelling. |
1995-12-18 |
2023-08-12 |
Not clear |
| T Uchihara, C Duyckaerts, Y He, K Kobayashi, D Seilhean, P Amouyel, J J Hau. ApoE immunoreactivity and microglial cells in Alzheimer's disease brain. Neuroscience letters. vol 195. issue 1. 1995-12-18. PMID:7478253. |
these data suggest that microglial cells play a more significant role than astrocytes in apoe deposition in senile plaques of alzheimer disease. |
1995-12-18 |
2023-08-12 |
Not clear |
| A S Henderson, S Easteal, A F Jorm, A J Mackinnon, A E Korten, H Christensen, L Croft, P A Jacom. Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample. Lancet (London, England). vol 346. issue 8987. 1995-12-15. PMID:7475820. |
from clinically based series it has been proposed that, in homozygotes for the apolipoprotein e epsilon 4 (apoe epsilon 4) allele, alzheimer's disease is almost inevitable by the age of 80. |
1995-12-15 |
2023-08-12 |
human |
| C Bennett, F Crawford, A Osborne, P Diaz, J Hoyne, R Lopez, P Roques, R Duara, M Rossor, M Mulla. Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative. American journal of medical genetics. vol 60. issue 1. 1995-12-15. PMID:7485228. |
evidence that the apoe locus influences rate of disease progression in late onset familial alzheimer's disease but is not causative. |
1995-12-15 |
2023-08-12 |
Not clear |
| C Bennett, F Crawford, A Osborne, P Diaz, J Hoyne, R Lopez, P Roques, R Duara, M Rossor, M Mulla. Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative. American journal of medical genetics. vol 60. issue 1. 1995-12-15. PMID:7485228. |
an association has been observed in several independent data sets between late onset alzheimer's disease (ad) and the apoe locus on chromosome 19. |
1995-12-15 |
2023-08-12 |
Not clear |
| M Gearing, J A Schneider, R S Robbins, R D Hollister, H Mori, D Games, B T Hyman, S S Mirr. Regional variation in the distribution of apolipoprotein E and A beta in Alzheimer's disease. Journal of neuropathology and experimental neurology. vol 54. issue 6. 1995-12-14. PMID:7595656. |
while the epsilon 4 allele of apolipoprotein e (apoe) has been identified as a risk factor in alzheimer's disease (ad), the mechanism by which this risk is conveyed is not understood. |
1995-12-14 |
2023-08-12 |
Not clear |
| Statement on use of apolipoprotein E testing for Alzheimer disease. American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer disease. JAMA. vol 274. issue 20. 1995-12-13. PMID:7474250. |
american college of medical genetics/american society of human genetics working group on apoe and alzheimer disease. |
1995-12-13 |
2023-08-12 |
human |
| Statement on use of apolipoprotein E testing for Alzheimer disease. American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer disease. JAMA. vol 274. issue 20. 1995-12-13. PMID:7474250. |
to evaluate the published data on the association between apolipoprotein e genotype (apoe) and alzheimer disease (ad) and determine whether the data support the use of genetic testing for diagnosis or prediction of disease. |
1995-12-13 |
2023-08-12 |
human |
| S Seshadri, D A Drachman, C F Lipp. Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know. Archives of neurology. vol 52. issue 11. 1995-12-12. PMID:7487559. |
published studies now show a clear association between alzheimer's disease (ad) and the apolipoprotein e epsilon 4 allele (apoe* epsilon 4). |
1995-12-12 |
2023-08-12 |
Not clear |
| G D Schellenber. Progress in Alzheimer's disease genetics. Current opinion in neurology. vol 8. issue 4. 1995-12-12. PMID:7582040. |
these are the amyloid precursor gene on chromosome 21, a gene for early-onset autosomal dominant alzheimer's disease on chromosome 14, and the risk-modifying gene apoe on chromosome 19. |
1995-12-12 |
2023-08-12 |
Not clear |
| D St Clair, M Rennie, E Slorach, J Norrman, C Yates, A Carother. Apolipoprotein E epsilon 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers. Journal of medical genetics. vol 32. issue 8. 1995-12-07. PMID:7473659. |
while apoliprotein e (apoe) epsilon 4 allele is now a well established risk factor for familial and sporadic senile alzheimer's disease (ad), its role in the development of the rarer presenile or early onset type is controversial. |
1995-12-07 |
2023-08-12 |
Not clear |
| F Mahieux, R Couderc, A Moulignier, S Bailleul, N Podrabinek, J Laude. [Isoform 4 of apolipoprotein E and Alzheimer disease. Specificity and clinical study]. Revue neurologique. vol 151. issue 4. 1995-11-29. PMID:7481373. |
we studied apolipoprotein e (apoe) phenotype in 113 patients with possible and probable alzheimer's disease (ad), 49 patients with parkinson's disease (including 11 patients with dementia) and 23 patients with mixed and vascular dementia. |
1995-11-29 |
2023-08-12 |
Not clear |
| R N Martins, R Clarnette, C Fisher, G A Broe, W S Brooks, P Montgomery, S E Gand. ApoE genotypes in Australia: roles in early and late onset Alzheimer's disease and Down's syndrome. Neuroreport. vol 6. issue 11. 1995-11-28. PMID:7579137. |
apoe genotypes in australia: roles in early and late onset alzheimer's disease and down's syndrome. |
1995-11-28 |
2023-08-12 |
Not clear |
| R N Martins, R Clarnette, C Fisher, G A Broe, W S Brooks, P Montgomery, S E Gand. ApoE genotypes in Australia: roles in early and late onset Alzheimer's disease and Down's syndrome. Neuroreport. vol 6. issue 11. 1995-11-28. PMID:7579137. |
we studied the apoe genotypes of 279 australians in order to determine what relationships might exist in this group between apoe genotype and dementia associated with either early- or late-onset sporadic alzheimer's disease (ad) or with down's syndrome (ds). |
1995-11-28 |
2023-08-12 |
Not clear |
| M S Kindy, A R King, G Perry, M C de Beer, F C de Bee. Association of apolipoprotein E with murine amyloid A protein amyloid. Laboratory investigation; a journal of technical methods and pathology. vol 73. issue 4. 1995-11-27. PMID:7474917. |
recent studies have suggested the importance of apolipoprotein e (apoe) in alzheimer's disease and systemic amyloidoses. |
1995-11-27 |
2023-08-12 |
mouse |
| D M Holtzman, R E Pitas, J Kilbridge, B Nathan, R W Mahley, G Bu, A L Schwart. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 21. 1995-11-14. PMID:7568158. |
the epsilon 4 allele of apolipoprotein e (apoe) is a major risk factor for alzheimer disease, suggesting that apoe may directly influence neurons in the aging brain. |
1995-11-14 |
2023-08-12 |
Not clear |
| E Levy-Lahad, A Lahad, E M Wijsman, T D Bird, G D Schellenber. Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease. Annals of neurology. vol 38. issue 4. 1995-11-09. PMID:7574468. |
the effect of the apolipoprotein e (apoe) epsilon 4 allele on age of onset was analyzed in two groups of families with early-onset alzheimer's disease (ad), (1) volga german (vg) kindreds, in which ad is caused by an unknown locus and (2) early-onset non-vg families showing evidence of linkage to chromosome 14. |
1995-11-09 |
2023-08-12 |
Not clear |
| D Y Huang, K H Weisgraber, M Goedert, A M Saunders, A D Roses, W J Strittmatte. ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neuroscience letters. vol 192. issue 3. 1995-11-06. PMID:7566652. |
the risk of alzheimer's disease is determined, in part, by inheritance of specific alleles of apoe. |
1995-11-06 |
2023-08-12 |
Not clear |
| M Ganguli, J A Cauley, S T DeKosky, M I Kambo. Dementia among elderly apolipoprotein E type 4/4 homozygotes: a prospective study. Genetic epidemiology. vol 12. issue 3. 1995-10-30. PMID:7557352. |
the e*4 allele of the apolipoprotein e (apoe) gene on chromosome 19 has been shown to be an age- and dose-related risk factor for alzheimer's disease. |
1995-10-30 |
2023-08-12 |
human |