| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Johnston, S Norgren, R Ravid, W Wasco, B Winblad, L Lannfelt, R F Cowbur. Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037522. |
quantification of app and aplp2 mrna in apoe genotyped alzheimer's disease brains. |
1997-05-29 |
2023-08-12 |
human |
| F Pasquier, D Ley. Why are stroke patients prone to develop dementia? Journal of neurology. vol 244. issue 3. 1997-05-29. PMID:9050953. |
secondly, post-stroke dementia may be due to an associated asymptomatic alzheimer pathology; the reasons for such an association are that (1) some cases of dementia occurring after a stroke are progressive and alzheimer's disease (ad) is the most frequent cause of progressive dementia; (2) age and apoe epsilon 4 genotype are risk factors for both ad and ischaemic stroke; (3) a vasculopathy is often associated with ad. |
1997-05-29 |
2023-08-12 |
Not clear |
| K Ishii, A Tamaoka, H Mizusawa, S Shoji, T Ohtake, P E Fraser, H Takahashi, S Tsuji, M Gearing, T Mizutani, S Yamada, M Kato, P H St George-Hyslop, S S Mirra, H Mor. Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease. Brain research. vol 748. issue 1-2. 1997-05-27. PMID:9067471. |
apolipoprotein e (apoe) epsilon4 allele is established to be a risk factor for the development of late-onset alzheimer's disease (ad) which is associated with increased frequency of senile plaques and extent of amyloid angiopathy. |
1997-05-27 |
2023-08-12 |
Not clear |
| O F Olesen, J D Mikkelsen, C Gerdes, P H Jense. Isoform-specific binding of human apolipoprotein E to the non-amyloid beta component of Alzheimer's disease amyloid. Brain research. Molecular brain research. vol 44. issue 1. 1997-05-22. PMID:9030704. |
the isoform-specific binding of nac to apoe may thus play an important role in amyloidogenesis and in the sequestering of apoe in senile plaques during the progress of alzheimer's disease. |
1997-05-22 |
2023-08-12 |
human |
| E Zunarelli, J A Nicoll, D I Graha. Presenilin-1 polymorphism and amyloid beta-protein deposition in fatal head injury. Neuroreport. vol 8. issue 1. 1997-05-20. PMID:9051750. |
a beta deposition occurs in alzheimer's disease (ad), for which approximately 50% of the genetic risk is attributed to apoe epsilon 4. |
1997-05-20 |
2023-08-12 |
Not clear |
| G M Murphy, J Taylor, H C Kraemer, J Yesavage, J R Tinklenber. No association between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer's disease. The American journal of psychiatry. vol 154. issue 5. 1997-05-19. PMID:9137113. |
the relationship between number of apolipoprotein e epsilon 4 (apoe epsilon 4) alleles and the rate of cognitive decline in patients with alzheimer's disease was examined. |
1997-05-19 |
2023-08-12 |
Not clear |
| Z Yamagata, T Asada, A Kinoshita, Y Zhang, A Asak. Distribution of apolipoprotein E gene polymorphisms in Japanese patients with Alzheimer's disease and in Japanese centenarians. Human heredity. vol 47. issue 1. 1997-05-14. PMID:9017975. |
we have demonstrated an association between apolipoprotein e (apoe) gene polymorphisms and alzheimer's disease (ad) in 163 japanese patients by means of pcr. |
1997-05-14 |
2023-08-12 |
Not clear |
| G S Zubenko, R Henderson, J S Stiffler, S Stabler, J Rosen, B B Kapla. Association of the APOE epsilon 4 allele with clinical subtypes of late life depression. Biological psychiatry. vol 40. issue 10. 1997-05-13. PMID:8915560. |
we specifically tested the hypothesis that the frequency of the apoe epsilon 4 allele is elevated in depressed elders with cognitive impairment or psychotic features, subtypes that have been reported to be at increased risk of developing alzheimer's disease (ad). |
1997-05-13 |
2023-08-12 |
Not clear |
| W J Strittmatter, A D Rose. Apolipoprotein E and Alzheimer's disease. Annual review of neuroscience. vol 19. 1997-05-12. PMID:8833436. |
the apolipoprotein e locus (apoe) is associated with variations in the age of onset and risk of alzheimer's disease. |
1997-05-12 |
2023-08-12 |
Not clear |
| S Higuchi, H Arai, T Nakagawa, T Muramatsu, H Sasaki, J Q Trojanowsk. The apolipoprotein E gene in Binswanger's disease and vascular dementia. Clinical genetics. vol 50. issue 6. 1997-05-09. PMID:9147873. |
we investigated the polymorphism of the apolipoprotein e (apoe) gene using a pcr-rflp method in patients with binswanger's disease (bd), non-bd vascular dementia, or alzheimer's disease (ad). |
1997-05-09 |
2023-08-12 |
Not clear |
| C L Lendon, C J Talbot, N J Craddock, S W Han, M Wragg, J C Morris, A M Goat. Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population. Neuroscience letters. vol 222. issue 3. 1997-05-09. PMID:9148246. |
the epsilon 4 allele of the apolipoprotein e gene (apoe) is associated with an increased risk for sporadic and some familial forms of alzheimer's disease (ad) but the precise mechanism of pathogenesis is unknown. |
1997-05-09 |
2023-08-12 |
Not clear |
| H Payami, H Grimslid, B Oken, R Camicioli, G Sexton, A Dame, D Howieson, J Kay. A prospective study of cognitive health in the elderly (Oregon Brain Aging Study): effects of family history and apolipoprotein E genotype. American journal of human genetics. vol 60. issue 4. 1997-05-08. PMID:9106542. |
the aim of this study was to determine whether the genetic risk factors for alzheimer disease (ad)--namely, apolipoprotein e (apoe) epsilon4 allele and a family history of dementia-continue to be important factors in the cognitive health of the very old. |
1997-05-08 |
2023-08-12 |
human |
| Y Shao, M Gearing, S S Mirr. Astrocyte-apolipoprotein E associations in senile plaques in Alzheimer disease and vascular lesions: a regional immunohistochemical study. Journal of neuropathology and experimental neurology. vol 56. issue 4. 1997-05-01. PMID:9100668. |
while apolipoprotein e (apoe) and beta-amyloid (a beta) co-localize in senile plaques in cortex and cerebellum in alzheimer disease (ad), the a beta-positive, predominantly diffuse plaques in the striatum do not exhibit apoe immunoreactivity regardless of disease duration. |
1997-05-01 |
2023-08-12 |
Not clear |
| N J Cairns, P F Atkinson, T Kovács, A J Lees, S E Daniel, P L Lanto. Apolipoprotein E e4 allele frequency in patients with multiple system atrophy. Neuroscience letters. vol 221. issue 2-3. 1997-04-18. PMID:9121689. |
the apoe e4 allele frequency in the alzheimer's disease subjects was significantly increased (0.44, p < 0.001), as has been reported previously. |
1997-04-18 |
2023-08-12 |
human |
| D M Mann, T Iwatsubo, S M Pickering-Brown, F Owen, T C Saido, R H Perr. Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele. Neuroscience letters. vol 221. issue 2-3. 1997-04-18. PMID:9121705. |
the effect of apolipoprotein e (apoe) genotype on the deposition of amyloid beta protein (abeta) was examined in 54 patients with alzheimer's disease. |
1997-04-18 |
2023-08-12 |
Not clear |
| E Masliah, M Mallory, I Veinbergs, A Miller, W Samue. Alterations in apolipoprotein E expression during aging and neurodegeneration. Progress in neurobiology. vol 50. issue 5-6. 1997-04-17. PMID:9015824. |
the main objective of the manuscript is to review the current progress in understanding the functions of apoe in the nervous system and how malfunctioning of this molecule might result in neurodegenerative disorders such as alzheimer's disease. |
1997-04-17 |
2023-08-12 |
Not clear |
| C G Lyketsos, L Baker, A Warren, C Steele, J Brandt, M Steinberg, S Kopunek, A Bake. Depression, delusions, and hallucinations in Alzheimer's disease: no relationship to apolipoprotein E genotype. The Journal of neuropsychiatry and clinical neurosciences. vol 9. issue 1. 1997-04-17. PMID:9017530. |
the apolipoprotein e (apoe) locus on chromosome 19 has been shown to modify risk, and age at onset, of alzheimer's disease (ad). |
1997-04-17 |
2023-08-12 |
Not clear |
| X Y Dai, M Hattori, J Yoshizawa, H Matsuda, H Arai, S Akizuki, S Nank. No association between c-fos gene polymorphisms and sporadic Alzheimer's disease. Psychiatry and clinical neurosciences. vol 50. issue 6. 1997-04-10. PMID:9014232. |
although apoe epsilon 4 is a major risk factor for sporadic alzheimer's disease (ad), 20-30% of sporadic ad patients do not have this allele. |
1997-04-10 |
2023-08-12 |
Not clear |
| E H Corder, V Jelic, H Basun, L Lannfelt, S Valind, B Winblad, A Nordber. No difference in cerebral glucose metabolism in patients with Alzheimer disease and differing apolipoprotein E genotypes. Archives of neurology. vol 54. issue 3. 1997-04-10. PMID:9074396. |
recent findings of a reduced cerebral metabolic rate of glucose (cmrglu) in at-risk relatives of patients with alzheimer disease (ad) who carry the apolipoprotein e (apoe) epsilon 4 allele suggest a causative role for the e4 isoform in cognitive changes that lead to ad. |
1997-04-10 |
2023-08-12 |
Not clear |
| G W Small, E P Noble, S S Matsuyama, L F Jarvik, S Komo, A Kaplan, T Ritchie, M L Pritchard, A M Saunders, P M Conneally, A D Roses, J L Haines, M A Pericak-Vanc. D2 dopamine receptor A1 allele in Alzheimer disease and aging. Archives of neurology. vol 54. issue 3. 1997-04-10. PMID:9074397. |
the apolipoprotein e4 (apoe*4) allele is a major risk factor for the common forms of late-onset alzheimer disease (ad), but does not account for all the genetic variation in late-onset ad; hence, other genetic markers must be examined. |
1997-04-10 |
2023-08-12 |
Not clear |