| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Lovestone, B H Anderton, C Hartley, T G Jensen, A L Jorgense. The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific. Neuroreport. vol 7. issue 5. 1996-12-11. PMID:8804040. |
this isoform difference in the intracellular distribution of apoe is dependent upon tau expression and, although tau phosphorylation was not affected by apoe, these results suggest that apoe interactions with the cytoskeleton might be important in the molecular pathogenesis of alzheimer's disease. |
1996-12-11 |
2023-08-12 |
Not clear |
| M Nakai, T Kawamata, T Taniguchi, K Maeda, C Tanak. Expression of apolipoprotein E mRNA in rat microglia. Neuroscience letters. vol 211. issue 1. 1996-12-06. PMID:8809843. |
apolipoprotein e (apoe) is a major risk factor for alzheimer disease (ad), which is the most common cause of progressive dementing illness. |
1996-12-06 |
2023-08-12 |
rat |
| J Pérez-Tur, D Campion, M Martinez, A Brice, S Tardieu, D Hannequin, Y Agid, A Delacourte, F Clerget-Darpoux, M C Chartier-Harli. Evidence for apolipoprotein E epsilon 4 association in early-onset Alzheimer's patients with late-onset relatives. American journal of medical genetics. vol 60. issue 6. 1996-12-05. PMID:8825894. |
recently several reports have extended the apolipoprotein e (apoe) epsilon 4 association found in late-onset alzheimer's disease (load) patients to early-onset (eo) ad patients. |
1996-12-05 |
2023-08-12 |
human |
| M L Pritchard, A M Saunders, P C Gaskell, G W Small, P M Conneally, B Rosi, L H Yamaoka, A D Roses, J L Haines, M A Pericak-Vanc. No association between very low density lipoprotein receptor (VLDL-R) and Alzheimer disease in American Caucasians. Neuroscience letters. vol 209. issue 2. 1996-12-04. PMID:8761993. |
the very low density lipoprotein receptor gene (vldl-r) is a receptor for apolipoprotein-epsilon (apoe)-containing lipoproteins, and thus has been suggested as a possible risk factor for alzheimer disease (ad). |
1996-12-04 |
2023-08-12 |
Not clear |
| M Landén, A Thorsell, A Wallin, K Blenno. The apolipoprotein E allele epsilon 4 does not correlate with the number of senile plaques or neurofibrillary tangles in patients with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 61. issue 4. 1996-12-04. PMID:8890772. |
apolipoprotein e (apoe) has been implicated in regenerative processes in the brain after trauma, as well as in the pathogenesis of alzheimer's disease. |
1996-12-04 |
2023-08-12 |
Not clear |
| L Liu, C Forsell, L Lilius, K Axelman, E H Corder, L Lannfel. Allelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families. American journal of medical genetics. vol 67. issue 3. 1996-12-03. PMID:8725748. |
an association between the epsilon 4 allele of the apolipoprotein e gene (apoe) and late-onset alzheimer's disease (ad) was recently demonstrated. |
1996-12-03 |
2023-08-12 |
Not clear |
| R Sulkava, K Kainulainen, A Verkkoniemi, L Niinistö, E Sobel, Z Davanipour, T Polvikoski, M Haltia, K Kontul. APOE alleles in Alzheimer's disease and vascular dementia in a population aged 85+. Neurobiology of aging. vol 17. issue 3. 1996-12-03. PMID:8725898. |
apoe alleles in alzheimer's disease and vascular dementia in a population aged 85+. |
1996-12-03 |
2023-08-12 |
Not clear |
| H S Soininen, P J Riekkine. Apolipoprotein E, memory and Alzheimer's disease. Trends in neurosciences. vol 19. issue 6. 1996-12-03. PMID:8761956. |
apolipoprotein e (apoe) epsilon 4 is a well-documented risk factor for alzheimer's disease (ad). |
1996-12-03 |
2023-08-12 |
human |
| G Li, J M Silverman, L D Altstiel, V Haroutunian, D P Perl, D Purohit, S Birstein, M Lantz, R C Mohs, K L Davi. Apolipoprotein E-epsilon 4 allele and familial risk in Alzheimer's disease. Genetic epidemiology. vol 13. issue 3. 1996-12-03. PMID:8797010. |
recent studies have found an association between presence of apolipoprotein e (apoe) epsilon 4 allele and alzheimer's disease (ad). |
1996-12-03 |
2023-08-12 |
Not clear |
| S Helisalmi, K Linnaranta, M Lehtovirta, A Mannermaa, O Heinonen, M Ryynänen, P Riekkinen, H Soinine. Apolipoprotein E polymorphism in patients with different neurodegenerative disorders. Neuroscience letters. vol 205. issue 1. 1996-12-03. PMID:8867021. |
apolipoprotein e (apoe) is associated with alzheimer's disease (ad) neurofibrillary tangles and beta-amyloid protein in senile plaques. |
1996-12-03 |
2023-08-12 |
Not clear |
| R N Rosenberg, R W Richter, R C Risser, K Taubman, I Prado-Farmer, E Ebalo, J Posey, D Kingfisher, D Dean, M F Weiner, D Svetlik, P Adams, L S Honig, C M Cullum, F V Schaefer, G D Schellenber. Genetic factors for the development of Alzheimer disease in the Cherokee Indian. Archives of neurology. vol 53. issue 10. 1996-11-27. PMID:8859062. |
to study the relationship between the genetic degree of cherokee ancestry, the apolipoprotein e *e4 (apoe*e4) allele type, and the development of alzheimer disease (ad) in individuals from the cherokee nation who reside in northeastern oklahoma. |
1996-11-27 |
2023-08-12 |
Not clear |
| A Kurz, R Egensperger, M Haupt, N Lautenschlager, B Romero, M B Graeber, U Mülle. Apolipoprotein E epsilon 4 allele, cognitive decline, and deterioration of everyday performance in Alzheimer's disease. Neurology. vol 47. issue 2. 1996-11-26. PMID:8757017. |
many studies have demonstrated an association between the apolipoprotein e (apoe) epsilon 4 allele and alzheimer's disease (ad). |
1996-11-26 |
2023-08-12 |
Not clear |
| J H Growdon, J J Locascio, S Corkin, T Gomez-Isla, B T Hyma. Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease. Neurology. vol 47. issue 2. 1996-11-26. PMID:8757018. |
inheritance of the apolipoprotein e (apoe) epsilon 4 allele is a risk factor for developing alzheimer's disease (ad) and is associated with a lower age of dementia onset. |
1996-11-26 |
2023-08-12 |
Not clear |
| T Asada, T Kariya, Z Yamagata, T Kinoshita, A Asak. ApoE epsilon 4 allele and cognitive decline in patients with Alzheimer's disease. Neurology. vol 47. issue 2. 1996-11-26. PMID:8757051. |
apoe epsilon 4 allele and cognitive decline in patients with alzheimer's disease. |
1996-11-26 |
2023-08-12 |
Not clear |
| B Nacmias, A Tedde, S Latorraca, S Piacentini, L Bracco, L Amaducci, B M Guarnieri, C Petruzzi, L Ortenzi, S Sorb. Apolipoprotein E and alpha1-antichymotrypsin polymorphism in Alzheimer's disease. Annals of neurology. vol 40. issue 4. 1996-11-22. PMID:8871590. |
a recent observation has shown that a common polymorphism in the alpha1-antichymotrypsin (act) gene modifies the apolipoprotein e (apoe) epsilon4-associated alzheimer's disease (ad) risk identifying the combination of the act/aa and apoe epsilon4/epsilon4 genotypes as a potential susceptibility marker for ad. |
1996-11-22 |
2023-08-12 |
Not clear |
| S B Chargé, M M Esiri, C A Bethune, B C Hansen, A Clar. Apolipoprotein E is associated with islet amyloid and other amyloidoses: implications for Alzheimer's disease. The Journal of pathology. vol 179. issue 4. 1996-11-15. PMID:8869295. |
apolipoprotein e (apoe) has recently been proposed as an aetiological factor of alzheimer's disease (ad): apoe is co-localized to amyloid plaques and neurofibrillary tangles in the brain and binds to a beta-protein in vitro. |
1996-11-15 |
2023-08-12 |
mouse |
| S Itabashi, H Arai, S Higuchi, H Sasaki, J Q Trojanowsk. APOE epsilon 4 allele in Alzheimer's and non-Alzheimer's dementias. Lancet (London, England). vol 348. issue 9032. 1996-11-08. PMID:8843828. |
apoe epsilon 4 allele in alzheimer's and non-alzheimer's dementias. |
1996-11-08 |
2023-08-12 |
Not clear |
| C Brayne, C R Harrington, C M Wischik, F A Huppert, L Y Chi, J H Xuereb, D W O'Connor, E S Payke. Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population. Dementia (Basel, Switzerland). vol 7. issue 3. 1996-11-07. PMID:8740632. |
an increased apolipoprotein e (apoe) type epsilon 4 allele frequency is associated with both sporadic and familial late-onset alzheimer's disease (ad). |
1996-11-07 |
2023-08-12 |
Not clear |
| S J Wood, W Chan, R Wetze. Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E. Biochemistry. vol 35. issue 38. 1996-11-05. PMID:8823200. |
seeding of a beta fibril formation is inhibited by all three isotypes of apolipoprotein e. apolipoprotein e is immunochemically localized to amyloid plaque in alzheimer's brains, and the allelic distribution of apoe in individuals is associated with a disposition toward alzheimer's disease. |
1996-11-05 |
2023-08-12 |
cattle |
| Z Zhou, J D Smith, P Greengard, S Gand. Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E. Molecular medicine (Cambridge, Mass.). vol 2. issue 2. 1996-11-01. PMID:8726460. |
alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein e. the apolipoprotein e (apoe) type epsilon 4 isoform specifies increased cerebral and cerebrovascular accumulation of amyloid-beta protein (a beta) and contributes to the genetic susceptibility underlying a large proportion (approximately 60%) of typical, sporadic alzheimer disease. |
1996-11-01 |
2023-08-12 |
Not clear |