| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Houlden, R Crook, H Backhovens, G Prihar, M Baker, M Hutton, M Rossor, J J Martin, C Van Broeckhoven, J Hard. ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families. American journal of medical genetics. vol 81. issue 1. 1998-05-13. PMID:9514597. |
the apolipoprotein e (apoe) genotype is a significant risk factor and modulator of age of onset of alzheimer's disease (ad). |
1998-05-13 |
2023-08-12 |
Not clear |
| S Tanaka, J Kawamata, S Shimohama, H Akaki, I Akiguchi, J Kimura, K Ued. Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease. X-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies. Dementia and geriatric cognitive disorders. vol 9. issue 2. 1998-05-05. PMID:9524800. |
inferior temporal lobe atrophy and apoe genotypes in alzheimer's disease. |
1998-05-05 |
2023-08-12 |
Not clear |
| S Tanaka, J Kawamata, S Shimohama, H Akaki, I Akiguchi, J Kimura, K Ued. Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease. X-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies. Dementia and geriatric cognitive disorders. vol 9. issue 2. 1998-05-05. PMID:9524800. |
the apolipoprotein e (apoe) gene epsilon 4 allele is known to be associated with late-onset familial and sporadic alzheimer's disease (ad). |
1998-05-05 |
2023-08-12 |
Not clear |
| Y Sun, S Wu, G Bu, M K Onifade, S N Patel, M J LaDu, A M Fagan, D M Holtzma. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 9. 1998-05-05. PMID:9547235. |
the epsilon4 allele of apolipoprotein e (apoe) is associated with increased risk for alzheimer's disease (ad) and poor outcome after brain injury. |
1998-05-05 |
2023-08-12 |
mouse |
| Y Komatsu, M Horiuchi, N Ishiguro, T Matsui, M Shinagaw. Characterization of the sheep apolipoprotein E (ApoE) gene and allelic variations of the ApoE gene in scrapie Suffolk sheep. Gene. vol 208. issue 2. 1998-05-04. PMID:9524247. |
human apoe epsilon 4 allele is known as a risk factor for alzheimer's disease, and an association of the human apoe genotype with the human prion disease, creutzfeldt-jakob disease, is suggested, albeit controversial. |
1998-05-04 |
2023-08-12 |
human |
| C Holmes, C Russ, G Kirov, K J Aitchison, J F Powell, D A Collier, S Loveston. Apolipoprotein E: depressive illness, depressive symptoms, and Alzheimer's disease. Biological psychiatry. vol 43. issue 3. 1998-04-30. PMID:9494696. |
depressive illness of late onset is also a risk factor for alzheimer's disease (ad), and there is some evidence that the apoe epsilon 2 allele is associated with depressive symptomatology in ad. |
1998-04-30 |
2023-08-12 |
Not clear |
| L Chen, L Baum, H K Ng, Y S Chan, Y T Mak, J Woo, H Chiu, C P Pan. No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese. Neuroscience letters. vol 241. issue 1. 1998-04-28. PMID:9502209. |
the epsilon4 allele of apolipoprotein e (apoe) is a risk factor in late-onset alzheimer's disease (ad). |
1998-04-28 |
2023-08-12 |
Not clear |
| A L Bergem, L Lannfel. Apolipoprotein E type epsilon4 allele, heritability and age at onset in twins with Alzheimer disease and vascular dementia. Clinical genetics. vol 52. issue 5. 1998-04-24. PMID:9520135. |
the apolipoprotein e (apoe) epsilon4 allele is a risk factor in alzheimer disease (ad), but not in vascular dementia (vad). |
1998-04-24 |
2023-08-12 |
Not clear |
| U Beffert, N Aumont, D Dea, S Lussier-Cacan, J Davignon, J Poirie. Beta-amyloid peptides increase the binding and internalization of apolipoprotein E to hippocampal neurons. Journal of neurochemistry. vol 70. issue 4. 1998-04-23. PMID:9523562. |
the frequency of the epsilon4 allele of apolipoprotein e (apoe) is increased in late-onset and sporadic forms of alzheimer's disease (ad). |
1998-04-23 |
2023-08-12 |
human |
| J G Sayi, N B Patel, D R Premkumar, A Adem, B Winblad, W B Matuja, E P Mtui, S Gatere, R P Friedland, E Koss, R N Kalari. Apolipoprotein E polymorphism in elderly east Africans. East African medical journal. vol 74. issue 10. 1998-04-23. PMID:9529753. |
current advances have shown the apolipoprotein e (apoe)-epsilon 4 allele to be highly associated with late-onset familial and sporadic alzheimer's disease (ad) in western populations. |
1998-04-23 |
2023-08-12 |
human |
| M R Farlow, D K Lahiri, J Poirier, J Davignon, L Schneider, S L Hu. Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease. Neurology. vol 50. issue 3. 1998-04-17. PMID:9521254. |
we studied the effects of apolipoprotein e (apoe) genotype and gender on clinical response to tacrine in patients with mild to moderate alzheimer's disease (ad). |
1998-04-17 |
2023-08-12 |
human |
| J C Lambert, F Pasquier, D Cottel, B Frigard, P Amouyel, M C Chartier-Harli. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease. Human molecular genetics. vol 7. issue 3. 1998-04-16. PMID:9467014. |
a new polymorphism in the apoe promoter associated with risk of developing alzheimer's disease. |
1998-04-16 |
2023-08-12 |
Not clear |
| J C Lambert, F Pasquier, D Cottel, B Frigard, P Amouyel, M C Chartier-Harli. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease. Human molecular genetics. vol 7. issue 3. 1998-04-16. PMID:9467014. |
the epsilon4 allele of the apolipoprotein e gene (apoe), one of the main allele of apoe polymorphism, is a major risk factor for the development of alzheimer's disease. |
1998-04-16 |
2023-08-12 |
Not clear |
| J C Lambert, F Pasquier, D Cottel, B Frigard, P Amouyel, M C Chartier-Harli. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease. Human molecular genetics. vol 7. issue 3. 1998-04-16. PMID:9467014. |
we studied the impact of this new polymorphism with those of other markers of the apoe locus in a large case-control study and observed that th1/e47cs modulated the influence of the apoe epsilon4 allele on the risk of alzheimer's disease. |
1998-04-16 |
2023-08-12 |
Not clear |
| S J Allen, S H MacGowan, S Tyler, G K Wilcock, A G Robertson, P H Holden, S K Smith, D Dawbar. Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype. Neuroscience letters. vol 239. issue 1. 1998-04-15. PMID:9547165. |
apolipoprotein e (apoe) is a potent risk factor for alzheimer's disease. |
1998-04-15 |
2023-08-12 |
human |
| J G Crawfor. Alzheimer's disease risk factors as related to cerebral blood flow: additional evidence. Medical hypotheses. vol 50. issue 1. 1998-04-14. PMID:9488178. |
in this report an attempt is made to strengthen a hypothesis that reduced cerebral blood flow may be a required cofactor in the cause of alzheimer's disease with examples of additional putative risks, including aluminum, apoe 4 alleles, estrogen deficiency, family history of dementia, low education-attainment, olfactory deficit, and underactivity coupled with gender, considered to have a relationship or potential relationship with reduced cerebral blood flow. |
1998-04-14 |
2023-08-12 |
Not clear |
| T C Dickson, H L Saunders, J C Vicker. Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease. Neuropathology and applied neurobiology. vol 23. issue 6. 1998-04-10. PMID:9460714. |
although the inheritance of certain apolipoprotein e (apoe) alleles has been recognized as a genetic risk factor for alzheimer's disease, the role of apoe in the pathology underlying this disease is unclear. |
1998-04-10 |
2023-08-12 |
Not clear |
| T C Dickson, H L Saunders, J C Vicker. Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease. Neuropathology and applied neurobiology. vol 23. issue 6. 1998-04-10. PMID:9460714. |
in alzheimer's disease cases, beta-amyloid plaques showing high apoe immunoreactivity were localized to layers ii, iii and v of the neocortex. |
1998-04-10 |
2023-08-12 |
Not clear |
| T C Dickson, H L Saunders, J C Vicker. Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease. Neuropathology and applied neurobiology. vol 23. issue 6. 1998-04-10. PMID:9460714. |
in preclinical alzheimer's disease cases, most plaques were double labelled for beta-amyloid and apoe. |
1998-04-10 |
2023-08-12 |
Not clear |
| O Combarros, C Leno, A Oterino, J Berciano, J L Fernández-Luna, C Fernández-Viadero, N Peña, J Miró, M Delgad. Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease. Acta neurologica Scandinavica. vol 97. issue 1. 1998-04-06. PMID:9482681. |
the role of gender in alzheimer's disease (ad), and its possible interaction with apolipoprotein e (apoe), has been controversial. |
1998-04-06 |
2023-08-12 |
Not clear |