| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Moulard, A Sefiani, A Laamri, A Malafosse, W Cam. Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis. Journal of the neurological sciences. vol 139 Suppl. 1997-02-12. PMID:8899655. |
recently, in alzheimer's disease (ad) apolipoprotein e (apoe) alleles have been shown to play an important role in disease phenotype. |
1997-02-12 |
2023-08-12 |
human |
| S Satoh, T Tokuda, S Ikeda, Y Sekijima, N Yanagisawa, H Hidaka, F Kametan. No association between apolipoprotein E epsilon4 allele and the age of onset in type I familial amyloid polyneuropathy. Neuroscience letters. vol 204. issue 3. 1997-02-06. PMID:8938267. |
it has been shown that the apolipoprotein e (apoe) epsilon4 allele increases the risk of developing alzheimer's disease (ad) and lowers the age of its onset. |
1997-02-06 |
2023-08-12 |
Not clear |
| C Schwab, J C Steele, H Akiyama, P L McGee. Distinct distribution of apolipoprotein E and beta-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam. Acta neuropathologica. vol 92. issue 4. 1997-02-05. PMID:8891070. |
the distribution of apolipoprotein e (apoe) was studied in the brain tissue of cases of the amyotrophic lateral sclerosis-parkinsonism-dementia complex of guam, locally known as lytico bodig disease (lb), and compared with cases of alzheimer's disease (ad) and normal brain tissue. |
1997-02-05 |
2023-08-12 |
Not clear |
| C Holmes, R Levy, D M McLoughlin, J F Powell, S Loveston. Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 61. issue 6. 1997-02-04. PMID:8971103. |
to determine the association between the epsilon2 and epsilon4 alleles of apolipoprotein e (apoe) and independent measures of cognitive decline and non-cognitive symptomatology in late onset alzheimer's disease. |
1997-02-04 |
2023-08-12 |
Not clear |
| M X Tang, G Maestre, W Y Tsai, X H Liu, L Feng, W Y Chung, M Chun, P Schofield, Y Stern, B Tycko, R Mayeu. Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993479. |
effect of age, ethnicity, and head injury on the association between apoe genotypes and alzheimer's disease. |
1997-02-04 |
2023-08-12 |
Not clear |
| M X Tang, G Maestre, W Y Tsai, X H Liu, L Feng, W Y Chung, M Chun, P Schofield, Y Stern, B Tycko, R Mayeu. Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993479. |
the association between apolipoprotein e (apoe)-epsilon 4 and alzheimer's disease has been confirmed worldwide. |
1997-02-04 |
2023-08-12 |
Not clear |
| M X Tang, G Maestre, W Y Tsai, X H Liu, L Feng, W Y Chung, M Chun, P Schofield, Y Stern, B Tycko, R Mayeu. Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993479. |
in this review we describe a new method we developed to compare relative risks by apoe genotypes in an expanded cohort of cases and controls from three ethnic groups in a new york city community and discuss the association as between apoe epsilon 4 and alzheimer's disease as modified by head injury. |
1997-02-04 |
2023-08-12 |
Not clear |
| M X Tang, G Maestre, W Y Tsai, X H Liu, L Feng, W Y Chung, M Chun, P Schofield, Y Stern, B Tycko, R Mayeu. Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993479. |
compared to persons with apoe epsilon 3/epsilon 3 genotypes, relative risk (rr) for alzheimer's disease associated with apoe epsilon 4 homozygosity was similar across ethnic groups (african-american rr = 3.3; 95% c.i. |
1997-02-04 |
2023-08-12 |
Not clear |
| M X Tang, G Maestre, W Y Tsai, X H Liu, L Feng, W Y Chung, M Chun, P Schofield, Y Stern, B Tycko, R Mayeu. Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993479. |
a 10-fold increase in the risk of alzheimer's disease was associated with both apoe epsilon 4 and a history of traumatic head injury, compared to a twofold increase in risk with apoe epsilon 4 alone. |
1997-02-04 |
2023-08-12 |
Not clear |
| M X Tang, G Maestre, W Y Tsai, X H Liu, L Feng, W Y Chung, M Chun, P Schofield, Y Stern, B Tycko, R Mayeu. Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993479. |
these results imply that in alzheimer's disease genotypic risk associated with apoe may be influenced by age, ethnicity, and certain environmental factors. |
1997-02-04 |
2023-08-12 |
Not clear |
| M Mullan, P Scibelli, R Duara, D Fallin, M Gold, J Schinka, J Hoyne, A Osborne, S Sevush, F Crawfor. Familial and population-based studies of apolipoprotein E and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993480. |
the finding of an association between the epsilon 4 allele of the apoe locus and the early expression of late-onset alzheimer's disease (ad) is robust. |
1997-02-04 |
2023-08-12 |
Not clear |
| S T DeKosky, C E Aston, M I Kambo. Polygenic determinants of Alzheimer's disease: modulation of the risk by alpha-1-antichymotrypsin. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993481. |
the identification of apolipoprotein e (apoe) as a genetic risk factor modifying the chances of developing alzheimer's disease (ad) has opened the possibility that other susceptibility genes exist that either independently modify the risk of developing ad or alter the risk imparted by apoe. |
1997-02-04 |
2023-08-12 |
Not clear |
| A D Rose. Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993484. |
the alzheimer's association and the national institute on aging sponsored a meeting of experts in alzheimer's disease (ad), geneticists, social scientists, and ethicists in chicago in october 1995 to discuss the use of apolipoprotein e (apoe) genotyping in alzheimer's disease. |
1997-02-04 |
2023-08-12 |
Not clear |
| A D Rose. Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993484. |
the genetic association of apoe genotypes with the age of onset distribution and risk of alzheimer's disease was reviewed. |
1997-02-04 |
2023-08-12 |
Not clear |
| R C Petersen, S C Waring, G E Smith, E G Tangalos, S N Thibodea. Predictive value of APOE genotyping in incipient Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993485. |
predictive value of apoe genotyping in incipient alzheimer's disease. |
1997-02-04 |
2023-08-12 |
human |
| G W Small, S Komo, A La Rue, S Saxena, M E Phelps, J C Mazziotta, A M Saunders, J L Haines, M A Pericak-Vance, A D Rose. Early detection of Alzheimer's disease by combining apolipoprotein E and neuroimaging. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993486. |
the discovery of the apolipoprotein e epsilon 4 allele (apoe epsilon 4) as a major risk factor for ad offers promise of assisting in early detection and prediction of alzheimer's disease, particularly when genetic assessments are combined with other biomarkers such as neuroimaging. |
1997-02-04 |
2023-08-12 |
Not clear |
| M R Farlow, D K Lahiri, J Poirier, J Davignon, S Hu. Apolipoprotein E genotype and gender influence response to tacrine therapy. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993489. |
our objective is to evaluate the effects of apolipoprotein e genotype (apoe) on clinical response to treatment with tacrine, in patients with alzheimer's disease (ad). |
1997-02-04 |
2023-08-12 |
Not clear |
| S G Pos. On not jumping the gun: ethical aspects of APOE gene testing for Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993490. |
on not jumping the gun: ethical aspects of apoe gene testing for alzheimer's disease. |
1997-02-04 |
2023-08-12 |
Not clear |
| L M Flec. Just caring: the moral and economic costs of APOE genotyping for Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993492. |
just caring: the moral and economic costs of apoe genotyping for alzheimer's disease. |
1997-02-04 |
2023-08-12 |
Not clear |
| M B Kap. Medicolegal, employment, and insurance issues in APOE genotyping and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993493. |
medicolegal, employment, and insurance issues in apoe genotyping and alzheimer's disease. |
1997-02-04 |
2023-08-12 |
Not clear |