| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Gearing, H Mori, S S Mirr. Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease. Annals of neurology. vol 39. issue 3. 1996-05-09. PMID:8602762. |
apolipoprotein e (apoe) epsilon4 allele, a risk factor for the development of alzheimer's disease (ad), is associated with increased amyloid deposition. |
1996-05-09 |
2023-08-12 |
Not clear |
| I Genis, I Gordon, E Sehayek, D M Michaelso. Phosphorylation of tau in apolipoprotein E-deficient mice. Neuroscience letters. vol 199. issue 1. 1996-03-19. PMID:8584225. |
it has been suggested that the deleterious effects of the allele e4 of apolipoprotein e (apoe) in alzheimer's disease (ad) are related to its inability to interact with the microtubule associated protein tau and to thereby prevent its hyperphosphorylation. |
1996-03-19 |
2023-08-12 |
mouse |
| T Asada, Z Yamagata, T Kinoshita, A Kinoshita, T Kariya, A Asaka, T Kakum. Prevalence of dementia and distribution of ApoE alleles in Japanese centenarians: an almost-complete survey in Yamanashi Prefecture, Japan. Journal of the American Geriatrics Society. vol 44. issue 2. 1996-03-14. PMID:8576504. |
to determine the prevalence and types of dementia in centenarians and to examine whether the apoe epsilon 4 allele has significant impact on the development of alzheimer's disease (ad) in the population. |
1996-03-14 |
2023-08-12 |
Not clear |
| Y Itoh, M Yamada, N Suematsu, M Matsushita, E Otom. Influence of apolipoprotein E genotype on cerebral amyloid angiopathy in the elderly. Stroke. vol 27. issue 2. 1996-03-06. PMID:8571412. |
the inheritance of the epsilon 4 allele of the apolipoprotein e gene (apoe) is associated with increased risk of developing dementia of the alzheimer type (dat). |
1996-03-06 |
2023-08-12 |
Not clear |
| T Gomez-Isla, H L West, G W Rebeck, S D Harr, J H Growdon, J J Locascio, T T Perls, L A Lipsitz, B T Hyma. Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease. Annals of neurology. vol 39. issue 1. 1996-03-05. PMID:8572669. |
inheritance of the apolipoprotein e (apoe) epsilon 4 allele is associated with a high likelihood of developing alzheimer's disease (ad). |
1996-03-05 |
2023-08-12 |
Not clear |
| M A Cariolou, A Kokkofitou, P Manoli, S Christou, A Karagrigoriou, L Middleto. Underexpression of the apolipoprotein E2 and E4 alleles in the Greek Cypriot population of Cyprus. Genetic epidemiology. vol 12. issue 5. 1996-02-27. PMID:8557181. |
apolipoprotein e (apoe) plays an important role in the multifactorial etiology of both cardiovascular disease and alzheimer's disease. |
1996-02-27 |
2023-08-12 |
Not clear |
| M A Cariolou, A Kokkofitou, P Manoli, S Christou, A Karagrigoriou, L Middleto. Underexpression of the apolipoprotein E2 and E4 alleles in the Greek Cypriot population of Cyprus. Genetic epidemiology. vol 12. issue 5. 1996-02-27. PMID:8557181. |
the greek cypriot population will be studied further for elucidating the effect(s) and the role of apoe in cardiovascular disease and the apoe4 allele as a possible metabolic factor affecting the rate of expression of both alzheimer's disease and vascular dementia. |
1996-02-27 |
2023-08-12 |
Not clear |
| Y T Mak, H Chiu, J Woo, R Kay, Y S Chan, E Hui, K H Sze, C Lum, T Kwok, C P Pan. Apolipoprotein E genotype and Alzheimer's disease in Hong Kong elderly Chinese. Neurology. vol 46. issue 1. 1996-02-23. PMID:8559364. |
we studied the apolipoprotein e (apoe) allele frequencies in 65 chinese patients with late-onset alzheimer's disease (ad) and 82 age- and sex-matched controls. |
1996-02-23 |
2023-08-12 |
Not clear |
| M C Tierney, J P Szalai, W G Snow, R H Fisher, T Tsuda, H Chi, D R McLachlan, P H St George-Hyslo. A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment. Neurology. vol 46. issue 1. 1996-02-23. PMID:8559365. |
given the relationship between the presence of apoe epsilon 4 and alzheimer's disease (ad), were studied whether knowledge of epsilon 4 status would predict which memory-impaired patients would develop ad over time. |
1996-02-23 |
2023-08-12 |
Not clear |
| G Jarvik, E B Larson, K Goddard, G D Schellenberg, E M Wijsma. Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample. American journal of human genetics. vol 58. issue 1. 1996-02-21. PMID:8554056. |
the epsilon 4 allele of the apolipoprotein e locus (apoe) has been found to be an important predictor of alzheimer disease (ad). |
1996-02-21 |
2023-08-12 |
Not clear |
| O Heinonen, M Lehtovirta, H Soininen, S Helisalmi, A Mannermaa, H Sorvari, O Kosunen, L Paljärvi, M Ryynänen, P J Riekkine. Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele. Neurobiology of aging. vol 16. issue 4. 1996-02-14. PMID:8544899. |
a recent report suggested that brains of alzheimer patients homozygous for apoe epsilon 4 show increased amyloid pathology compared to apoe epsilon 3 homozygotes. |
1996-02-14 |
2023-08-12 |
Not clear |
| J Hard. Apolipoprotein E in the genetics and epidemiology of Alzheimer's disease. American journal of medical genetics. vol 60. issue 5. 1996-02-13. PMID:8546162. |
the role of apolipoprotein e (apoe) alleles and isoforms in the etiology and pathogenesis of alzheimer's disease is discussed. |
1996-02-13 |
2023-08-12 |
Not clear |
| A al-Chalabi, Z E Enayat, M C Bakker, P C Sham, D M Ball, C E Shaw, C M Lloyd, J F Powell, P N Leig. Association of apolipoprotein E epsilon 4 allele with bulbar-onset motor neuron disease. Lancet (London, England). vol 347. issue 8995. 1996-02-09. PMID:8544551. |
variants of the apolipoprotein e (apoe) gene influence the age of onset of alzheimer's disease. |
1996-02-09 |
2023-08-12 |
Not clear |
| A S Plump, J L Breslo. Apolipoprotein E and the apolipoprotein E-deficient mouse. Annual review of nutrition. vol 15. 1996-01-31. PMID:8527231. |
several studies have demonstrated that genetic variation at the apoe locus is associated with an increased risk of developing atherosclerosis, and recent studies implicate this same genetic variation in determining susceptibility to alzheimer's disease. |
1996-01-31 |
2023-08-12 |
mouse |
| M G Martinoli, J Q Trojanowski, M L Schmidt, S E Arnold, T M Fujiwara, V M Lee, H Hurtig, J P Julien, C Clar. Association of apolipoprotein epsilon 4 allele and neuropathologic findings in patients with dementia. Acta neuropathologica. vol 90. issue 3. 1996-01-19. PMID:8525796. |
recent findings suggest that the presence of apoe 4 is associated with an increased risk for both familial alzheimer's disease and late-onset alzheimer's disease. |
1996-01-19 |
2023-08-12 |
Not clear |
| M G Martinoli, J Q Trojanowski, M L Schmidt, S E Arnold, T M Fujiwara, V M Lee, H Hurtig, J P Julien, C Clar. Association of apolipoprotein epsilon 4 allele and neuropathologic findings in patients with dementia. Acta neuropathologica. vol 90. issue 3. 1996-01-19. PMID:8525796. |
we extended these observations by determining the frequency of apoe alleles in patients with pathologically confirmed alzheimer's disease (ad), parkinson's disease (pd), diffuse lewy body disease (dlbd), ad with concomitant pd pathology, demented pd patients without or with concomitant ad pathology and in schizophrenics with a progressive dementia (schiz+dem). |
1996-01-19 |
2023-08-12 |
Not clear |
| M Gearing, J A Schneider, G W Rebeck, B T Hyman, S S Mirr. Alzheimer's disease with and without coexisting Parkinson's disease changes: apolipoprotein E genotype and neuropathologic correlates. Neurology. vol 45. issue 11. 1996-01-18. PMID:7501146. |
the frequency of the apolipoprotein e (apoe) epsilon 4 allele and its relationship with coexistent parkinson's disease (pd) neuropathology in alzheimer's disease (ad) have not been extensively explored. |
1996-01-18 |
2023-08-12 |
Not clear |
| E Masliah, M Mallory, N Ge, M Alford, I Veinbergs, A D Rose. Neurodegeneration in the central nervous system of apoE-deficient mice. Experimental neurology. vol 136. issue 2. 1996-01-17. PMID:7498401. |
these results support the contention that apoe might play an important role in maintaining the stability of the synapto-dendritic apparatus and that altered or deficient functioning of this molecule could underlie the synaptic and cytoskeletal alterations in alzheimer's disease. |
1996-01-17 |
2023-08-12 |
mouse |
| L A Farrer, L A Cupples, C M van Duijn, A Kurz, R Zimmer, U Müller, R C Green, V Clarke, J Shoffner, D C Wallac. Apolipoprotein E genotype in patients with Alzheimer's disease: implications for the risk of dementia among relatives. Annals of neurology. vol 38. issue 5. 1995-12-28. PMID:7486872. |
numerous studies have shown that the risk of alzheimer's disease (ad) is associated with the dose of the epsilon 4 allele of apolipoprotein e (apoe). |
1995-12-28 |
2023-08-12 |
Not clear |
| L Sokol, J T Prcha. Human genome--chromosome no. 19. Casopis lekaru ceskych. vol 134. issue 19. 1995-12-26. PMID:7585875. |
apolipoprotein e (apoe) locus plays a role in pathogenesis of the late onset familial alzheimer's disease. |
1995-12-26 |
2023-08-12 |
human |