| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Babin, C Thisse, M Durliat, M Andre, M A Akimenko, B Thiss. Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 16. 1997-09-08. PMID:9238027. |
besides its role in cardiovascular diseases, accumulating evidence has suggested that apoe could play a role in neurodegenerative diseases, such as alzheimer disease. |
1997-09-08 |
2023-08-12 |
human |
| D E Kang, T Saitoh, X Chen, Y Xia, E Masliah, L A Hansen, R G Thomas, L J Thal, R Katzma. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease. Neurology. vol 49. issue 1. 1997-09-03. PMID:9222170. |
the presence of the apoe epsilon 4 allele encoding apolipoprotein e4 (apoe4) is the major genetic risk factor for late-onset alzheimer's disease (ad). |
1997-09-03 |
2023-08-12 |
human |
| G E Alexander, A M Saunders, J Szczepanik, T L Strassburger, P Pietrini, A Dani, M L Furey, M J Mentis, A D Roses, S I Rapoport, M B Schapir. Relation of age and apolipoprotein E to cognitive function in Down syndrome adults. Neuroreport. vol 8. issue 8. 1997-08-29. PMID:9223061. |
to test the cognitive effects of aging and apolipoprotein e (apoe) in individuals at high risk for alzheimer's disease (ad), we assessed apoe genotypes and performance on a battery of neuropsychological tests in 41 non-demented, down syndrome (ds) adults. |
1997-08-29 |
2023-08-12 |
human |
| A M Cataldo, J L Barnett, C Pieroni, R A Nixo. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 16. 1997-08-28. PMID:9236226. |
it is the site of internalization and initial processing of amyloid precursor protein (app) and apolipoprotein e (apoe), two proteins of etiological importance in alzheimer's disease, and a putative site of beta-amyloid peptide (abeta) formation. |
1997-08-28 |
2023-08-12 |
human |
| F M LaFerla, J C Troncoso, D K Strickland, C H Kawas, G Ja. Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. The Journal of clinical investigation. vol 100. issue 2. 1997-08-15. PMID:9218507. |
neuronal cell death in alzheimer's disease correlates with apoe uptake and intracellular abeta stabilization. |
1997-08-15 |
2023-08-12 |
Not clear |
| A Yoshiiwa, K Kamino, H Yamamoto, T Kobayashi, M Imagawa, Y Nonomura, H Yoneda, T Sakai, Y Nishiwaki, N Sato, H Rakugi, T Miki, T Ogihar. alpha 1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E epsilon 4 allele carriers. Annals of neurology. vol 42. issue 1. 1997-08-12. PMID:9225693. |
in the japanese population, sporadic late-onset alzheimer's disease (load) cases had significantly higher frequencies of the a allele of alpha 1-antichymotrypsin (act) gene as well as the epsilon 4 allele of apolipoprotein e (apoe) gene than controls. |
1997-08-12 |
2023-08-12 |
Not clear |
| S E Arnold, E Joo, M G Martinoli, N Roy, J Q Trojanowski, R E Gur, T Cannon, R A Pric. Apolipoprotein E genotype in schizophrenia: frequency, age of onset, and neuropathologic features. Neuroreport. vol 8. issue 6. 1997-08-07. PMID:9172167. |
however, the apoe epsilon 4 genotype was associated with a younger age of onset of schizophrenia, and in an elderly subsample, individuals with the epsilon 4 allele more frequently exhibited co-existent dementia and had more neurofibrillary pathology (although none of the cases met criteria for alzheimer's disease). |
1997-08-07 |
2023-08-12 |
Not clear |
| A Calenda, V Jallageas, S Silhol, M Bellis, N Bon. Identification of a unique apolipoprotein E allele in Microcebus murinus; ApoE brain distribution and co-localization with beta-amyloid and tau proteins. Neurobiology of disease. vol 2. issue 3. 1997-08-07. PMID:9174000. |
the distribution of the corresponding apoe protein in the brain was found in association with the pathological proteins characteristic of alzheimer's disease (ad). |
1997-08-07 |
2023-08-12 |
human |
| A L Biere, B Ostaszewski, H Zhao, S Gillespie, S G Younkin, D J Selko. Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing. Neurobiology of disease. vol 2. issue 3. 1997-08-07. PMID:9174001. |
apolipoprotein e (apoe) is the major genetic risk factor for alzheimer's disease (ad). |
1997-08-07 |
2023-08-12 |
human |
| C Haas, P Cazorla, C D Miguel, F Valdivieso, J Vázque. Apolipoprotein E forms stable complexes with recombinant Alzheimer's disease beta-amyloid precursor protein. The Biochemical journal. vol 325 ( Pt 1). 1997-08-07. PMID:9224643. |
apolipoprotein e (apoe), a protein genetically linked to the incidence of alzheimer's disease, forms sds-stable complexes in vitro with beta-amyloid peptide (abeta), the primary component of senile plaques. |
1997-08-07 |
2023-08-12 |
human |
| H Arai, S Higuchi, H Sasak. Apolipoprotein E genotyping and cerebrospinal fluid tau protein: implications for the clinical diagnosis of Alzheimer's disease. Gerontology. vol 43 Suppl 1. 1997-08-04. PMID:9187933. |
apolipoprotein e (apoe) genotyping was conducted in sporadic alzheimer's disease (ad, n = 91) as well as in other dementing disorders including parkinson's disease (pd, n = 73), autopsy-confirmed diffuse lewy body disease (dlbd, n = 16), progressive supranuclear palsy (n = 13), vascular dementia (n = 55), alcoholic dementia (n =25) and normal control subjects (n = 77). |
1997-08-04 |
2023-08-12 |
human |
| M Ezquerra, R Blesa, E Tolosa, S Lopez Pousa, M Aguilar, J Peña, C Van Broeckhoven, F Ballesta, R Oliv. The genotype 2/2 of the presenilin-1 polymorphism is decreased in Spanish early-onset Alzheimer's disease. Neuroscience letters. vol 227. issue 3. 1997-07-28. PMID:9185685. |
we have found a significantly lower frequency of the presenilin-1 (ps-1) intronic polymorphism 2/2 genotype in early-onset alzheimer's disease (ad) patients without apoe epsilon4 alleles (2/2 = 0.054; p = 0.009) as compared to age matched non-epsilon4 controls (2/2 = 0.227). |
1997-07-28 |
2023-08-12 |
Not clear |
| D Fallin, A C Gauntlett, P Scibelli, X Cai, R Duara, M Gold, F Crawford, M Mulla. No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease nor interaction with the apolipoprotein E gene in population-based and clinic samples. Genetic epidemiology. vol 14. issue 3. 1997-07-24. PMID:9181358. |
it is now commonly known that possession of one of the three common alleles of the apolipoprotein e (apoe) gene (allele epsilon 4) confers an increased risk for both familial and sporadic alzheimer's disease (ad), and that this risk is dose-dependent. |
1997-07-24 |
2023-08-12 |
Not clear |
| S W Barger, M P Mattso. Isoform-specific modulation by apolipoprotein E of the activities of secreted beta-amyloid precursor protein. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202294. |
the genes for both the beta-amyloid precursor protein and apolipoprotein e (apoe) have been linked to alzheimer's disease. |
1997-07-24 |
2023-08-12 |
rat |
| V Jelic, P Julin, M Shigeta, A Nordberg, L Lannfelt, B Winblad, L O Wahlun. Apolipoprotein E epsilon4 allele decreases functional connectivity in Alzheimer's disease as measured by EEG coherence. Journal of neurology, neurosurgery, and psychiatry. vol 63. issue 1. 1997-07-24. PMID:9221969. |
the epsilon4 allele of apolipoprotein e (apoe) represents a major biological risk factor for late onset alzheimer's disease. |
1997-07-24 |
2023-08-12 |
Not clear |
| O Didierjean, M Martinez, D Campion, D Hannequin, B Dubois, C Martin, M Puel, C Thomas Anterion, F Pasquier, O Moreau, M C Babron, C Penet, Y Agid, F Clerget-Darpoux, T Frebourg, A Bric. No effect of the alpha1-antichymotrypsin A allele in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 63. issue 1. 1997-07-24. PMID:9221977. |
the apolipoprotein e (apoe)-epsilon4 allele is associated in a dose dependent manner to an increased risk for alzheimer's disease. |
1997-07-24 |
2023-08-12 |
Not clear |
| O Didierjean, M Martinez, D Campion, D Hannequin, B Dubois, C Martin, M Puel, C Thomas Anterion, F Pasquier, O Moreau, M C Babron, C Penet, Y Agid, F Clerget-Darpoux, T Frebourg, A Bric. No effect of the alpha1-antichymotrypsin A allele in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 63. issue 1. 1997-07-24. PMID:9221977. |
the apoe and aact genotypes were analysed in 314 patients with alzheimer's disease and 173 healthy controls, confirming the dose dependent effect of the apoe-epsilon4 allele. |
1997-07-24 |
2023-08-12 |
Not clear |
| L Minthon, C Hesse, M Sjögren, E Englund, L Gustafson, K Blenno. The apolipoprotein E epsilon4 allele frequency is normal in fronto-temporal dementia, but correlates with age at onset of disease. Neuroscience letters. vol 226. issue 1. 1997-07-21. PMID:9153643. |
these dementing diseases have neuronal and synaptic degeneration in common with alzheimer's disease (ad), for which the presence of the apoe epsilon4 allele is a known risk factor, and lowers the age of onset of disease. |
1997-07-21 |
2023-08-12 |
Not clear |
| B D Jordan, N R Relkin, L D Ravdin, A R Jacobs, A Bennett, S Gand. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA. vol 278. issue 2. 1997-07-17. PMID:9214529. |
given the similarities between alzheimer disease and dementia pugilistica, we evaluated the relationship between apolipoprotein e (apoe) genotype and chronic traumatic brain injury (ctbi) in boxers to determine whether there is a genetic susceptibility to the effects of head trauma. |
1997-07-17 |
2023-08-12 |
Not clear |
| M I Kamboh, D K Sanghera, C E Aston, C H Bunker, R F Hamman, R E Ferrell, S T DeKosk. Gender-specific nonrandom association between the alpha 1-antichymotrypsin and apolipoprotein E polymorphisms in the general population and its implication for the risk of Alzheimer's disease. Genetic epidemiology. vol 14. issue 2. 1997-07-16. PMID:9129962. |
a common polymorphism in the alpha 1-antichymotrypsin (act) gene has been found co modify the apoe*4-associated risk of alzheimer's disease due to an apparent interaction between the two loci. |
1997-07-16 |
2023-08-12 |
Not clear |