| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ezquerra, R Blesa, E Tolosa, F Ballesta, R Oliv. Alpha-antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish population. Neuroscience letters. vol 240. issue 2. 1998-04-02. PMID:9486483. |
the alpha-antichymotrypsin (act) and the apoe polymorphisms have been determined in 136 alzheimer's disease (ad) patients and in 92 age-matched controls. |
1998-04-02 |
2023-08-12 |
human |
| B Schmand, C Hooijer, C Jonker, J Lindeboom, L M Haveke. Apolipoprotein E phenotype is not related to late-life depression in a population-based sample. Social psychiatry and psychiatric epidemiology. vol 33. issue 1. 1998-03-19. PMID:9448441. |
it was expected that apoe epsilon 4 allele frequencies would be elevated not only in alzheimer's disease and dementia in general, but also in first episode, late-life depression accompanied by subtle cognitive impairment (possibly organic depression). |
1998-03-19 |
2023-08-12 |
Not clear |
| W A Kukull, G M Marti. APOE polymorphisms and late-onset Alzheimer disease: the importance of ethnicity. JAMA. vol 279. issue 10. 1998-03-19. PMID:9508157. |
apoe polymorphisms and late-onset alzheimer disease: the importance of ethnicity. |
1998-03-19 |
2023-08-12 |
Not clear |
| H Lamb, J Christie, A B Singleton, A Leake, R H Perry, P G Ince, I G McKeith, L M Melton, J A Edwardson, C M Morri. Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies. Distinctions between diseases. Neurology. vol 50. issue 2. 1998-03-16. PMID:9484359. |
the possibility of gene interactions in alzheimer's disease (ad) has been suggested by the finding of an association of the aa genotype of the alpha-1 antichymotrypsin (aact) gene and the apolipoprotein e (apoe) epsilon 4/4 genotype in ad. |
1998-03-16 |
2023-08-12 |
Not clear |
| X Wang, G Ciraolo, R Morris, E Gruenstei. Identification of a neuronal endocytic pathway activated by an apolipoprotein E (apoE) receptor binding peptide. Brain research. vol 778. issue 1. 1998-03-13. PMID:9462872. |
in addition apoe has also been implicated in neural regenerative processes and in the etiology of alzheimer's disease. |
1998-03-13 |
2023-08-12 |
human |
| J R Guyton, S E Miller, M E Martin, W A Khan, A D Roses, W J Strittmatte. Novel large apolipoprotein E-containing lipoproteins of density 1.006-1.060 g/ml in human cerebrospinal fluid. Journal of neurochemistry. vol 70. issue 3. 1998-03-12. PMID:9489746. |
although the critical role of apolipoprotein e (apoe) allelic variation in alzheimer's disease and in the outcome of cns injury is now recognized, the functions of apoe in the cns remain obscure, particularly with regard to lipid metabolism. |
1998-03-12 |
2023-08-12 |
human |
| C Zarow, J Victorof. Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning. Experimental neurology. vol 149. issue 1. 1998-03-06. PMID:9454617. |
the distribution of apolipoprotein e (apoe) mrna was characterized in the hippocampus of humans with alzheimer disease (ad) and in rats with experimental lesions (unilateral ablation of the entorhinal cortex) that model selected features of ad. |
1998-03-06 |
2023-08-12 |
rat |
| G W Rebeck, N C Alonzo, O Berezovska, S D Harr, R B Knowles, J H Growdon, B T Hyman, A J Mende. Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes. Experimental neurology. vol 149. issue 1. 1998-03-06. PMID:9454626. |
recent data have implicated apolipoprotein e (apoe) in neuritic outgrowth, synaptic stability, and alzheimer's disease; these data led us to examine the normal role of apoe-containing lipoproteins in the central nervous system (cns). |
1998-03-06 |
2023-08-12 |
human |
| D C Ewban. Effects of age and ethnicity on the link between APOE epsilon4 and Alzheimer disease. JAMA. vol 279. issue 8. 1998-03-05. PMID:9486746. |
effects of age and ethnicity on the link between apoe epsilon4 and alzheimer disease. |
1998-03-05 |
2023-08-12 |
Not clear |
| M F Shadle. Effects of age and ethnicity on the link between APOE epsilon4 and Alzheimer disease. JAMA. vol 279. issue 8. 1998-03-05. PMID:9486747. |
effects of age and ethnicity on the link between apoe epsilon4 and alzheimer disease. |
1998-03-05 |
2023-08-12 |
Not clear |
| T Muramatsu, M Kato, T Matsui, H Yoshimasu, A Yoshino, S Matsushita, S Higuchi, H Kashim. Apolipoprotein E epsilon 4 allele distribution in Wernicke-Korsakoff syndrome with or without global intellectual deficits. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451723. |
recent genetic studies show that the apolipoprotein e (apoe) epsilon 4 allele is a risk factor for alzheimer's disease (ad). |
1998-02-26 |
2023-08-12 |
Not clear |
| L Dupont-Wallois, C Soulié, N Sergeant, N Wavrant-de Wrieze, M C Chartier-Harlin, A Delacourte, M L Caillet-Boudi. ApoE synthesis in human neuroblastoma cells. Neurobiology of disease. vol 4. issue 5. 1998-02-24. PMID:9440124. |
apolipoprotein e (apoe) is associated with the two hallmarks of alzheimer's disease: a beta deposits and neurofibrillary tangles. |
1998-02-24 |
2023-08-12 |
human |
| L Dupont-Wallois, C Soulié, N Sergeant, N Wavrant-de Wrieze, M C Chartier-Harlin, A Delacourte, M L Caillet-Boudi. ApoE synthesis in human neuroblastoma cells. Neurobiology of disease. vol 4. issue 5. 1998-02-24. PMID:9440124. |
nevertheless, different studies on apoe immunoreactivity reported the presence of apoe in neurons of alzheimer, control, and necrosis pontisubicular brains. |
1998-02-24 |
2023-08-12 |
human |
| R Mayeux, A M Saunders, S Shea, S Mirra, D Evans, A D Roses, B T Hyman, B Crain, M X Tang, C H Phelp. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. The New England journal of medicine. vol 338. issue 8. 1998-02-19. PMID:9468467. |
the epsilon4 allele of the gene encoding apolipoprotein e (apoe) is strongly associated with alzheimer's disease, but its value in the diagnosis remains uncertain. |
1998-02-19 |
2023-08-12 |
Not clear |
| D Fallin, A Kundtz, T Town, A C Gauntlett, R Duara, W Barker, F Crawford, M Mulla. No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample. Neuroscience letters. vol 233. issue 2-3. 1998-01-29. PMID:9350853. |
it is now commonly known that possession of the epsilon4 allele of the apolipoprotein e (apoe) gene confers an increased risk for both familial and sporadic alzheimer's disease (ad), in a dose-dependent way. |
1998-01-29 |
2023-08-12 |
Not clear |
| M J Bullido, M J Artiga, M Recuero, I Sastre, M A García, J Aldudo, C Lendon, S W Han, J C Morris, A Frank, J Vázquez, A Goate, F Valdivies. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia. Nature genetics. vol 18. issue 1. 1998-01-29. PMID:9425904. |
a polymorphism in the regulatory region of apoe associated with risk for alzheimer's dementia. |
1998-01-29 |
2023-08-12 |
Not clear |
| M J Bullido, M J Artiga, M Recuero, I Sastre, M A García, J Aldudo, C Lendon, S W Han, J C Morris, A Frank, J Vázquez, A Goate, F Valdivies. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia. Nature genetics. vol 18. issue 1. 1998-01-29. PMID:9425904. |
the epsilon4 allele of the apolipoprotein e gene (apoe) has been associated with an increased risk of developing alzheimer's disease (ad; refs 1,2). |
1998-01-29 |
2023-08-12 |
Not clear |
| J Jordán, M F Galindo, R J Miller, C A Reardon, G S Getz, M J LaD. Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412500. |
although the genetic link between the epsilon4 allele of apolipoprotein e (apoe) and alzheimer's disease is well established, the isoform-specific activity of apoe underlying this correlation remains unclear. |
1998-01-16 |
2023-08-12 |
human |
| K Shimada, M Yasuda, K Maed. [Apolipoprotein E genotype as a risk factor in Japanese patients with early-onset and late-onset Alzheimer's disease]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 99. issue 8. 1998-01-09. PMID:9369084. |
recent studies have provided evidence of an association of apolipoprotein e (apoe) epsilon 4 allele and late-onset sporadic alzheimer's disease (ad). |
1998-01-09 |
2023-08-12 |
human |
| T J Montine, K S Montine, L L Swif. Central nervous system lipoproteins in Alzheimer's disease. The American journal of pathology. vol 151. issue 6. 1998-01-02. PMID:9403708. |
alzheimer's disease (ad) is the most common form of dementia in the united states and has been associated with apoe genotype. |
1998-01-02 |
2023-08-12 |
Not clear |