| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N R Relkin, Y J Kwon, J Tsai, S Gand. The National Institute on Aging/Alzheimer's Association recommendations on the application of apolipoprotein E genotyping to Alzheimer's disease. Annals of the New York Academy of Sciences. vol 802. 1997-02-04. PMID:8993494. |
in a conference held in chicago during october 1995, a working group of the national institute of aging (nia) and the alzheimer's association (alza) drafted consensus recommendations on research and clinical applications of apoe genetic susceptibility testing for alzheimer's disease (ad). |
1997-02-04 |
2023-08-12 |
Not clear |
| T Uchihara, C Duyckaerts, F Lazarini, K Mokhtari, D Seilhean, P Amouyel, J J Hau. Inconstant apolipoprotein E (ApoE)-like immunoreactivity in amyloid beta protein deposits: relationship with APOE genotype in aging brain and Alzheimer's disease. Acta neuropathologica. vol 92. issue 2. 1997-02-03. PMID:8841664. |
inconstant apolipoprotein e (apoe)-like immunoreactivity in amyloid beta protein deposits: relationship with apoe genotype in aging brain and alzheimer's disease. |
1997-02-03 |
2023-08-12 |
Not clear |
| J G Sheng, R E Mrak, W S Griffi. Apolipoprotein E distribution among different plaque types in Alzheimer's disease: implications for its role in plaque progression. Neuropathology and applied neurobiology. vol 22. issue 4. 1997-01-23. PMID:8875468. |
we sought to determine the pattern of apoe immunoreactivity in mesial temporal lobe tissue from 12 alzheimer patients, age 66-88, and to determine the distribution of this immunoreactivity among different plaque types representing hypothesized stages of plaque evolution. |
1997-01-23 |
2023-08-12 |
Not clear |
| J G Sheng, R E Mrak, W S Griffi. Apolipoprotein E distribution among different plaque types in Alzheimer's disease: implications for its role in plaque progression. Neuropathology and applied neurobiology. vol 22. issue 4. 1997-01-23. PMID:8875468. |
our results are also consistent with a role for apoe in the condensation of diffuse amyloid deposits into a beta-pleated-sheet form that occurs concomitant with dystrophic neurite formation in the neuritic beta-amyloid plaques of alzheimer's disease. |
1997-01-23 |
2023-08-12 |
Not clear |
| R Mayeu. Development of a national prospective study of Alzheimer disease. Alzheimer disease and associated disorders. vol 10 Suppl 1. 1997-01-16. PMID:8876789. |
the association between alzheimer disease and apoe also varies with age, genetic background, and ethnic group. |
1997-01-16 |
2023-08-12 |
Not clear |
| R Mayeu. Development of a national prospective study of Alzheimer disease. Alzheimer disease and associated disorders. vol 10 Suppl 1. 1997-01-16. PMID:8876789. |
while the use of apoe genotyping has provided a method to identify individuals at greatest risk of alzheimer disease, how other factors modify the degrees of the apoe-related risk needs to be further investigated. |
1997-01-16 |
2023-08-12 |
Not clear |
| A M Fagan, G Bu, Y Sun, A Daugherty, D M Holtzma. Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. The Journal of biological chemistry. vol 271. issue 47. 1997-01-13. PMID:8939961. |
presence of the epsilon4 allele of apolipoprotein e (apoe) is a risk factor for alzheimer's disease (ad), although the mechanism(s) by which it confers this risk is unknown. |
1997-01-13 |
2023-08-12 |
Not clear |
| S Zhu, M M Nöthen, S Uhlhaas, M Rietschel, J Körner, M Lanczik, R Fimmers, P Proppin. Apolipoprotein E genotype distribution in schizophrenia. Psychiatric genetics. vol 6. issue 2. 1997-01-10. PMID:8840393. |
we examined the hypothesis that apolipoprotein e (apoe) isoforms-besides their well-established role in the aetiology of early and late onset alzheimer's disease (ad)-may be involved in the development of schizophrenia. |
1997-01-10 |
2023-08-12 |
Not clear |
| M Landén, C Hesse, P Fredman, B Regland, A Wallin, K Blenno. Apolipoprotein E in cerebrospinal fluid from patients with Alzheimer's disease and other forms of dementia is reduced but without any correlation to the apoE4 isoform. Dementia (Basel, Switzerland). vol 7. issue 5. 1997-01-10. PMID:8872419. |
apolipoprotein e (apoe) has been suggested to play a role in regenerative processes in the brain after trauma, and also in the pathogenesis of alzheimer's disease (ad). |
1997-01-10 |
2023-08-12 |
Not clear |
| D L Murman, N L Foster, S P Kilgore, C A McDonagh, J K Fin. Apolipoprotein E and Alzheimer's disease: strength of association is related to age at onset. Dementia (Basel, Switzerland). vol 7. issue 5. 1997-01-10. PMID:8872415. |
apolipoprotein e (apoe) epsilon 4 allele frequency among alzheimer's disease (ad) patients is increased compared to control subjects and is influenced by the presence of other genetic factors and age at symptom onset. |
1997-01-10 |
2023-08-12 |
human |
| E Jönsson, L Lannfelt, B Engvall, G Sedval. Lack of association between schizophrenia and the apolipoprotein E epsilon 4 allele. European archives of psychiatry and clinical neuroscience. vol 246. issue 4. 1997-01-08. PMID:8832195. |
the association between the epsilon 4 allele of the apolipoprotein e (apoe) gene and alzheimer's disease (ad) has been reported. |
1997-01-08 |
2023-08-12 |
human |
| M A García, J Vázquez, C Giménez, F Valdivieso, F Zafr. Transcription factor AP-2 regulates human apolipoprotein E gene expression in astrocytoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 23. 1997-01-06. PMID:8922411. |
apoe is involved in processes of degeneration and regeneration after nerve lesions as well as in the pathogenesis of alzheimer's disease (ad). |
1997-01-06 |
2023-08-12 |
human |
| K H Weisgraber, R W Mahle. Human apolipoprotein E: the Alzheimer's disease connection. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 10. issue 13. 1997-01-03. PMID:8940294. |
in a variety of populations worldwide, one of the three common alleles of apoe, apoe4, is overrepresented in alzheimer's subjects compared with age- and sex-matched controls. |
1997-01-03 |
2023-08-12 |
human |
| K H Weisgraber, R W Mahle. Human apolipoprotein E: the Alzheimer's disease connection. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 10. issue 13. 1997-01-03. PMID:8940294. |
the genetic and epidemiologic evidence suggests that apoe is a major susceptibility gene for alzheimer's disease; it likely accounts for a major portion of the genetic heterogeneity in the disease. |
1997-01-03 |
2023-08-12 |
human |
| K H Weisgraber, R W Mahle. Human apolipoprotein E: the Alzheimer's disease connection. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 10. issue 13. 1997-01-03. PMID:8940294. |
although its role in the development of alzheimer's disease is unknown, biochemical and cell biology studies are providing important insights into how apoe may be involved in neurodegenerative disorders. |
1997-01-03 |
2023-08-12 |
human |
| M Lehtovirta, J Partanen, M Könönen, H Soininen, S Helisalmi, A Mannermaa, M Ryynänen, P Hartikainen, P Riekkine. Spectral analysis of EEG in Alzheimer's disease: relation to apolipoprotein E polymorphism. Neurobiology of aging. vol 17. issue 4. 1996-12-20. PMID:8832625. |
apolipoprotein e (apoe) epsilon 4 allele is a risk factor for late-onset alzheimer's disease (ad) and proposed to have a direct impact on cholinergic function in ad. |
1996-12-20 |
2023-08-12 |
Not clear |
| T Pirttilä, H Soininen, O Heinonen, T Lehtimäki, N Bogdanovic, L Paljärvi, O Kosunen, B Winblad, P Riekkinen, H M Wisniewski, P D Meht. Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls. Brain research. vol 722. issue 1-2. 1996-12-18. PMID:8813351. |
apolipoprotein e (apoe) levels in brains from alzheimer disease patients and controls. |
1996-12-18 |
2023-08-12 |
Not clear |
| T Pirttilä, H Soininen, O Heinonen, T Lehtimäki, N Bogdanovic, L Paljärvi, O Kosunen, B Winblad, P Riekkinen, H M Wisniewski, P D Meht. Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls. Brain research. vol 722. issue 1-2. 1996-12-18. PMID:8813351. |
we measured apolipoprotein e (apoe) level in neutral and acidic ph extracts of the frontal, temporal and cerebellar cortices from patients with definite alzheimer's disease (ad) and controls, and analyzed the relationship among apoe levels, clinical and neuropathological findings, and apoe genotype. |
1996-12-18 |
2023-08-12 |
Not clear |
| J Poirie. Apolipoprotein E in the brain and its role in Alzheimer's disease. Journal of psychiatry & neuroscience : JPN. vol 21. issue 2. 1996-12-17. PMID:8820179. |
the recent discovery that a peculiar form of apoe, the apoe4, is strongly linked to both sporadic and familial late onset alzheimer's disease (ad) raises the possibility that a dysfunction of the lipid transport system associated with compensatory sprouting and synaptic remodelling could be central to the ad process. |
1996-12-17 |
2023-08-12 |
Not clear |
| S Lovestone, B H Anderton, C Hartley, T G Jensen, A L Jorgense. The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific. Neuroreport. vol 7. issue 5. 1996-12-11. PMID:8804040. |
the apolipoprotein e (apoe) gene has been identified as a susceptibility gene for alzheimer's disease, although the mechanism whereby apoe exerts this effect has not been determined. |
1996-12-11 |
2023-08-12 |
Not clear |