| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Nacmias, G Marcon, A Tedde, P Forleo, S Latorraca, S Piacentini, L Amaducci, S Sorb. Implication of alpha1-antichymotrypsin polymorphism in familial Alzheimer's disease. Neuroscience letters. vol 244. issue 2. 1998-06-16. PMID:9572591. |
using the polymerase chain reaction, we analyzed the segregation of the act and apoe polymorphisms in familial alzheimer's disease (fad) patients carrying mutations in presenilin (ps) and app genes and in both early onset (eo) and late onset (lo) fad patients without known mutations. |
1998-06-16 |
2023-08-12 |
Not clear |
| S Sorbi, B Nacmias, A Tedde, S Latorraca, P Forleo, B M Guarnieri, C Petruzzi, E Daneluzzo, L Ortenzi, S Piacentini, L Amaducc. No implication of apolipoprotein E polymorphism in Italian schizophrenic patients. Neuroscience letters. vol 244. issue 2. 1998-06-16. PMID:9572600. |
numerous studies have provided evidence for a genetic association of the apolipoprotein e (apoe) epsilon4 allele and late onset familial and sporadic alzheimer's disease (ad). |
1998-06-16 |
2023-08-12 |
Not clear |
| H Yamanaka, K Kamimura, H Tanahashi, K Takahashi, T Asada, T Tabir. Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE. Neurobiology of aging. vol 19. issue 1 Suppl. 1998-06-12. PMID:9562467. |
genetic risk factors in japanese alzheimer's disease patients: alpha1-act, vldlr, and apoe. |
1998-06-12 |
2023-08-12 |
human |
| H Yamanaka, K Kamimura, H Tanahashi, K Takahashi, T Asada, T Tabir. Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE. Neurobiology of aging. vol 19. issue 1 Suppl. 1998-06-12. PMID:9562467. |
we studied the polymorphism of alpha1-antichymotrypsin (act), very low density lipoprotein receptor (vldlr) and apolipoprotein e (apoe) genes in 200 control subjects and 65 patients with alzheimer's disease (ad) in japanese. |
1998-06-12 |
2023-08-12 |
human |
| A D Roses, J Gilbert, P T Xu, P Sullivan, B Popko, D S Burkhart, T Christian-Rothrock, A M Saunders, N Maeda, D E Schmeche. Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice. Neurobiology of aging. vol 19. issue 1 Suppl. 1998-06-12. PMID:9562469. |
the question of whether apoe is expressed at a comparatively low level in human neurons compared to astrocytes, or whether apoe enters neuronal cytoplasm via altered endosomal metabolism is important to understanding potential pathogenic roles for apoe as a susceptibility gene in alzheimer disease. |
1998-06-12 |
2023-08-12 |
mouse |
| M M Lalowski, K Czyzewski, A Pfeffer, M Barcikowska, H Kwiecińsk. ApoE polymorphism in Polish patients with Alzheimer's disease. Acta neurobiologiae experimentalis. vol 58. issue 1. 1998-06-08. PMID:9583189. |
apoe polymorphism in polish patients with alzheimer's disease. |
1998-06-08 |
2023-08-12 |
Not clear |
| D T Laskowitz, K Horsburgh, A D Rose. Apolipoprotein E and the CNS response to injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 5. 1998-06-04. PMID:9591838. |
although originally described in the context of cholesterol metabolism, interest in the neurobiology of apoe has intensified following the association between apoe genotype and risk of developing alzheimer's disease. |
1998-06-04 |
2023-08-12 |
Not clear |
| D T Laskowitz, K Horsburgh, A D Rose. Apolipoprotein E and the CNS response to injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 5. 1998-06-04. PMID:9591838. |
thus, in addition to the study of disease-specific mechanisms by which apoe may modulate susceptibility of developing alzheimer's disease, there has been an increasing focus on its role in modulating the cns response to acute injury. |
1998-06-04 |
2023-08-12 |
Not clear |
| K S Montine, E Reich, M D Neely, K R Sidell, S J Olson, W R Markesbery, T J Montin. Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype. Journal of neuropathology and experimental neurology. vol 57. issue 5. 1998-06-04. PMID:9596412. |
distribution of reducible 4-hydroxynonenal adduct immunoreactivity in alzheimer disease is associated with apoe genotype. |
1998-06-04 |
2023-08-12 |
Not clear |
| M S Kindy, D J Rade. Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice. The American journal of pathology. vol 152. issue 5. 1998-06-02. PMID:9588907. |
recent studies have demonstrated that apolipoprotein e (apoe), alone or in combination with apolipoprotein j (apoj), and other lipoproteins appear to enhance deposition of amyloid fibrils both in systemic and cerebral amyloids, especially alzheimer's disease (ad). |
1998-06-02 |
2023-08-12 |
mouse |
| J Tyrrell, M Cosgrave, Z Hawi, J McPherson, C O'Brien, J McCalvert, M McLaughlin, B Lawlor, M Gil. A protective effect of apolipoprotein E e2 allele on dementia in Down's syndrome. Biological psychiatry. vol 43. issue 6. 1998-05-28. PMID:9532343. |
the apolipoprotein e (apoe) e4 allele has been associated with an increased risk for alzheimer's disease, whereas the e2 allele has been shown to be protective. |
1998-05-28 |
2023-08-12 |
Not clear |
| I L Notkola, R Sulkava, J Pekkanen, T Erkinjuntti, C Ehnholm, P Kivinen, J Tuomilehto, A Nissine. Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology. vol 17. issue 1. 1998-05-28. PMID:9549720. |
the epsilon 4 allele of the apolipoprotein e (apoe) is associated with alzheimer's disease (ad) and also with elevated serum total cholesterol and low-density lipoprotein levels. |
1998-05-28 |
2023-08-12 |
Not clear |
| E Ilveskoski, T Lehtimäki, T Erkinjuntti, T Koivula, P J Karhune. Rapid apolipoprotein E genotyping from mailed buccal swabs. Journal of neuroscience methods. vol 79. issue 1. 1998-05-26. PMID:9531454. |
genetic polymorphism of apolipoprotein e (apoe) is linked with the risk of cardiovascular and alzheimer's disease (ad). |
1998-05-26 |
2023-08-12 |
Not clear |
| A Fisher, R Brandeis, S Chapman, Z Pittel, D M Michaelso. M1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice. Journal of neurochemistry. vol 70. issue 5. 1998-05-18. PMID:9572284. |
recent studies suggest that apolipoprotein e (apoe) plays a specific role in brain cholinergic function and that the e4 allele of apoe (apoe4), a major risk factor for alzheimer's disease (ad), may predict the extent of cholinergic dysfunction and the efficacy of cholinergic therapy in this disease. |
1998-05-18 |
2023-08-12 |
mouse |
| M J LaDu, S M Gilligan, J R Lukens, V G Cabana, C A Reardon, L J Van Eldik, D M Holtzma. Nascent astrocyte particles differ from lipoproteins in CSF. Journal of neurochemistry. vol 70. issue 5. 1998-05-18. PMID:9572293. |
study of the functional properties of both astrocyte-secreted and csf lipoproteins isolated by techniques that preserve native particle structure may also provide insight into the function of apoe in the pathophysiology of specific neurological diseases such as alzheimer's disease. |
1998-05-18 |
2023-08-12 |
human |
| A Merched, Y Xia, A Papadopoulou, G Siest, S Visviki. Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease. Neuroscience letters. vol 242. issue 2. 1998-05-14. PMID:9533408. |
in order to evaluate genetic apolipoprotein polymorphisms as risk factors for alzheimer's disease (ad), we studied apolipoprotein (apo) aiv after apoe, an apolipoprotein also present in the brain. |
1998-05-14 |
2023-08-12 |
human |
| J C Breitner, G P Jarvik, B L Plassman, A M Saunders, K A Wels. Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years. Alzheimer disease and associated disorders. vol 12. issue 1. 1998-05-14. PMID:9539409. |
the epsilon4 allele at apoe, the polymorphic locus for apolipoprotein e, increases the risk of alzheimer disease (ad), especially among those with the homozygous epsilon4/epsilon4 genotype. |
1998-05-14 |
2023-08-12 |
Not clear |
| R Inzelberg, J Chapman, T A Treves, A Asherov, S Kipervasser, O Hilkewicz, R Verchovsky, S Klimowitzky, A D Korczy. Apolipoprotein E4 in Parkinson disease and dementia: new data and meta-analysis of published studies. Alzheimer disease and associated disorders. vol 12. issue 1. 1998-05-14. PMID:9539410. |
the authors examined whether the epsilon4 allele might be associated with dementia in parkinson disease (pd), given that the dementia of pd shares neuroanatomic and neurochemical features with alzheimer disease (ad) and that many recent studies have found a high prevalence of the epsilon4 allele of apolipoprotein e (apoe) in ad. |
1998-05-14 |
2023-08-12 |
Not clear |
| J M Meyer, J C Breitne. Multiple threshold model for the onset of Alzheimer's disease in the NAS-NRC twin panel. American journal of medical genetics. vol 81. issue 1. 1998-05-13. PMID:9514594. |
the three common alleles at the apoe locus influence the onset and lifetime risk of typical late-onset alzheimer's disease (ad). |
1998-05-13 |
2023-08-12 |
Not clear |
| H Houlden, R Crook, H Backhovens, G Prihar, M Baker, M Hutton, M Rossor, J J Martin, C Van Broeckhoven, J Hard. ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families. American journal of medical genetics. vol 81. issue 1. 1998-05-13. PMID:9514597. |
apoe genotype is a risk factor in nonpresenilin early-onset alzheimer's disease families. |
1998-05-13 |
2023-08-12 |
Not clear |